Probiotics for childhood functional gastrointestinal disorders: a systematic review and meta-analysis
Abstract
UNLABELLED: A systematic review and meta-analysis were performed to investigate the quantity and quality of the current evidence regarding the effect of different probiotic strains in the treatment of functional gastrointestinal disorders (FGID) in children and adolescents. CONCLUSION: Probiotics are more effective than placebo in the treatment of patients with abdominal pain-related FGID, especially with respect to patients with irritable bowel syndrome. To date, however, probiotics have not proved effective for children with functional constipation.
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Similar studies with pediatric patients do not support the efficacy of probiotics on pediatric functional constipation.
“However, similar studies with pediatric patients do not support the efficacy of probiotics on pediatric FC [ 85 , 86 ].”
From Role of gut microbiota in functional constipation (2021) · cites this paper as [85]
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“However, similar studies with pediatric patients do not support the efficacy of probiotics on pediatric FC [85, 86].”
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- Authors
- Korterink, J. J., Ockeloen, L., Benninga, M. A., Tabbers, M. M., Hilbink, M., & Deckers‐Kocken, J. M.
- Affiliations
- Jeroen Bosch Ziekenhuis (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Korterink, Judith J
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 2014-01-07
- Volume
- 103
- Issue
- 4
- Pages
- 365-372
- ISSN
- 0365-1436 (ISSN-L)
- 0803-5253
- 1651-2227
- OpenAlex
- W1965957847
- Cited by
- 115
- References
- 37
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 9 · 2022: 10 · 2021: 12 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 8
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Paediatrica (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, functional gastrointestinal disorders, childhood, irritable bowel syndrome, abdominal pain, functional constipation, probiotic strains, adolescents, placebo comparison
- MeSH terms
- Adolescent, Child, Child, Preschool, Gastrointestinal Diseases, Humans, Infant, Probiotics
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