A mechanistic look at the effects of adversity early in life on cardiovascular disease risk during adulthood

Loria, A. S.; Ho, D. H.; Pollock, J. S.

doi:10.1111/apha.12189

Cited by 53Birth, Development, and HealthChild Abuse and TraumaStress Responses and Cortisol

A mechanistic look at the effects of adversity early in life on cardiovascular disease risk during adulthood

Open access

Loria, A. S., Ho, D. H., Pollock, J. S.·2014·Acta Physiologica

DOI 10.1111/apha.12189PMC PMC4105322

Open this paper in CoChat — free account

Abstract

Early origins of adult disease may be defined as adversity or challenges during early life that alter physiological responses and prime the organism to chronic disease in adult life. Adverse childhood experiences or early life stress (ELS) may be considered a silent independent risk factor capable of predicting future cardiovascular disease risk. M aternal separation (M at S ep) provides a suitable model to elucidate the underlying molecular mechanisms by which ELS increases the risk to develop cardiovascular disease in adulthood. The aim of this review is to describe the links between behavioural stress early in life and chronic cardiovascular disease risk in adulthood. We will discuss the following: (i) adult cardiovascular outcomes in humans subjected to ELS, (ii) M at S ep as an animal model of ELS as well as the limitations and advantages of this model in rodents and (iii) possible ELS‐induced mechanisms that predispose individuals to greater cardiovascular risk. Overall, exposure to a behavioural stressor early in life sensitizes the response to a second stressor later in life, thus unmasking an exaggerated cardiovascular dysfunction that may influence quality of life and life expectancy in adulthood.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/apha.12189

Cites

124 of 124 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Emerging epidemiologic evidence strongly supports that ELS/CT is an independent albeit silent risk factor of future chronic cardiovascular risk through various systemic and molecular mechanisms.
“Emerging epidemiologic evidence strongly supports that ELS/CT is an independent albeit silent risk factor of future chronic cardiovascular risk through various systemic and molecular mechanisms (267–272)”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [269]
The Abstract (page unavailable) describes ELS as a possible silent, independent predictor of future cardiovascular risk and discusses possible molecular mechanisms. The section “ELS and adult cardiovascular outcomes in humans” reports strong epidemiologic associations, but the paper does not establish that those associations operate through the proposed mechanisms; the claim presents that link more definitively than the review does. (LLM, conf=0.85)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults
Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., Koss, M. P., & Marks, J. S. (1998) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(98)00017-8 · Cited by 18,943 · see citing works
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531 · cited 1× · see citing works
“Childhood abuse alters HPA stress responses and increases the risk of suicide, both of which are associated with the epigenetic regulation of hippocampal GR expression (Fish et al. 2004, McGowan et al. 2009, Murgatroyd et al. 2009).”
Background
Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations
Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708 · cited 2× · see citing works
“The dam’s separation from the pups may change or disturb their normal maternal care, enhancing the effects of the stressor in the pups once they are retuned with the litter (Meaney 2001, Champagne et al. 2004); however, a thorough in-depth study of this phenomenon is lacking.”
BackgroundInfluential
Fetal origins of adult disease: strength of effects and biological basis
Barker, D., Eriksson, J., Forsén, T., & Osmond, C. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.6.1235 · Cited by 2,024 · cited 1× · see citing works
“…result from developmental plasticity, which is the ability of a single genotype to produce more than one alternative form of structure and/or function in response to environmental conditions (Barker et al. 2002, Gluckman & Hanson 2004, McMillen & Robinson 2005, Nuyt 2008, Nuyt & Alexander 2009).”
Background
Living with the Past: Evolution, Development, and Patterns of Disease
Gluckman, P. D., & Hanson, M. A. (2004) · Science · doi:10.1126/science.1095292 · Cited by 1,917 · cited 1× · see citing works
“…result from developmental plasticity, which is the ability of a single genotype to produce more than one alternative form of structure and/or function in response to environmental conditions (Barker et al. 2002, Gluckman & Hanson 2004, McMillen & Robinson 2005, Nuyt 2008, Nuyt & Alexander 2009).”
Background
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
Mcmillen, I. C., & Robinson, J. S. (2005) · Physiological Reviews · doi:10.1152/physrev.00053.2003 · Cited by 1,910 · cited 1× · see citing works
“…result from developmental plasticity, which is the ability of a single genotype to produce more than one alternative form of structure and/or function in response to environmental conditions (Barker et al. 2002, Gluckman & Hanson 2004, McMillen & Robinson 2005, Nuyt 2008, Nuyt & Alexander 2009).”
Background
Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638 · cited 1× · see citing works
“Exaggerated behavioral and cardiovascular stress-related response (Enthoven et al. 2008b, Plotsky and Meaney, 1993, Renard et al. 2007).”
Background
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447 · cited 5× · see citing works
“Increased risk of adult psychiatric disorders, altered stress regulation, altered immune cell function (Klengel et al. 2013).”
BackgroundInfluential
Childhood maltreatment predicts adult inflammation in a life-course study
Danese, A., Pariante, C. M., Caspi, A., Taylor, A., & Poulton, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610362104 · Cited by 1,264 · cited 3× · see citing works
“For example, in the human literature, ELS induces heightened inflammatory status that parallels what is observed in rodent models of ELS (Pace et al. 2006, Danese et al. 2007, O’Mahony et al. 2009, Herbert et al. 2012).”
Background
Dynamic DNA methylation programs persistent adverse effects of early-life stress
Murgatroyd, C., Patchev, A. V., Wu, Y., Micale, V., Bockmühl, Y., Fischer, D., Holsboer, F., Wotjak, C. T., Almeida, O. F. X., & Spengler, D. (2009) · Nature Neuroscience · doi:10.1038/nn.2436 · Cited by 1,162 · cited 1× · see citing works
“Childhood abuse alters HPA stress responses and increases the risk of suicide, both of which are associated with the epigenetic regulation of hippocampal GR expression (Fish et al. 2004, McGowan et al. 2009, Murgatroyd et al. 2009).”
Background
Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses
O'Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A.-M., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.026 · Cited by 1,069 · cited 1× · see citing works
“For example, in the human literature, ELS induces heightened inflammatory status that parallels what is observed in rodent models of ELS (Pace et al. 2006, Danese et al. 2007, O’Mahony et al. 2009, Herbert et al. 2012).”
Background
Insights Into Causal Pathways for Ischemic Heart Disease: Adverse Childhood Experiences Study
Dong, M., Giles, W. H., Felitti, V. J., Dube, S. R., Williams, J. E., Chapman, D. P., & Anda, R. F. (2004) · Circulation · doi:10.1161/01.cir.0000143074.54995.7f · Cited by 1,027 · cited 4× · see citing works
“…defined as adverse childhood experience(s) capable of inducing behavioural and emotional stress, anxiety, fear and discomfort in the individual (Dong et al. 2004, Pace et al. 2006), changes the sensitivity of certain physiological responses that will precipitate an adaptive response to an…”
BackgroundMethodInfluential
Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene–environment interactions, and epigenetics
Heim, C., & Binder, E. B. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.10.032 · Cited by 986 · cited 1× · see citing works
“Also, rodent models mimic the behavioural outcome of ELS in humans such as anxiety and depression (Uchida et al. 2010, Schmidt et al. 2011, Heim & Binder 2012).”
Background
Cohort profile: 1958 British birth cohort (National Child Development Study)
Power, C., & Elliott, J. (2005) · International Journal of Epidemiology · doi:10.1093/ije/dyi183 · Cited by 978 · cited 1× · see citing works
“…across the distribution of childhood cognition are associated with the improvements in cardiovascular risk profile in midlife (Power et al. 1987, 2002, Power & Elliott 2006) ABCD-Amsterdam 2003 2014 Holland Explains socio-economic inequalities in childhood blood pressure and pre-hypertension…”
Background
Diet-Induced Obesity in Female Mice Leads to Offspring Hyperphagia, Adiposity, Hypertension, and Insulin Resistance: A Novel Murine Model of Developmental Programming
Samuelsson, A.-M., Matthews, P. A., Argenton, M., Christie, M. R., McConnell, J. M., Jansen, E. H. J. M., Piersma, A. H., Ozanne, S. E., Twinn, D. F., Remacle, C., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.101477 · Cited by 923 · see citing works
Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling
Miller, G. E., Chen, E., Fok, A. K., Walker, H., Lim, A., Nicholls, E. F., Cole, S., & Kobor, M. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902971106 · Cited by 822 · cited 2× · see citing works
“inflammatory system and hypothalamicpituitary-adrenal (HPA) axis] may favour exaggerated responses that contribute to the pathogenesis of cardiovascular disease, some types of cancer and respiratory disease (Miller et al. 2009).”
Background
Increased Stress-Induced Inflammatory Responses in Male Patients With Major Depression and Increased Early Life Stress
Pace, T. W. W., Mletzko, T. C., Alagbe, O., Musselman, D. L., Nemeroff, C. B., Miller, A. H., & Heim, C. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1630 · Cited by 810 · cited 2× · see citing works
“For example, in the human literature, ELS induces heightened inflammatory status that parallels what is observed in rodent models of ELS (Pace et al. 2006, Danese et al. 2007, O’Mahony et al. 2009, Herbert et al. 2012).”
Background
The Association of Anger and Hostility With Future Coronary Heart Disease
Chida, Y., & Steptoe, A. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.11.044 · Cited by 774 · cited 1× · see citing works
“…commonly occurring in the first decade of life, is induced by behavioural stressors or adverse childhood experiences and is highly correlative with ischaemic heart disease in adulthood, more so than the traditional risk factors (Taylor & Seeman 1999, Chida & Steptoe 2009, Alciati et al. 2011).”
Background
Are poor living conditions in childhood and adolescence an important risk factor for arteriosclerotic heart disease?
Forsdahl, A. (1977) · Journal of Epidemiology & Community Health · doi:10.1136/jech.31.2.91 · Cited by 747 · cited 1× · see citing works
“In addition to the traditional adverse environmental factors, such as chemical compounds, toxins and diet, behavioural stress also has a significant impact in the developing organism (Forsdahl 1979, Felitti 1993, Dong et al. 2004).”
Background
Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health
Meaney, M. J., Moshe Szyf, A., & Seckl, J. R. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.05.003 · Cited by 660 · cited 2× · see citing works
“…with respect to the HPA axis and SAM system, specifically glucocorticoid receptor (GR) expression in the frontal cortex of the brain and the regulation of GR activity (Weaver et al. 2004, Meaney et al. 2007, Cameron et al. 2008, Szyf et al. 2005, Navailles et al. 2010, Klengel et al. 2013).”
Background
Developmental determinants of sensitivity and resistance to stress
Levine, S. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.03.013 · Cited by 574 · cited 2× · see citing works
“Overall, compelling data suggest that repeated exposure to adversity in early life programmes a ‘defensive’ phenotype, which displays a functional resistance to stress-induced responses (Levine 2005, Lyons et al. 2010).”
Background
Variations in maternal care in infancy regulate the development of stress reactivity
Caldji, C., Diorio, J. C., & Meaney, M. J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01084-2 · Cited by 574 · cited 2× · see citing works
“…fully represent the spectrum of early life adversity in humans such as physical abuse, sexual abuse, mental abuse, natural disaster, war-time atrocities, etc. Alterations in maternal warmth induce changes in molecular mediators regulating the HPA axis sensitivity in offspring (Caldji et al. 2000).”
Background
Psychosocial Resources and the SES‐Health Relationship
Taylor, S. E., & Seeman, T. E. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08117.x · Cited by 473 · cited 2× · see citing works
“…low socio-economic status as well is a factor that strongly correlates with the presence of adversity and has been used to approximate ELS in many epidemiological studies (Taylor & Seeman 1999, Holness et al. 2000, Dong et al. 2004, Kelishadi et al. 2009, Chen et al. 2011, Alastalo et al. 2012).”
BackgroundMethod
Risk Factors for Abdominal Aortic Aneurysms
Forsdahl, S. H., Singh, K., Solberg, S. K., & Jacobsen, B. K. (2009) · Circulation · doi:10.1161/circulationaha.108.817619 · Cited by 464 · cited 1× · see citing works
“…correlation between childhood poverty/poor living conditions and adult coronary and atherosclerotic heart disease 3–6 decades later (Forsdahl 1978, Forsdahl et al. 2009) British Birth 1946 1985 UK Low socio-economic status correlated with higher blood pressure in 40-year-old patients…”
Background
Chapter 21 Like mother, like daughter: evidence for non-genomic transmission of parental behavior and stress responsivity
Champagne, F., & Meaney, M. J. (2001) · Progress in Brain Research · doi:10.1016/s0079-6123(01)33022-4 · Cited by 455 · cited 1× · see citing works
“The dam’s separation from the pups may change or disturb their normal maternal care, enhancing the effects of the stressor in the pups once they are retuned with the litter (Meaney 2001, Champagne et al. 2004); however, a thorough in-depth study of this phenomenon is lacking.”
Background
Effects of repeated maternal separation on anxiety- and depression-related phenotypes in different mouse strains.
Millstein, R. A., & Holmes, A. (2007) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.05.003 · Cited by 407 · see citing works
Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat
Champagne, F. A., Chretien, P., Stevenson, C. W., Zhang, T. Y., Gratton, A., & Meaney, M. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5322-03.2004 · Cited by 398 · see citing works
Epigenetic programming of stress responses through variations in maternal care
FISH, E. W., SHAHROKH, D., BAGOT, R., CALDJI, C., BREDY, T., SZYF, M., & MEANEY, M. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1330.011 · Cited by 361 · cited 1× · see citing works
“Childhood abuse alters HPA stress responses and increases the risk of suicide, both of which are associated with the epigenetic regulation of hippocampal GR expression (Fish et al. 2004, McGowan et al. 2009, Murgatroyd et al. 2009).”
Background
Long-term behavioural and molecular alterations associated with maternal separation in rats
Lippmann, M., Bress, A., Nemeroff, C. B., Plotsky, P. M., & Monteggia, L. M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05522.x · Cited by 355 · cited 3× · see citing works
“Maternal separation in rats involves the removal of pups from the dam for 3–4 h a day starting at postnatal day 2 (P2) and ending at P14 (Lehmann et al. 2000, Lippmann et al. 2007, Loria et al. 2010a).”
Background
Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat
Szyf, M., Weaver, I. C. G., Champagne, F. A., Diorio, J., & Meaney, M. J. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.10.002 · Cited by 348 · see citing works
Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood
Chen, E., Miller, G. E., Kobor, M. S., & Cole, S. W. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.53 · Cited by 340 · cited 2× · see citing works
“…low socio-economic status as well is a factor that strongly correlates with the presence of adversity and has been used to approximate ELS in many epidemiological studies (Taylor & Seeman 1999, Holness et al. 2000, Dong et al. 2004, Kelishadi et al. 2009, Chen et al. 2011, Alastalo et al. 2012).”
BackgroundMethod
Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus
Suderman, M., McGowan, P. O., Sasaki, A., Huang, T. C. T., Hallett, M. T., Meaney, M. J., Turecki, G., & Szyf, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121260109 · Cited by 327 · cited 1× · see citing works
“Hippocampal samples were compared from deceased people who experienced childhood abuse and committed suicide, comparing these with non-abused controls (Suderman et al. 2012).”
Background
Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig
Moeser, A. J., Klok, C. V., Ryan, K. A., Wooten, J. G., Little, D., Cook, V. L., & Blikslager, A. T. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00197.2006 · Cited by 320 · see citing works
Stressful Life Events and Depression Symptoms: The Effect of Childhood Emotional Abuse on Stress Reactivity
Shapero, B. G., Black, S. K., Liu, R. T., Klugman, J., Bender, R. E., Abramson, L. Y., & Alloy, L. B. (2013) · Journal of Clinical Psychology · doi:10.1002/jclp.22011 · Cited by 317 · see citing works
Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents
Uchida, S., Hara, K., Kobayashi, A., Funato, H., Hobara, T., Otsuki, K., Yamagata, H., McEwen, B. S., & Watanabe, Y. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1436-10.2010 · Cited by 310 · cited 2× · see citing works
“Adult and juvenile rats and mice exposed to ELS display heightened reactivity to stressors, increased anxiety as well as depression-like behaviours such as reduced anhedonia (George et al. 2010, Uchida et al. 2010, Schmidt et al. 2011).”
Background
Gene–environment interactions: early life stress and risk for depressive and anxiety disorders
Nugent, N. R., Tyrka, A. R., Carpenter, L. L., & Price, L. H. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2151-x · Cited by 269 · cited 1× · see citing works
“In humans, ELS has long been linked to anxiety disorders and depression in adulthood (Nugent et al. 2011, Shapero et al. 2013).”
Background
Lifestyle and environmental factors associated with inflammation, oxidative stress and insulin resistance in children
Kelishadi, R., Mirghaffari, N., Poursafa, P., & Gidding, S. S. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.06.022 · Cited by 264 · cited 2× · see citing works
“…low socio-economic status as well is a factor that strongly correlates with the presence of adversity and has been used to approximate ELS in many epidemiological studies (Taylor & Seeman 1999, Holness et al. 2000, Dong et al. 2004, Kelishadi et al. 2009, Chen et al. 2011, Alastalo et al. 2012).”
BackgroundMethod
Early Weaning Stress in Pigs Impairs Innate Mucosal Immune Responses to Enterotoxigenic E. coli Challenge and Exacerbates Intestinal Injury and Clinical Disease
McLamb, B., Gibson, A. J., Overman, E. L., Stahl, C. H., & Moeser, A. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059838 · Cited by 257 · see citing works
Cohort Profile: The Amsterdam Born Children and their Development (ABCD) Study
van Eijsden, M., Vrijkotte, T. G. M., Gemke, R. J. B. J., & van der Wal, M. F. (2010) · International Journal of Epidemiology · doi:10.1093/ije/dyq128 · Cited by 220 · cited 1× · see citing works
“…2002, Power & Elliott 2006) ABCD-Amsterdam 2003 2014 Holland Explains socio-economic inequalities in childhood blood pressure and pre-hypertension (van Eijsden et al. 2011) ELS clinic Stanford Ongoing USA Early interventions for children and families who have experienced an acute or chronic…”
Background
Childhood Sexual Abuse, Depression, and Family Dysfunction in Adult Obese Patients: A Case Control Study
FELITTI, V. J. (1993) · Southern Medical Journal · doi:10.1097/00007611-199307000-00002 · Cited by 219 · cited 1× · see citing works
“In addition to the traditional adverse environmental factors, such as chemical compounds, toxins and diet, behavioural stress also has a significant impact in the developing organism (Forsdahl 1979, Felitti 1993, Dong et al. 2004).”
Background
Long-term effects of prenatal stress experience and postnatal maternal separation on emotionality and attentional processes
Lehmann, J., Stöhr, T., & Feldon, J. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00122-9 · Cited by 217 · cited 1× · see citing works
“Maternal separation in rats involves the removal of pups from the dam for 3–4 h a day starting at postnatal day 2 (P2) and ending at P14 (Lehmann et al. 2000, Lippmann et al. 2007, Loria et al. 2010a).”
Background
The relationship of adverse childhood experiences to a history of premature death of family members
Anda, R. F., Dong, M., Brown, D. W., Felitti, V. J., Giles, W. H., Perry, G. S., Valerie, E. J., & Dube, S. R. (2009) · BMC Public Health · doi:10.1186/1471-2458-9-106 · Cited by 216 · cited 5× · see citing works
“In addition to the traditional adverse environmental factors, such as chemical compounds, toxins and diet, behavioural stress also has a significant impact in the developing organism (Forsdahl 1979, Felitti 1993, Dong et al. 2004).”
BackgroundInfluential
Consequences of repeated early isolation in domestic piglets (Sus scrofa) on their behavioural, neuroendocrine, and immunological responses
Kanitz, E., Tuchscherer, M., Puppe, B., Tuchscherer, A., & Stabenow, B. (2004) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(03)00085-0 · Cited by 200 · see citing works
Living conditions in childhood and subsequent development of risk factors for arteriosclerotic heart disease. The cardiovascular survey in Finnmark 1974-75.
Forsdahl, A. (1978) · Journal of Epidemiology & Community Health · doi:10.1136/jech.32.1.34 · Cited by 199 · cited 1× · see citing works
“…Positive correlation between childhood poverty/poor living conditions and adult coronary and atherosclerotic heart disease 3–6 decades later (Forsdahl 1978, Forsdahl et al. 2009) British Birth 1946 1985 UK Low socio-economic status correlated with higher blood pressure in 40-year-old…”
Background
Oestrogen Receptor α is Essential for Female‐Directed Chemo‐Investigatory Behaviour but is not Required for the Pheromone‐Induced Luteinizing Hormone Surge in Male Mice
Wersinger, S. R., & Rissman, E. F. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00418.x · Cited by 198 · see citing works
Childhood and adulthood risk factors for socio-economic differentials in psychological distress: evidence from the 1958 British birth cohort
Power, C., Stansfeld, S. A., Matthews, S., Manor, O., & Hope, S. (2002) · Social Science & Medicine · doi:10.1016/s0277-9536(01)00325-2 · Cited by 187 · cited 1× · see citing works
“…revealed that increments across the distribution of childhood cognition are associated with the improvements in cardiovascular risk profile in midlife (Power et al. 1987, 2002, Power & Elliott 2006) ABCD-Amsterdam 2003 2014 Holland Explains socio-economic inequalities in childhood blood…”
Background
Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys
Feng, X., Wang, L., Yang, S., Qin, D., Wang, J., Li, C., Lv, L., Ma, Y., & Hu, X. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010943108 · Cited by 181 · see citing works
Postnatal Stress in Birds: A Novel Model of Glucocorticoid Programming of the Hypothalamic-Pituitary-Adrenal Axis
Spencer, K. A., Evans, N. P., & Monaghan, P. (2008) · Endocrinology · doi:10.1210/en.2008-1471 · Cited by 180 · see citing works
Mechanisms underlying developmental programming of elevated blood pressure and vascular dysfunction: evidence from human studies and experimental animal models
Nuyt, A. M. (2007) · Clinical Science · doi:10.1042/cs20070113 · Cited by 178 · cited 1× · see citing works
“…result from developmental plasticity, which is the ability of a single genotype to produce more than one alternative form of structure and/or function in response to environmental conditions (Barker et al. 2002, Gluckman & Hanson 2004, McMillen & Robinson 2005, Nuyt 2008, Nuyt & Alexander 2009).”
Background
Early life stress paradigms in rodents: potential animal models of depression?
Schmidt, M. V., Wang, X., & Meijer, O. C. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2096-0 · Cited by 171 · cited 2× · see citing works
“Adult and juvenile rats and mice exposed to ELS display heightened reactivity to stressors, increased anxiety as well as depression-like behaviours such as reduced anhedonia (George et al. 2010, Uchida et al. 2010, Schmidt et al. 2011).”
Background
Blood pressure in a national birth cohort at the age of 36 related to social and familial factors, smoking, and body mass.
Wadsworth, M. E. J., Cripps, H. A., Midwinter, R. E., & Colley, J. R. (1985) · BMJ · doi:10.1136/bmj.291.6508.1534 · Cited by 167 · cited 1× · see citing works
“…(Forsdahl 1978, Forsdahl et al. 2009) British Birth 1946 1985 UK Low socio-economic status correlated with higher blood pressure in 40-year-old patients (Wadsworth et al. 1985, Hardy et al. 2004, Kuh et al. 2008) Helsinki Birth 1934–1944 2011 Finland Participants separated during childhood for…”
Background
Epigenetic Programming of Phenotypic Variations in Reproductive Strategies in the Rat Through Maternal Care
Cameron, N. M., Shahrokh, D. K., Corpo, A. D., Dhir, S. K., Moshe Szyf, A., Champagne, F. A., & Meaney, M. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01725.x · Cited by 167 · cited 2× · see citing works
“…with respect to the HPA axis and SAM system, specifically glucocorticoid receptor (GR) expression in the frontal cortex of the brain and the regulation of GR activity (Weaver et al. 2004, Meaney et al. 2007, Cameron et al. 2008, Szyf et al. 2005, Navailles et al. 2010, Klengel et al. 2013).”
BackgroundInfluential
Hypothalamic-pituitary-adrenal axis
Honour, J. W. (1994) · Respiratory Medicine · doi:10.1016/s0954-6111(05)80035-6 · Cited by 164 · see citing works
Maternal separation with early weaning: A novel mouse model of early life neglect
George, E. D., Bordner, K. A., Elwafi, H. M., & Simen, A. A. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-123 · Cited by 163 · cited 2× · see citing works
“Adult and juvenile rats and mice exposed to ELS display heightened reactivity to stressors, increased anxiety as well as depression-like behaviours such as reduced anhedonia (George et al. 2010, Uchida et al. 2010, Schmidt et al. 2011).”
Background
Animal models of early life stress: Implications for understanding resilience
Lyons, D. M., Parker, K. J., & Schatzberg, A. F. (2010) · Developmental Psychobiology · doi:10.1002/dev.20429 · Cited by 157 · see citing works
Developmental programming and hypertension
Nuyt, A. M., & Alexander, B. T. (2009) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e328326092c · Cited by 157 · cited 1× · see citing works
“…result from developmental plasticity, which is the ability of a single genotype to produce more than one alternative form of structure and/or function in response to environmental conditions (Barker et al. 2002, Gluckman & Hanson 2004, McMillen & Robinson 2005, Nuyt 2008, Nuyt & Alexander 2009).”
Background
Early-Life Stress and the Development of Obesity and Insulin Resistance in Juvenile Bonnet Macaques
Kaufman, D., Banerji, M. A., Shorman, I., Smith, E. L. P., Coplan, J. D., Rosenblum, L. A., & Kral, J. G. (2007) · Diabetes · doi:10.2337/db06-1409 · Cited by 138 · cited 1× · see citing works
“…Maternal Separation in rodents Early life stress can influence mechanism(s) of metabolic and mental disorders as well as cardiovascular disease in animal models (Tucker & Johnson 1984, Kaufman et al. 2007, Sanders & Anticevic 2007, Enthoven et al. 2008a, Samuelsson et al. 2008, Loria et al. 2010a).”
Background
Early Life Stress and Inherited Variation in Monkey Hippocampal Volumes
Lyons, D. M., Yang, C., Sawyer-Glover, A. M., Moseley, M. E., & Schatzberg, A. F. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.12.1145 · Cited by 134 · see citing works
Maternal Behavior in the Rat
Stone, C. P., Wiesner, B. P., & Sheard, N. M. (1934) · The American Journal of Psychology · doi:10.2307/1416582 · Cited by 133 · see citing works
Early-life programming of susceptibility to dysregulation of glucose metabolism and the development of Type 2 diabetes mellitus
Holness, M. J., LANGDOWN, M. L., & Sugden, M. C. (2000) · Biochemical Journal · doi:10.1042/bj3490657 · Cited by 132 · cited 2× · see citing works
“Immunological responses Kanitz et al. (2004), Tuchscherer et al.”
Method
Suppressed immune response in infant monkeys associated with maternal separation
Laudenslager, M. L., Reite, M. L., & Harbeck, R. J. (1982) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(82)90223-0 · Cited by 118 · see citing works
Deprivation of maternal care has long-lasting consequences for the hypothalamic–pituitary–adrenal axis of zebra finches
Banerjee, S. B., Arterbery, A. S., Fergus, D. J., & Adkins–Regan, E. (2011) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2011.1265 · Cited by 118 · cited 2× · see citing works
“pituitary-adrenal axis activation Mate choice Banerjee et al. (2012) and Spencer et al. (2009)”
Background
Cardiovascular health of Finnish war evacuees 60 years later
Alastalo, H., Räikkönen, K., Pesonen, A.-K., Osmond, C., Barker, D. J. P., Kajantie, E., Heinonen, K., Forsén, T. J., & Eriksson, J. G. (2009) · Annals of Medicine · doi:10.1080/07853890802301983 · Cited by 116 · cited 1× · see citing works
“…2011 Finland Participants separated during childhood for safety reasons used medications for coronary heart disease more frequently 60 year later (Alastalo et al. 2009, 2012, 2013) Guangzhou Biobank 2003 2008 China ELS was negatively associated with some cardiovascular risk factors,…”
Background
Birthweight, childhood growth, and blood pressure at 43 years in a British birth cohort
Hardy, R. (2004) · International Journal of Epidemiology · doi:10.1093/ije/dyh027 · Cited by 110 · cited 1× · see citing works
“…et al. 2009) British Birth 1946 1985 UK Low socio-economic status correlated with higher blood pressure in 40-year-old patients (Wadsworth et al. 1985, Hardy et al. 2004, Kuh et al. 2008) Helsinki Birth 1934–1944 2011 Finland Participants separated during childhood for safety reasons…”
Background
Mild early life stress enhances prefrontal-dependent response inhibition in monkeys
Parker, K. J., Buckmaster, C. L., Justus, K. R., Schatzberg, A. F., & Lyons, D. M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.12.024 · Cited by 109 · see citing works
Animal models of early life stress: Implications for understanding resilience
Lyons, D. M., Parker, K. J., & Schatzberg, A. F. (2010) · Developmental Psychobiology · doi:10.1002/dev.20500 · Cited by 109 · cited 5× · see citing works
“This mismatch may explain why there is a disparity in effects between rodent models and primate models (Lyons et al. 2010).”
BackgroundInfluential
Neural correlates of maternal separation in rhesus monkeys
Rilling, J. K., Winslow, J., O’Brien, D., Gutman, D. A., Hoffman, J. M., & Kilts, C. D. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00977-x · Cited by 108 · see citing works
Neonatal maternal separation and sex‐specific plasticity of the hypoxic ventilatory response in awake rat
Genest, S., Gulemetova, R., Laforest, S., Drolet, G., & Kinkead, R. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.052894 · Cited by 108 · cited 1× · see citing works
“Dysregulation of the HPA axis sensitivity (Lippmann et al. 2007, Meaney et al. 2007, Genest et al. 2004, O’Mahony et al. 2008).”
Background
Resistance to Early-Life Stress in Mice: Effects of Genetic Background and Stress Duration
Savignac, H. M., Dinan, T. G., & Cryan, J. F. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00013 · Cited by 103 · cited 2× · see citing works
“Also, strain differences in MatSep mice have been extensively explored (Labarba et al. 1973, Savignac et al. 2011).”
Background
Death-Rates in Great Britain and Sweden: Expression of Specific Mortality Rates as Products of Two Factors, and some Consequences thereof
Kermack, W. O., McKendrick, A. G., & Mckinlay, P. L. (1934) · Epidemiology and Infection · doi:10.1017/s0022172400043230 · Cited by 98 · cited 2× · see citing works
“Wales and Sweden 1751–1930 1934 UK Sweden Death rates fell as a result of better childhood living conditions (Kermack et al. 1934)”
Background
Sexually dimorphic effects of maternal separation stress on corticotrophin‐releasing factor and vasopressin systems in the adult rat brain
Desbonnet, L., Garrett, L., Daly, E., McDermott, K. W. G., & Dinan, T. G. (2008) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2008.02.004 · Cited by 97 · see citing works
Glucocorticoid Effects on the Programming of AT1b Angiotensin Receptor Gene Methylation and Expression in the Rat
Bogdarina, I. G., Haase, A., Langley‐Evans, S. C., & Clark, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009237 · Cited by 93 · cited 2× · see citing works
“Published by John Wiley & Sons Ltd, doi: 10.1111/apha.12189282 outcomes involved in the programming of the adult phenotype (Champagne & Meaney 2001, Cameron et al. 2008, Bogdarina et al. 2010).”
BackgroundInfluential
Early life stress and novelty seeking behavior in adolescent monkeys
Parker, K. J., Rainwater, K. L., Buckmaster, C. L., Schatzberg, A. F., Lindley, S. E., & Lyons, D. M. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.05.008 · Cited by 89 · see citing works
Strain-specific cognitive deficits in adult mice exposed to early life stress.
Mehta, M., & Schmauss, C. (2011) · Behavioral Neuroscience · doi:10.1037/a0021952 · Cited by 84 · cited 1× · see citing works
“For example, the innately anxious Balb-c mice appear to be more susceptible to the cognitive ill-effects of MatSep than C57BL6 mice, such as reduced recognition and spatial working memory (Mehta & Schmauss 2011).”
Background
A single exposure to social isolation in domestic piglets activates behavioural arousal, neuroendocrine stress hormones, and stress-related gene expression in the brain
Kanitz, E., Puppe, B., Tuchscherer, M., Heberer, M., Viergutz, T., & Tuchscherer, A. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.05.007 · Cited by 81 · see citing works
Maternal separation with early weaning: a rodent model providing novel insights into neglect associated developmental deficits
Carlyle, B. C., Duque, A., Kitchen, R. R., Bordner, K. A., Coman, D., Doolittle, E., Papademetris, X., Hyder, F., Taylor, J. R., & Simen, A. A. (2012) · Development and Psychopathology · doi:10.1017/s095457941200079x · Cited by 80 · see citing works
Sexual dimorphism in rats: effects of early maternal separation and variable chronic stress on pituitary‐adrenal axis and behavior
Renard, G. M., Rivarola, M. A., & Suárez, M. M. (2007) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.07.001 · Cited by 80 · cited 1× · see citing works
“Exaggerated behavioral and cardiovascular stress-related response (Enthoven et al. 2008b, Plotsky and Meaney, 1993, Renard et al. 2007).”
Background
Early Life Stress Sensitizes Rats to Angiotensin II–Induced Hypertension and Vascular Inflammation in Adult Life
Loria, A. S., Pollock, D. M., & Pollock, J. S. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.145391 · Cited by 74 · cited 3× · see citing works
“Reduced NO buffering capacity and increased AngII-induced constriction (Loria et al. 2011, Loria et al. 2010a, Loria et al. 2010b).”
BackgroundSelf-citation
Maternal behavior and offspring resiliency to maternal separation in c57bl/6 mice
Own, L. S., & Patel, P. D. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.11.010 · Cited by 72 · cited 1× · see citing works
“In primates, some researchers have detected resilience rather than a behavioural instability in the face of MatSep (Lyons et al. 2010, Own & Patel 2012).”
Background
Early life stress and blood pressure levels in late adulthood
Alastalo, H., Räikkönen, K., Pesonen, A., Osmond, C., Barker, D. J. P., Heinonen, K., Kajantie, E., & Eriksson, J. G. (2012) · Journal of Human Hypertension · doi:10.1038/jhh.2012.6 · Cited by 67 · cited 2× · see citing works
“…1A. ELS consistently demonstrated a cardiovascular risk phenotype, including exacerbation of inflammatory markers and lipid profiles that may enhance the underlying risk of cardiovascular disease (Danese et al. 2007, Kelishadi et al. 2009, Chen et al. 2011, Vig et al. 2010, Alastalo et al. 2013).”
Background
Effects of postnatal social isolation on hormonal and immune responses of pigs to an acute endotoxin challenge
Tuchscherer, M., Kanitz, E., Puppe, B., Tuchscherer, A., & Stabenow, B. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.04.056 · Cited by 66 · see citing works
Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model
O’Mahony, S. M., Chua, A., Quigley, E. M. M., Clarke, G. A., Shanahan, F., Keeling, P. W. N., & Dinan, T. G. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.01065.x · Cited by 64 · see citing works
Maternal separation enhances neuronal activation and cardiovascular responses to acute stress in borderline hypertensive rats
SANDERS, B., & Anticevic, A. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.05.020 · Cited by 61 · cited 2× · see citing works
“Published by John Wiley & Sons Ltd, doi: 10.1111/apha.12189 281 is elevated in response to acute stress in MatSep borderline hypertensive rats (Sanders & Anticevic 2007).”
BackgroundInfluential
Hypothalamic-Pituitary-Adrenal Axis Activity of Newborn Mice Rapidly Desensitizes to Repeated Maternal Absence but Becomes Highly Responsive to Novelty
Enthoven, L., Oitzl, M. S., Koning, N. R., van der Mark, M. H., & de Kloet, E. R. (2008) · Endocrinology · doi:10.1210/en.2008-0238 · Cited by 60 · cited 2× · see citing works
“…Maternal Separation in rodents Early life stress can influence mechanism(s) of metabolic and mental disorders as well as cardiovascular disease in animal models (Tucker & Johnson 1984, Kaufman et al. 2007, Sanders & Anticevic 2007, Enthoven et al. 2008a, Samuelsson et al. 2008, Loria et al. 2010a).”
Background
The influence of maternal separation on plasma concentrations of ACTH, epinephrine, and norepinephrine in guinea pig pups
Hennessy, M. B., Harvey, A. T., Schiml, P. A., & Lucot, J. B. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90101-7 · Cited by 52 · see citing works
Dietary n-3 polyunsaturated fatty acid deprivation together with early maternal separation increases anxiety and vulnerability to stress in adult rats
Mathieu, G., Oualian, C., Denis, I., Lavialle, M., Gisquet-Verrier, P., & Vancassel, S. (2011) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2011.07.001 · Cited by 49 · see citing works
Anti-inflammatory agents attenuate the passive responses of guinea pig pups: Evidence for stress-induced sickness behavior during maternal separation
Hennessy, M. B., Schiml‐Webb, P. A., Miller, E. E., Maken, D. S., Bullinger, K. L., & Terrence Deak, B. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.03.004 · Cited by 49 · see citing works
Early life stress enhances angiotensin II-mediated vasoconstriction by reduced endothelial nitric oxide buffering capacity
Loria, A. S., Kang, K.-T., Pollock, D. M., & Pollock, J. S. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.168674 · Cited by 48 · cited 3× · see citing works
“Reduced NO buffering capacity and increased AngII-induced constriction (Loria et al. 2011, Loria et al. 2010a, Loria et al. 2010b).”
BackgroundSelf-citation
Clinical depression, antidepressant use and risk of future cardiovascular disease
Rahman, I., Humphreys, K., Bennet, A., Ingelsson, E., Pedersen, N. L., & Magnusson, P. K. E. (2013) · European Journal of Epidemiology · doi:10.1007/s10654-013-9821-z · Cited by 47 · cited 1× · see citing works
“These ELS-induced pro-anxiety and prodepression traits have been suggested to correlate with the promotion of cardiovascular outcomes such as stroke, atherosclerosis and hypertension (Beutel et al. 2013, Rahman et al. 2013); however, these parameters have not been consistently measured and reported.”
Background
The Relationship between Childhood Parental Loss and Metabolic Syndrome in Obese Subjects
Alciati, A., Gesuele, F., Casazza, G., & Foschi, D. (2011) · Stress and Health · doi:10.1002/smi.1435 · Cited by 47 · cited 1× · see citing works
“…commonly occurring in the first decade of life, is induced by behavioural stressors or adverse childhood experiences and is highly correlative with ischaemic heart disease in adulthood, more so than the traditional risk factors (Taylor & Seeman 1999, Chida & Steptoe 2009, Alciati et al. 2011).”
Background
Oestrus synchronisation of rabbit does at early post-partum by doe–litter separation or ECG injection: Reproductive parameters and endocrine profiles
Rebollar, P. G., Milanés, A., Pereda, N., Millán, P., Cano, P., Esquifino, A. I., Villarroel, M., Silván, G., & Lorenzo, P. L. (2005) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2005.06.032 · Cited by 47 · cited 1× · see citing works
“Some insight can be gained from rabbit models of MatSep where maternal lactation and circulating hormones have been shown to change during separation from pups (Cano et al. 2005b, Rebollar et al. 2006).”
Background
Early social isolation alters behavioral and physiological responses to an endotoxin challenge in piglets
Tuchscherer, M., Kanitz, E., Puppe, B., & Tuchscherer, A. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.026 · Cited by 45 · see citing works
Neonatal Maternal Separation Alters Immune, Endocrine, and Behavioral Responses to Acute Theiler’s Virus Infection in Adult Mice
Meagher, M. W., Sieve, A. N., Johnson, R. R., Satterlee, D. M., Belyavskyi, M., Mi, W., Prentice, T. W., Welsh, T. H., & Welsh, C. J. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9333-5 · Cited by 45 · cited 2× · see citing works
“Exaggerated response to LPS and E coli infection (Meagher et al. 2010).”
Background
A longitudinal study on the significance of environmental and individual factors associated with the development of essential hypertension.
Lindgärde, F., Furu, M., & Ljung, B. (1987) · Journal of Epidemiology & Community Health · doi:10.1136/jech.41.3.220 · Cited by 44 · cited 2× · see citing works
“The effects of ELS on the endocrine, inflammatory and neural system have been studied (Lindgarde et al. 1987).”
BackgroundInfluential
Early life stress interacts with the diet deficiency of omega-3 fatty acids during the life course increasing the metabolic vulnerability in adult rats
Bernardi, J. R., Ferreira, C. F., Senter, G., Krolow, R., de Aguiar, B. W., Portella, A. K., Kauer-Sant'Anna, M., Kapczinski, F., Dalmaz, C., Goldani, M. Z., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062031 · Cited by 43 · see citing works
Early life stress sensitizes the renal and systemic sympathetic system in rats
Loria, A. S., Brands, M. W., Pollock, D. M., & Pollock, J. S. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00008.2013 · Cited by 43 · cited 3× · see citing works
“Impaired chronic blood pressure control (Loria et al. 2013).”
BackgroundInfluentialSelf-citation
Expression of Glucocorticoid Receptor and Early Growth Response Gene 1 during Postnatal Development of Two Inbred Strains of Mice Exposed to Early Life Stress
Navailles, S., Zimnisky, R. M., & Schmauss, C. (2010) · Developmental Neuroscience · doi:10.1159/000293989 · Cited by 41 · cited 1× · see citing works
“…with respect to the HPA axis and SAM system, specifically glucocorticoid receptor (GR) expression in the frontal cortex of the brain and the regulation of GR activity (Weaver et al. 2004, Meaney et al. 2007, Cameron et al. 2008, Szyf et al. 2005, Navailles et al. 2010, Klengel et al. 2013).”
Background
Early life stress downregulates endothelin receptor expression and enhances acute stress-mediated blood pressure responses in adult rats
Loria, A. S., D’Angelo, G., Pollock, D. M., & Pollock, J. S. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00333.2009 · Cited by 41 · cited 6× · see citing works
“Maternal separation in rats involves the removal of pups from the dam for 3–4 h a day starting at postnatal day 2 (P2) and ending at P14 (Lehmann et al. 2000, Lippmann et al. 2007, Loria et al. 2010a).”
BackgroundResultInfluentialSelf-citation
Postnatal maternal separation modifies the response to an obesogenic diet in adulthood
Paternain, L., Martisova, E., Milagro, F. I., Ramírez, M. J., Martínez, J. A., & Campión, J. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.009043 · Cited by 39 · see citing works
Differential development of stress system (re)activity at weaning dependent on time of disruption of maternal care
Enthoven, L., de Kloet, E. R., & Oitzl, M. S. (2008) · Brain Research · doi:10.1016/j.brainres.2008.04.009 · Cited by 37 · cited 2× · see citing works
“…Maternal Separation in rodents Early life stress can influence mechanism(s) of metabolic and mental disorders as well as cardiovascular disease in animal models (Tucker & Johnson 1984, Kaufman et al. 2007, Sanders & Anticevic 2007, Enthoven et al. 2008a, Samuelsson et al. 2008, Loria et al. 2010a).”
Background
Central dopamine turnover in guinea pig pups during separation from their mothers in a novel environment.
Tamborski, A., Lucot, J. B., & Hennessy, M. B. (1990) · Behavioral Neuroscience · doi:10.1037//0735-7044.104.4.607 · Cited by 34 · see citing works
Cardiovascular morbidity and mortality in Finnish men and women separated temporarily from their parents in childhood–a life course study
Alastalo, H., Räikkönen, K., Pesonen, A.-K., Osmond, C., Barker, D. J. P., Heinonen, K., Kajantie, E., & Eriksson, J. G. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31825b3d76 · Cited by 32 · cited 2× · see citing works
“…low socio-economic status as well is a factor that strongly correlates with the presence of adversity and has been used to approximate ELS in many epidemiological studies (Taylor & Seeman 1999, Holness et al. 2000, Dong et al. 2004, Kelishadi et al. 2009, Chen et al. 2011, Alastalo et al. 2012).”
BackgroundMethod
Maternal separation produces, and a second separation enhances, core temperature and passive behavioral responses in guinea pig pups
Hennessy, M. B., Terrence Deak, B., Schiml‐Webb, P. A., Carlisle, C. W., & O'Brien, E. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.02.024 · Cited by 31 · see citing works
The effects of 13 days maternal separation on infant rhesus monkeys compared with those of shorter and repeated separations
Spencer‐Booth, Y., & Hinde, R. A. (1971) · Animal Behaviour · doi:10.1016/s0003-3472(71)80117-3 · Cited by 31 · see citing works
Early maternal separation has mild effects on cardiac autonomic balance and heart structure in adult male rats
Trombini, M., Hulshof, H. J., Graiani, G., Carnevali, L., Meerlo, P., Quaini, F., & Sgoifo, A. (2011) · Stress · doi:10.3109/10253890.2011.639414 · Cited by 31 · cited 2× · see citing works
“Mild effects on cardiomyocyte hypertrophy and myocardial fibrosis (Trombini et al. 2012).”
Background
Central dopamine turnover in guinea pig pups during separation from their mothers in a novel environment.
Tamborski, A., Lucot, J. B., & Hennessy, M. B. (1990) · Behavioral Neuroscience · doi:10.1037/0735-7044.104.4.607 · Cited by 31 · see citing works
Both prevention of physical contact and removal of distal cues mediate cortisol and vocalization responses of guinea pig pups to maternal separation in a novel environment
Hennessy, M. B. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90369-1 · Cited by 31 · cited 1× · see citing works
“Circulating cortisol levels and vocalization in novel environment Core temperature and behaviour Hennessy (1988), Hennessy et al.”
Background
The arcuate NPY, POMC, and CART expressions responding to food deprivation are exaggerated in young female rats that experienced neonatal maternal separation
Yoo, S. B., Ryu, V., Park, E. Y., Kim, B.-T., Kang, D. W., Lee, J.-H., & Jahng, J. W. (2011) · Neuropeptides · doi:10.1016/j.npep.2011.07.005 · Cited by 30 · see citing works
Incidence of Renal Stones in 18 British Towns A Collaborative Study
Power, C., Barker, D. J. P., & Blacklock, N. J. (1987) · British Journal of Urology · doi:10.1111/j.1464-410x.1987.tb04798.x · Cited by 29 · cited 1× · see citing works
“…revealed that increments across the distribution of childhood cognition are associated with the improvements in cardiovascular risk profile in midlife (Power et al. 1987, 2002, Power & Elliott 2006) ABCD-Amsterdam 2003 2014 Holland Explains socio-economic inequalities in childhood blood…”
Background
Influence of neonatal handling on blood pressure, locomotor activity, and preweanling heart rate in spontaneously hypertensive and Wistar Kyoto rats
Tucker, D. C., & Johnson, A. K. (1984) · Developmental Psychobiology · doi:10.1002/dev.420170603 · Cited by 26 · cited 1× · see citing works
“…Maternal Separation in rodents Early life stress can influence mechanism(s) of metabolic and mental disorders as well as cardiovascular disease in animal models (Tucker & Johnson 1984, Kaufman et al. 2007, Sanders & Anticevic 2007, Enthoven et al. 2008a, Samuelsson et al. 2008, Loria et al. 2010a).”
Background
Effects of maternal separation, early handling, and gonadal sex on regional metabolic capacity of the preweanling rat brain
Spivey, J. M., Padilla‐Tolentino, E., Shumake, J., & Gonzalez-Lima, F. (2010) · Brain Research · doi:10.1016/j.brainres.2010.10.038 · Cited by 26 · cited 1× · see citing works
“Insulin resistance and metabolic syndrome Increased body weight and metabolic syndrome (Spivey et al. 2011).”
Background
Are poor living conditions in childhood and adolescence an important risk factor for arteriosclerotic heart disease?
Forsdahl, A. (1979) · International Journal of Rehabilitation Research · doi:10.1097/00004356-197905000-00008 · Cited by 25 · see citing works
Parental Death during Childhood and Adult Cardiovascular Risk in a Developing Country: The Guangzhou Biobank Cohort Study
Schooling, C. M., Jiang, C., Lam, T. H., Zhang, W., Cheng, K. K., & Leung, G. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019675 · Cited by 23 · cited 1× · see citing works
“…et al. 2009, 2012, 2013) Guangzhou Biobank 2003 2008 China ELS was negatively associated with some cardiovascular risk factors, particularly among men (Schooling et al. 2011) (B) Prospective studies Study name Start End Population Outcomes Dunedin health and development 1972 2006 New Zealand…”
Background
Voluntary and involuntary maternal separation in guinea pig pups with mothers required to forage
Hennessy, M. B., & Sharp, K. (1990) · Developmental Psychobiology · doi:10.1002/dev.420230803 · Cited by 23 · see citing works
History of depression but not current depression is associated with signs of atherosclerosis: data from the Gutenberg Health Study
Beutel, M. E., Wiltink, J., Kirschner, Y., Sinning, C., Espinola–Klein, C., Wild, P. S., Münzel, T. F., Blettner, M., Zwiener, I., Lackner, K. J., et al. (2013) · Psychological Medicine · doi:10.1017/s0033291713001542 · Cited by 21 · see citing works
Development of asthmatic inflammation in mice following early-life exposure to ambient environmental particulates and chronic allergen challenge
Herbert, C. A., Siegle, J. S., Shadie, A. M., Nikolaysen, S., Garthwaite, L. L., Hansbro, N. G., Foster, P. S., & Kumar, R. K. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.010728 · Cited by 19 · cited 1× · see citing works
“For example, in the human literature, ELS induces heightened inflammatory status that parallels what is observed in rodent models of ELS (Pace et al. 2006, Danese et al. 2007, O’Mahony et al. 2009, Herbert et al. 2012).”
Background
The Effect of Early-Life Stress on Airway Inflammation in Adult Mice
VIG, R. S., Gordon, J., Thébaud, B., Befus, A. D., & Vliagoftis, H. (2010) · NeuroImmunoModulation · doi:10.1159/000290039 · Cited by 15 · cited 1× · see citing works
“…1A. ELS consistently demonstrated a cardiovascular risk phenotype, including exacerbation of inflammatory markers and lipid profiles that may enhance the underlying risk of cardiovascular disease (Danese et al. 2007, Kelishadi et al. 2009, Chen et al. 2011, Vig et al. 2010, Alastalo et al. 2013).”
Background
Letter to the editor
Mascitelli, L., Pezzetta, F., & Sullivan, J. L. (2006) · Gender Medicine · doi:10.1016/s1550-8579(06)80221-4 · Cited by 12 · see citing works
Offspring birth weight, gestational age and maternal characteristics in relation to glucose status at age 53 years: evidence from a national birth cohort
Kuh, D. J., Mishra, G. D., Black, S., Lawlor, D. A., Smith, G. D., Okell, L., Wadsworth, M. E. J., & Hardy, R. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2008.02427.x · Cited by 10 · cited 1× · see citing works
“…Birth 1946 1985 UK Low socio-economic status correlated with higher blood pressure in 40-year-old patients (Wadsworth et al. 1985, Hardy et al. 2004, Kuh et al. 2008) Helsinki Birth 1934–1944 2011 Finland Participants separated during childhood for safety reasons used medications for coronary…”
Background
Effect of litter separation on 24-hour rhythmicity of plasma prolactin, follicle-stimulating hormone and luteinizing hormone levels in lactating rabbit does
Cano, P., Jiménez, V., Alvarez, M. P., Alvariño, M., Cardinali, D. P., & Esquifino, A. I. (2005) · Journal of Circadian Rhythms · doi:10.1186/1740-3391-3-9 · Cited by 9 · see citing works
Compensatory social responses of older pigtailed monkeys to maternal separation
Bernstein, I. S., & Dobrofsky, M. (1981) · Developmental Psychobiology · doi:10.1002/dev.420140210 · Cited by 8 · see citing works
Effect of rabbit doe-litter separation on 24-hour changes of luteinizing hormone, follicle stimulating hormone and prolactin release in female and male suckling pups
Cano, P., Jiménez‐Ortega, V., Alvarez, M. P., Alvariño, M., Cardinali, D. P., & Esquifino, A. I. (2005) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-3-50 · Cited by 8 · see citing works
Maternal Separation and Emotional Reactivity in Balb/C Mice
Barba, R. C. L., Hibbs, S. E., & White, J. L. (1973) · Psychological Reports · doi:10.2466/pr0.1973.32.1.107 · Cited by 4 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

Mascitelli L Pezzetta F Sullivan JL Why women live longer than men: sex differences in longevity Gend Med 2006 3 341 author reply 342 17582374

Sorted by citations

Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation
Agorastos, A., Pervanidou, P., Chrousos, G. P., & Baker, D. G. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00118 · Cited by 385 · see citing works
Stress & sleep: A relationship lasting a lifetime
Martire, V. L., Caruso, D., Palagini, L., Zoccoli, G., & Bastianini, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.08.024 · Cited by 296 · see citing works
Fetal Programming and Cardiovascular Pathology
Alexander, B. T., Dasinger, J. H., & Intapad, S. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140036 · Cited by 217 · see citing works
How age, sex and genotype shape the stress response
Novais, A., Monteiro, S., Roque, S., Correia‐Neves, M., & Sousa, N. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.11.004 · Cited by 140 · see citing works
“…from mothers with depression or neglected/abused infants, is associated with increased susceptibility to the effects of stress later in life and vulnerability to develop stress-related psychiatric disorders (Graham et al., 1999; Nugent et al., 2011) and cardiovascular diseases (Loria et al., 2014).”
Background
Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents
Murphy, M. O., Cohn, D. M., & Loria, A. S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.018 · Cited by 117 · see citing works
“…associated with the consequences of emotional trauma have been shown to impact the cardiovascular system of rodents in a similar fashion to the observed in adult humans (Beutel et al., 2014; Loria et al., 2013a; Mascitelli et al., 2006; Rahman et al., 2013; Sanders and Anticevic, 2007).”
BackgroundResultInfluentialSelf-citation
Social Determinants of Cardiovascular Health: Early Life Adversity as a Contributor to Disparities in Cardiovascular Diseases
Suglia, S. F., Campo, R., Brown, A. G. M., Stoney, C. M., Boyce, C. A., Appleton, A. A., Bleil, M. E., Boynton‐Jarrett, R., Dube, S. R., Dunn, E. C., et al. (2020) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2019.12.063 · Cited by 88 · see citing works
Early life adversity as a risk factor for cognitive impairment and Alzheimer’s disease
Huang, Z., Jordan, J. D., & Zhang, Q. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00355-z · Cited by 92 · see citing works
Adverse childhood experiences and health-related quality of life in adulthood: revelations from a community needs assessment
Salinas‐Miranda, A., Salemi, J. L., King, L., Baldwin, J. A., Berry, E., Austin, D., Scarborough, K., Spooner, K. K., Zoorob, R., & Salihu, H. M. (2015) · Health and Quality of Life Outcomes · doi:10.1186/s12955-015-0323-4 · Cited by 80 · see citing works
“Our study confirms this association and is consistent with previous findings [7, 11–15].”
BackgroundResult
Understanding Mental Health for the Prevention and Control of Cardiovascular Diseases
Mensah, G. A., & Collins, P. Y. (2015) · Global Heart · doi:10.1016/j.gheart.2015.08.003 · Cited by 60 · see citing works
The roles of sensitization and neuroplasticity in the long-term regulation of blood pressure and hypertension
Johnson, A. K., Zhang, Z., Clayton, S., Beltz, T. G., Hurley, S. W., Thunhorst, R. L., & Xue, B. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00037.2015 · Cited by 55 · see citing works
The impact of adverse childhood experiences on the health and health behaviors of young Australian women
Loxton, D. J., Forder, P., Cavenagh, D., Townsend, N., Holliday, E. G., Chojenta, C., & Melka, A. S. (2020) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2020.104771 · Cited by 55 · see citing works
Low on energy? An energy supply-demand perspective on stress and depression
Østergaard, L., Jørgensen, M. B., & Knudsen, G. M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.08.007 · Cited by 52 · see citing works
Early life stress in male mice induces superoxide production and endothelial dysfunction in adulthood
Ho, D. H., Burch, M. L., Musall, B., Musall, J. B., Hyndman, K. A., & Pollock, J. S. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00016.2016 · Cited by 34 · see citing works
Self-citation
Examining the Influence of Early Life Stress on Serum Lipid Profiles and Cognitive Functioning in Depressed Patients
Péterfalvi, Á., Németh, N., Herczeg, R., Tényi, T., Miseta, A., Czéh, B., & Simon, M. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01798 · Cited by 30 · see citing works
Effects of early‐life stress and sex on blood–brain barrier permeability and integrity in juvenile and adult rats
Solarz, A., Majcher‐Maślanka, I., & Chocyk, A. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22846 · Cited by 29 · see citing works
Transgenerational Epigenetics: The Role of Maternal Effects in Cardiovascular Development
Ho, D. H. (2014) · Integrative and Comparative Biology · doi:10.1093/icb/icu031 · Cited by 26 · see citing works
“Convergent data from a wide variety of animals indicate that suboptimal maternal care sensitizes the offspring’s HPA axis to subsequent stressors by altering release of glucocorticoid and catecholamine, and the expression of glucocorticoid receptor (reviewed by Sanchez 2006; Meaney et al. 2007; Loria et al. 2014).”
BackgroundSelf-citation
Postnatal treatment with metyrapone attenuates the effects of diet-induced obesity in female rats exposed to early-life stress
Murphy, M. O., Herald, J. B., Wills, C., Unfried, S. G., Cohn, D. M., & Loria, A. S. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00308.2016 · Cited by 25 · see citing works
“It is widely accepted that maternal separation (MatSep), a chronic behavioral stress model during postnatal life in rodents, exerts long-term effects on the hypothalamic-pituitaryadrenal (HPA) axis function, negatively influencing behavioral responses (34, 39).”
BackgroundSelf-citation
Early life stress induces immune priming in kidneys of adult male rats
Miguel, C. D., Obi, I. E., Ho, D. H., Loria, A. S., & Pollock, J. S. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00590.2016 · Cited by 25 · see citing works
“In humans, ELS is defined as prolonged adverse childhood experiences (ACE) typically occurring during the first decade of life (38).”
BackgroundSelf-citation
Early-life stress affects peripheral, blood-brain barrier, and brain responses to immune challenge in juvenile and adult rats
Solarz, A., Majcher‐Maślanka, I., Kryst, J., & Chocyk, A. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.11.005 · Cited by 24 · see citing works
The Link Between Childhood Adversity and Cardiovascular Disease Risk: Role of Cerebral and Systemic Vasculature
Rodriguez‐Miguelez, P., Looney, J. C., Blackburn, M., Thomas, J., Pollock, J. S., & Harris, R. A. (2022) · Function · doi:10.1093/function/zqac029 · Cited by 23 · see citing works
“Results are presented as (1) maximal hyperemic response (Peak), (2) area under the curve (Area), and (3) time-to-peak (TTP), which represents the time from the start of the stimuli to the maximal hyperemic response.”
BackgroundMethodSelf-citation
Adverse Childhood Experiences and Healthcare Costs in Adult Life
Loxton, D. J., Townsend, N., Dolja‐Gore, X., Forder, P., & Coles, J. Y. (2018) · Journal of Child Sexual Abuse · doi:10.1080/10538712.2018.1523814 · Cited by 22 · see citing works
Decreased serum total cholesterol is associated with a history of childhood physical violence in depressed outpatients
Kraav, S., Tolmunen, T., Kärkkäinen, O. K., Ruusunen, A. A., Viinamäki, H. T., Mäntyselkä, P. T., Koivumaa-Honkanen, H. T., Valkonen‐Korhonen, M., Honkalampi, K. M., Herzig, K., et al. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.12.108 · Cited by 22 · see citing works
Adverse childhood experiences, sex, and cardiovascular habituation to repeated stress
Tyra, A. T., Cook, T. E., Young, D. A., Hurley, P. E., Oosterhoff, B. J., John‐Henderson, N. A., & Ginty, A. T. (2021) · Biological Psychology · doi:10.1016/j.biopsycho.2021.108175 · Cited by 19 · see citing works
Fetal Programming and Cardiovascular Pathology
Alexander, B. T., Dasinger, J. H., & Intapad, S. (2015) · Comprehensive physiology · doi:10.1002/j.2040-4603.2015.tb00618.x · Cited by 19 · see citing works
“In addition, psychosocial stress in early life can impact later CV and metabolic health (for review, see 115).”
Influential
Exposure to Vicarious Social Defeat Stress and Western-Style Diets During Adolescence Leads to Physiological Dysregulation, Decreases in Reward Sensitivity, and Reduced Antidepressant Efficacy in Adulthood
Sial, O. K., Gnecco, T., Cardona-Acosta, A. M., Vieregg, E., Cardoso, E. A., Parise, L. F., & Bolaños‐Guzmán, C. A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.701919 · Cited by 18 · see citing works
H2S and Oxytocin Systems in Early Life Stress and Cardiovascular Disease
McCook, O., Denoix, N., Radermacher, P., Waller, C., & Merz, T. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10163484 · Cited by 16 · see citing works
The stress of maternal separation causes misprogramming in the postnatal maturation of rat resistance arteries
Reho, J. J., & Fisher, S. A. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00567.2015 · Cited by 16 · see citing works
The Interaction of the Endogenous Hydrogen Sulfide and Oxytocin Systems in Fluid Regulation and the Cardiovascular System
Denoix, N., McCook, O., Ecker, S., Wang, R., Waller, C., Radermacher, P., & Merz, T. (2020) · Antioxidants · doi:10.3390/antiox9080748 · Cited by 13 · see citing works
Stress
Persson, P. B., & Zakrisson, A. (2015) · Acta Physiologica · doi:10.1111/apha.12641 · Cited by 10 · see citing works
“…the maternal and the foetal organism seem to be somewhat disregarded, and also, the close connection between a behavioural stressor early in life and organic, for example, cardiovascular dysfunction appears as a relatively novel concept in the literature (Loria et al. 2014, Patchev et al. 2014).”
Background
Early-Life Stress Influences the Transcriptional Activation of Alpha-2A Adrenergic Receptor and Associated Protein Kinase A Signaling Molecules in the Frontal Cortex of Rats
Ali, S., & Dwivedi, Y. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04578-7 · Cited by 9 · see citing works
Reduced left ventricular dimension and function following early life stress: A thrifty phenotype hypothesis engendering risk for mood and anxiety disorders
Coplan, J. D., Rozenboym, A. V., Fulton, S. L., Panthangi, V., Tang, J. E., Thiramangalakdi, L., Perera, T. D., Liu, Y., Kamran, H., Owens, M. J., et al. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2017.01.001 · Cited by 8 · see citing works
Maternal verbally aggressive behavior in early infancy is associated with blood pressure at age 5–6
Smarius, L. J. C. A., Strieder, T. G. A., DORELEIJERS, T. A. H., Vrijkotte, T. G. M., & de Rooij, S. R. (2018) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174418000041 · Cited by 8 · see citing works
“Increasing evidence indicates that early life stress such as adverse childhood experiences may have long-term consequences for cardiovascular health, possibly by altering the sensitivity of stress-related physiological systems predisposing to adverse cardiovascular outcomes.(1,2) Exposure to parental aggression in chi…”
Background
The ACE effect
Zarnello, L. (2018) · Nursing · doi:10.1097/01.nurse.0000530408.46074.64 · Cited by 7 · see citing works
Dietary supplements: health from the ocean?
Persson, P. B., & Zakrisson, A. (2015) · Acta Physiologica · doi:10.1111/apha.12594 · Cited by 6 · see citing works
“…anti-inflammatory capacity and may thus beneficially affect diseases in whose pathophysiology inflammatory processes are involved – not only in the (adult) subject, but, given the appropriate circumstances, effects on their offspring are being discussed (Hou et al. 2014, Loria et al. 2014).”
Background
Common oxytocin polymorphisms interact with maternal verbal aggression in early infancy impacting blood pressure at age 5-6: The ABCD study
Smarius, L. J. C. A., Strieder, T. G. A., DORELEIJERS, T. A. H., Vrijkotte, T. G. M., Zafarmand, M. H., & de Rooij, S. R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216035 · Cited by 6 · see citing works
Biological Connection of Psychological Stress and Polytrauma under Intensive Care: The Role of Oxytocin and Hydrogen Sulfide
Merz, T., McCook, O., Denoix, N., Radermacher, P., Waller, C., & Kapapa, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179192 · Cited by 6 · see citing works
Early life stress induces dysregulation of the heme pathway in adult mice
Pettway, Y. D., Neder, T. H., Ho, D. H., Fox, B. M., Burch, M., Colson, J. C., Liu, X., Kellum, C. E., Hyndman, K. A., & Pollock, J. S. (2021) · Physiological Reports · doi:10.14814/phy2.14844 · Cited by 5 · see citing works
“Rodent models of ELS, such as the mouse model utilized in this study, all demonstrate anxiety and depression in adulthood and have begun to provide insight into the role of ELS in CVD (Ho et al., 2016; Loria et al., 2014; Murphy et al., 2017; Obi et al., 2019).”
MethodSelf-citation
Early Life Stress, Coping, and Cardiovascular Reactivity to Acute Social Stress
Mrug, S., Pollock, J. S., Pollock, D. M., Seifert, M. E., Johnson, K. A., & Knight, D. C. (2022) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001165 · Cited by 6 · see citing works
“ELS is associated with elevated resting SBP and DBP as early as in adolescence and young adulthood (8,9) and serves as a robust risk factor for hypertension and CVD throughout the life span (10,11).”
BackgroundSelf-citation
Prenatal exposition to haloperidol: A preclinical narrative review
Santos, A. V. S., Cardoso, D. S., Takada, S. H., & Echeverry, M. B. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105470 · Cited by 5 · see citing works
Perinatal asphyxia and Alzheimer's disease: is there a correlation?
Arruda, B. P., Martins, P. P., Kihara, A. H., & Takada, S. H. (2025) · Frontiers in Pediatrics · doi:10.3389/fped.2025.1567719 · Cited by 5 · see citing works
Epigenetics in the Developmental Origin of Cardiovascular Disorders
Gilbert, J. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801383-0.00008-6 · Cited by 4 · see citing works
Opiate of the masses
Persson, P. B. (2016) · Acta Physiologica · doi:10.1111/apha.12736 · Cited by 3 · see citing works
“So are early life events, whose underlying biological mechanisms are slowly being understood (Loria et al. 2014) (Patchev et al. 2014).”
Background
Role of Sex and Early Life Stress Experience on Porcine Cardiac and Brain Tissue Expression of the Oxytocin and H2S Systems
Münz, F., Abele, N., Zink, F., Wolfschmitt, E.-M., Hogg, M., Barck, C., Anetzberger, J., Hoffmann, A., Gröger, M., Calzia, E., et al. (2024) · Biomolecules · doi:10.3390/biom14111385 · Cited by 1 · see citing works
Rats exposed to a low resource environment in early life display sex differences in blood pressure and pro-inflammatory markers in the brain and kidney during adulthood
Smith, J., Smith, S., Jones, K., Castillo, A., Bolton, J. L., Howard, A., Colón-Pérez, L. M., Femi-Ogunyemi, F., Burkes, A., & Cunningham, M. (2026) · Biology of Sex Differences · doi:10.1186/s13293-026-00842-8 · Cited by 1 · see citing works
Early life stress and disruption of the ageing trajectory in female rats: Insights into the origins and mechanisms underlying the risk of hypertension
Marques, D. A., Guay, L. M., Koogler, A. A., Ostrowski, T. D., de Souza, A. M. A., Sandberg, K. L., & Kinkead, R. (2026) · Experimental Physiology · doi:10.1113/ep093539 · Cited by 1 · see citing works
“Our findings, therefore, bring valuable support to the ‘two-hit hypothesis’ proposed by Loria, Ho and Pollock (Loria et al., 2013b) in which early life stress is the first hit that augments cardiovascular vulnerability, and experiencing a second environmental stressor later in life induces…”
Stressful life events in childhood and incident stroke: cross-national, longitudinal cohort analyses of HRS and CHARLS
Han, Y., Wang, H., & Feng, H. (2026) · BMC Public Health · doi:10.1186/s12889-026-26425-1 · Cited by 1 · see citing works
Neighbourhood socioeconomic disparities in immunohaematologic risk in a paediatric analytic cohort
Berg, K. A., Lad, S. U., Rose, H., Fiegl, J., Blazel, M., Einstadter, D., & Perzynski, A. T. (2025) · Longitudinal and Life Course Studies · doi:10.1332/17579597y2025d000000045 · Cited by 1 · see citing works
Chronische Immunaktivierung
Straub, R. H. (2022) · Springer eBooks · doi:10.1007/978-3-662-65238-1_4
Chronic Immune System Activation
Straub, R. H. (2023) · Springer eBooks · doi:10.1007/978-3-662-66751-4_4
A model that discusses human behavior entirelyPreprint
Cai, K., & Wang, L. (2023) · Research Square · doi:10.21203/rs.3.rs-3410388/v1
The influence of captivity on cardiac structure and function across age, in rhesus macaquesPreprint
Dawkins, T. G., Curry, B. A., Drane, A. L., Rivas, V. N., Ueda, Y., Stern, J. A., Philips, D., Valle, J. E. N.-D., Higham, J. P., Snyder‐Mackler, N., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.20.683517
The influence of age and captivity on cardiac structure and function in rhesus macaques
Dawkins, T. G., Curry, B. A., Drane, A. L., Rivas, V. N., Ueda, Y., Stern, J. A., Philips, D., Valle, J. E. N.-D., Brent, L. J. N., Higham, J., et al. (2026) · GeroScience · doi:10.1007/s11357-026-02209-8
Height variation independent of known genetic variants and health in later life: a cohort study
Zhang, Y., Li, Y., Xue, X., Wang, T., Moon, J., Isasi, C. R., Yu, B., Rohan, T. E., Kaplan, R. C., & Qi, Q. (2026) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2026.101425

Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents
Murphy, M. O., Cohn, D. M., & Loria, A. S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.018 · Cited by 117 · see citing works
Self-citation
Association of early life adversity with cardiovascular disease and its potential mechanisms: a narrative review
Tan, H., Zhou, H., Chen, J., Ren, H., Guo, Y., & Jiang, X. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1341266 · Cited by 10 · see citing works
Timing, duration, and differential susceptibility to early life adversities and cardiovascular disease risk across the lifespan: Implications for future research
Suglia, S. F., Appleton, A. A., Bleil, M. E., Campo, R. A., Dube, S. R., Fagundes, C. P., Heard-Garris, N. J., Johnson, S. B., Slopen, N., Stoney, C. M., et al. (2021) · Preventive Medicine · doi:10.1016/j.ypmed.2021.106736 · Cited by 31 · see citing works
Early life stress results in an exaggerated pressor response to acute air jet stress in adult male, but not female rats
Pollock, D. M., D’Angelo, G., Bobo, J. A., & Pollock, J. S. (2006) · The FASEB Journal · doi:10.1096/fasebj.20.5.a1192
Self-citation
Early Life Stress, Parental Emotion Socialization, and Cardiovascular Health in Young Adulthood
Kemp, K. M., Reddy, R., Johnston, B., Orihuela, C. A., Marashi, S., Kelly, G., Heim, M., Siefert, M., Mrug, S., & Pollock, J. S. (2025) · Physiology · doi:10.1152/physiol.2025.40.s1.2053
Self-citation

Authors: Loria, A. S., Ho, D. H., & Pollock, J. S.
Affiliations: Augusta University (US)
Corresponding author: Pollock, J. S.
ORCID: Loria, A. S.
Pollock, J. S.
Venue: Acta Physiologica
Publisher: Wiley
Published: 2013-12-13
Volume: 210
Issue: 2
Pages: 277-287
ISSN: 1748-1708 (ISSN-L)
1748-1716
DOI: 10.1111/apha.12189
PMC: PMC4105322
OpenAlex: W2044259294
Cited by: 53
References: 123
Citations by year: 2026: 5 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 9 · 2014: 1
FWCI: 0.71
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Acta Physiologica (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (P01HL069999, K99HL111354, R00HL111354)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: childhood adversity, adverse childhood experiences, early life stress, cardiovascular risk, maternal separation, behavioural stress, stress sensitization, cardiovascular dysfunction, chronic disease risk
MeSH terms: Animals, Cardiovascular Diseases, Humans, Maternal Deprivation, Risk Factors, Stress, Psychological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A mechanistic look at the effects of adversity early in life on cardiovascular disease risk during adulthood

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks