Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity

Ochedalski, T.; Subburaju, S.; Wynn, P. C.; Aguilera, G.

doi:10.1111/j.1365-2826.2006.01525.x

Cited by 133Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity

Ochedalski, T., Subburaju, S., Wynn, P. C., Aguilera, G.·2007·Journal of Neuroendocrinology

DOI 10.1111/j.1365-2826.2006.01525.x

Open this paper in CoChat — free account

Abstract

In addition to its role in reproduction, oxytocin has central actions modulating behavioural and hypothalamic-pituitary-adrenal (HPA) axis responses during late pregnancy and lactation. The hypothesis that ovarian hormones modulate the effects of oxytocin on HPA axis activity was studied in 7-day ovariectomised rats receiving oestradiol with or without progesterone replacement and intracerebroventricular (i.c.v) minipump infusion of oxytocin (100 ng/h). In an initial experiment, i.c.v. oxytocin had no effect on basal or restraint-stimulated plasma adrenocorticotrophic hormone (ACTH) and corticosterone concentrations or hypothalamic corticotrophin-releasing factor (CRF) mRNA expression with low oestradiol replacement alone but it had a stimulatory effect in the presence of low oestradiol and progesterone. To investigate further whether oestradiol modulates central actions of oxytocin, rats received low dioestrous (low), pro-oestrous (medium) or pregnancy (high) oestradiol replacement levels, yielding plasma concentrations of < 5, 17.3 +/- 4.5 and 258 +/- 32 pg/ml, respectively, with or without i.c.v. oxytocin. Oestradiol caused dose-dependent increases in basal plasma ACTH and corticosterone concentrations but decreased the ACTH response to restraint stress. In parallel to the changes in basal plasma ACTH, high oestrogen increased basal CRF hnRNA, CRF mRNA in the paraventricular nucleus and pro-opiomelanocortin (POMC) mRNA in the pituitary gland, while decreasing restraint stress-stimulated levels. Intracerebroventricular administration of oxytocin reduced basal and stress-stimulated plasma ACTH, hypothalamic CRF hnRNA (30 min), CRF mRNA and pituitary POMC mRNA (4 h) levels parallel to the increases induced by elevating plasma oestradiol. The present study demonstrates the converse effects of oestradiol on basal and restraint stress-stimulated basal HPA axis activity, and that the ability of central oxytocin to inhibit HPA axis activity depends on the levels of circulating oestradiol.

Integrity signals

Registry

Crossref · 10.1111/j.1365-2826.2006.01525.x

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Estradiol treatment increases Crh gene expression and basal ACTH levels in ovariectomized rats.
“Estradiol treatment increases Crh gene expression and basal levels of ACTH in ovariectomized rats”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as Ochedalski, Subburaju, Wynn, & Aguilera, 2007
ERβ-driven reduction in stress-induced CORT and ACTH levels and PVN neuronal activation is very similar to that observed following OT treatment.
“Interestingly, the ERβ-driven reduction in stress-induced CORT and ACTH levels, and PVN neuronal activation is very similar to that observed following OT treatment (Ochedalski, Subburaju, Wynn, & Aguilera, 2007; Windle et al., 2006, 2004).”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as Ochedalski, Subburaju, Wynn, & Aguilera, 2007
Estradiol both enhances and inhibits HPA function in laboratory observations.
“These opposing actions of estradiol—with ER-α amplifying, and ER-β reducing HPA function—are in agreement with laboratory observations that estradiol both enhances (72, 73) and inhibits (74, 75) HPA function.”
From Higher Circulating Cortisol in the Follicular vs. Luteal Phase of the Menstrual Cycle: A Meta-Analysis (2020) · cites this paper as [74]

Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo–pituitary–adrenocortical responsiveness
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586 · see citing works
Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059 · see citing works
Gonadal Steroid Hormone Receptors and Sex Differences in the Hypothalamo-Pituitary-Adrenal Axis
Handa, R. J., Burgess, L. H., Kerr, J. E., & O'Keefe, J. A. (1994) · Hormones and Behavior · doi:10.1006/hbeh.1994.1044 · Cited by 793 · see citing works
Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Nishimori, K., Young, L. J., Guo, Q., Wang, Z., Insel, T. R., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11699 · Cited by 734 · see citing works
Variations in the hypothalamic-pituitary-adrenal response to stress during the estrous cycle in the rat
VIAU, V., & MEANEY, M. J. (1991) · Endocrinology · doi:10.1210/endo-129-5-2503 · Cited by 666 · see citing works
Inhibition of oxytocin receptor function by direct binding of progesterone
Grazzini, E., Guillon, G., Mouillac, B., & Zingg, H. H. (1998) · Nature · doi:10.1038/33176 · Cited by 466 · see citing works
Brain Oxytocin Inhibits Basal and Stress‐Induced Activity of the Hypothalamo‐Pituitary‐Adrenal Axis in Male and Female Rats: Partial Action Within the Paraventricular Nucleus
Neumann, Wigger, Torner, Holsboer, & Landgraf (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00442.x · Cited by 452 · see citing works
Chronic estrogen-induced alterations in adrenocorticotropin and corticosterone secretion, and glucocorticoid receptor-mediated functions in female rats
Burgess, L. H., & Handa, R. J. (1992) · Endocrinology · doi:10.1210/endo.131.3.1324155 · Cited by 445 · see citing works
Brain Oxytocin Correlates with Maternal Aggression: link to Anxiety
Bosch, O. J., Meddle, S. L., Beiderbeck, D. I., Douglas, A. J., & Neumann, I. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1342-05.2005 · Cited by 439 · see citing works
Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. Potential implications for the sexual dimophism of the stress response and immune/inflammatory reaction.
Vamvakopoulos, N. C., & Chrousos, G. P. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116782 · Cited by 422 · see citing works
Oxytocin Attenuates Stress-Induced c-<i>fos</i>mRNA Expression in Specific Forebrain Regions Associated with Modulation of Hypothalamo–Pituitary–Adrenal Activity
Windle, R. J., Kershaw, Y. M., Shanks, N., Wood, S. A., Lightman, S. L., & Ingram, C. D. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3432-03.2004 · Cited by 408 · see citing works
The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat
Carey, M. P., Deterd, C. H., de Koning, J., Helmerhorst, F., & de Kloet, E. R. (1995) · Journal of Endocrinology · doi:10.1677/joe.0.1440311 · Cited by 385 · see citing works
Attenuated neuroendocrine responses to emotional and physical stressors in pregnant rats involve adenohypophysial changes
Neumann, I. D., Johnstone, H. A., Hatzinger, M., Liebsch, G., Shipston, M. J., Russell, J. A., Landgraf, R., & Douglas, A. J. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.289br.x · Cited by 365 · see citing works
An Anxiolytic Action of Oxytocin is Enhanced by Estrogen in the Mouse
MCCARTHY, M. M., MCDONALD, C. H., BROOKS, P. J., & GOLDMAN, D. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00212-0 · Cited by 328 · see citing works
The magnocellular oxytocin system, the fount of maternity: Adaptations in pregnancy
Russell, J. A., Leng, G., & Douglas, A. J. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(02)00104-8 · Cited by 295 · see citing works
Brain oxytocin inhibits the (re)activity of the hypothalamo–pituitary–adrenal axis in male rats: involvement of hypothalamic and limbic brain regions
Neumann, I. D., Krömer, S. A., Toschi, N., & Ebner, K. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00197-x · Cited by 285 · see citing works
Release of oxytocin and vasopressin by magnocellular nuclei in vitro : specific facilitatory effect of oxytocin on its own release
Moos, F., Freund‐Mercier, M. J., Guerné, Y., Jm, G., Stoeckel, M. E., & Richard, P. (1984) · Journal of Endocrinology · doi:10.1677/joe.0.1020063 · Cited by 269 · see citing works
Gonadectomy reverses the sexually diergic patterns of circadian and stress-induced hypothalamic-pituitary-adrenal axis activity in male and female rats
Seale, J. V., Wood, S. A., Atkinson, H. C., Bate, E., Lightman, S. L., Ingram, C. D., Jessop, D. S., & Harbuz, M. S. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01195.x · Cited by 243 · see citing works
Gonadal Steroid Replacement Reverses Gonadectomy‐Induced Changes in the Corticosterone Pulse Profile and Stress‐Induced Hypothalamic‐Pituitary‐Adrenal Axis Activity of Male and Female Rats
Seale, J. V., Wood, S. A., Atkinson, H. C., Harbuz, M. S., & Lightman, S. L. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01258.x · Cited by 235 · see citing works
Estrogen Supplementation Attenuates Glucocorticoid and Catecholamine Responses to Mental Stress in Perimenopausal Women1
Komesaroff, P. A., Esler, M., & Sudhir, K. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5447 · Cited by 229 · see citing works
Stress increases oxytocin release within the hypothalamic paraventricular nucleus
Nishioka, T., Anselmo-Franci, J. A., Li, P., Callahan, M. F., & Morris, M. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01159-1 · Cited by 214 · see citing works
Behavioral stress responses in premenopausal and postmenopausal women and the effects of estrogen
Lindheim, S. R., Legro, R. S., Bernstein, L., Stanczyk, F. Z., Vijod, M. A., Presser, S. C., & Løbo, R. A. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(92)91783-7 · Cited by 209 · see citing works
Gonadal steroids regulate oxytocin receptors but not vasopressin receptors in the brain of male and female rats. An autoradiographical study
Tribollet, E., Audigier, S., Dubois-Dauphin, M., & Dreifuss, J. J. (1990) · Brain Research · doi:10.1016/0006-8993(90)90232-z · Cited by 203 · see citing works
Chapter 8 Peripartum plasticity within the hypothalamo-pituitary-adrenal axis
Lightman, S. L., Windle, R. J., Wood, S. A., Kershaw, Y. M., Shanks, N. M., & Ingram, C. D. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33009-1 · Cited by 171 · see citing works
Effects of Estrogen Antagonists and Agonists on the ACTH Response to Restraint Stress in Female Rats
Young, E. A. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00301-3 · Cited by 171 · see citing works
Emotional Stress Triggers Intrahypothalamic But Not Peripheral Release of Oxytocin in Male Rats
Engelmann, Ebner, Landgraf, Holsboer, & Wotjak (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00403.x · Cited by 170 · see citing works
Central Oxytocin Administration Reduces Stress-Induced Corticosterone Release and Anxiety Behavior in Rats<sup>1</sup>
Windle, R. J., Shanks, N., Lightman, S. L., & Ingram, C. D. (1997) · Endocrinology · doi:10.1210/en.138.7.2829 · Cited by 170 · see citing works
Changes in Oxytocin Receptor mRNA in Rat Brain During Pregnancy and the Effects of Estrogen and Interleukin‐6
Young, L. J., Muns, S., Wang, Z., & Insel, T. R. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00654.x · Cited by 160 · see citing works
Oxytocin Released within the Supraoptic Nucleus of the Rat Brain by Positive Feedback Action is Involved in Parturition‐Related Events
Neumann, I. D., Douglas, A. J., Pittman, Q. J., Russell, J. A., & Landgraf, R. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.04557.x · Cited by 159 · see citing works
Attenuation of Hypothalamic‐Pituitary‐Adrenal Axis Stress Responses in Late Pregnancy: Changes in Feedforward and Feedback Mechanisms
Johnstone, H. A., Wigger, A., Douglas, A. J., Neumann, I. D., Landgraf, R., Seckl, J. R., & Russell, J. A. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00525.x · Cited by 156 · see citing works
Stress‐Specific Regulation of Corticotropin Releasing Hormone Receptor Expression in the Paraventricular and Supraoptic Nuclei of the Hypothalamus in the Rat
Luo, X., Kiss, A., Makara, G. B., Lolait, S. J., & Aguilera, G. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00636.x · Cited by 148 · see citing works
Self-citation
An oxytocin receptor antagonist infused into the supraoptic nucleus attenuates intranuclear and peripheral release of oxytocin during suckling in conscious rats
Neumann, I. D., Koehler, E., Landgraf, R., & Summy‐Long, J. Y. (1994) · Endocrinology · doi:10.1210/endo.134.1.8275928 · Cited by 146 · see citing works
Septal and Hippocampal Release of Vasopressin and Oxytocin during Late Pregnancy and Parturition in the Rat
Landgraf, R., Neumann, I. D., & Pittman, Q. J. (2008) · Neuroendocrinology · doi:10.1159/000125917 · Cited by 137 · see citing works
Estrogen Supplementation Attenuates Glucocorticoid and Catecholamine Responses to Mental Stress in Perimenopausal Women
Komesaroff, P. A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.2.606 · Cited by 117 · see citing works
Estradiol induces oxytocin binding sites in rat hypothalamic ventromedial nucleus
de Kloet, E. R., Voorhuis, T. A. M., & Elands, J. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90679-x · Cited by 116 · see citing works
Gonadal steroids have paradoxical effects on brain oxytocin receptors
Insel, T. R., Young, L., Witt, D. M., & Crews, D. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00531.x · Cited by 113 · see citing works
Fast Glucocorticoid Feedback Inhibition of ACTH Secretion in the Ovariectomized Rat: Effect of Chronic Estrogen and Progesterone
Redei, E. E., Li, L., Halasz, I., McGivern, R. F., & Aird, F. (2008) · Neuroendocrinology · doi:10.1159/000126741 · Cited by 110 · see citing works
Estrogen desensitizes 5-HT1A receptors and reduces levels of Gz, Gi1 and Gi3 proteins in the hypothalamus
Raap, D. K., DonCarlos, L. L., García, F., Muma, N. A., Wolf, W. A., Battaglia, G., & de Kar, L. D. V. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00264-6 · Cited by 105 · see citing works
Regulation of the hypothalamic-pituitary-adrenal axis during water deprivation.
Aguilera, G., Lightman, S. L., & KISS, A. J. (1993) · Endocrinology · doi:10.1210/endo.132.1.8380375 · Cited by 97 · see citing works
Self-citation
Estrogen Receptor (ER)β Isoforms Rather Than ERα Regulate Corticotropin-Releasing Hormone Promoter Activity through an Alternate Pathway
Miller, W. J. S., Suzuki, S., Miller, L. K., Handa, R. J., & Uht, R. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5540-03.2004 · Cited by 93 · see citing works
Oxytocin-induced excitation of neurones in the rat central and medial amygdaloid nuclei
Terenzi, M. G., & Ingram, C. D. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.04.004 · Cited by 91 · see citing works
Oxytocin Modulates Glutamatergic Synaptic Transmission between Cultured Neonatal Spinal Cord Dorsal Horn Neurons
Jo, Y.-H., Stoeckel, M.-E., Freund-Mercier, M.-J., & Schlichter, R. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02377.1998 · Cited by 90 · see citing works
Gonadal Steroid Modulation of Stress-Induced Hypothalamo-Pituitary-Adrenal Activity and Anxiety Behavior: Role of Central Oxytocin
Windle, R. J., Gamble, L. E., Kershaw, Y. M., Wood, S. A., Lightman, S. L., & Ingram, C. D. (2006) · Endocrinology · doi:10.1210/en.2005-1079 · Cited by 90 · see citing works
Time Course of the Estradiol-Dependent Induction of Oxytocin Receptor Binding in the Ventromedial Hypothalamic Nucleus of the Rat*
Johnson, A. E., Ball, G. F., Coirini, H., Harbaugh, C. R., McEwen, B. S., & Insel, T. R. (1989) · Endocrinology · doi:10.1210/endo-125-3-1414 · Cited by 87 · see citing works
Participation of α 1 -Adrenergic Receptors in the Secretion of Hypothalamic Corticotropin- Releasing Hormone during Stress
KISS, A. J., & Aguilera, G. (2008) · Neuroendocrinology · doi:10.1159/000126223 · Cited by 85 · see citing works
Self-citation
Chapter 4 Cholesterol and steroid hormones: modulators of oxytocin receptor function
Gimpl, G., Wiegand, V., Burger, K., & Fahrenholz, F. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39006-x · Cited by 81 · see citing works
Expression and Region-Specific Regulation of the Oxytocin Receptor Gene in Rat Brain
Breton, C., & Zingg, H. H. (1997) · Endocrinology · doi:10.1210/endo.138.5.5127 · Cited by 78 · see citing works
Electrophysiological Actions of Oxytocin on Hypothalamic Neurons in vitro: Neuropharmacological Characterization and Effects of Ovarian Steroids
Kow, L., Johnson, A. E., Ogawa, S., & Pfaff, D. W. (2008) · Neuroendocrinology · doi:10.1159/000125948 · Cited by 73 · see citing works
Noradrenergic facilitation of the adrenocorticotropin response to stress is absent during lactation in the rat
Toufexis, D. J., & Walker, C. (1996) · Brain Research · doi:10.1016/0006-8993(96)00627-0 · Cited by 71 · see citing works
Effects of estrogen and estrous cycle on glucocorticoid and catecholamine responses to stress in sheep
Komesaroff, P. A., Esler, M., Clarke, I. J., Fullerton, M. J., & Funder, J. W. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.4.e671 · Cited by 70 · see citing works
Oxytocin receptor gene expression in rat uterus: regulation by ovarian steroids
Murata, T., Murata, E., Liu, C., Narita, K., Honda, K., & Higuchi, T. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1660045 · Cited by 60 · see citing works
The Modulatory Role of Estrogens on Corticotropin‐Releasing Factor Gene Expression in the Hypothalamic Paraventricular Nucleus of Ovariectomized Rats: Role of the Adrenal Gland
Paulmyer‐Lacroix, O., Héry, M., PUGEAT, M. M., & Grino, M. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.04835.x · Cited by 55 · see citing works
Regulation of the hypothalamic-pituitary-adrenal axis during water deprivation
Aguilera, G. (1993) · Endocrinology · doi:10.1210/en.132.1.241 · Cited by 49 · see citing works
Self-citation
No Stress Response of the Hypothalamo-Pituitary-Adrenal Axis in Parturient Rats: Lack of Involvement of Brain Oxytocin
Neumann, I. D., Bosch, O. J., Toschi, N., Torner, L., & Douglas, A. J. (2003) · Endocrinology · doi:10.1210/en.2003-0037 · Cited by 43 · see citing works
Post-partum increase in oxytocin-induced excitation of neurones in the bed nuclei of the stria terminalis in vitro
Ingram, C. D., & Wakerley, J. B. (1993) · Brain Research · doi:10.1016/0006-8993(93)90697-l · Cited by 38 · see citing works
Effects of adrenocortical and gonadal steroids on the secretion in vitro of corticotrophin and its hypothalamic releasing factor
Buckingham, J. C. (1982) · Journal of Endocrinology · doi:10.1677/joe.0.0930123 · Cited by 37 · see citing works
Stimulation of expression of the oxytocin gene in rat supraoptic neurons at parturition
Douglas, A. J., Meeren, H. K. M., Johnstone, L. E., Pfaff, D. W., Russell, J. A., & Brooks, P. J. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01275-4 · Cited by 37 · see citing works
Thermal, osmotic and chemical modulation of neural activity in the paraventricular nucleus: In vitro studies
Yamashita, H., Inenaga, K., & Dyball, R. E. J. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90098-6 · Cited by 32 · see citing works
Electrophysiology of Oxytocin Actions on Central Neuronsa
Dreifuss, J. J., Dubois‐Dauphin, M., Widmer, H., & Raggenbass, M. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34345.x · Cited by 28 · see citing works
Oxytocin inhibits nonphasically firing supraoptic and paraventricular neurons in the virgin female rat
Kuriyama, K., Nakashima, T., Kawarabayashi, T., & Kiyohara, T. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90141-w · Cited by 24 · see citing works
Brain oxytocin augments stress-induced long-lasting plasma adrenocorticotropic hormone elevation in rats
Nakashima, T., Noguchi, T., Furukawa, T., Yamasaki, M., Makino, S., Miyata, S., & Kiyohara, T. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02548-4 · Cited by 19 · see citing works
A correlated morphological and biochemical study on the rat adrenal steroidogenesis.
Mm, M., Mc, M., Ml, G., et al. (1987) · PubMed · Cited by 8 · see citing works
Stimulation of paraventricular neurosecretory cells by oxytocin applied iontophoretically.
Cross, B. A., Dyball, R. E., & Rl, M. (1972) · PubMed · Cited by 7 · see citing works
Corticosterone and methylation of noradrenaline in vitro.
Cross, B. A., Dyball, R. E., & Moss, R. L. (1972) · PubMed · Cited by 3 · see citing works

Flagged first, then by citations

Sorted by citations

Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity
Oyola, M. G., & Handa, R. J. (2017) · Stress · doi:10.1080/10253890.2017.1369523 · Cited by 710 · see citing works
The Hypothalamic-Pituitary-Adrenal Axis: Development, Programming Actions of Hormones, and Maternal-Fetal Interactions
Sheng, J. A., Bales, N. J., Myers, S. A., Bautista, A. I., Roueinfar, M., Hale, T. M., & Handa, R. J. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.601939 · Cited by 418 · see citing works
Gonadal steroid hormones and the hypothalamo–pituitary–adrenal axis
Handa, R. J., & Weiser, M. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.11.001 · Cited by 408 · see citing works
Adaptive Responses of the Maternal Hypothalamic‐Pituitary‐Adrenal Axis during Pregnancy and Lactation
Brunton, P. J., Russell, J. A., & Douglas, A. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01735.x · Cited by 298 · see citing works
Estrogen impairs glucocorticoid dependent negative feedback on the hypothalamic–pituitary–adrenal axis via estrogen receptor alpha within the hypothalamus
Weiser, M. J., & Handa, R. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.12.058 · Cited by 250 · see citing works
The molecular physiology of CRH neurons
Aguilera, G., & Liu, Y. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.08.002 · Cited by 198 · see citing works
Self-citation
Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review
Crockford, C., Deschner, T., Ziegler, T. E., & Wittig, R. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00068 · Cited by 187 · see citing works
Variation in oxytocin is related to variation in affiliative behavior in monogamous, pairbonded tamarins
Snowdon, C. T., Pieper, B. A., Boe, C. Y., Cronin, K. A., Kurian, A. V., & Ziegler, T. E. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.014 · Cited by 133 · see citing works
Oxytocin and Estrogen Receptor β in the Brain: An Overview
Acevedo-Rodriguez, A., Mani, S. K., & Handa, R. J. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00160 · Cited by 124 · see citing works
Higher Circulating Cortisol in the Follicular vs. Luteal Phase of the Menstrual Cycle: A Meta-Analysis
Hamidovic, A., Karapetyan, K., Serdarevic, F., Choi, S. H., Eisenlohr-Moul, T., & Pinna, G. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00311 · Cited by 99 · see citing works
From stress to postpartum mood and anxiety disorders: How chronic peripartum stress can impair maternal adaptations
Hillerer, K. M., Neumann, I. D., & Slattery, D. A. (2012) · Neuroendocrinology · doi:10.1159/000330445 · Cited by 82 · see citing works
Distribution and chemical composition of estrogen receptor β neurons in the paraventricular nucleus of the female and male mouse hypothalamus
Oyola, M. G., Thompson, M. K., Handa, A. Z., & Handa, R. J. (2017) · Journal of Comparative Neurology · doi:10.1002/cne.24295 · Cited by 53 · see citing works
Strongly bonded family members in common marmosets show synchronized fluctuations in oxytocin
Finkenwirth, C., van Schaik, C., Ziegler, T. E., & Burkart, J. M. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.07.034 · Cited by 59 · see citing works
Transcriptional regulation of corticotropin-releasing hormone gene in stress response
Zhou, J.-N., & Fang, H. (2018) · IBRO Reports · doi:10.1016/j.ibror.2018.08.003 · Cited by 36 · see citing works
Actions of intravenous injections of <scp>AVP</scp> and oxytocin on plasma <scp>ACTH</scp>, <scp>GH</scp>, insulin and glucagon concentrations in goats
Roh, S., Koiwa, K., Sato, K., Ohtani, Y., Takahashi, T., & Katoh, K. (2014) · Animal Science Journal · doi:10.1111/asj.12142 · Cited by 7 · see citing works

Facilitatory effect of oxytocin on oxytocin cell background activity in the rat is suckling-dependent
Meyer, C., Freund‐Mercier, M. J., & Richard, P. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90079-6 · Cited by 12 · see citing works
Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in menPreprint
Quintana, D. S., Westlye, L. T., Smerud, K. T., et al. (2018) · doi:10.31219/osf.io/s7ngd · Cited by 2 · see citing works
Oxytocin 주입분만이 신생아 혈청담적소치에 미치는 효과에 관한 임상적 연구
차동수, 김수녕, 이명식, et al. (1983) · Obstetrics & Gynecology Science
Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in men
Quintana, D. S., Westlye, L. T., Smerud, K. T., Mahmoud, R. A., Andreassen, O. A., & Djupesland, P. G. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.05.004 · Cited by 52 · see citing works
FATE OF SYNTHETIC OXYTOCIN ANALOGUES IN THE RAT
Mw, S., & Ginsburg, M. (1961) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1961.tb01083.x · Cited by 9 · see citing works

Authors: Ochedalski, T., Subburaju, S., Wynn, P. C., & Aguilera, G.
Affiliations: National Institutes of Health (US)
The University of Sydney (AU)
Corresponding author: Aguilera, G.
ORCID: Subburaju, S.
Wynn, P. C.
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 2007-01-08
Volume: 19
Issue: 3
Pages: 189-197
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1111/j.1365-2826.2006.01525.x
OpenAlex: W2114431169
Cited by: 133
References: 64
Citations by year: 2026: 1 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 5 · 2021: 10 · 2020: 7 · 2019: 3 · 2018: 10 · 2017: 6 · 2016: 3 · 2015: 9 · 2014: 6 · 2013: 9 · 2012: 5
FWCI: 13.27
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, estradiol, hypothalamic-pituitary-adrenal axis, ACTH, corticosterone, corticotropin-releasing factor, proopiomelanocortin, restraint stress, progesterone, ovariectomy, paraventricular nucleus, pregnancy, lactation, ovarian hormones
MeSH terms: Adrenocorticotropic Hormone, Analysis of Variance, Animals, Corticosterone, Corticotropin-Releasing Hormone, Dose-Response Relationship, Drug, Estradiol, Female, Hypothalamo-Hypophyseal System, Injections, Intraventricular, Oxytocin, Pituitary-Adrenal System, Progesterone, RNA, Messenger, Stress, Psychological, Rats, Sprague-Dawley, Statistics, Nonparametric, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks