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Cited by 31Child Abuse and TraumaHealth disparities and outcomesBirth, Development, and Health

Timing, duration, and differential susceptibility to early life adversities and cardiovascular disease risk across the lifespan: Implications for future research

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Suglia, Shakira F., Appleton, Allison A., Bleil, Maria E., Campo, Rebecca A., Dube, Shanta R., Fagundes, Christopher P., Heard-Garris, Nia J., Johnson, Sara B. +3 more·2021·Preventive Medicine
DOI 10.1016/j.ypmed.2021.106736PMC PMC8595689
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Abstract

Early life adversities (ELA), include experiences such as child maltreatment, household dysfunction, bullying, exposure to crime, discrimination, bias, and victimization, and are recognized as social determinants of cardiovascular disease (CVD). Strong evidence shows exposure to ELA directly impacts cardiometabolic risk in adulthood and emerging evidence suggests there may be continuity in ELA's prediction of cardiometabolic risk over the life course. Extant research has primarily relied on a cumulative risk framework to evaluate the relationship between ELA and CVD. In this framework, risk is considered a function of the number of risk factors or adversities that an individual was exposed to across developmental periods. The cumulative risk exposure approach treats developmental periods and types of risk as equivalent and interchangeable. Moreover, cumulative risk models do not lend themselves to investigating the chronicity of adverse exposures or consider individual variation in susceptibility, differential contexts, or adaptive resilience processes, which may modify the impact of ELA on CVD risk. To date, however, alternative models have received comparatively little consideration. Overall, this paper will highlight existing gaps and offer recommendations to address these gaps that would extend our knowledge of the relationship between ELA and CVD development. We focus specifically on the roles of: 1) susceptibility and resilience, 2) timing and developmental context; and 3) variation in risk exposure. We propose to expand current conceptual models to incorporate these factors to better guide research that examines ELA and CVD risk across the life course.

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Both MDD and physical diseases are more common in people from disadvantaged backgrounds.

    “There is clear evidence that both MDD and physical diseases are more common in people from disadvantaged backgrounds160,161.”

    From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [161]

    The “Variation in Risk of Exposure to ELA” section links socioeconomic disadvantage to greater exposure to early-life adversity and discusses disparities in cardiometabolic disease. The “Resilience” section reports higher lifetime depression prevalence with greater adversity exposure. The paper does not directly establish that MDD is more common among people from disadvantaged backgrounds, and its physical-health discussion is chiefly about cardiometabolic conditions rather than physical diseases generally. (LLM, conf=0.84)

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Research works printed but not linked: 2

  1. Crenshaw K, 1990. A Black Feminist Critique of Antidiscrimination Law and Politics, in: Kairys D (Ed.), The politics of law: a progressive critique Pantheon Books, New York, pp. 195– 217.
  2. Low CA, Matthews KA, Hall M.J.P.m., 2013. Elevated CRP in adolescents: roles of stress and coping. 75: 449. PMC3679199 23576771

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Authors
Suglia, S. F., Appleton, A. A., Bleil, M. E., Campo, R. A., Dube, S. R., Fagundes, C. P., Heard-Garris, N. J., Johnson, S. B., Slopen, N., Stoney, C. M., & Watamura, S. E.
Affiliations
  • Emory University (US)
  • State University of New York (US)
  • University of Washington (US)
  • National Institutes of Health (US)
  • Wingate University (US)
  • The University of Texas MD Anderson Cancer Center (US)
  • Johns Hopkins University (US)
  • Harvard University (US)
  • University of Denver (US)
Corresponding author
Suglia, Shakira F.
ORCID
Venue
Preventive Medicine
Publisher
Elsevier BV
Published
2021-12
Volume
153
Pages
106736
ISSN
0091-7435 (ISSN-L)
DOI
10.1016/j.ypmed.2021.106736
PMC
PMC8595689
OpenAlex
W3185285610
Cited by
31
References
148
Citations by year
2026: 3 · 2025: 9 · 2024: 7 · 2023: 8 · 2022: 2 · 2021: 2
FWCI
0.63
Type
journal article
Language
en
Open access
Licence
Locations
  • Preventive Medicine (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart Lung and Blood Institute (K01HL147995, R01HL125761)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Social Sciences › Health › Health disparities and outcomes
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
childhood adversity, cardiovascular risk, cardiometabolic risk, cumulative risk model, differential susceptibility, resilience, developmental context, life course, child abuse, household dysfunction, discrimination, victimization, bullying
MeSH terms
Adult, Cardiovascular Diseases, Child, Child Abuse, Humans, Life Change Events, Longevity, Risk Factors, Bullying, Social Determinants of Health

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