Evaluation of autonomic nervous system by salivary alpha-amylase level and heart rate variability in patients with schizophrenia
Abstract
Several researches indicate that autonomic nervous system (ANS) dysfunction in patients with schizophrenia. Recently, salivary alpha-amylase (sAA) has been employed as a useful marker for ANS function. We investigated the extent of ANS dysfunction by measuring sAA and heart rate variability (HRV) of 25 patients with schizophrenia compared with controls. Schizophrenia group demonstrated a significant increase in sAA and markedly lower parasympathetic nervous system (PNS) activity in the HRV. However, there were no significant differences between two groups in sympathetic nervous system (SNS) activity. We concluded that PNS might be suppressed and the SNS shows relatively high activity in schizophrenia.
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Salivary alpha-amylase activity levels are significantly higher in schizophrenia outpatients compared with healthy controls.
“For instance, in two studies that assessed SAA in SCZ, SAA activity levels were significantly higher in a group of SCZ outpatients compared to HC’s14,15.”
From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [15]
Higher BPRS scores among schizophrenia patients have been correlated with higher SAA levels.
“Moreover, higher BPRS scores among SCZ patients have also been correlated with higher SAA levels14,15, as well as higher EDA levels during rest and in response to novel innocuous stimuli63,64.”
From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [15]
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“In the study by Ieda et al.(15), there were significant reductions in HF-HRV in SCZ compared to the HC group; however, there were no significant differences in LF/HF ratio, which can be taken as an estimate of sympathetic activity(15).”
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- Authors
- Ieda, M., Miyaoka, T., Wake, R., Liaury, K., Tsuchie, K., Fukushima, M., Araki, T., Ezoe, S., Inagaki, T., & Horiguchi, J.
- Affiliations
- Shimane University (JP)
- Corresponding author
- Miyaoka, Tsuyoshi
- Venue
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2013-05-05
- Volume
- 264
- Issue
- 1
- Pages
- 83-87
- ISSN
- 0003-9373 (ISSN-L)
- 0940-1334
- 1433-8491
- OpenAlex
- W2053407060
- Cited by
- 41
- References
- 42
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2021: 6 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 3
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shimane University
- Japan Society for the Promotion of Science
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- schizophrenia, autonomic dysfunction, salivary amylase, heart rate variability, parasympathetic activity, sympathetic activity, stress biomarkers
- MeSH terms
- Adult, Autonomic Nervous System Diseases, Female, Heart Rate, Humans, Male, Middle Aged, Schizophrenia, Statistics as Topic, Salivary alpha-Amylases
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