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Cited by 353

The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.

A Review of Low-Intensity Pulsed Ultrasound for Therapeutic Applications

Jiang, Xiaoxue, Savchenko, Oleksandra, Li, Yufeng, Qi, Shiang, Yang, Tianlin, Zhang, Wei, Chen, Jie·2019·IEEE Transactions on Biomedical Engineering
DOI 10.1109/tbme.2018.2889669
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Abstract

Ultrasound therapy has a long history of novel applications in medicine. Compared to high-intensity ultrasound used for tissue heating, low-intensity ultrasound has drawn increasing attention recently due to its ability to induce therapeutic changes without biologically significant temperature increase. Low-intensity pulsed ultrasound (LIPUS) is a specific type of ultrasound that delivers at a low intensity and outputs in the mode of pulsed waves. It has minimal thermal effects while maintaining the transmission of acoustic energy to the target tissue, which is able to provide noninvasive physical stimulation for therapeutic applications. LIPUS has been demonstrated to accelerate the healing of fresh fracture, nonunion and delayed union in both animal and clinical studies. The effectiveness of LIPUS for the applications of soft-tissue regeneration and inhibiting inflammatory responses has also been investigated experimentally. Additionally, research has shown that LIPUS is a promising modality for neuromodulation. The purpose of this review is to provide an overview of the recent developments of LIPUS for therapeutic applications, based on the papers that report positive effects, and to present the findings on the understanding of its mechanism. Current available LIPUS devices are also briefly described in this paper.

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Metadata

Authors
Jiang, X., Savchenko, O., Li, Y., Qi, S., Yang, T., Zhang, W., & Chen, J.
Venue
IEEE Transactions on Biomedical Engineering
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Published
2019-10
Volume
66
Issue
10
Pages
2704-2718
ISSN
  • 0018-9294 (ISSN-L)
  • 1558-2531
DOI
10.1109/tbme.2018.2889669
OpenAlex
W2906406205
Cited by
353
References
103
FWCI
5.38
Type
journal article
Language
en
Open access
closed

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