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Gut microbiota richness promotes its stability upon increased dietary fibre intake in healthy adults
Open accessAbstract
Summary: Gut microbiota richness and stability are important parameters in host–microbe symbiosis. Diet modification, notably using dietary fibres, might be a way to restore a high richness and stability in the gut microbiota. In this work, during a 6‐week nutritional trial, 19 healthy adults consumed a basal diet supplemented with 10 or 40 g dietary fibre per day for 5 days, followed by 15‐day washout periods. Fecal samples were analysed by a combination of 16S r RNA gene pyrosequencing, intestinal cell genotoxicity assay, metatranscriptomics sequencing approach and short‐chain fatty analysis. This short‐term change in the dietary fibre level did not have the same impact for all individuals but remained significant within each individual gut microbiota at genus level. Higher microbiota richness was associated with higher microbiota stability upon increased dietary fibre intake. Increasing fibre modulated the expression of numerous microbiota metabolic pathways such as glycan metabolism, with genes encoding carbohydrate‐active enzymes active on fibre or host glycans. High microbial richness was also associated with high proportions of Prevotella and Coprococcus species and high levels of caproate and valerate. This study provides new insights on the role of gut microbial richness in healthy adults upon dietary changes and host microbes' interaction
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“increased intake of dietary fiber has been associated with an increase in gut microbial richness and/or diversity, especially in individuals with reduced diversity [206].”
From The athletic gut microbiota (2020) · cites this paper as [206]
In the citing paper
“whereas intact cereal fibers (e.g., wholegrain cereals, barley fiber, wheat bran, and rye fiber) increase the abundance of Actinobacteria, Bifidobacterium, Clostridium, Lachnospira, Akkermansia, and Roseburia in humans (63,65,66,73).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [66]
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“Baseline bacterial richness and diversity might be another important predictor of the success of a dietary intervention (66,504).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [66]
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Metadata
- Authors
- Tap, J., Furet, J., Bensaada, M., Philippe, C., Roth, H., Rabot, S., Lakhdari, O., Lombard, V., Henrissat, B., Corthier, G., Fontaine, E., Doré, J., & Leclerc, M.
- Affiliations
- Microbiologie de l’alimentation au service de la santé (FR)
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- INRA Micalis Institute UMR1319 Jouy‐en‐Josas 78350 France
- Corresponding author
- Leclerc, Marion
- ORCID
- Venue
- Environmental Microbiology
- Publisher
- Wiley
- Published
- 2015-09-03
- Volume
- 17
- Issue
- 12
- Pages
- 4954-4964
- ISSN
- 1462-2912 (ISSN-L)
- 1462-2920
- OpenAlex
- W1790787093
- Cited by
- 397
- References
- 51
- Citations by year
- 2026: 14 · 2025: 33 · 2024: 34 · 2023: 28 · 2022: 62 · 2021: 53 · 2020: 54 · 2019: 46 · 2018: 24 · 2017: 26 · 2016: 21
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Environmental Microbiology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- Funders
- French National Agency for Research (ANR/DEDD/PNRA/PROJ/200206-01-01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Keywords
- microbiome stability, dietary fiber, short-chain fatty acids, host-microbe symbiosis, carbohydrate-active enzymes, glycan metabolism, Prevotella, Coprococcus, caproate, valerate, metatranscriptomics, healthy adults
- MeSH terms
- Eubacteriales, Gastrointestinal Microbiome, Adult, Diet, Dietary Fiber, Fatty Acids, Feces, Female, Humans, Male, RNA, Ribosomal, 16S, Symbiosis, Prevotella, Dietary Supplements, Young Adult
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