Factors underlying prefrontal and insula structural alterations in smokers

Zhang, Xiaochu; Salmeron, Betty Jo; Ross, Thomas J.; Geng, Xiujuan; Yang, Yihong; Stein, Elliot A.

doi:10.1016/j.neuroimage.2010.08.008

Cited by 188Smoking Behavior and CessationSubstance Abuse Treatment and OutcomesFunctional Brain Connectivity Studies

Factors underlying prefrontal and insula structural alterations in smokers

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Zhang, Xiaochu, Salmeron, Betty Jo, Ross, Thomas J., Geng, Xiujuan, Yang, Yihong, Stein, Elliot A.·2011·NeuroImage

DOI 10.1016/j.neuroimage.2010.08.008PMC PMC2962727

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Abstract

Based upon previous reports of alterations in white matter integrity and gray matter density in smokers, we examined these markers in a large, well-matched sample of smokers and non-smokers. We further investigated the effect of heavy cigarette exposure by using pack-years and the effects of two relatively stable, highly heritable traits in smokers (Fagerström Test of Nicotine Dependence (FTND), a measure of severity of nicotine dependence and Toronto Alexithymia Scale (TAS-20), a stable personality trait related to smoking). Forty-eight nicotine-dependent subjects and 48 matched controls were included in the analyses, with smokers also subdivided into high/low dependence and high/low pack-years smokers. White matter integrity (fractional anisotropy (FA)) and gray matter density (voxel-based morphometry (VBM)) were measured and compared across groups. Gray matter density was lower in left prefrontal cortex (PFC) in high pack-years smokers and was inversely related to pack-years. In contrast, left insular cortex gray matter density was higher in smokers and associated with TAS-20 total score and with difficulty-identifying-feelings factor. Further, the most highly dependent smokers showed lower prefrontal FA, which was negatively correlated with FTND. There was no correlation between pack-years and FTND in our smoker population. These data suggest chronic tobacco use is correlated with prefrontal gray matter damage , while differences in insula gray matter and PFC white matter appear to reflect stable and heritable differences between smokers and non-smokers.

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Heavy nicotine use through smoking tobacco is linked to neuropathy, often appearing as prefrontal gray matter atrophy.
“Heavy nicotine use in the form of smoking tobacco has been linked to neuropathy (Brody, 2006), often manifesting as prefrontal gray matter atrophy (Gallinat et al., 2006; Zhang et al., 2011).”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Zhang et al., 2011
Regular nicotine use is associated with lower FA.
“Regular nicotine use has been associated with lower FA (Huang et al., 2013; Liao et al., 2011; Zhang et al., 2011)”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Zhang et al., 2011
One study found that smokers had increased gray matter densities in the insula.
“Although the majority seem to suggest a decrease in cortical thickness and gray matter density, one study found the opposite effect, such that smokers had increased gray matter densities (Zhang et al., 2011).”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Zhang et al., 2011

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Authors: Zhang, X., Salmeron, B. J., Ross, T. J., Geng, X., Yang, Y., & Stein, E. A.
Affiliations: National Institutes of Health (US)
Corresponding author: Stein, Elliot A.
ORCID: Zhang, Xiaochu
Salmeron, Betty Jo
Ross, Thomas J.
Geng, Xiujuan
Yang, Yihong
Stein, Elliot A.
Venue: NeuroImage
Publisher: Elsevier BV
Published: 2011-01
Volume: 54
Issue: 1
Pages: 42-48
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1016/j.neuroimage.2010.08.008
PMC: PMC2962727
OpenAlex: W1984123427
Cited by: 188
References: 65
Citations by year: 2026: 1 · 2025: 7 · 2024: 8 · 2023: 4 · 2022: 9 · 2021: 15 · 2020: 10 · 2019: 11 · 2018: 14 · 2017: 11 · 2016: 21 · 2015: 16 · 2014: 20 · 2013: 18 · 2012: 14
FWCI: 8.88
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (Z01DA000470, ZIADA000470)
Topics: Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: smoking, prefrontal cortex, insula, gray matter density, white matter integrity, fractional anisotropy, nicotine dependence, pack-years, alexithymia, brain structural changes
MeSH terms: Brain Damage, Chronic, Cerebral Cortex, Emotions, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Nerve Degeneration, Smoke, Smoking, Thinking, Prefrontal Cortex

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Factors underlying prefrontal and insula structural alterations in smokers

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