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Cited by 272

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: a substudy of the PREDIMED trial

Open access
Medina‐Remón, Alexander, Casas, Rosa, Tressserra‐Rimbau, Anna, Ros, Emilio, Martínez‐González, Miguel A., Fitó, Montserrat, Corella, Dolores, Salas‐Salvadó, Jordi, Lamuela‐Raventos, Rosa M., Estruch, Ramón, on behalf of the PREDIMED Study Investigators·2017·British Journal of Clinical Pharmacology
DOI 10.1111/bcp.12986
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Abstract

High dietary polyphenol intake is associated with reduced all‐cause mortality and a lower incidence of cardiovascular events. However, the mechanisms involved are not fully understood. The aim of the present substudy of the PREvención con DIetaMEDiterránea (Prevention with Mediterranean diet; PREDIMED) trial was to analyse the relationship between polyphenol intake measured by total urinary polyphenol excretion (TPE), and circulating inflammatory biomarkers and cardiovascular risk factors in elderly individuals. A substudy of 1139 high‐risk participants was carried out within the PREDIMED trial. The subjects were randomly assigned to a low‐fat control diet or to two Mediterranean diets, supplemented with either extra‐virgin olive oil or nuts. Dietary intake, anthropometric data, clinical and laboratory assessments, including inflammatory biomarkers, and urinary TPE were measured at baseline and after the one‐year intervention. Participants in the highest tertile of changes in urinary TPE (T3) showed significantly lower plasma levels of inflammatory biomarkers [vascular cell adhesion molecule 1 (VCAM‐1) (–9.47 ng ml–1), intercellular adhesion molecule 1 (–14.71 ng ml–1), interleukin 6 (–1.21 pg ml–1), tumour necrosis factor alpha (–7.05 pg ml–1) and monocyte chemotactic protein 1 (–3.36 pg ml–1)] than those inthe lowest tertile (T1, P < 0.02; all). A significant inverse correlation existed between urinary TPE and the plasma concentration of\VCAM‐1 (r = –0.301; P < 0.001). In addition, systolic and diastolic blood pressure (BP) decreased and plasma high‐density lipoprotein cholesterol increased in parallel with increasing urinary TPE (T3 vs. T1) (P < 0.005 and P = 0.004, respectively). Increases in polyphenol intake measured as urinary TPE are associated with decreased inflammatory biomarkers, suggesting a dose‐dependent anti‐inflammatory effect of polyphenols. In addition, high polyphenol intake improves cardiovascular risk factors– mainly BP and the lipid profile.

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Metadata

Authors
Medina‐Remón, A., Casas, R., Tressserra‐Rimbau, A., Ros, E., Martínez‐González, M. A., Fitó, M., Corella, D., Salas‐Salvadó, J., Lamuela‐Raventos, R. M., Estruch, R., & on behalf of the PREDIMED Study Investigators
Venue
British Journal of Clinical Pharmacology
Publisher
Wiley
Published
2016-05-19
Volume
83
Issue
1
Pages
114-128
ISSN
  • 0306-5251 (ISSN-L)
  • 1365-2125
DOI
10.1111/bcp.12986
OpenAlex
W2339424168
Cited by
272
References
14
FWCI
26.60
Type
journal article
Language
en
Open access
bronze

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

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