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Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype
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“Clinical and experimental studies demonstrate that diminished GH/IGF-1 axis contributes to generalized vascular dysfunction (Bickel et al., 2023), characterized by increased microvascular fragility and genesis of cerebral microhemorrhages (Tarantini et al., 2017; Miller et al., 2022), BBB disruption, impaired angiogenesis and microvascular rarefaction (Sonntag et al., 2013; Tarantini et al., 2016)”
From Acute neuroendocrine changes after traumatic brain injury (2024) · cites this paper as Tarantini et al., 2017
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Citations
Cites
Association of Cerebral Microbleeds With Cognitive Decline and Dementia
Akoudad, S., Wolters, F. J., Viswanathan, A., de Bruijn, R. F., van der Lugt, A., Hofman, A., Koudstaal, P. J., Ikram, M. A., & Vernooij, M. W. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.1017 · Cited by 403 · cited 4×
“Clinical and experimental evidence confirm that the presence of CMHs is associated with decreases in processing speed and cognitive function (Poels et al. 2012; Akoudad et al. 2016), and manifestation of gait disturbances (de Laat et al.”
BackgroundInfluentialClinical Significance of Microbleeds in Subcortical Vascular Dementia
Won Seo, S., Hwa Lee, B., Kim, E.-J., Chin, J., Sun Cho, Y., Yoon, U., & Na, D. L. (2007) · Stroke · doi:10.1161/strokeaha.106.477315 · Cited by 185
Tarantini, S., Tucsek, Z., Valcarcel-Ares, M. N., Toth, P., Gautam, T., Giles, C. B., Ballabh, P., Wei, J. Y., Wren, J. D., Ashpole, N. M., et al. (2016) · AGE · doi:10.1007/s11357-016-9931-0 · Cited by 98
Self-citationChoi, P., Ren, M., Phan, T. G., Callisaya, M., Ly, J. V., Beare, R., Chong, W., & Srikanth, V. (2012) · Stroke · doi:10.1161/strokeaha.111.647271 · Cited by 83
Research works printed but not linked: 24
- Bailey-Downs, 2012, Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging, J. Gerontol. Biol. Med. Sci., 67, 313, 10.1093/gerona/glr164 · DOI
- Baumbach, 1989, Remodeling of cerebral arterioles in chronic hypertension, Hypertension, 13, 968, 10.1161/01.HYP.13.6.968 · DOI · Paper page
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- Kato, 2002, Silent cerebral microbleeds on T2*-weighted MRI: correlation with stroke subtype, stroke recurrence, and leukoaraiosis, Stroke, 33, 1536, 10.1161/01.STR.0000018012.65108.86 · DOI · Paper page
- Laat, 2011, Microbleeds are independently related to gait disturbances in elderly individuals with cerebral small vessel disease, Stroke, 42, 494, 10.1161/STROKEAHA.110.596122 · DOI
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- Toth, 2015b, Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection, Aging Cell, 14, 400, 10.1111/acel.12315 · DOI · Paper page
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Cited by
Ungvari, Z., Tarantini, S., Donato, A. J., Galvan, V., & Csiszar, A. (2018) · Circulation Research · doi:10.1161/circresaha.118.311378 · Cited by 919
Self-citationHypertension-induced cognitive impairment: From pathophysiology to public health
Ungvari, Z., Toth, P., Tarantini, S., Prodan, C. I., Sorond, F., Merkely, B., & Csiszar, A. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00430-6 · Cited by 544
Self-citationKiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., DelFavero, J., Yabluchanskiy, A., Csipo, T., Farkas, E., Wiley, G., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00177-1 · Cited by 203
Self-citationKiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A., Csipo, T., Farkas, E., Wren, J. D., Garman, L., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00165-5 · Cited by 163
Self-citationFekete, M., Szarvas, Z., Fazekas-Pongor, V., Feher, A., Csipo, T., Forrai, J., Dosa, N., Peterfi, A., Lehoczki, A., Tarantini, S., et al. (2022) · Nutrients · doi:10.3390/nu15010047 · Cited by 137
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Metadata
- Authors
- Tarantini, S., Valcarcel-Ares, N. M., Yabluchanskiy, A., Springo, Z., Fulop, G. A., Ashpole, N., Gautam, T., Giles, C. B., Wren, J. D., Sonntag, W. E., Csiszar, A., & Ungvari, Z.
- Affiliations
- Reynolds Oklahoma Center on Aging; Translational Geroscience Laboratory; Department of Geriatric Medicine; University of Oklahoma Health Sciences Center; Oklahoma City OK USA
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2017-03-14
- Volume
- 16
- Issue
- 3
- Pages
- 469-479
- ISSN
- 1474-9718
- Cited by
- 107
- References
- 4
- Language
- en
- Licence
- doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
- creativecommons.org/licenses/by/4.0/ (vor)
- Funders
- American Heart Association
- National Center for Complementary and Alternative Medicine (R01-AT006526)
- National Institute on Aging (R01-AG047879, R01-AG038747, 3P30AG050911-02S1)
- National Institute of Neurological Disorders and Stroke (R01-NS056218)
- Arkansas Claude Pepper Older Americans Independence Center at University of Arkansas Medical Center (P30 AG028718)
- Oklahoma Center for the Advancement of Science and Technology
- Oklahoma IDeA Network for Biomedical Research Excellence
- Reynolds Foundation
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- CoChat. (2026). Citation check: Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype. https://app.cochat.ai/papers/10.1111/acel.12583
- The paper
- Tarantini, S., Valcarcel-Ares, N. M., Yabluchanskiy, A., Springo, Z., Fulop, G. A., Ashpole, N., Gautam, T., Giles, C. B., Wren, J. D., Sonntag, W. E., Csiszar, A., & Ungvari, Z. (2017). Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype. Aging Cell. https://doi.org/10.1111/acel.12583
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
