Modeling the glucose sensor error
Abstract
Continuous glucose monitoring (CGM) sensors are portable devices, employed in the treatment of diabetes, able to measure glucose concentration in the interstitium almost continuously for several days. However, CGM sensors are not as accurate as standard blood glucose (BG) meters. Studies comparing CGM versus BG demonstrated that CGM is affected by distortion due to diffusion processes and by time-varying systematic under/overestimations due to calibrations and sensor drifts. In addition, measurement noise is also present in CGM data. A reliable model of the different components of CGM inaccuracy with respect to BG (briefly, "sensor error") is important in several applications, e.g., design of optimal digital filters for denoising of CGM data, real-time glucose prediction, insulin dosing, and artificial pancreas control algorithms. The aim of this paper is to propose an approach to describe CGM sensor error by exploiting n multiple simultaneous CGM recordings. The model of sensor error description includes a model of blood-to-interstitial glucose diffusion process, a linear time-varying model to account for calibration and sensor drift-in-time, and an autoregressive model to describe the additive measurement noise. Model orders and parameters are identified from the n simultaneous CGM sensor recordings and BG references. While the model is applicable to any CGM sensor, here, it is used on a database of 36 datasets of type 1 diabetic adults in which n = 4 Dexcom SEVEN Plus CGM time series and frequent BG references were available simultaneously. Results demonstrates that multiple simultaneous sensor data and proper modeling allow dissecting the sensor error into its different components, distinguishing those related to physiology from those related to technology.
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Continuous glucose monitoring and intensive treatment of type 1 diabetes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0805017 · Cited by 1,559 · see citing works
<i>In Silico</i> Preclinical Trials: A Proof of Concept in Closed-Loop Control of Type 1 Diabetes
Kovatchev, B. P., Breton, M., Dalla Man, C., & Cobelli, C. (2009) · Journal of Diabetes Science and Technology · doi:10.1177/193229680900300106 · Cited by 760 · see citing works
Artificial Pancreas: Past, Present, Future
Cobelli, C., Renard, E., & Kovatchev, B. (2011) · Diabetes · doi:10.2337/db11-0654 · Cited by 600 · see citing works
Hovorka, R., Allen, J. M., Elleri, D., Chassin, L. J., Harris, J. R., Xing, D., Kollman, C., Hovorka, T., Larsen, A. M. F., Nodale, M., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61998-x · Cited by 448 · see citing works
Nocturnal Glucose Control with an Artificial Pancreas at a Diabetes Camp
Phillip, M., Battelino, T., Atlas, E., Kordonouri, O., Bratina, N., Miller, S., Biester, T., Stefanija, M. A., Muller, I., Nimri, R., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1206881 · Cited by 431 · see citing works
Rebrin, K., Steil, G. M., van Antwerp, W. P., & Mastrototaro, J. J. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.3.e561 · Cited by 367 · see citing works
Fully Integrated Artificial Pancreas in Type 1 Diabetes
Breton, M., Farret, A., Bruttomesso, D., Anderson, S., Magni, L., Patek, S., Dalla Man, C., Place, J., Demartini, S., Del Favero, S., et al. (2012) · Diabetes · doi:10.2337/db11-1445 · Cited by 315 · see citing works
Symmetrization of the Blood Glucose Measurement Scale and Its Applications
Kovatchev, B. P., Cox, D. J., Gonder-Frederick, L. A., & Clarke, W. L. (1997) · Diabetes Care · doi:10.2337/diacare.20.11.1655 · Cited by 258 · see citing works
Comparison of the Numerical and Clinical Accuracy of Four Continuous Glucose Monitors
Kovatchev, B. P., Anderson, S. M., Heinemann, L., & Clarke, W. L. (2008) · Diabetes Care · doi:10.2337/dc07-2401 · Cited by 236 · see citing works
Service, F. J. (2013) · Diabetes · doi:10.2337/db12-1396 · Cited by 222 · see citing works
Continuous Glucose Monitoring: Real-Time Algorithms for Calibration, Filtering, and Alarms
Bequette, B. W. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400222 · Cited by 193 · see citing works
Blood Glucose Control in Type 1 Diabetes With a Bihormonal Bionic Endocrine Pancreas
Russell, S. J., El-Khatib, F. H., Nathan, D. M., Magyar, K. L., Jiang, J., & Damiano, E. R. (2012) · Diabetes Care · doi:10.2337/dc12-0071 · Cited by 176 · see citing works
Analysis, Modeling, and Simulation of the Accuracy of Continuous Glucose Sensors
Breton, M. D., & Kovatchev, B. P. (2008) · Journal of Diabetes Science and Technology · doi:10.1177/193229680800200517 · Cited by 173 · see citing works
Pilot Studies of Wearable Outpatient Artificial Pancreas in Type 1 Diabetes
Cobelli, C., Renard, É., Kovatchev, B. P., Keith-Hynes, P., Brahim, N. B., Place, J., Favero, S. D., Breton, M. D., Farret, A., Bruttomesso, D., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0660 · Cited by 119 · see citing works
A Comparative Effectiveness Analysis of Three Continuous Glucose Monitors
Damiano, E. R., El-Khatib, F. H., Zheng, H., Nathan, D. M., & Russell, S. J. (2012) · Diabetes Care · doi:10.2337/dc12-0070 · Cited by 109 · see citing works
Real-Time Improvement of Continuous Glucose Monitoring Accuracy
Facchinetti, A., Sparacino, G., Guerra, S., Luijf, Y. M., DeVries, J. H., Mader, J. K., Ellmerer, M., Benesch, C., Heinemann, L., Bruttomesso, D., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0736 · Cited by 106 · see citing works
Self-citation“Smart” Continuous Glucose Monitoring Sensors: On-Line Signal Processing Issues
Sparacino, G., Facchinetti, A., & Cobelli, C. (2010) · Sensors · doi:10.3390/s100706751 · Cited by 95 · see citing works
Self-citationEnhanced Accuracy of Continuous Glucose Monitoring by Online Extended Kalman Filtering
Facchinetti, A., Sparacino, G., & Cobelli, C. (2010) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2009.0158 · Cited by 70 · see citing works
Self-citationJoubert, M., & Reznik, Y. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.12.010 · Cited by 70 · see citing works
Analysis of Time Lags and Other Sources of Error of the DexCom SEVEN Continuous Glucose Monitor
Kamath, A., Mahalingam, A., & Brauker, J. H. (2009) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2009.0060 · Cited by 69 · see citing works
Facchinetti, A., Sparacino, G., & Cobelli, C. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400102 · Cited by 67 · see citing works
Self-citationMcGarraugh, G. V., & Bergenstal, R. M. (2009) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2008.0047 · Cited by 61 · see citing works
Enhancing the Accuracy of Subcutaneous Glucose Sensors: A Real-Time Deconvolution-Based Approach
Guerra, S., Facchinetti, A., Sparacino, G., Nicolao, G. D., & Cobelli, C. (2012) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2012.2191782 · Cited by 61 · see citing works
Self-citationFacchinetti, A., Sparacino, G., & Cobelli, C. (2011) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2011.2161083 · Cited by 60 · see citing works
Self-citationGlycemic Variability: Measurement and Utility in Clinical Medicine and Research—One Viewpoint
Rodbard, D. (2011) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2011.0104 · Cited by 54 · see citing works
Lane, J. E., Shivers, J. P., & Zisser, H. (2013) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32835edb9d · Cited by 50 · see citing works
Zecchin, C., Facchinetti, A., Sparacino, G., & Cobelli, C. (2013) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2012.0208 · Cited by 47 · see citing works
Self-citationA Dynamic Risk Measure from Continuous Glucose Monitoring Data
Guerra, S., Sparacino, G., Facchinetti, A., Schiavon, M., Man, C. D., & Cobelli, C. (2011) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2011.0006 · Cited by 37 · see citing works
Self-citationLunn, D. J., Wei, C., & Hovorka, R. (2011) · Statistics in Medicine · doi:10.1002/sim.4254 · Cited by 34 · see citing works
The Accuracy Benefit of Multiple Amperometric Glucose Sensors in People With Type 1 Diabetes
Castle, J. R., Pitts, A., Hanavan, K., Muhly, R., Youssef, J. E., Karvetski, C., Kovatchev, B. P., & Ward, W. K. (2012) · Diabetes Care · doi:10.2337/dc11-1929 · Cited by 30 · see citing works
An Overview of Continuous Glucose Monitoring Systems
Cox, M. A. (2009) · Journal of Pediatric Health Care · doi:10.1016/j.pedhc.2009.06.002 · Cited by 25 · see citing works
Methods of Evaluating the Utility of Continuous Glucose Monitor Alerts
Kamath, A., Mahalingam, A., & Brauker, J. H. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400108 · Cited by 12 · see citing works
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Bhavnani, S. P., Narula, J., & Sengupta, P. P. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv770 · Cited by 460 · see citing works
Chase, J., Preiser, J., Dickson, J. L., Pironet, A., Chiew, Y., Pretty, C., Shaw, G., Benyó, B., Moeller, K., Safaei, S., et al. (2018) · BioMedical Engineering OnLine · doi:10.1186/s12938-018-0455-y · Cited by 169 · see citing works
Juan, C. G., Bronchalo, E., Potelon, B., Quendo, C., Ávila-Navarro, E., & Sabater-Navarro, J. M. (2018) · IEEE Transactions on Instrumentation and Measurement · doi:10.1109/tim.2018.2866743 · Cited by 177 · see citing works
Continuous glucose monitoring sensors: past, present and future algorithmic challenges
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Self-citationThe Artificial Pancreas: How Closed-Loop Control Is Revolutionizing Diabetes
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Artificial Pancreas: Model Predictive Control Design from Clinical Experience
Toffanin, C., Messori, M., Palma, F. D., Nicolao, G. D., Cobelli, C., & Magni, L. (2013) · Journal of Diabetes Science and Technology · doi:10.1177/193229681300700607 · Cited by 106 · see citing works
Continuous glucose monitoring in neonates: a review
McKinlay, C. J. D., Chase, J. G., Dickson, J. L., Harris, D. L., Alsweiler, J. M., & Harding, J. E. (2017) · Maternal Health Neonatology and Perinatology · doi:10.1186/s40748-017-0055-z · Cited by 87 · see citing works
Facchinetti, A., Del Favero, S., Sparacino, G., & Cobelli, C. (2015) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-014-1226-y · Cited by 80 · see citing works
Self-citationResalat, N., El Youssef, J., Tyler, N., Castle, J., & Jacobs, P. G. (2019) · PLOS ONE · doi:10.1371/journal.pone.0217301 · Cited by 78 · see citing works
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Zhou, T., Dickson, J. L., Shaw, G. M., & Chase, J. G. (2017) · Journal of Diabetes Science and Technology · doi:10.1177/1932296817738791 · Cited by 26 · see citing works
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Vettoretti, M., Facchinetti, A., Favero, S. D., Sparacino, G., & Cobelli, C. (2015) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2015.2426217 · Cited by 25 · see citing works
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Camerlingo, N., Siviero, I., Vettoretti, M., Sparacino, G., Favero, S. D., & Facchinetti, A. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1280233 · Cited by 12 · see citing works
Self-citationJafar, A., Pasqua, M., Olson, B., & Haidar, A. (2023) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2023.102749 · Cited by 11 · see citing works
Fault Detection in Artificial Pancreas: A Model-Free approach
Meneghetti, L., Terzi, M., Susto, G. A., Favero, S. D., & Cobelli, C. (2018) · IEEE Conference on Decision and Control (CDC) · doi:10.1109/cdc.2018.8619048 · Cited by 11 · see citing works
Boiroux, D., Aradóttir, T. B., Hagdrup, M., Poulsen, N. K., Madsen, H., & Jørgensen, J. B. (2015) · IFAC-PapersOnLine · doi:10.1016/j.ifacol.2015.10.132 · Cited by 11 · see citing works
A Nonlinear Model Predictive Control Strategy for Glucose Control in People with Type 1 Diabetes
Boiroux, D., & Jørgensen, J. B. (2018) · IFAC-PapersOnLine · doi:10.1016/j.ifacol.2018.11.644 · Cited by 11 · see citing works
Jia, Z., Huang, L., Liu, H., Huang, Y., Li, W., Pi, X., & Zheng, X. (2019) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-019-03142-7 · Cited by 11 · see citing works
A New Stochastic Approach for Modeling Glycemic Disturbances in Type 2 Diabetes
Clausen, H. G., Knudsen, T., Ahdab, M. A., Aradóttir, T. B., Schmidt, S., Nørgaard, K., & Leth, J. (2021) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2021.3074868 · Cited by 10 · see citing works
Calibrating Glucose Sensors at the Edge: A Stress Generation Model for Tiny ML Drift Compensation
Sabatini, A., Cenerini, C., Vollero, L., & Pau, D. P. (2024) · BioMedInformatics · doi:10.3390/biomedinformatics4020083 · Cited by 9 · see citing works
Adaptive Unscented Kalman Filter using Maximum Likelihood Estimation
Mahmoudi, Z., Poulsen, N. K., Madsen, H., & Jørgensen, J. B. (2017) · IFAC-PapersOnLine · doi:10.1016/j.ifacol.2017.08.356 · Cited by 9 · see citing works
Knopp, J. L., Signal, M., Harris, D. L., Marics, G., Weston, P. J., Harding, J. E., Tóth‐Heyn, P., Homlok, J., Benyó, B. I., & Chase, J. G. (2018) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2018.10.005 · Cited by 9 · see citing works
Faggionato, E., Schiavon, M., Ekhlaspour, L., Buckingham, B. A., & Man, C. D. (2023) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2023.3324206 · Cited by 8 · see citing works
Identification of CGM Time Delays and Implications for BG Control in T1DM
Reiterer, F., Polterauer, P., Freckmann, G., & del Re, L. (2016) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-3-319-32703-7_39 · Cited by 8 · see citing works
Model-based glycaemic control: methodology and initial results from neonatal intensive care
Dickson, J. L., Chase, J. G., Lynn, A. M., & Shaw, G. M. (2016) · Biomedizinische Technik/Biomedical Engineering · doi:10.1515/bmt-2016-0051 · Cited by 8 · see citing works
The state of variability: A vision for descriptors of glycaemia
Zhou, T., Knopp, J. L., & Chase, J. G. (2019) · Annual Reviews in Control · doi:10.1016/j.arcontrol.2019.06.004 · Cited by 8 · see citing works
DeJournett, J., & DeJournett, L. (2017) · Journal of Diabetes Science and Technology · doi:10.1177/1932296817711297 · Cited by 7 · see citing works
Simulating Realistic Continuous Glucose Monitor Time Series By Data Augmentation
Gomez, L., Toye, A. A., Hum, R. S., & Kleinberg, S. (2023) · Journal of Diabetes Science and Technology · doi:10.1177/19322968231181138 · Cited by 5 · see citing works
Discrete LPV Modeling of Diabetes Mellitus for Control Purposes
Eigner, G., Siket, M., Szakál, A., Rudas, I. J., & Kovács, L. (2018) · Conference proceedings/Conference proceedings - IEEE International Conference on Systems, Man, and Cybernetics · doi:10.1109/smc.2018.00438 · Cited by 5 · see citing works
Calibration of an optical sensor for in vivo blood glucose maeasurenaent
Bagal, T., & Bhole, K. (2019) · International Conference on Intelligent Computing, Instrumentation and Control Technologies (ICICICT) · doi:10.1109/icicict46008.2019.8993348 · Cited by 5 · see citing works
Autoencoder-Based Detection of Insulin Pump Faults in Type 1 Diabetes Treatment
Idi, E., Prendin, F., Sparacino, G., & Favero, S. D. (2024) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2024.3518233 · Cited by 5 · see citing works
Enhancing Glucose Sensor Models: Modeling the Drop-Outs
Emami, A., RABASA-LHORET, R. P. R., & Haidar, A. (2015) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2014.0309 · Cited by 5 · see citing works
Deichmann, J., & Kaltenbach, H. (2023) · Journal of Process Control · doi:10.1016/j.jprocont.2023.103042 · Cited by 5 · see citing works
Manzoni, E., Idi, E., Camerlingo, N., Facchinetti, A., Sparacino, G., & Favero, S. D. (2025) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2025.3536805 · Cited by 4 · see citing works
Self-citationSetford, S. J. (2025) · Journal of Diabetes Science and Technology · doi:10.1177/19322968251377026 · Cited by 4 · see citing works
Fera, N., Procopio, A., Zaffino, P., Cutruzzolà, A., Irace, C., & Cosentino, C. (2026) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2026.111601 · Cited by 4 · see citing works
Somers, R. J., Walkinshaw, N., Hierons, R. M., Elliott, D., Iqbal, A., & Walkinshaw, E. (2025) · Software Testing Verification and Reliability · doi:10.1002/stvr.70000 · Cited by 8 · see citing works
The development of advanced mathematical models for continuous glucose sensors
Gao, M. Z., & Orazem, M. E. (2021) · Electrochimica Acta · doi:10.1016/j.electacta.2021.138226 · Cited by 4 · see citing works
Kovács, L., Siket, M., Rudas, I. J., Szakál, A., & Eigner, G. (2019) · Conference proceedings/Conference proceedings - IEEE International Conference on Systems, Man, and Cybernetics · doi:10.1109/smc.2019.8914014 · Cited by 4 · see citing works
Kalman Filtering of Discrete LPV Diabetes Mellitus Model for Control Purposes
Eigner, G., Siket, M., & Kovács, L. (2018) · IEEE International Symposium on Computational Intelligence and Informatics (CINTI) · doi:10.1109/cinti.2018.8928205 · Cited by 4 · see citing works
Garnica, Ó., Lanchares, J., Velasco, J. M., Hidalgo, J. I., & Botella, M. (2020) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2020.101934 · Cited by 4 · see citing works
State Space Temporal Gaussian Processes for Glucose Measurements
Ahdab, M. A., Knudsen, T., & Leth, J. (2022) · European Control Conference (ECC) · doi:10.23919/ecc55457.2022.9838040 · Cited by 4 · see citing works
Bidarahalli, N., Rajesh, M., Velappan, V., & Krishnan, P. T. (2018) · International Conference on Circuits, Control, Communication and Computing (I4C) · doi:10.1109/cimca.2018.8739339 · Cited by 3 · see citing works
Continuous Glucose Monitoring: Using CGM to Guide Insulin Therapy Virtual Trials Results
Mombaerts, L., Thomas, F., Signal, M., Desaive, T., & Chase, J. G. (2015) · IFAC-PapersOnLine · doi:10.1016/j.ifacol.2015.10.124 · Cited by 3 · see citing works
A Modular Open-Source Framework for In-Browser Diabetes Simulation
Peuscher, H., Schrills, T., Eichenlaub, M., & Jørgensen, J. B. (2024) · IFAC-PapersOnLine · doi:10.1016/j.ifacol.2024.11.055 · Cited by 3 · see citing works
Boiroux, D., Ritschel, T. K. S., Poulsen, N. K., Madsen, H., & Jørgensen, J. B. (2019) · IEEE Conference on Decision and Control (CDC) · doi:10.1109/cdc40024.2019.9029672 · Cited by 3 · see citing works
- Authors
- Facchinetti, A., Del Favero, S., Sparacino, G., Castle, J. R., Ward, W. K., & Cobelli, C.
- Affiliations
- University of Padua (IT)
- Oregon Health & Science University (US)
- Venue
- IEEE Transactions on Biomedical Engineering
- Published
- 2014-03
- Volume
- 61
- Issue
- 3
- Pages
- 620-629
- ISSN
- 0018-9294 (ISSN-L)
- 1558-2531
- OpenAlex
- W2028300946
- Cited by
- 130
- References
- 32
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 8 · 2023: 11 · 2022: 2 · 2021: 8 · 2020: 10 · 2019: 15 · 2018: 17 · 2017: 18 · 2016: 16 · 2015: 9 · 2014: 4 · 2013: 1
- FWCI
- 7.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Transactions on Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Physical Sciences › Engineering › Control and Systems Engineering › Control Systems and Identification
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Keywords
- continuous glucose monitoring, sensor error modeling, sensor drift, calibration error, measurement noise, autoregressive noise model, linear time-varying model, type 1 diabetes
- MeSH terms
- Algorithms, Blood Glucose, Calibration, Diabetes Mellitus, Type 1, Humans, Models, Biological, Databases, Factual, Monitoring, Ambulatory
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