Incidence, prevalence and clinical correlates of antidepressant-emergent mania in bipolar depression: a systematic review and meta-analysis
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Background: Treatment‐emergent mania (TEM) represents a common phenomenon inconsistently reported across primary studies, warranting further assessment. Methods: A systematic review and meta‐analysis following the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) and Meta‐Analysis of Observational Studies in Epidemiology (MOOSE) guidelines were conducted. Major electronic databases were searched from inception to May 2017 to assess the incidence and prevalence rates and clinical features associated with manic switch among bipolar depressed patients receiving antidepressants, using meta‐regression and subgroup analysis. Results: Overall, 10 098 depressed patients with bipolar disorder (BD) across 51 studies/arms were included in the quantitative analysis. The cumulative incidence of cases (TEM+) among 4767 patients with BD over 15 retrospective studies was 30.9% (95% confidence interval [CI] 19.6‐45.0%, I2 = 97.9%). The cumulative incidence of TEM+ among 1929 patients with BD over 12 prospective open studies was 14.4% (95% CI 7.4‐26.1%, I2 = 93.7%). The cumulative incidence of TEM+ among 1316 patients with BD over 20 randomized controlled trials (RCT s) was 11.8% (95% CI 8.4‐16.34%, I2 = 73.46%). The pooled prevalence of TEM+ among 2086 patients with BD over four cross‐sectional studies was 30.9% (95% CI 18.1‐47.4%, I2 = 95.6%). Overall, concurrent lithium therapy predicted the lowest TEM rates. Inconsistent operational definitions of TEM were recorded, and the lack of information about age, sex, co‐occurring anxiety, and other clinically relevant moderators precluded further stratification of the results. Conclusions: Rates of TEM vary primarily depending on study setting, which is concordant with the high degree of heterogeneity of the included records. Forthcoming RCT studies should adopt consistent operational definitions of TEM and broaden the number of moderators, in order to contribute most effectively to the identification of clear‐cut sub‐phenotypes of BD and patient‐tailored pharmacotherapy.
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Antidepressants carry risk for switch to mania.
“Moreover, antidepressants carry risk for switch to mania, 10 but how individual agents differ in this regard, and which other treatments may reduce this risk, needs to be addressed in a quantitative way.”
From Comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults: a systematic review and network meta-analysis (2023) · cites this paper as [10]
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Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042 · see citing works
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
PRISMA-P Group, Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015) · Systematic Reviews · doi:10.1186/2046-4053-4-1 · Cited by 26,223 · see citing works
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623 · see citing works
Duval, S., & Tweedie, R. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00455.x · Cited by 14,099 · see citing works
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962 · see citing works
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455 · see citing works
A Rating Scale for Mania: Reliability, Validity and Sensitivity
Young, R. C., Biggs, J. T., Ziegler, V. E., & Meyer, D. A. (1978) · British Journal of Psychiatry · doi:10.1192/bjp.133.5.429 · Cited by 8,744 · see citing works
Downs, S. H., & Black, N. (1998) · Journal of Epidemiology and Community Health · doi:10.1136/jech.52.6.377 · Cited by 8,252 · see citing works
The environment and disease: association or causation?
Hill, A. B. (2015) · Journal of the Royal Society of Medicine · doi:10.1177/0141076814562718 · Cited by 7,302 · see citing works
Causation and Causal Inference in Epidemiology
Rothman, K. J., & Greenland, S. (2005) · American Journal of Public Health · doi:10.2105/ajph.2004.059204 · Cited by 1,265 · see citing works
Tohen, M., Vieta, E., Calabrese, J., Ketter, T. A., Sachs, G., Bowden, C., Mitchell, P. B., Centorrino, F., Risser, R., Baker, R. W., et al. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.11.1079 · Cited by 908 · see citing works
Pacchiarotti, I., Bond, D. J., Baldessarini, R. J., Nolen, W. A., Grunze, H., Licht, R. W., Post, R. M., Berk, M., Goodwin, G. M., Sachs, G. S., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13020185 · Cited by 770 · see citing works
Akiskal, H. S., Akiskal, K. K., Haykal, R. F., Manning, J. S., & Connor, P. D. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2004.12.001 · Cited by 655 · see citing works
Antidepressant-induced mania and cycle acceleration: a controversy revisited
Altshuler, L. L., Post, R. M., Leverich, G. S., Mikalauskas, K., ROSOFF, A. S., & Ackerman, L. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.8.1130 · Cited by 607 · see citing works
What is a Cause and How Do We Know One? A Grammar for Pragmatic Epidemiology
Susser, M. W. (1991) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115939 · Cited by 536 · see citing works
Sachs, G. S., Thase, M. E., Otto, M. W., Bauer, M. S., Miklowitz, D. J., Wisniewski, S. R., Lavori, P. W., Lebowitz, B. D., Rudorfer, M., Frank, E., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00165-3 · Cited by 532 · see citing works
Tohen, M. F., Frank, E., Bowden, C. L., Colom, F., Ghaemi, S. N., Yatham, L. N., Malhi, G. S., Calabrese, J. R., Nolen, W. A., Vieta, E., et al. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00726.x · Cited by 513 · see citing works
The Role of the Extracellular Signal-Regulated Kinase Signaling Pathway in Mood Modulation
Einat, H., Yuan, P., Gould, T. D., Li, J., Du, J., Zhang, L., Manji, H. K., & Chen, G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-19-07311.2003 · Cited by 475 · see citing works
Reporting bias in medical research - a narrative review
McGauran, N., Wieseler, B., Kreis, J., Schüler, Y.-B., Kölsch, H., & Kaiser, T. (2010) · Trials · doi:10.1186/1745-6215-11-37 · Cited by 452 · see citing works
Nemeroff, C. B., Evans, D. L., Gyulai, L., Sachs, G. S., Bowden, C. L., Gergel, I. P., Oakes, R., & Pitts, C. D. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.6.906 · Cited by 406 · see citing works
Antidepressants in bipolar disorder: the case for caution
Ghaemi, S. N., Hsu, D. J., Soldani, F., & Goodwin, F. K. (2003) · Bipolar Disorders · doi:10.1046/j.1399-5618.2003.00074.x · Cited by 391 · see citing works
Mood switch in bipolar depression: comparison of adjunctive venlafaxine, bupropion and sertraline
Post, R. M., Altshuler, L. L., Leverich, G. S., Frye, M. A., Nolen, W. A., Kupka, R. W., Suppes, T., McElroy, S., Keck, P. E., Denicoff, K. D., et al. (2006) · British Journal of Psychiatry · doi:10.1192/bjp.bp.105.013045 · Cited by 350 · see citing works
McElroy, S. L., Weisler, R. H., Chang, W., Olausson, B., Paulsson, B., Brecher, M., Agambaram, V., Merideth, C., Nordenhem, A., Young, A. H., et al. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04942gre · Cited by 328 · see citing works
Patterns of Psychotropic Drug Prescription for U.S. Patients With Diagnoses of Bipolar Disorders
Baldessarini, R. J., Leahy, L., Arcona, S., Gause, D. O., Zhang, W., & Hennen, J. A. (2007) · Psychiatric Services · doi:10.1176/ps.2007.58.1.85 · Cited by 279 · see citing works
Antidepressant Treatment in Bipolar Versus Unipolar Depression
Ghaemi, S. N., Rosenquist, K. J., Ko, J. Y., Baldassano, C. F., Kontos, N. J., & Baldessarini, R. J. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.163 · Cited by 270 · see citing works
Mania associated with antidepressant treatment: comprehensive meta‐analytic review
Tondo, L., Vázquez, G., & Baldessarini, R. J. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01514.x · Cited by 256 · see citing works
A Placebo-Controlled Evaluation of Adjunctive Modafinil in the Treatment of Bipolar Depression
Frye, M. A., Grunze, H., Suppes, T. M., McElroy, S. L., Keck, P. E., Walden, J., Leverich, G. S., Altshuler, L. L., Nakelsky, S., Hwang, S., et al. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06060981 · Cited by 246 · see citing works
Viktorin, A., Lichtenstein, P., Thase, M. E., Larsson, H., Lundholm, C., Magnusson, P. K. E., & Landén, M. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13111501 · Cited by 246 · see citing works
Vieta, E., Martínez‐Arán, A., Goikolea, J. M., Torrent, C., Colom, F., Benabarre, A., & Reinares, M. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n0607 · Cited by 227 · see citing works
Young, L. T., Joffe, R. T., Robb, J. C., MacQUEEN, G. M., MARRIOTT, M. J., & Patelis‐Siotis, I. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.124 · Cited by 211 · see citing works
Antidepressant-Induced Mania in Bipolar Patients: Identification of Risk Factors
Henry, C., Sorbara, F., Lacoste, J., Gindre, C., & Leboyer, M. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n0406 · Cited by 198 · see citing works
Frye, M. A., Hellemann, G., McElroy, S. L., Altshuler, L. L., Black, D. O., Keck, P. E., Nolen, W. A., Kupka, R., Leverich, G. S., Grunze, H., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08030322 · Cited by 194 · see citing works
Estimating Time to Conduct a Meta-analysis From Number of Citations Retrieved
Allen, I. E. (1999) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.282.7.634 · Cited by 163 · see citing works
Textbook of Psychiatric Epidemiology
(2011) · Wiley eBooks · doi:10.1002/9780470976739 · Cited by 151 · see citing works
The "Switch Process" in Manic-Depressive Illness
Bunney, W. E. (1972) · Archives of General Psychiatry · doi:10.1001/archpsyc.1972.01750270014002 · Cited by 145 · see citing works
Bond, D. J., Noronha, M. M., Kauer‐Sant’Anna, M., Lam, R. W. M., & Yatham, L. N. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n1009 · Cited by 139 · see citing works
The Bipolar Spectrum and the Antidepressant View of the World
Ghaemi, S. N., Ko, J. Y., & Goodwin, F. K. (2001) · Journal of Psychiatric Practice · doi:10.1097/00131746-200109000-00002 · Cited by 137 · see citing works
Agomelatine adjunctive therapy for acute bipolar depression: preliminary open data
Calabrese, J. R., Guelfi, J. D., Perdrizet-Chevallier, C., & the Agomelatine Bipolar Study Group (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00507.x · Cited by 130 · see citing works
Prevalence and clinical features associated with bipolar disorder polypharmacy: a systematic review
Fornaro, M., Berardis, D. D., Koshy, A. S., Perna, G., Vancampfort, D., Stubbs, B., & Valchera, A. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s100846 · Cited by 115 · see citing works
Self-citationPost, R. M., Altshuler, L. L., Frye, M. A., Suppes, T. M., Rush, A. J., Keck, P. E., McElroy, S. L., Denicoff, K. D., Leverich, G. S., Kupka, R., et al. (2001) · Bipolar Disorders · doi:10.1034/j.1399-5618.2001.030505.x · Cited by 113 · see citing works
Post, R. M., Altshuler, L. L., Frye, M. A., Suppes, T. M., Rush, A. J., Keck, P. E., McElroy, S. L., Denicoff, K. D., Leverich, G. S., Kupka, R., et al. (2001) · Bipolar Disorders · doi:10.1034/j.1399-5618.2001.30505.x · Cited by 105 · see citing works
Amsterdam, J. D., & Justine Shults, A. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.02.018 · Cited by 100 · see citing works
The Association Between Substance Abuse and Antidepressant-Induced Mania in Bipolar Disorder
Goldberg, J. F., & Whiteside, J. E. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n0907 · Cited by 97 · see citing works
The bipolar spectrum: Conceptions and misconceptions
Ghaemi, S. N., & Dalley, S. (2014) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413504830 · Cited by 88 · see citing works
Risk Factors for Antidepressant-Related Switch to Mania
Valentí, M., Pacchiarotti, I., Bonnín, C. D. M., Rosa, A. R., Popović, D., Nivoli, A., Goikolea, J. M., Murru, A., Undurraga, J. P., Colom, F., et al. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.11m07166 · Cited by 86 · see citing works
Antidepressant-associated chronic irritable dysphoria (ACID) in STEP-BD patients
El‐Mallakh, R. S., Ghaemi, S. N., Sagduyu, K., Thase, M. E., Wisniewski, S. R., Nierenberg, A. A., Zhang, H. W., Pardo, T. A., & Sachs, G. S. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.03.025 · Cited by 81 · see citing works
Altshuler, L. L., Post, R. M., Hellemann, G., Leverich, G. S., Nolen, W. A., Frye, M. A., Keck, P. E., Kupka, R., Grunze, H., McElroy, S. L., et al. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04191 · Cited by 80 · see citing works
Tondo, L., Baldessarini, R. J., Vázquez, G. H., Lepri, B., & Visioli, C. (2012) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12023 · Cited by 79 · see citing works
Joffe, R. T., MacQUEEN, G. M., MARRIOTT, M. J., Robb, J. C., Bégin, H., & Young, L. T. (2002) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2002.02360.x · Cited by 79 · see citing works
Yatham, L. N., Vieta, E., Goodwin, G. M., Bourin, M., de Bodinat, C., Laredo, J., & Calabrese, J. R. (2015) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.114.147587 · Cited by 79 · see citing works
Amsterdam, J. D., Justine Shults, A., Brunswick, D. J., & Hundert, M. (2004) · Bipolar Disorders · doi:10.1046/j.1399-5618.2003.00083.x · Cited by 78 · see citing works
Olanzapine/fluoxetine combination vs. lamotrigine in the 6-month treatment of bipolar I depression
Brown, E., Dunner, D. L., McElroy, S. L., Keck, P. E., Adams, D. H., Degenhardt, E., Tohen, M., & Houston, J. P. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009735 · Cited by 73 · see citing works
Amsterdam, J. D., & Justine Shults, A. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318166c4e6 · Cited by 71 · see citing works
Altshuler, L. L., Sugar, C. A., McElroy, S. L., Calimlim, B., Gitlin, M., Keck, P. E., Aquino-Elias, A., Martens, B. E., Fischer, E. G., English, T. L., et al. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.15040558 · Cited by 68 · see citing works
Fornaro, M., McCarthy, M. J., De Berardis, D., Pasquale, D., Martino, Colicchio, Cattaneo, D'Angelo, Fornaro, P., & Tabaton (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s41557 · Cited by 67 · see citing works
Self-citationOlanzapine/Fluoxetine Combination for the Treatment of Mixed Depression in Bipolar I Disorder
Benazzi, F., Berk, M., Frye, M. A., Wang, W., Barraco, A., & Tohen, M. F. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04772gre · Cited by 65 · see citing works
Pacchiarotti, I., Valentí, M., Colom, F., Rosa, A. R., Nivoli, A., Murru, A., Sánchez‐Moreno, J., & Vieta, E. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.07.036 · Cited by 62 · see citing works
Woo, Y. S., Shim, I. H., Wang, H.-R., Song, H. R., Jun, T., & Bahk, W. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.11.034 · Cited by 54 · see citing works
Nolen, W. A., Kupka, R., Hellemann, G., Frye, M. A., Altshuler, L. L., Leverich, G. S., Suppes, T. M., Keck, P. E., McElroy, S. L., Grunze, H., et al. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.00993.x · Cited by 53 · see citing works
Gao, K., Kemp, D. E., Ganocy, S. J., Muzina, D. J., Xia, G., Findling, R. L., & Calabrese, J. R. (2008) · Bipolar Disorders · doi:10.1111/j.1399-5618.2008.00637.x · Cited by 49 · see citing works
Fornaro, M., Berardis, D. D., Iasevoli, F., Pistorio, M. L., D'Angelo, E., Mungo, S., Martino, M., Ventriglio, A., Cattaneo, C. I., Favaretto, E., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.07.004 · Cited by 48 · see citing works
Self-citationLee, H.-J., Son, G.-H., & Geum, D. (2013) · Psychiatry Investigation · doi:10.4306/pi.2013.10.3.225 · Cited by 48 · see citing works
Vieta, E., Angst, J., Reed, C. C., Bertsch, J., & Haro, J. M. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.02.007 · Cited by 46 · see citing works
One‐year outcome with antidepressant – treatment of bipolar depression
Joffe, R. T., MacQUEEN, G. M., MARRIOTT, M. J., & Young, L. T. (2005) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2005.00583.x · Cited by 46 · see citing works
Affective temperaments and antidepressant response in the clinical management of mood disorders
Ferreira, A. D. A., Vasconcelos, A. G., Neves, F. S., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.10.038 · Cited by 45 · see citing works
Current Nosology of Treatment Resistant Depression: A Controversy Resistant to Revision
Fornaro, M., & Giosuè, P. (2010) · Clinical Practice and Epidemiology in Mental Health · doi:10.2174/1745017901006010020 · Cited by 42 · see citing works
Self-citationClinical variables related to antidepressant-induced mania in bipolar disorder
Mundo, E., Cattaneo, E., Russo, M., & Altamura, A. C. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.01.028 · Cited by 42 · see citing works
Clinical features of antidepressant associated manic and hypomanic switches in bipolar disorder
Serretti, A., Artioli, P., Zanardi, R., & Rossini, D. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00104-0 · Cited by 40 · see citing works
Goldberg, J. F., & Ghaemi, S. N. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00251.x · Cited by 40 · see citing works
Bipolar II Disorder: An Overview of Recent Developments
Hadjipavlou, G. A., Mok, H., & Yatham, L. N. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404901203 · Cited by 37 · see citing works
Bipolar depression: relationship between episode length and antidepressant treatment
Frankle, W. G., Perlis, R. H., Deckersbach, T., et al. (2002) · Psychological Medicine · doi:10.1017/s0033291702006165 · Cited by 37 · see citing works
Frye, M. A., McElroy, S. L., Prieto, M. L., Harper, K. L., Walker, D. L., Kung, S., Chauhan, M., Crow, S. J., Sutor, B., Galardy, C. W., et al. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m09127 · Cited by 36 · see citing works
Predictors of switch from depression to mania in bipolar disorder
Niitsu, T., Fabbri, C., & Serretti, A. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.04.014 · Cited by 36 · see citing works
Antidepressant‐associated switches from depression to mania in severe bipolar disorder
Carlson, G. A., Finch, S. J., Fochtmann, L. J., Ye, Q., Wáng, Q., Naz, B., & Bromet, E. J. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00424.x · Cited by 35 · see citing works
Allain, N., Leven, C., Falissard, B., Allain, J., Batail, J.-M. V., Polard, É., Montastruc, F., Drapier, D., & Naudet, F. (2016) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12672 · Cited by 29 · see citing works
Takeshima, M., & Oka, T. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.05.077 · Cited by 28 · see citing works
Tundo, A., Calabrese, J. R., Proietti, L., & de Filippis, R. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.09.019 · Cited by 22 · see citing works
An Open Trial of Adjunctive Escitalopram in Bipolar Depression
Fonseca, M., Soares, J. C., Hatch, J. P., Santin, A. M. P., & Kapczinski, F. P. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0115 · Cited by 19 · see citing works
Sepede, G., Di lorio, G., Lupi, M., Sarchione, F., Acciavatti, T., Fiori, F., Santacroce, R., Martinotti, G., Gambi, F., & Di Giannantonio, M. (2014) · Clinical Neuropharmacology · doi:10.1097/wnf.0000000000000011 · Cited by 16 · see citing works
Lieberman, D. Z., Kolodner, G., Massey, S. H., & Williams, K. P. (2009) · Journal of Addictive Diseases · doi:10.1080/10550880903182994 · Cited by 13 · see citing works
Gorwood, P. A. P. M., Richard‐Devantoy, S., Sentissi, O., Strat, Y. L., & Olié, J. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.04.071 · Cited by 13 · see citing works
Fornaro, M., Berardis, D. D., Iasevoli, F., Pistorio, M. L., D׳Angelo, E., Mungo, S., Martino, M., Ventriglio, A., Cattaneo, C. I., Favaretto, E., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.08.014 · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 5
- [17]17. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of obser- vational studies in epidemiology: a proposal for reporting. JAMA. 2000;283:2008-2012.
- [22]22. Borenstein M, Hedges L, Higgins J, Rothstein H. Comprehensive Meta- Analysis Version 2. Englewood, NJ: Biostat; 2005:104.
- [58]58. Sarisoy G, Pazvantoglu O. Sociodemographic and clinical features of antidepressant-induced hypomanic and manic switch in patients with bipolardisorder. Dusunen Adam. 2013;26:122-130.
- [79]79. J Affect Disord C. 2014;170:22.
- [80]80. Niitsu T, Fabbri C, Serretti A. Predictors of switch from depression to mania in bipolar disorder. J Psychiatr Res. 2015;66:45-53.
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- Authors
- Fornaro, M., Anastasia, A., Novello, S., Fusco, A., Solmi, M., Monaco, F., Veronese, N., De Berardis, D., & de Bartolomeis, A.
- Affiliations
- Federico II University Hospital (IT)
- University of Padua (IT)
- University of Salerno (IT)
- Azienda Ospedale - Università Padova (IT)
- National Health Service Department of Mental Health Psychiatric Service of Diagnosis and Treatment Teramo Italy
- Section of Psychiatry Department of Neuroscience, Reproductive Sciences and Odontostomatology Federico II University Naples Italy
- Corresponding author
- Fornaro, Michele
- Venue
- Bipolar Disorders
- Publisher
- Wiley
- Published
- 2018-02-14
- Volume
- 20
- Issue
- 3
- Pages
- 195-227
- ISSN
- 1398-5647 (ISSN-L)
- 1399-5618
- OpenAlex
- W2790303747
- Cited by
- 93
- References
- 86
- Citations by year
- 2026: 15 · 2025: 9 · 2024: 8 · 2023: 12 · 2022: 8 · 2021: 11 · 2020: 16 · 2019: 7 · 2018: 7
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Bipolar Disorders (publishedVersion)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- International Society for Bipolar Disorders
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- treatment-emergent mania, antidepressant-induced mania, bipolar depression, bipolar disorder, antidepressants, incidence, prevalence, manic switch, operational definitions
- MeSH terms
- Antidepressive Agents, Bipolar Disorder, Depression, Humans, Incidence, Prevalence
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