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MiR‐124 Regulates Apoptosis and Autophagy Process in MPTP Model of P arkinson's Disease by Targeting to B im

Wang, Huiqing, Ye, Yongyi, Zhu, Zhiyuan, Mo, Liqian, Lin, Chunnan, Wang, Qifu, Wang, Haoyuan, Gong, Xin +4 more·2016·Brain Pathology
DOI 10.1111/bpa.12267
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Abstract

P arkinson's disease (PD) is the most prevalent movement disorder characterized by selective loss of midbrain dopaminergic (DA) neurons. MicroRNA‐124 (mi R‐124) is abundantly expressed in the DA neurons and its expression level decreases in the 1‐methyl‐4‐pheny‐1, 2, 3, 6‐tetrahydropyridine (MPTP) model of PD. However, whether the upregulation of miR‐124 could attenuate neurodegeneration remains unknown. Here, we employed miR‐124 agomir and miR‐124 mimics to upregulate mi R‐124 expression in MPTP‐treated mice and MPP+‐intoxicated SH‐SY5Y cells, respectively. We found that loss of DA neurons and striatal dopamine in MPTP‐treated mice was significantly reduced by upregulating mi R‐124. In addition, we identified a target of mi R‐124, B im that mediated the neuroprotection of mi R‐124. Indeed, treatment of mi R‐124 agomir in MPTP‐treated mice inhibited B im expression, thus suppressing B ax translocation to mitochondria. Moreover, impaired autophagy process in MPTP‐treated mice and MPP+‐intoxicated SH‐SY5Y cells characterized as autophagosomes (AP) accumulation and lysosomal depletion were alleviated by the upregulation of miR‐124. Taken together, these results indicate that upregulation of mi R‐124 could regulate apoptosis and impaired autophagy process in the MPTP model of PD, thus reducing the loss of DA neurons.

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Crossref · 10.1111/bpa.12267

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  • Altered expression of miR-124 is associated with multiple neuroinflammatory disorders such as Parkinson's, Alzheimer's, and Huntington's disease.

    “Notably, altered expression of miR-124 has been associated with multiple neuroinflammatory disorders such as Parkinson’s (Kanagaraj et al., 2014; Wang et al., 2016; Dong et al., 2018; Yao et al., 2018, 2019), Alzheimer’s Diseases (Lukiw, 2007; Smith et al., 2011; Fang et al., 2012; Zhou et al., 2018), and Huntington’s disease (Johnson and Buckley, 2009).”

    From Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia (2020) · cites this paper as Wang et al., 2016

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Authors
Wang, H., Ye, Y., Zhu, Z., Mo, L., Lin, C., Wang, Q., Wang, H., Gong, X., He, X., Lu, G., Lu, F., & Zhang, S.
Affiliations
  • Department of Neurosurgery Zhujiang Hospital Southern Medical University Guangzhou China
  • Department of Pharmacy Nanfang Hospital Southern Medical University Guangzhou China
  • The National Key Clinic Specialty The Neurosurgery Institute of Guangdong Province Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration Southern Medical University Guangzhou China
  • Department of Neurosurgery the First Affiliated Hospital of Nanchang University Nanchang China
Venue
Brain Pathology
Publisher
Wiley
Published
2015-06-11
Volume
26
Issue
2
Pages
167-176
ISSN
  • 1015-6305
  • 1750-3639
DOI
10.1111/bpa.12267
Cited by
173
References
6
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
National Natural Science Foundation of China (81371397)

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