Magnetic resonance imaging structural alterations in brain of alcohol abusers and its association with impulsivity: Alcohol, impulsivity and brain MRI
Abstract
Despite the suggestion that impulsivity plays a central role in the transfer from a recreational drug use to a substance use disorder, very few studies focused on neurobiological markers for addiction. This study aimed to identify volumetric alterations in a sample of patients with mild alcohol use disorder with a short history of alcohol use, compared with a control group, and also focused on its association with impulsivity levels. Most magnetic resonance imaging studies have focused on severe alcohol use disorder, formerly called alcohol-dependent patients, showing alcohol-related structural alterations and their association with alcohol use history variables but not with personality parameters like impulsivity. Our hypothesis is that our group of alcohol users may already display structural alterations especially in brain regions related to inhibitory control like medial-prefrontal regions, and that those structural alterations could be more associated to personality traits like impulsivity than to drug use variables. Our results clearly demonstrate that our population showed lower regional grey and white matter volumes in the medial-prefrontal and orbitofrontal cortices, as well as higher regional white matter volume in the ventral striatum and the internal capsule. Volumetric alterations were associated to the Barratt's impulsivity score: the more impulsive the subjects, the lower the medial-prefrontal cortex grey matter volume.
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White matter macrostructural differences are not always detectable in people with mild alcohol use disorder or a shorter history of alcohol abuse.
“such macrostructural differences are not always detectable in those with mild alcohol use disorder or a shorter history of alcohol abuse (Asensio et al., 2016)”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Asensio et al., 2016
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- Authors
- Asensio, S., Morales, J. L., Senabre, I., Romero, M. J., Beltran, M. A., Flores-Bellver, M., Barcia, J. M., & Romero, F. J.
- Affiliations
- Universidad Cardenal Herrera CEU (ES)
- Valencia Catholic University Saint Vincent Martyr (ES)
- Servicios Centrales; Hospital General de Castellón; Spain
- Facultad de Medicina y Odontología; Universidad Católica de Valencia ‘San Vicente Mártir’; Spain
- Corresponding author
- Romero, Francisco J.
- Venue
- Addiction Biology
- Publisher
- Wiley
- Published
- 2015-05-18
- Volume
- 21
- Issue
- 4
- Pages
- 962-971
- ISSN
- 1355-6215 (ISSN-L)
- OpenAlex
- W1543035500
- Cited by
- 33
- References
- 56
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 1
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Addiction Biology (publishedVersion)
- PubMed (publishedVersion)
- CEU Repositorio Institucional (Fundación Universitaria San Pablo CEU) (submittedVersion)
- Funders
- Ministerio de Ciencia e Innovación, Madrid, Spain (SAF2007/66801)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- alcoholism, impulsivity, brain structural changes, gray matter volume, white matter volume, medial prefrontal cortex, orbitofrontal cortex, ventral striatum, internal capsule, inhibitory control, Barratt Impulsiveness Scale
- MeSH terms
- Adolescent, Adult, Alcoholism, Brain, Brain Mapping, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Organ Size, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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