Co-occurring tobacco use and posttraumatic stress disorder: Smoking cessation treatment implications: Tobacco Use in Posttraumatic Stress Disorder
Abstract
BACKGROUND AND OBJECTIVES: PTSD and cigarette smoking frequently co-occur for reasons that are not well understood. The current behavioral and pharmacological treatments and emerging new treatment targets for smoking cessation are discussed. METHODS: Here we describe recent research on PTSD and smoking with an emphasis on 1) the clinical characteristics of smokers with PTSD, 2) smoking treatment trials that specifically targeted smokers with PTSD, 3) recent research on stress-response and affect regulation pathways that might link the two disorders and 4) potential ways to leverage new findings on stress response systems and affect regulation mechanisms to improve treatment outcomes for smokers with PTSD. RESULTS: Smokers with PTSD have higher rates of smoking compared to the general population and have greater difficulty quitting compared to smokers without PTSD. There have been several studies of adjunctive and integrated smoking cessation interventions for smokers with PTSD, but fewer tailored interventions that intensively target stress-response pathways or affect regulation related to both tobacco use and PTSD. Stress-response pathways and affect regulation appear to be important mechanisms involved in the development and maintenance of smoking in individuals with PTSD. CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: Additional research that focuses on smokers with PTSD is warranted given that successful tobacco treatment response is low and the negative health effects of each disorder can be greatly amplified.
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Although applying ACT principles for smoking cessation in smokers with anxiety and depression has shown initial promise, these interventions have primarily been delivered through face-to-face psychotherapy.
“Although applying ACT principles for smoking cessation in smokers with anxiety and depression has shown initial promise [10,11], these interventions have primarily delivered through face-to-face psychotherapy.”
From Personalized chat‐based support for smoking cessation among smokers with mental health symptoms in the workplace: A randomized controlled trial. (2025) · cites this paper as [11]
Cites
Kessler, R. C., Petukhova, M., Sampson, N. A., Zaslavsky, A. M., & Wittchen, H. (2012) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.1359 · Cited by 2,947 · see citing works
Cognitive processing therapy for sexual assault victims.
Resick, P. A., & Schnicke, M. K. (1992) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.60.5.748 · Cited by 1,490 · see citing works
Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.5.624 · Cited by 721 · see citing works
Cook, B. L., Wayne, G. F., Kafali, E. N., Liu, Z., Shu, C., & Flores, M. (2014) · JAMA · doi:10.1001/jama.2013.284985 · Cited by 519 · see citing works
A New First Step in Activation of Steroid Receptors
Davies, T. H., Ning, Y.-M., & Sánchez, E. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100531200 · Cited by 427 · see citing works
Nicotine withdrawal versus other drug withdrawal syndromes: similarities and dissimilarities
HUGHES, J. R., HIGGINS, S. T., & BICKEL, W. K. (1994) · Addiction · doi:10.1111/j.1360-0443.1994.tb03744.x · Cited by 312 · see citing works
Roy, A., Gorodetsky, E., Yuan, Q., Goldman, D., & Enoch, M.-A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.236 · Cited by 282 · see citing works
Zimmermann, P., Brückl, T., Nocon, A., Pfister, H., Binder, E. B., Uhr, M., Lieb, R., Moffitt, T. E., Caspi, A., Holsboer, F., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10111577 · Cited by 262 · see citing works
Post-Traumatic Stress Disorder and Incidence of Coronary Heart Disease
Vaccarino, V., Goldberg, J., Rooks, C., Shah, A. J., Veledar, E., Faber, T. L., Votaw, J. R., Forsberg, C. W., & Bremner, J. D. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.04.085 · Cited by 247 · see citing works
Selective inhibitors of the FK506-binding protein 51 by induced fit
Gaali, S., Kirschner, A., Cuboni, S., Hartmann, J., Kozany, C., Balsevich, G., Namendorf, C., Fernandez-Vizarra, P., Sippel, C., Zannas, A. S., et al. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1699 · Cited by 245 · see citing works
Feldner, M. T., Babson, K. A., & Zvolensky, M. J. (2007) · Clinical Psychology Review · doi:10.1016/j.cpr.2006.08.004 · Cited by 240 · see citing works
Stress reinstates nicotine seeking but not sucrose solution seeking in rats
Buczek, Y., Lê, A. D., Wang, A., Stewart, J., & Shaham, Y. (1999) · Psychopharmacology · doi:10.1007/s002130050992 · Cited by 206 · see citing works
Piper, M. E., Smith, S. S., Schlam, T. R., Fleming, M. F., Bittrich, A. A., Brown, J. L., Leitzke, C. J., Zehner, M. E., Fiore, M. C., & Baker, T. B. (2010) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0018065 · Cited by 150 · see citing works
Bevilacqua, L. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.152 · Cited by 137 · see citing works
Zvolensky, M., Gibson, L., Vujanovic, A., Gregor, K., Bernstein, A., Kahler, C., Legues, C. W., Brown, R., & Feldner, M. (2008) · Nicotine & Tobacco Research · doi:10.1080/14622200802238951 · Cited by 104 · see citing works
McKee, S. A., Potenza, M. N., Kober, H., Sofuoglu, M., Arnsten, A. F., Picciotto, M. R., Weinberger, A. H., Ashare, R., & Sinha, R. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114562091 · Cited by 75 · see citing works
Self-citationSmoking withdrawal in smokers with and without posttraumatic stress disorder
Dedert, E. A., Calhoun, P. S., Harper, L. A., Dutton, C. E., McClernon, F. J., & Beckham, J. C. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntr142 · Cited by 42 · see citing works
Kelly, M. M., Sido, H., Forsyth, J. P., Ziedonis, D. M., Kalman, D., & Cooney, J. L. (2015) · Journal of Dual Diagnosis · doi:10.1080/15504263.2014.992201 · Cited by 34 · see citing works
Self-citationCalhoun, P. S., Wagner, H. R., McClernon, F. J., Lee, S., Dennis, M. F., Vrana, S. R., Clancy, C. P., Collie, C. F., Johnson, Y. C., & Beckham, J. C. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2144-9 · Cited by 28 · see citing works
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- Authors
- Kelly, M. M., Jensen, K. P., & Sofuoglu, M.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Yale University (US)
- Corresponding author
- Kelly, Megan M.
- Venue
- The American Journal on Addictions
- Publisher
- Wiley
- Published
- 2015-11-19
- Volume
- 24
- Issue
- 8
- Pages
- 695-704
- ISSN
- 1055-0496 (ISSN-L)
- OpenAlex
- W2221521272
- Cited by
- 23
- References
- 19
- Citations by year
- 2025: 2 · 2024: 3 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 5 · 2017: 5
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal on Addictions (publishedVersion)
- PubMed (publishedVersion)
- Funders
- VISN 1 Mental Illness Research, Education, and Clinical Center
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- post-traumatic stress disorder, tobacco use, smoking cessation, comorbidities, stress response, emotion regulation, smoking cessation interventions, pharmacological smoking cessation
- MeSH terms
- Combined Modality Therapy, Humans, Stress Disorders, Post-Traumatic, Tobacco Use Disorder, Smoking Cessation, Treatment Outcome, Diagnosis, Dual (Psychiatry)
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