Fecal microbiota transplantation beyond Clostridioides difficile infections

Wortelboer, Koen; Nieuwdorp, Max; Herrema, Hilde

doi:10.1016/j.ebiom.2019.05.066

Cited by 163Gut microbiota and healthClostridium difficile and Clostridium perfringens researchGastrointestinal motility and disorders

Fecal microbiota transplantation beyond Clostridioides difficile infections

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Wortelboer, Koen, Nieuwdorp, Max, Herrema, Hilde·2019·eBioMedicine

DOI 10.1016/j.ebiom.2019.05.066PMC PMC6606746

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Abstract

The importance of the commensal microbiota to human health and well-being has become increasingly evident over the past decades. From a therapeutic perspective, the popularity of fecal microbiota transplantation (FMT) to restore a disrupted microbiota and amend imbalances has increased. To date, most clinical experience with FMT originates from the treatment of recurrent or refractory Clostridioides difficile infections (rCDI), with resolution rates up to 90%. In addition to CDI, a role for the intestinal microbiome has been implicated in several disorders. FMT has been tested in several randomized controlled trials for the treatment of inflammatory bowel disease, irritable bowel disease and constipation with mixed results. FMT has also been explored for extra-gastrointestinal disorders such as metabolic syndrome, hepatic encephalopathy and graft-versus-host disease. With the exception of recurrent CDI, FMT is currently used in experimental settings only and should not yet be offered as standard care. In addition, it is critical to further standardize and optimize procedures for FMT preparation. This includes determination of active components of FMT to develop (personalized) approaches to treat disease.

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Together with the rapidly growing utility of FMT for treating several other conditions in recent years, FMT offers the greatest immediate hope for producing clinically meaningful therapeutic modulation of the gut microbiome in prodromal and early PD.
“Together with the rapidly growing utility of FMT for treating several other conditions in recent years [210, 211], FMT offers the greatest immediate hope for producing clinically meaningful therapeutic modulation of the gut microbiome in prodromal and early PD.”
From The gut–brain axis in early Parkinson’s disease: from prodrome to prevention (2025) · cites this paper as [211]
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“Contents lists available at ScienceDirect EBioMedicine j ourna l homepage: www.eb iomedic ine.com Review Fecal microbiota transplantation beyond Clostridioides difficile infections Koen Wortelboer a,⁎, Max Nieuwdorp b,c,d, Hilde Herrema a a Department of Experimental Vascular Medicine, Amsterdam University Medical Cen…”
Background
Long-term follow-up of the effects of fecal microbiota transplantation in combination with soluble dietary fiber as a therapeutic regimen in slow transit constipation
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Serial Frozen Fecal Microbiota Transplantation in the Treatment of Chronic Intestinal Pseudo-obstruction: A Preliminary Study
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[39]Costello S.P. Waters O. Bryant R.V. Katsikeros R. Makanyanga J. Schoeman M. Short duration, low intensity, pooled fecal microbiota transplantation induces remission in patients with mild-moderately active ulcerative colitis: a randomised controlled trial Gastroenterology 152 5 2017 (S198–9) Costello SP, Waters O, Bryant R V., Katsikeros R, Makanyanga J, Schoeman M, et al. Short Duration, Low Intensity, Pooled Fecal Microbiota Transplantation Induces Remission in Patients with Mild-Moderately Active Ulcerative Colitis: A Randomised Controlled Trial. Gastroenterology. 2017;152(5):S198–9.

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Authors: Wortelboer, K., Nieuwdorp, M., & Herrema, H.
Affiliations: Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author: Wortelboer, Koen
ORCID: Wortelboer, Koen
Nieuwdorp, Max
Herrema, Hilde
Venue: eBioMedicine
Publisher: Elsevier BV
Published: 2019-06
Volume: 44
Pages: 716-729
ISSN: 2352-3964 (ISSN-L)
DOI: 10.1016/j.ebiom.2019.05.066
PMC: PMC6606746
OpenAlex: W2951800528
Cited by: 163
References: 101
Citations by year: 2026: 12 · 2025: 24 · 2024: 29 · 2023: 24 · 2022: 24 · 2021: 27 · 2020: 16 · 2019: 7
FWCI: 1.66
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: EBioMedicine (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion, other-oa)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Novo Nordisk Fonden (2018)
ZonMw
Hartstichting
Fondation Leducq
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: fecal microbiota transplantation, Clostridium difficile infection, gut microbiota, inflammatory bowel disease, irritable bowel syndrome, constipation, metabolic syndrome, hepatic encephalopathy, graft-versus-host disease
MeSH terms: Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Animals, Mental Disorders, Clostridium Infections, Gastrointestinal Diseases, Humans, Immune System Diseases, Metabolic Diseases, Nervous System Diseases, Clostridioides difficile

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Fecal microbiota transplantation beyond Clostridioides difficile infections

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