The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Fascicular Perineurium Thickness, Size, and Position Affect Model Predictions of Neural Excitation
Open accessAbstract
The number of applications using neural prosthetic interfaces is expanding. Computer models are a valuable tool to evaluate stimulation techniques and electrode designs. Although our understanding of neural anatomy has improved, its impact on the effects of neural stimulation is not well understood. This study evaluated the effects of fascicle perineurial thickness, diameter, and position on axonal excitation thresholds and population recruitment using finite element models and NEURON simulations. The perineurial thickness of human fascicles was found to be 3.0% +/- 1.0% of the fascicle diameter. Increased perineurial thickness and fascicle diameter increased activation thresholds. The presence of a large neighboring fascicle caused a significant change in activation of a smaller target fascicle by as much as 80% +/- 11% of the total axon population. Smaller fascicles were recruited at lower amplitudes than neighboring larger fascicles. These effects were further illustrated in a realistic model of a human femoral nerve surrounded by a nerve cuff electrode. The data suggest that fascicular selectivity is strongly dependent upon the anatomy of the nerve being stimulated. Therefore, accurate representations of nerve anatomy are required to develop more accurate computer models to evaluate and optimize nerve electrode designs for neural prosthesis applications.
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“Since the electrodes and the nerve fibers are separated by the perineurium, higher stimulation currents are required to achieve sensations than the case of intra-fascicular interfaces (Grinberg et al., 2008).”
From Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review. (2017) · cites this paper as Grinberg et al., 2008
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, since the contacts are separated from the nerve fibers by the perineurium, higher stimulation currents are required to achieve sensation than for intra-fascicular electrodes (Grinberg et al., 2008).”
From Biomimetic approaches to bionic touch through a peripheral nerve interface (2015) · cites this paper as Grinberg et al., 2008
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In the citing paper
“This is because the size of the perineurium is directly proportional to the size of the fascicle.”
From Directed stimulation with interfascicular interfaces for peripheral nerve stimulation (2021) · cites this paper as [51]
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“This shunting can cause the current from an extraneural source to be directed away from a larger, more resistive fascicle toward a smaller, less resistive fascicle [51].”
From Directed stimulation with interfascicular interfaces for peripheral nerve stimulation (2021) · cites this paper as [51]
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“The threshold for activation of a smaller fascicle is generally lower than a larger fascicle [51].”
From Directed stimulation with interfascicular interfaces for peripheral nerve stimulation (2021) · cites this paper as [51]
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Citations
Cites
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InfluentialTECHNIQUES FOR PRIMARY NERVE REPAIR
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Cited by
Sorted by citations
Oddo, C. M., Raspopović, S., Artoni, F., Mazzoni, A., Spigler, G., Petrini, F. M., Giambattistelli, F., Vecchio, F., Miraglia, F., Zollo, L., et al. (2016) · eLife · doi:10.7554/elife.09148 · Cited by 339
“Perineurium had a thickness of 3% of the diameter of the fascicles (Grinberg et al., 2008) , and coordinates were interpolated.”
BackgroundSchiefer, M., Tan, D., Sidek, S. M., & Tyler, D. J. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/1/016001 · Cited by 255
Self-citationBiomimetic approaches to bionic touch through a peripheral nerve interface
Saal, H. P., & Bensmaia, S. J. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.06.010 · Cited by 179
“However, since the contacts are separated from the nerve fibers by the perineurium, higher stimulation currents are required to achieve sensation than for intra-fascicular electrodes (Grinberg et al., 2008).”
Tan, D. W., Schiefer, M. A., Keith, M. W., Anderson, J. R., & Tyler, D. J. (2015) · Journal of Neural Engineering · doi:10.1088/1741-2560/12/2/026002 · Cited by 175
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“The perineurium was also modeled as an isotropic conductor according to [ 25 ] with a value of 0.0021 S/m.”
MethodInfluential
Metadata
- Authors
- Grinberg, Y., Schiefer, M. A., Tyler, D. J., & Gustafson, K. J.
- Affiliations
- Case Western Reserve University (US)
- Venue
- IEEE Transactions on Neural Systems and Rehabilitation Engineering
- Published
- 2008-12
- Volume
- 16
- Issue
- 6
- Pages
- 572-581
- ISSN
- 1534-4320 (ISSN-L)
- 1558-0210
- PMC
- PMC2918421
- OpenAlex
- W2097925212
- Cited by
- 145
- References
- 38
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 7 · 2023: 17 · 2022: 15 · 2021: 10 · 2020: 12 · 2019: 8 · 2018: 13 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 2 · 2013: 4 · 2012: 6
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- IEEE Transactions on Neural Systems and Rehabilitation Engineering (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- OhioLink ETD Center (Ohio Library and Information Network) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 077089, R01DK077089)
- National Institute of Biomedical Imaging and Bioengineering (EB-001889, R01EB001889)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- peripheral nerve stimulation, cuff electrodes, femoral nerve, finite element analysis, neural simulation, nerve anatomy
- MeSH terms
- Action Potentials, Animals, Computer Simulation, Differential Threshold, Electric Stimulation, Electrodes, Implanted, Electric Stimulation Therapy, Femoral Nerve, Humans, Models, Neurological, Peripheral Nerves
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