Neuroprogression as an illness trajectory in bipolar disorder: a selective review of the current literature
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Bipolar disorder (BD) is a chronic and disabling psychiatric condition that is linked to significant disability and psychosocial impairment. Although current neuropsychological, molecular, and neuroimaging evidence support the existence of neuroprogression and its effects on the course and outcome of this condition, whether and to what extent neuroprogressive changes may impact the illness trajectory is still poorly understood. Thus, this selective review was aimed toward comprehensively and critically investigating the link between BD and neurodegeneration based on the currently available evidence. According to the most relevant findings of the present review, most of the existing neuropsychological, neuroimaging, and molecular evidence demonstrates the existence of neuroprogression, at least in a subgroup of BD patients. These studies mainly focused on the most relevant effects of neuroprogression on the course and outcome of BD. The main implications of this assumption are discussed in light of specific shortcomings/limitations, such as the inability to carry out a meta-analysis, the inclusion of studies with small sample sizes, retrospective study designs, and different longitudinal investigations at various time points.
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The neuroprogression hypothesis in bipolar disorder postulates that recurrent mood swings lead to growing damage in neurons and glia, impairing the integrity of neuronal circuits, reinforcing brain vulnerability to future mood episodes, and finally leading to neurodegeneration.
“Once BD has manifested, the neuroprogression hypothesis in BD postulates that the recurrent mood swings might lead to growing damage in both neurons and glia, impairing the integrity of neuronal circuits and reinforce brain vulnerability to emerging mood episodes in the future (35), and finally leading to neurodegeneration (36).”
From The detrimental effects of smoking on the course and outcome in adults with bipolar disorder—A narrative review (2023) · cites this paper as [36]
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Flagged first, then by citations
Research works printed but not linked: 1
- [116]Sporns O. Networks of the Brain MIT Press Cambridge, MA, USA 2010
Cited by
Sorted by citations
Grunze, A., Mosolov, S., Grunze, H., & Born, C. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1114432 · Cited by 11 · see citing works
- Authors
- Serafini, G., Pardini, M., Monacelli, F., Orso, B., Girtler, N., Brugnolo, A., Amore, M., Nobili, F., & Team on Dementia of the IRCCS Ospedale Policlinico San Martino
- Affiliations
- Ospedale Policlinico San Martino (IT)
- University of Genoa (IT)
- Corresponding author
- Serafini, Gianluca
- ORCID
- Venue
- Brain Sciences
- Publisher
- MDPI AG
- Published
- 2021-02-23
- Volume
- 11
- Issue
- 2
- Pages
- 276
- ISSN
- 2076-3425 (ISSN-L)
- PMC
- PMC7926350
- OpenAlex
- W3132421449
- Cited by
- 56
- References
- 122
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 7 · 2023: 16 · 2022: 14 · 2021: 4
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- bipolar disorder, neuroprogression, neurodegeneration, illness trajectory, course and outcome, neuropsychological deficits, neuroimaging, molecular mechanisms
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