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Staging systems in bipolar disorder: an International Society for Bipolar Disorders Task Force Report
Open accessAbstract
Objective: We discuss the rationale behind staging systems described specifically for bipolar disorders. Current applications, future directions and research gaps in clinical staging models for bipolar disorders are outlined. Method: We reviewed the literature pertaining to bipolar disorders, focusing on the first episode onwards. We systematically searched data on staging models for bipolar disorders and allied studies that could inform the concept of staging. Results: We report on several dimensions that are relevant to staging concepts in bipolar disorder. We consider whether staging offers a refinement to current diagnoses by reviewing clinical studies of treatment and functioning and the potential utility of neurocognitive, neuroimaging and peripheral biomarkers. Conclusion: Most studies to date indicate that globally defined late‐stage patients have a worse overall prognosis and poorer response to standard treatment, consistent with patterns for end‐stage medical disorders. We believe it is possible at this juncture to speak broadly of ‘early’‐ and ‘late’‐stage bipolar disorder. Next steps require further collaborative efforts to consider the details of preillness onset and intermediary stages, and how many additional stages are optimal.
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Metadata
- Authors
- Kapczinski, F., Magalhães, P. V. S., Balanzá‐Martinez, V., Dias, V. V., Frangou, S., Gama, C. S., Gonzalez‐Pinto, A., Grande, I., Ha, K., Kauer‐Sant'Anna, M., Kunz, M., Kupka, R., Leboyer, M., Lopez‐Jaramillo, C., Post, R. M., Rybakowski, J. K., Scott, J., Strejilevitch, S., Tohen, M., Vazquez, G., Yatham, L., Vieta, E., & Berk, M.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- National Institute for Translational Medicine Hospital de Clínicas de Porto Alegre Federal University of Rio Grande do Sul Porto Alegre Brazil
- Section of Psychiatry Department of Medicine University of Valencia‐CIBERSAM and Hospital Universitari Doctor Peset Valencia Spain
- University of Lisbon (PT)
- King's College London (GB)
- Hospital Universitario de Alava (Santiago) University of the Basque Country CIBERSAM Vitoria Spain
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Seoul National University (KR)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Université Paris-Est Créteil (FR)
- Department of Psychiatry Mood Disorders Program School of Medicine University of Antioquia Medellin Colombia
- Bipolar Collaborative Network Bethesda MD USA
- Poznan University of Medical Sciences (PL)
- Newcastle University (GB)
- Bipolar Disorder Program Neurosciences Institute Favaloro University Buenos Aires Argentina
- University of New Mexico (US)
- Department of Neurosciences University of Palermo Buenos Aires Argentina
- University of British Columbia (CA)
- Barwon Health (AU)
- Corresponding author
- Kapczinski, F.
- ORCID
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2014-06-25
- Volume
- 130
- Issue
- 5
- Pages
- 354-363
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2124464277
- Cited by
- 217
- References
- 85
- Citations by year
- 2026: 13 · 2025: 10 · 2024: 5 · 2023: 5 · 2022: 18 · 2021: 18 · 2020: 19 · 2019: 24 · 2018: 23 · 2017: 23 · 2016: 22 · 2015: 29 · 2014: 7
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Figshare (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, disease staging, prognosis, treatment response, neuroimaging biomarkers, peripheral biomarkers, first-episode bipolar disorder
- MeSH terms
- Bipolar Disorder, Humans, Severity of Illness Index, Societies, Medical, Biomarkers, Disease Progression, Advisory Committees
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