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Cited by 420

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Nanosecond pulsed electric field (nsPEF) effects on cells and tissues: apoptosis induction and tumor growth inhibition

Beebe, S.J., Fox, P.M., Rec, L.J., Somers, K., Stark, R.H., Schoenbach, K.H.·2002·IEEE Transactions on Plasma Science
DOI 10.1109/tps.2002.1003872
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Abstract

Pulse power technology using high intensity (up to 300 kV/cm) nanosecond pulsed electric fields (nsPEF) has been applied for decontamination and amelioration of biofouling, but until now effects on human cells have not been investigated. To analyze structural and functional changes in human cells and solid tumors following exposure to nsPEF, we utilized flow cytometry and immunofluorescence microscopy. We provide further support for the hypothesis that as the pulse duration is decreased, there is a lower incidence of electric field interactions at the plasma membrane and a higher incidence of interactions with intracellular structures. The nsPEF effects are pulse duration/electric field intensity-dependent and energy density- or temperature-independent. We also show that nsPEF induces programmed cell. death (apoptosis) in cultured cells as indicated by cell shrinkage, Annexin-V-FITC binding to phosphatidylserine on intact cells, and caspase activation. Mouse fibrosarcoma tumors exposed to nsPEF exhibit fragmented DNA and reduced tumor growth in a mouse model. These studies show that nsPEF effects are distinctly different than electroporation pulses and provide the first evidence for the potential application of nsPEF to induce apoptosis and inhibit tumor growth.

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Metadata

Authors
Beebe, S. J., Fox, P. M., Rec, L. J., Somers, K., Stark, R. H., & Schoenbach, K. H.
Venue
IEEE Transactions on Plasma Science
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Published
2002-02
Volume
30
Issue
1
Pages
286-292
ISSN
0093-3813 (ISSN-L)
DOI
10.1109/tps.2002.1003872
OpenAlex
W2149458424
Cited by
420
References
19
FWCI
15.56
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Nanosecond pulsed electric field (nsPEF) effects on cells and tissues: apoptosis induction and tumor growth inhibition. https://app.cochat.ai/papers/10.1109/tps.2002.1003872
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Beebe, S. J., Fox, P. M., Rec, L. J., Somers, K., Stark, R. H., & Schoenbach, K. H. (2002). Nanosecond pulsed electric field (nsPEF) effects on cells and tissues: apoptosis induction and tumor growth inhibition. IEEE Transactions on Plasma Science. https://doi.org/10.1109/tps.2002.1003872

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.