The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Elevated Nicotianamine Levels in Arabidopsis halleri Roots Play a Key Role in Zinc Hyperaccumulation
Open accessAbstract
Zn deficiency is among the leading health risk factors in developing countries. Breeding of Zn-enriched crops is expected to be facilitated by molecular dissection of plant Zn hyperaccumulation (i.e., the ability of certain plants to accumulate Zn to levels >100-fold higher than normal plants). The model hyperaccumulators Arabidopsis halleri and Noccaea caerulescens share elevated nicotianamine synthase (NAS) expression relative to nonaccumulators among a core of alterations in metal homeostasis. Suppression of Ah-NAS2 by RNA interference (RNAi) resulted in strongly reduced root nicotianamine (NA) accumulation and a concomitant decrease in root-to-shoot translocation of Zn. Speciation analysis by size-exclusion chromatography coupled to inductively coupled plasma mass spectrometry showed that the dominating Zn ligands in roots were NA and thiols. In NAS2-RNAi plants, a marked increase in Zn-thiol species was observed. Wild-type A. halleri plants cultivated on their native soil showed elemental profiles very similar to those found in field samples. Leaf Zn concentrations in NAS2-RNAi lines, however, did not reach the Zn hyperaccumulation threshold. Leaf Cd accumulation was also significantly reduced. These results demonstrate a role for NAS2 in Zn hyperaccumulation also under near-natural conditions. We propose that NA forms complexes with Zn(II) in root cells and facilitates symplastic passage of Zn(II) toward the xylem.
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Cites
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A long way ahead: understanding and engineering plant metal accumulation
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Self-citationZinc transporters and the cellular trafficking of zinc
Eide, D. J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.03.005 · Cited by 874
Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4
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Self-citationKrämer, U., Talke, I. N., & Hanikenne, M. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.04.010 · Cited by 583
Self-citationBecher, M., Talke, I. N., Krall, L., & Krämer, U. (2004) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01959.x · Cited by 568
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“Regardless of soil Zn content, A. halleri shows Zn hyperaccumulation (Bert et al., 2000).”
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Cited by
The zinc homeostasis network of land plants
Sinclair, S. A., & Krämer, U. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.05.016 · Cited by 502
Self-citationTrace metal metabolism in plants
Andresen, E., Peiter, E., & Küpper, H. (2018) · Journal of Experimental Botany · doi:10.1093/jxb/erx465 · Cited by 431
A review of green remediation strategies for heavy metal contaminated soil
Wang, L., Rinklebe, J., Tack, F. M. G., & Hou, D. (2021) · Soil Use and Management · doi:10.1111/sum.12717 · Cited by 317
Compartmentation and complexation of metals in hyperaccumulator plants
Leitenmaier, B., & Küpper, H. (2013) · Frontiers in Plant Science · doi:10.3389/fpls.2013.00374 · Cited by 272
Physiological and molecular mechanisms of metal accumulation in hyperaccumulator plants
Sytar, O., Ghosh, S., Malinska, H., Zivcak, M., & Brestic, M. (2020) · Physiologia Plantarum · doi:10.1111/ppl.13285 · Cited by 192
Metadata
- Authors
- Deinlein, U., Weber, M., Schmidt, H., Rensch, S., Trampczynska, A., Hansen, T. H., Husted, S., Schjoerring, J. K., Talke, I. N., Krämer, U., & Clemens, S.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-02
- Volume
- 24
- Issue
- 2
- Pages
- 708-723
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2102189122
- Cited by
- 226
- References
- 10
- FWCI
- 26.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Deinlein, U., Weber, M., Schmidt, H., Rensch, S., Trampczynska, A., Hansen, T. H., Husted, S., Schjoerring, J. K., Talke, I. N., Krämer, U., & Clemens, S. (2012). Elevated Nicotianamine Levels in Arabidopsis halleri Roots Play a Key Role in Zinc Hyperaccumulation. The Plant Cell. https://doi.org/10.1105/tpc.111.095000
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