Managing Chronic Pain in Children and Adolescents: A Clinical Review
Abstract
Chronic pain in children and adolescents can be difficult for a single provider to manage in a busy clinical setting. Part of this difficulty is that pediatric chronic pain not only impacts the child but also the families of these children. In this review article, we discuss etiology and pathophysiology of chronic pain, along with variables that impact the severity of chronic pain and functional loss. We review diagnosis and management of selected chronic pain conditions in pediatric patients, including headache, low back pain, hypermobility, chronic fatigue, postural orthostatic tachycardia syndrome, abdominal pain, fibromyalgia, and complex regional pain syndrome. For each condition, we create a road map that contains therapy prescriptions, exercise recommendations, and variables that may influence pain severity. Potential medications for these pain conditions and associated symptoms are reviewed. A multidisciplinary approach for managing children with these conditions, including pediatric pain rehabilitation programs, is emphasized. Lastly, we discuss psychological factors and interventions for pediatric chronic pain and potential complementary and alternative natural products and interventions.
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Parental overprotective behaviour can increase distress and disability in young people with FSS.
“parental overprotective behaviour can increase distress and disability in the young [18–21]”
From Feasibility of group-based acceptance and commitment therapy for adolescents (AHEAD) with multiple functional somatic syndromes: A pilot study (2020) · cites this paper as [18]
Active interventions (e.g., exercise) have a more significant role than passive interventions (e.g., massage or TENS) in pediatric chronic pain rehabilitation because the goal is to promote independence and return to functioning.
“Because the goal of these therapies is to promote independence (i.e., ability to manage daily life without excessive support from parents and caregivers) and a return to functioning (e.g., return to school and sport), active interventions (e.g., exercise) have a more significant role than passive interventions (e.g., massage or transcutaneous electrical nerve stimulation (TENS)) [21].”
From Best-evidence for the rehabilitation of chronic pain part 1: Pediatric pain (2019) · cites this paper as [21]
Cites
The american college of rheumatology 1990 criteria for the classification of fibromyalgia
Wolfe, F., Smythe, H. A., Yunus, M. B., Bennett, R. M., Bombardier, C., Goldenberg, D. L., Tugwell, P., Campbell, S. M., Abeles, M., Clark, P., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330203 · Cited by 9,563 · see citing works
The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study
Fukuda, K., Straus, S. E., Hickie, I., Sharpe, M. C., Dobbins, J. G., Komaroff, A., & and International Chronic Fatigue Syndrome Study Group. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-12-199412150-00009 · Cited by 4,969 · see citing works
RELIEVING PAIN IN AMERICA: A BLUEPRINT FOR TRANSFORMING PREVENTION, CARE, EDUCATION, AND RESEARCH
Simon, L. S. (2012) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.3109/15360288.2012.678473 · Cited by 2,185 · see citing works
The epidemiology of chronic pain in children and adolescents revisited: A systematic review
King, S., Chambers, C. T., Huguet, A., MacNevin, R. C., McGrath, P. J., Parker, L., & MacDonald, A. J. (2011) · Pain · doi:10.1016/j.pain.2011.07.016 · Cited by 1,688 · see citing works
Pain in children and adolescents: a common experience
Perquin, C. W., Hazebroek-Kampschreur, A. A. J. M., Hunfeld, J. A. M., Bohnen, A. M., van Suijlekom-Smit, L. W. A., Passchier, J., & van der Wouden, J. C. (2000) · Pain · doi:10.1016/s0304-3959(00)00269-4 · Cited by 1,114 · see citing works
Neuropathic pain: mechanisms and their clinical implications
Cohen, S. P., & Mao, J. (2014) · BMJ · doi:10.1136/bmj.f7656 · Cited by 802 · see citing works
Prevalence of headache and migraine in schoolchildren
Abu-Arefeh, I., & Russell, G. (1994) · BMJ · doi:10.1136/bmj.309.6957.765 · Cited by 770 · see citing works
Heim, C., Newport, D. J., Bonsall, R., Miller, A. H., & Nemeroff, C. B. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.4.575 · Cited by 746 · see citing works
Systematic review and meta-analysis of psychological therapies for children with chronic pain
Fisher, E., Heathcote, L., Palermo, T. M., de C Williams, A. C., Lau, J., & Eccleston, C. (2014) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsu008 · Cited by 710 · see citing works
Clinical Effectiveness and Cost-Effectiveness of Treatments for Patients With Chronic Pain
Turk, D. C. (2002) · Clinical Journal of Pain · doi:10.1097/00002508-200211000-00003 · Cited by 642 · see citing works
Exercise for treating fibromyalgia syndrome
Busch, A. J., Barber, K. A. R., Overend, T. J., Peloso, P. M. J., & Schachter, C. L. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003786.pub2 · Cited by 609 · see citing works
Idiopathic postural orthostatic tachycardia syndrome: An attenuated form of acute pandysautonomia?
Schondorf, R., & Low, P. A. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.132 · Cited by 548 · see citing works
Palermo, T. M., Eccleston, C., Lewandowski, A. S., de C. Williams, A. C., & Morley, S. (2010) · Pain · doi:10.1016/j.pain.2009.10.004 · Cited by 489 · see citing works
Häuser, W., Klose, P., Langhorst, J., Moradi, B., Steinbach, M., Schiltenwolf, M., & Busch, A. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3002 · Cited by 436 · see citing works
Lewis, D. W., Ashwal, S., Hershey, A. D., Hirtz, D., Yonker, M. E., & Silberstein, S. D. (2004) · Neurology · doi:10.1212/01.wnl.0000147332.41993.90 · Cited by 433 · see citing works
A Systematic Review and Meta-analysis of Yoga for Low Back Pain
Cramer, H., Lauche, R., Haller, H., & Dobos, G. (2012) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31825e1492 · Cited by 406 · see citing works
Cannabinoids for treatment of chronic non‐cancer pain; a systematic review of randomized trials
Lynch, M. E., & Campbell, F. (2011) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2011.03970.x · Cited by 397 · see citing works
Epidemiology of Adolescent Spinal Pain
Jeffries, L. J., Milanese, S., & Grimmer, K. A. (2007) · Spine · doi:10.1097/brs.0b013e318158d70b · Cited by 397 · see citing works
Groenewald, C. B., Essner, B. S., Wright, D., Fesinmeyer, M. D., & Palermo, T. M. (2014) · The Journal of Pain · doi:10.1016/j.jpain.2014.06.002 · Cited by 391 · see citing works
Complex Regional Pain Syndromes: Guidelines for Therapy
Stanton-Hicks, M., Baron, R., Boas, R., Gordh, T., Harden, N., Hendler, N., Koltzenburg, M., Raj, P., & Wilder, R. (1998) · The Clinical Journal of Pain · doi:10.1097/00002508-199806000-00012 · Cited by 378 · see citing works
Self-citationBeyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Clayton, E. W. (2015) · JAMA · doi:10.1001/jama.2015.1346 · Cited by 349 · see citing works
Walker, L. S., Williams, S. E., Smith, C. A., Garber, J., Van Slyke, D. A., & Lipani, T. A. (2006) · Pain · doi:10.1016/j.pain.2005.12.020 · Cited by 348 · see citing works
Sherry, D. D., Wallace, C. A., Kelley, C. A., Kidder, M., & Sapp, L. R. (1999) · Clinical Journal of Pain · doi:10.1097/00002508-199909000-00009 · Cited by 345 · see citing works
Resistance exercise training for fibromyalgia
Busch, A. J., Webber, S. C., Richards, R. S., Bidonde, J., Schachter, C. L., Schafer, L. A., Danyliw, A., Sawant, A., Dal Bello-Haas, V., Rader, T., et al. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010884 · Cited by 333 · see citing works
Jennings, E. M., Okine, B. N., Roche, M., & Finn, D. P. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.06.003 · Cited by 318 · see citing works
Stagg, N. J., Mata, H. P., Ibrahim, M. M., Henriksen, E. J., Porreca, F., Vanderah, T. W., & Philip Malan, T. (2011) · Anesthesiology · doi:10.1097/aln.0b013e318210f880 · Cited by 314 · see citing works
Kline, R. M., Kline, J. J., Palma, J. D., & Barbero, G. J. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.109606 · Cited by 313 · see citing works
Walker, L. S., Garber, J., & Greene, J. W. (1993) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.102.2.248 · Cited by 313 · see citing works
Non-specific musculoskeletal pain in preadolescents. Prevalence and 1-year persistence
Mikkelsson, M., Salminen, J. J., & Kautiainen, H. (1997) · Pain · doi:10.1016/s0304-3959(97)00073-0 · Cited by 310 · see citing works
Yunus, M. B., & Masi, A. T. (1985) · Arthritis & Rheumatism · doi:10.1002/art.1780280205 · Cited by 301 · see citing works
Vlieger, A. M., Frankenhuis, C., Wolfkamp, S. C., Tromp, E., & Benninga, M. A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.072 · Cited by 298 · see citing works
Kennedy, J., Roll, J. M., Schraudner, T., Murphy, S., & McPherson, S. (2014) · The Journal of Pain · doi:10.1016/j.jpain.2014.05.009 · Cited by 292 · see citing works
Wilder, R. T., Berde, C. B., Wolohan, M., Vieyra, M. A. B., Masek, B. J., & Micheli, L. J. (1992) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199274060-00013 · Cited by 291 · see citing works
Self-citationCognitive Behavioral Therapy Plus Amitriptyline for Chronic Migraine in Children and Adolescents
Powers, S. W., Kashikar‐Zuck, S., Allen, J. R., LeCates, S. L., Slater, S. K., Zafar, M., Kabbouche, M. A., O’Brien, H. L., Shenk, C. E., Rausch, J. R., et al. (2013) · JAMA · doi:10.1001/jama.2013.282533 · Cited by 288 · see citing works
??-Endorphin Response to Exercise
Goldfarb, A. H., & Jamurtas, A. Z. (1997) · Sports Medicine · doi:10.2165/00007256-199724010-00002 · Cited by 281 · see citing works
Eccleston, C. (2003) · Archives of Disease in Childhood · doi:10.1136/adc.88.10.881 · Cited by 276 · see citing works
Bansell, J. C., & Valtueña, J. P. (2020) · Nursing Management · doi:10.1097/01.numa.0000719220.85627.ef · Cited by 276 · see citing works
Functional abdominal pain in childhood and adolescence increases risk for chronic pain in adulthood
Walker, L. S., Crish, S. D., Rippel, S., & Bruehl, S. P. (2010) · Pain · doi:10.1016/j.pain.2010.06.018 · Cited by 264 · see citing works
Exercise as migraine prophylaxis: A randomized study using relaxation and topiramate as controls
Varkey, E., Cider, Å., Carlsson, J. Y., & Linde, M. (2011) · Cephalalgia · doi:10.1177/0333102411419681 · Cited by 258 · see citing works
Animal-assisted therapy as a pain relief intervention for children
Braun, C., Stangler, T., Narveson, J., & Pettingell, S. L. (2009) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2009.02.008 · Cited by 249 · see citing works
Black, L. I., Clarke, T. C., Barnes, P. M., Stussman, B. J., & Nahin, R. L. (2015) · PubMed · Cited by 246 · see citing works
Walker, L. S., Garber, J., & Greene, J. W. (1993) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.102.2.248 · Cited by 233 · see citing works
Postural tachycardia in children and adolescents: what is abnormal?
Singer, W., Sletten, D. M., Opfer-Gehrking, T. L., Brands, C. K., Fischer, P. R., & Low, P. A. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2011.08.054 · Cited by 209 · see citing works
Self-citationRegular physical activity prevents development of chronic pain and activation of central neurons
Sluka, K. A., O'Donnell, J. M., Danielson, J. F., & Rasmussen, L. A. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01317.2012 · Cited by 207 · see citing works
Rimes, K. A., Goodman, R., Hotopf, M., Wessely, S., Meltzer, H., & Chalder, T. (2007) · PEDIATRICS · doi:10.1542/peds.2006-2231 · Cited by 200 · see citing works
Coenzyme Q10 Deficiency and Response to Supplementation in Pediatric and Adolescent Migraine
Hershey, A. D., Powers, S. W., Vockell, A.-L. B., LeCates, S. L., Ellinor, P. L., Segers, A. M., Burdine, D., Manning, P., & Kabbouche, M. A. (2007) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2007.00652.x · Cited by 197 · see citing works
Lynch, M. E., & Ware, M. A. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9600-6 · Cited by 195 · see citing works
Generalized Joint Hypermobility and Risk of Lower Limb Joint Injury During Sport
Pacey, V., Nicholson, L., Adams, R., Munn, J., & Munns, C. (2010) · American Journal of Sports Medicine · doi:10.1177/0363546510364838 · Cited by 192 · see citing works
Headache, Stomachache, Backache, and Morning Fatigue Among Adolescent Girls in the United States
Ghandour, R. M., Overpeck, M. D., Huang, Z. J., Kogan, M. D., & Scheidt, P. C. (2004) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.158.8.797 · Cited by 182 · see citing works
Caes, L., Vervoort, T., Eccleston, C., Vandenhende, M., & Goubert, L. (2010) · Pain · doi:10.1016/j.pain.2010.10.037 · Cited by 178 · see citing works
Severe Fatigue in Adolescents: A Common Phenomenon?
ter Wolbeek, M., van Doornen, L. J. P., Kavelaars, A., & Heijnen, C. J. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2575 · Cited by 174 · see citing works
Claar, R. L., Simons, L. E., & Logan, D. E. (2008) · Pain · doi:10.1016/j.pain.2007.12.005 · Cited by 173 · see citing works
Depression, coping, and functional disability in juvenile primary fibromyalgia syndrome
Kashikar-Zuck, S., Vaught, M. H., Goldschneider, K. R., Graham, T. B., & Miller, J. C. (2002) · The Journal of Pain · doi:10.1054/jpai.2002.126786 · Cited by 164 · see citing works
Herbal medicine for low-back pain
Oltean, H. N., Robbins, C. L., van Tulder, M. W., Berman, B., Bombardier, C., & Gagnier, J. J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004504.pub4 · Cited by 155 · see citing works
Feverfew for preventing migraine
Wider, B., Pittler, M. H., & Ernst, E. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002286.pub3 · Cited by 151 · see citing works
Simons, L., Claar, R., & Logan, D. (2008) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsn029 · Cited by 150 · see citing works
Acceptance and Commitment Therapy for Chronic Pain
(2012) · PsycEXTRA Dataset · doi:10.1037/e674542012-001 · Cited by 147 · see citing works
Prevalence of Low Back Pain and Its Effect on Health-Related Quality of Life in Adolescents
Pellisé, F., Balagué, F., Rajmil, L., Cedraschi, C., Aguirre, M., Fontecha, C. G., Pasarín, M., & Ferrer, M. (2009) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpediatrics.2008.512 · Cited by 147 · see citing works
Russek, L. N., & Errico, D. M. (2016) · Clinical Rheumatology · doi:10.1007/s10067-015-2951-9 · Cited by 143 · see citing works
Management of Pediatric Patients With Complex Regional Pain Syndrome
Wilder, R. T. (2006) · Clinical Journal of Pain · doi:10.1097/01.ajp.0000194283.59132.fb · Cited by 142 · see citing works
Self-citationPsychologic Aspects of Childhood Reflex Neurovascular Dystrophy
Sherry, D. D., & Weisman, R. (1988) · PEDIATRICS · doi:10.1542/peds.81.4.572 · Cited by 140 · see citing works
Flinn, M. V., Nepomnaschy, P. A., Muehlenbein, M. P., & Ponzi, D. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.01.005 · Cited by 139 · see citing works
Zeltzer, L. K., Tsao, J. C. I., Stelling, C., Powers, M. B., Levy, S., & Waterhouse, M. (2002) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(02)00506-7 · Cited by 139 · see citing works
ACSM's Exercise Management for Persons with Chronic Diseases and Disabilities
Eathorne, S. W. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199809000-00019 · Cited by 138 · see citing works
Symptomatic Treatment of Migraine in Children: A Systematic Review of Medication Trials
Damen, L., Bruijn, J., Verhagen, A. P., et al. (2005) · PEDIATRICS · doi:10.1542/peds.2004-2742 · Cited by 138 · see citing works
Michaleff, Z. A., Kamper, S. J., Maher, C. G., Evans, R., Broderick, C. R., & Henschke, N. (2014) · European Spine Journal · doi:10.1007/s00586-014-3461-1 · Cited by 135 · see citing works
Comorbidities in pediatric patients with postural orthostatic tachycardia syndrome
Ojha, A., Chelimsky, T. C., & Chelimsky, G. (2011) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.07.005 · Cited by 131 · see citing works
El‐Metwally, A., Salminen, J. J., Auvinen, A. P., Macfarlane, G. J., & Mikkelsson, M. (2007) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-8-46 · Cited by 131 · see citing works
Rombaut, L., Malfait, F., Wandele, I. D., Taes, Y., Thijs, Y., Paepe, A. D., & Calders, P. (2012) · Arthritis Care & Research · doi:10.1002/acr.21726 · Cited by 130 · see citing works
Hechler, T., Dobe, M., Kosfelder, J., Damschen, U., Hübner, B., Blankenburg, M., Sauer, C., & Zernikow, B. (2009) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e318185c1c9 · Cited by 130 · see citing works
Psychiatric Symptoms in Preadolescents With Musculoskeletal Pain and Fibromyalgia
Mikkelsson, M., Sourander, A., Piha, J., & Salminen, J. J. (1997) · PEDIATRICS · doi:10.1542/peds.100.2.220 · Cited by 129 · see citing works
Sieberg, C. B., Williams, S., & Simons, L. E. (2011) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsr043 · Cited by 128 · see citing works
Prevalence and tracking of back pain from childhood to adolescence
Kjær, P., Wedderkopp, N., Korsholm, L., & Leboeuf‐Yde, C. (2011) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-12-98 · Cited by 126 · see citing works
Boychuk, D., Goddard, G., Mauro, G., & Orellana, M. (2015) · Journal of Oral & Facial Pain and Headache · doi:10.11607/ofph.1274 · Cited by 126 · see citing works
Stephens, S., Feldman, B. M., Bradley, N. S., Schneiderman, J. E., Wright, F. V., Singh‐Grewal, D., Lefebvre, A., Benseler, S. M., Cameron, B., Laxer, R. M., et al. (2008) · Arthritis Care & Research · doi:10.1002/art.24115 · Cited by 125 · see citing works
Chatzitheodorou, D., Kabitsis, C., Malliou, P., & Mougios, V. (2007) · Physical Therapy · doi:10.2522/ptj.20060080 · Cited by 125 · see citing works
Campo, J. V., Perel, J. M., Lucas, A. N., Bridge, J. A., Ehmann, M., Kalas, C., Monk, K., Axelson, D., Birmaher, B. B., Ryan, N. D., et al. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000136563.31709.b0 · Cited by 122 · see citing works
Animal-Assisted Therapy at an Outpatient Pain Management Clinic
Marcus, D. A., Bernstein, C., Constantin, J. M., Kunkel, F. A., Breuer, P., & Hanlon, R. B. (2012) · Pain Medicine · doi:10.1111/j.1526-4637.2011.01294.x · Cited by 122 · see citing works
Adolescent Fatigue, POTS, and Recovery: A Guide for Clinicians
Kizilbash, S. J., Ahrens, S. P., Bruce, B. K., Chelimsky, G., Driscoll, S. W., Harbeck-Weber, C., Lloyd, R. M., Mack, K. J., Nelson, D. E., Ninis, N., et al. (2014) · Current Problems in Pediatric and Adolescent Health Care · doi:10.1016/j.cppeds.2013.12.014 · Cited by 120 · see citing works
Self-citationPostural Orthostatic Tachycardia Syndrome: A Clinical Review
Johnson, J. N., Mack, K. J., Kuntz, N. L., Brands, C. K., Porter, C. J., & Fischer, P. R. (2010) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2009.07.002 · Cited by 119 · see citing works
Self-citationChildhood headache at school entry
Aromaa, M. E., Sillanpää, M. L., Rautava, P. T., et al. (1998) · Neurology · doi:10.1212/wnl.50.6.1729 · Cited by 117 · see citing works
Weiss, K. E., Hahn, A. L., Wallace, D. P., Biggs, B. K., Bruce, B. K., & Harrison, T. E. (2013) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jst028 · Cited by 116 · see citing works
Korterink, J. J., Ockeloen, L., Benninga, M. A., Tabbers, M. M., Hilbink, M., & Deckers‐Kocken, J. M. (2014) · Acta Paediatrica · doi:10.1111/apa.12513 · Cited by 115 · see citing works
Herbal Medicine for Low Back Pain
Gagnier, J. J., Oltean, H. N., van Tulder, M. W., Berman, B., Bombardier, C., & Robbins, C. B. (2015) · Spine · doi:10.1097/brs.0000000000001310 · Cited by 115 · see citing works
Kashikar‐Zuck, S., Johnston, M., Ting, T. V., Graham, B., Lynch-Jordan, A. M., Verkamp, E., Passo, M. H., Schikler, K. N., Hashkes, P., Spalding, S., et al. (2010) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsq020 · Cited by 113 · see citing works
Smith, P. A. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.044 · Cited by 108 · see citing works
Randomized Controlled Trials of Pediatric Massage: A Review
Beider, S., & Moyer, C. A. (2006) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nel068 · Cited by 108 · see citing works
Juvenile fibromyalgia: current status of research and future developments
Kashikar-Zuck, S., & Ting, T. V. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.177 · Cited by 106 · see citing works
Varni, J. W., Burwinkle, T. M., Limbers, C. A., & Szer, I. S. (2007) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-5-9 · Cited by 100 · see citing works
Herbal Medicine for Low Back Pain
Gagnier, J. J., van Tulder, M. W., Berman, B., et al. (2007) · Spine · doi:10.1097/01.brs.0000249525.70011.fe · Cited by 100 · see citing works
Complex regional pain syndrome type I in children
Tan, E. C. T. H., Zijlstra, B., Essink, M., et al. (2008) · Acta Paediatrica · doi:10.1111/j.1651-2227.2008.00744.x · Cited by 99 · see citing works
Feverfew for preventing migraine
Pittler, M. H., & Ernst, E. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002286.pub2 · Cited by 99 · see citing works
BIGAL, M. E., & Lipton, R. B. (2011) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-010-0175-6 · Cited by 99 · see citing works
Cognitive-Behavioral Therapy for Chronic Pain in Children and Adolescents
Palermo, T. M. (2012) · doi:10.1093/med:psych/9780199763979.001.0001 · Cited by 98 · see citing works
Stewart, D. R., & Burden, S. B. (2004) · British Journal of Sports Medicine · doi:10.1136/bjsm.2003.004861 · Cited by 97 · see citing works
Oelkers‐Ax, R., Leins, A. K., Parzer, P., Hillecke, T. K., Bolay, H. V., Fischer, J., Bender, S., Hermanns, U., & Resch, F. (2007) · European Journal of Pain · doi:10.1016/j.ejpain.2007.06.003 · Cited by 96 · see citing works
Guenolé, F., Godbout, R., Nicolas, A., Franco, P., Claustrat, B., & Baleyte, J. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.02.001 · Cited by 96 · see citing works
Stress, depression and fibromyalgia.
Houdenhove, B. V., & Luyten, P. (2006) · PubMed · Cited by 95 · see citing works
Maynard, C., Amari, A., Wieczorek, B., Christensen, J. R., & Slifer, K. J. (2009) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsp038 · Cited by 95 · see citing works
Kenny, D. T., & Faunce, G. J. (2004) · Journal of Music Therapy · doi:10.1093/jmt/41.3.241 · Cited by 94 · see citing works
Harel, Z., Gascon, G. G., Riggs, S., et al. (2002) · Journal of Adolescent Health · doi:10.1016/s1054-139x(02)00349-x · Cited by 94 · see citing works
The effectiveness of therapeutic exercise for joint hypermobility syndrome: a systematic review
Palmer, S., Bailey, S., Barker, L., Barney, L., & Elliott, A. (2013) · Physiotherapy · doi:10.1016/j.physio.2013.09.002 · Cited by 93 · see citing works
Dolan, A. L., Hart, D., Doyle, D., Grahame, R., & Spector, T. D. (2003) · PubMed · Cited by 91 · see citing works
Wilson, A. C., Moss, A., Palermo, T. M., & Fales, J. L. (2013) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jst094 · Cited by 88 · see citing works
Management of functional abdominal pain and irritable bowel syndrome in children and adolescents
Chiou, E., & Nurko, S. (2010) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.10.28 · Cited by 87 · see citing works
Clinical Uses of Melatonin in Pediatrics
Sánchez‐Barceló, E. J., Mediavilla, M. D., & Reiter, R. J. (2011) · International Journal of Pediatrics · doi:10.1155/2011/892624 · Cited by 86 · see citing works
Pharmacologic Treatment in Pediatric Functional Abdominal Pain Disorders: A Systematic Review
Korterink, J., Rutten, J. M. T. M., Venmans, L. M. A. J., Benninga, M. A., & Tabbers, M. M. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.09.067 · Cited by 85 · see citing works
Articular hypermobility is a protective factor for hand osteoarthritis
Kraus, V. B., Li, Y., Martin, E. R., Jordan, J. M., Renner, J. B., Doherty, M., Wilson, A. G., Moskowitz, R. W., Hochberg, M. C., Loeser, R. F., et al. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20354 · Cited by 85 · see citing works
Kashikar‐Zuck, S., Flowers, S. R., Verkamp, E., Ting, T. V., Lynch-Jordan, A. M., Graham, T. B., Passo, M. H., Schikler, K. N., Hashkes, P. J., Spalding, S. J., et al. (2010) · Journal of Pain · doi:10.1016/j.jpain.2009.12.009 · Cited by 84 · see citing works
Kemp, S., Roberts, I., Gamble, C. L., Wilkinson, S., Davidson, J. E., Baildam, E. M., Cleary, A. G., McCann, L. J., & Beresford, M. W. (2009) · Rheumatology · doi:10.1093/rheumatology/kep362 · Cited by 84 · see citing works
A prospective, 1-year follow-up study of postural tachycardia syndrome
Kimpinski, K., Figueroa, J. J., Singer, W., Sletten, D. M., Iodice, V., Sandroni, P., Fischer, P. R., Opfer-Gehrking, T. L., Gehrking, J. A., & Low, P. A. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2012.02.020 · Cited by 81 · see citing works
Self-citationMind–Body Therapies for the Self-Management of Chronic Pain Symptoms
Lee, C., Crawford, C. C., Hickey, A. H., & Active Self-Care Therapies for Pain (PACT) Working Group (2014) · Pain Medicine · doi:10.1111/pme.12383 · Cited by 79 · see citing works
Quality of Life and Emotional Functioning in Youth With Chronic Migraine and Juvenile Fibromyalgia
Kashikar-Zuck, S., Zafar, M., Barnett, K. A., Aylward, B. S., Strotman, D., Slater, S. K., Allen, J. R., LeCates, S. L., Kabbouche, M. A., Ting, T. V., et al. (2013) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e3182850544 · Cited by 77 · see citing works
The Effect of Hypermobility on the Incidence of Injuries in Elite-Level Professional Soccer Players
Konopinski, M., Jones, G. J., & Johnson, M. I. (2011) · The American Journal of Sports Medicine · doi:10.1177/0363546511430198 · Cited by 76 · see citing works
Diagnosis and management of headaches in young people and adults: summary of NICE guidance
Carville, S., Padhi, S., Reason, T., Underwood, M., & on behalf of the Guideline Development Group (2012) · BMJ · doi:10.1136/bmj.e5765 · Cited by 74 · see citing works
Spine day 2012: spinal pain in Swiss school children– epidemiology and risk factors
Wirth, B., Knecht, C., & Humphreys, K. (2013) · BMC Pediatrics · doi:10.1186/1471-2431-13-159 · Cited by 74 · see citing works
Acceptance and commitment therapy for chronic pain
Vowles, K. E., & McCracken, L. M. (2009) · PsycEXTRA Dataset · doi:10.1037/e558122009-002 · Cited by 73 · see citing works
Joint protection and physical rehabilitation of the adult with hypermobility syndrome
Keer, R. J., & Simmonds, J. V. (2011) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328342d3af · Cited by 71 · see citing works
Home transcutaneous electrical stimulation to treat children with slow-transit constipation
Yik, Y. I., Ismail, K. A., Hutson, J. M., & Southwell, B. R. (2012) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2012.03.037 · Cited by 70 · see citing works
Borusiak, P., Biedermann, H., Boßerhoff, S., & Opp, J. (2009) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2009.01550.x · Cited by 64 · see citing works
Kaminski, A., Kamper, A., Thaler, K. J., Chapman, A. L., & Gartlehner, G. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008013.pub2 · Cited by 63 · see citing works
Smith, T. O., Bacon, H., Jerman, E., Easton, V., Armon, K., Poland, F. M., & MacGregor, A. J. (2013) · Disability and Rehabilitation · doi:10.3109/09638288.2013.819388 · Cited by 61 · see citing works
Postural Tachycardia Syndrome in Children and Adolescents
Jarjour, I. T. (2013) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2013.01.001 · Cited by 60 · see citing works
Pain intensity and quality of life perception in children with hypermobility syndrome
Fatoye, F., Palmer, S., Macmillan, F., Rowe, P. J., & van der Linden, M. L. (2011) · Rheumatology International · doi:10.1007/s00296-010-1729-2 · Cited by 57 · see citing works
Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: A systematic review
Agosti, R. M., Duke, R. K., CHRUBASIK, J., & Chrubasik, S. (2006) · Phytomedicine · doi:10.1016/j.phymed.2006.02.008 · Cited by 54 · see citing works
Psychological aspects. A series of 104 posttraumatic cases of reflex sympathetic dystrophy.
Barbier, O., Allington, N., & Rombouts, J. J. (1999) · PubMed · Cited by 53 · see citing works
Physical therapy treatments for low back pain in children and adolescents: a meta-analysis
Calvo, I., Gómez‐Conesa, A., & Sánchez‐Meca, J. (2013) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-14-55 · Cited by 49 · see citing works
Hayden, J. A., Mior, S. A., & Verhoef, M. J. (2003) · Journal of Manipulative and Physiological Therapeutics · doi:10.1067/mmt.2003.11 · Cited by 47 · see citing works
Chronic Idiopathic Nausea of Childhood
Kovacic, K. K., Miranda, A., Chelimsky, G. G., Williams, S. E., Simpson, P. M., & Li, B. U. K. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.01.046 · Cited by 44 · see citing works
Alp, R., İlhan, S., Palanci, Y., Sur, H., Börü, Ü. T., Özge, A., & Yapıcı, Z. (2010) · Cephalalgia · doi:10.1177/0333102409355837 · Cited by 43 · see citing works
Safder, S., Chelimsky, T. C., O’Riordan, M. A., & Chelimsky, G. G. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181d13623 · Cited by 42 · see citing works
Teitelbaum, J. E., & Arora, R. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318217df7c · Cited by 42 · see citing works
Headache in Children: Update on Complementary Treatments
Heinen, F., Kruse, S., Borggraefe, I., et al. (2013) · Neuropediatrics · doi:10.1055/s-0032-1333435 · Cited by 41 · see citing works
Banez, G. A., Frazier, T. W., Wojtowicz, A. A., Buchannan, K., Henry, D. E., & Benore, E. R. (2014) · Journal of Pediatric Rehabilitation Medicine · doi:10.3233/prm-140289 · Cited by 39 · see citing works
Clinical Practice: Chronic fatigue syndrome
Werker, C. L., Nijhof, S. L., & van de Putte, E. M. (2013) · European Journal of Pediatrics · doi:10.1007/s00431-013-2058-8 · Cited by 39 · see citing works
Acupuncture for Pediatric Pain
Golianu, B. J., Yeh, A. M., & Brooks, M. (2014) · Children · doi:10.3390/children1020134 · Cited by 35 · see citing works
Interventions in Pediatric Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Systematic Review
Knight, S., Scheinberg, A. M., & Harvey, A. R. (2013) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2013.03.009 · Cited by 35 · see citing works
Hestbæk, L., & Stochkendahl, M. J. (2010) · Chiropractic & Manual Therapies · doi:10.1186/1746-1340-18-15 · Cited by 35 · see citing works
J oint hypermobility syndrome: A review for clinicians
Pacey, V., Tofts, L., Wesley, A., Collins, F., & Singh‐Grewal, D. (2014) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.12731 · Cited by 35 · see citing works
Amplified pain syndromes in children
Hoffart, C. M., & Wallace, D. P. (2014) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000097 · Cited by 35 · see citing works
Capsicum plasters on acupoints decrease the incidence of emergence agitation in pediatric patients
Hakan Volkan, A. C. A. R., Yılmaz, A., Demir, G., et al. (2012) · Pediatric Anesthesia · doi:10.1111/j.1460-9592.2012.03876.x · Cited by 34 · see citing works
Physical Trauma and Infection as Precipitating Factors in Patients with Fibromyalgia
Jiao, J., Vincent, A., Cha, S., Luedtke, C., Kim, C.-H., & Oh, T. (2015) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000000300 · Cited by 31 · see citing works
Exercise performance in adolescents with autonomic dysfunction
Burkhardt, B. E. U., Fischer, P. R., Brands, C. K., Porter, C.-B. J., Weaver, A. L., Yim, P. J., & Pianosi, P. T. (2011) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.07.020 · Cited by 31 · see citing works
Self-citationManagement of patients with chronic abdominal pain in clinical practice
Camilleri, M. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00744.x · Cited by 30 · see citing works
Denner, S. S. (2007) · Holistic Nursing Practice · doi:10.1097/01.hnp.0000280932.65581.72 · Cited by 30 · see citing works
Hypermobility and musculoskeletal pain in children: a systematic review
McCluskey, G., O'Kane, E., Hann, D., Weekes, J., & Rooney, M. (2012) · Scandinavian Journal of Rheumatology · doi:10.3109/03009742.2012.676064 · Cited by 28 · see citing works
Horvath, A., Dziechciarz, P., & Szajewska, H. (2012) · Annals of Nutrition and Metabolism · doi:10.1159/000338965 · Cited by 24 · see citing works
Noninvasive Treatments for Pediatric Complex Regional Pain Syndrome: A Focused Review
Katholi, B. R., Daghstani, S. S., Banez, G. A., & Brady, K. (2014) · PM&R · doi:10.1016/j.pmrj.2014.04.007 · Cited by 24 · see citing works
Wyller, V. B., & Helland, I. B. (2013) · BioPsychoSocial Medicine · doi:10.1186/1751-0759-7-5 · Cited by 24 · see citing works
The effect of capsicum plaster in pain after inguinal hernia repair in children
Kim, K. S., Kim, D. W., & YU, Y. K. (2006) · Pediatric Anesthesia · doi:10.1111/j.1460-9592.2006.01927.x · Cited by 22 · see citing works
Gedye, A. (2001) · Medical Hypotheses · doi:10.1054/mehy.2000.1117 · Cited by 21 · see citing works
Castori, M. (2013) · PubMed · Cited by 18 · see citing works
Complementary, Holistic, and Integrative Medicine: Headaches
Kemper, K. J., & Breuner, C. C. (2010) · Pediatrics in Review · doi:10.1542/pir.31-2-e17 · Cited by 13 · see citing works
De Benedittis, G., & Massei, R. (1986) · PubMed · Cited by 12 · see citing works
Options for Pharmacoresistant Epilepsy in Children: When Medications Don’t Work
Sharp, G. B., Samanta, D., & Willis, E. (2015) · Pediatric Annals · doi:10.3928/00904481-20150203-11 · Cited by 10 · see citing works
L-5-Hydroxytryptophan Can Prevent Nociceptive Disorders in Man
Nicolodi, M., & Sicuteri, F. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4709-9_23 · Cited by 8 · see citing works
Eating disorders and reflex sympathetic dystrophy syndrome: is there a common pathway?
Silber, T. J. (1997) · Medical Hypotheses · doi:10.1016/s0306-9877(97)90305-4 · Cited by 8 · see citing works
Smith, S. N., & Crawley, E. M. (2013) · Archives of Disease in Childhood · doi:10.1136/archdischild-2013-304307 · Cited by 6 · see citing works
Boonstra, A. M., Reneman, M. F., Preuper, H. R. S., Waaksma, B. R., & Stewart, R. E. (2014) · International Journal of Rehabilitation Research · doi:10.1097/mrr.0000000000000047 · Cited by 6 · see citing works
CHRONIC DAILY HEADACHE IN CHILDREN
Mack, K. J. (2006) · Neuropediatrics · doi:10.1055/s-2006-946015 · Cited by 5 · see citing works
Self-citationChronic Daily Headache in Children
(2012) · SpringerReference · doi:10.1007/springerreference_120714 · Cited by 1 · see citing works
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Best-evidence for the rehabilitation of chronic pain part 1: Pediatric pain
Harrison, L. E., Pate, J. W., Richardson, P. A., Ickmans, K., Wicksell, R. K., & Simons, L. E. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091267 · Cited by 140 · see citing works
Pas, R., Meeus, M., Malfliet, A., Baert, I., Oosterwijck, S. V., Leysen, L., Nijs, J., & Ickmans, K. (2018) · Brazilian Journal of Physical Therapy · doi:10.1016/j.bjpt.2018.02.004 · Cited by 32 · see citing works
Kallesøe, K. H., Schröder, A., Wicksell, R. K., Preuss, T., Jensen, J. S., & Rask, C. U. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02862-z · Cited by 24 · see citing works
Collins, A. B. (2023) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2023.01.010 · Cited by 17 · see citing works
- Authors
- Landry, B. W., Fischer, P. R., Driscoll, S. W., Koch, K. M., Harbeck‐Weber, C., Mack, K. J., Wilder, R. T., Bauer, B. A., & Brandenburg, J. E.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Landry, Bradford W.
- ORCID
- Venue
- PM&R
- Publisher
- Wiley
- Published
- 2015-11
- Volume
- 7
- Issue
- 11S
- Pages
- S295-S315
- ISSN
- 1934-1482 (ISSN-L)
- 1934-1563
- OpenAlex
- W2176268595
- Cited by
- 128
- References
- 161
- Citations by year
- 2026: 2 · 2025: 20 · 2024: 14 · 2023: 14 · 2022: 13 · 2021: 14 · 2020: 17 · 2019: 16 · 2018: 12 · 2017: 6
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PM&R (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- pediatric chronic pain, children and adolescents, headache, low back pain, joint hypermobility, chronic fatigue, postural orthostatic tachycardia syndrome, abdominal pain, fibromyalgia, complex regional pain syndrome, pain intensity, functional loss, analgesics, exercise recommendations, multidisciplinary pain management, psychological factors in pain, complementary and alternative medicine
- MeSH terms
- Adolescent, Child, Combined Modality Therapy, Humans, Pain Measurement, Chronic Pain, Pain Management
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