Validation of differentially expressed brain‐enriched microRNAs in the plasma of PD patients

Circulating microRNAs as stable blood-based markers for cancer detection

Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969 · see citing works

MDS clinical diagnostic criteria for Parkinson’s disease

Postuma, R. B., Berg, D., Stern, M., Poewe, W., Olanow, C. W., Oertel, W., Obeso, J., Marek, K., Litvan, I., Lang, A. E., et al. (2015) · Movement Disorders · doi:10.1002/mds.26424 · Cited by 7,653 · see citing works

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 6,535 · see citing works

Systematic review of levodopa dose equivalency reporting in Parkinson's disease

Tomlinson, C. L., Stowe, R. L., Patel, S., Rick, C., Gray, R. G., & Clarke, C. E. (2010) · Movement Disorders · doi:10.1002/mds.23429 · Cited by 4,232 · see citing works

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

Bourtchuladze, R., Frenguelli, B., Blendy, J., Cioffi, D., Schutz, G., & Silva, A. J. (1994) · Cell · doi:10.1016/0092-8674(94)90400-6 · Cited by 1,800 · see citing works

DIANA-miRPath v3.0: deciphering microRNA function with experimental support

Vlachos, I. S., Zagganas, K., Paraskevopoulou, M. D., Georgakilas, G. K., Karagkouni, D., Vergoulis, T., Dalamagas, T., & Hatzigeorgiou, A. G. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv403 · Cited by 1,682 · see citing works

The clinical symptoms of Parkinson's disease.

Sveinbjornsdottir, S. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13691 · Cited by 1,410 · cited 1× · see citing works

Direct control of the Forkhead transcription factor AFX by protein kinase B

Kops, G. J. P. L., de Ruiter, N. D., de Vries-Smits, A. M. M., Powell, D. R., Bos, J. L., & Burgering, B. M. T. (1999) · Nature · doi:10.1038/19328 · Cited by 1,085 · see citing works

Diagnostic procedures for Parkinson's disease dementia: Recommendations from the movement disorder society task force

Dubois, B., Burn, D. J., Goetz, C. G., Aarsland, D., Brown, R. G., Broe, G. A., Dickson, D. W., Duyckaerts, C. J., Cummings, J., Gauthier, S. G., et al. (2007) · Movement Disorders · doi:10.1002/mds.21844 · Cited by 1,069 · see citing works

MicroRNA-mediated conversion of human fibroblasts to neurons

Yoo, A. S., Sun, A. X., Li, L., Shcheglovitov, A., Portmann, T., Li, Y., Lee-Messer, C., Dolmetsch, R. E., Tsien, R. W., & Crabtree, G. R. (2011) · Nature · doi:10.1038/nature10323 · Cited by 919 · see citing works

Dopamine-mediated regulation of corticostriatal synaptic plasticity

Calabresi, P., Picconi, B., Tozzi, A., & Di Filippo, M. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.001 · Cited by 865 · see citing works

Secreted microRNAs: a new form of intercellular communication

Chen, X., Liang, H., Zhang, J., Zen, K., & Zhang, C. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.12.001 · Cited by 761 · see citing works

Disruption of CREB function in brain leads to neurodegeneration

Mantamadiotis, T., Lemberger, T., Bleckmann, S. C., Kern, H., Kretz, O., Villalba, A. M., Tronche, F., Kellendonk, C., Gau, D., Kapfhammer, J., et al. (2002) · Nature Genetics · doi:10.1038/ng882 · Cited by 684 · see citing works

The Incidence of Parkinson's Disease: A Systematic Review and Meta-Analysis

Hirsch, L., Jetté, N., Frolkis, A. D., Steeves, T. D. L., & Pringsheim, T. M. (2016) · Neuroepidemiology · doi:10.1159/000445751 · Cited by 683 · see citing works

Long-term synaptic depression in the striatum: physiological and pharmacological characterization

Calabresi, P., Maj, R., Pisani, A., Mercuri, N. B., & Bernardi, G. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04224.1992 · Cited by 673 · see citing works

Neuropathology of Parkinson disease

Dickson, D. W. (2018) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2017.07.033 · Cited by 623 · see citing works

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

Gui, Y., Liu, H., Zhang, L., Lv, W., & Hu, X. (2015) · Oncotarget · doi:10.18632/oncotarget.6158 · Cited by 552 · see citing works

Post-transcriptional Regulation of α-Synuclein Expression by mir-7 and mir-153

Doxakis, E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.086827 · Cited by 485 · see citing works

Characterization of Small RNAs in Aplysia Reveals a Role for miR-124 in Constraining Synaptic Plasticity through CREB

Rajasethupathy, P., Fiumara, F., Sheridan, R., Betel, D., Puthanveettil, S. V., Russo, J. J., Sander, C., Tuschl, T., & Kandel, E. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.029 · Cited by 406 · see citing works

Biomarkers of Parkinson’s disease: Present and future

Miller, D. B., & O'Callaghan, J. P. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.030 · Cited by 403 · see citing works

Profiles of Extracellular miRNA in Cerebrospinal Fluid and Serum from Patients with Alzheimer's and Parkinson's Diseases Correlate with Disease Status and Features of Pathology

Burgos, K., Malenica, I., Metpally, R., Courtright, A., Rakela, B., Beach, T., Shill, H., Adler, C., Sabbagh, M., Villa, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094839 · Cited by 385 · see citing works

TransmiR v2.0: an updated transcription factor-microRNA regulation database

Tong, Z., Cui, Q., Wang, J., & Zhou, Y. (2019) · Nucleic Acids Research · doi:10.1093/nar/gky1023 · Cited by 356 · see citing works

Spaced training induces normal long-term memory in CREB mutant mice

Kogan, J. H., Frankland, P. W., Blendy, J. A., Coblentz, J., Marowitz, Z., Schütz, G., & Silva, A. J. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00022-4 · Cited by 350 · see citing works

Synaptic Dysfunction in Parkinson’s Disease

Picconi, B., Piccoli, G., & Calabresi, P. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-3-7091-0932-8_24 · Cited by 277 · see citing works

Inducible Enhancement of Memory Storage and Synaptic Plasticity in Transgenic Mice Expressing an Inhibitor of ATF4 (CREB-2) and C/EBP Proteins

Chen, A. Y.-C., Muzzio, I. A., Malleret, G., Bartsch, D., Verbitsky, M., Pavlidis, P., Yonan, A. L., Vronskaya, S., Grody, M. B., Cepeda, I. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00501-4 · Cited by 276 · see citing works

Identification of blood microRNAs associated to Parkinsońs disease

Margis, R., Margis, R., & Rieder, C. R. M. (2011) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2011.01.023 · Cited by 263 · see citing works

Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes

Jovičić, A., Roshan, R., Moisoi, N., Pradervand, S., Moser, R., Pillai, B., & Luthi-Carter, R. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0600-12.2013 · Cited by 251 · see citing works

Penetrance of Parkinson disease in glucocerebrosidase gene mutation carriers

Anheim, M., Elbaz, A., Lesage, S., Dürr, A., Condroyer, C., Viallet, F., Pollak, P., Bonaïti, B., Bonaïti‐Pellié, C., & Brice, A. (2012) · Neurology · doi:10.1212/wnl.0b013e318245f476 · Cited by 249 · see citing works

Visualizing genomic information across chromosomes with PhenoGram

Wolfe, D., DUDEK, S. M., Ritchie, M. D., & Pendergrass, S. A. (2013) · BioData Mining · doi:10.1186/1756-0381-6-18 · Cited by 243 · see citing works

Parkinson disease, 10 years after its genetic revolution: Multiple clues to a complex disorder

Klein, C., & Schlossmacher, M. G. (2007) · Neurology · doi:10.1212/01.wnl.0000271880.27321.a7 · Cited by 209 · see citing works

<scp>MiR</scp>‐124 Regulates Apoptosis and Autophagy Process in <scp>MPTP</scp> Model of <scp>P</scp>arkinson's Disease by Targeting to <scp>B</scp>im

Wang, H., Ye, Y., Zhu, Z., Mo, L., Lin, C., Wang, Q., Wang, H., Gong, X., He, X., Lu, G., et al. (2016) · Brain Pathology · doi:10.1111/bpa.12267 · Cited by 173 · see citing works

Plasma microRNA biomarkers for detection of mild cognitive impairment: Biomarker Validation Study

Sheinerman, K. S., Tsivinsky, V. G., Abdullah, L. I., Crawford, F., & Umansky, S. R. (2013) · Aging · doi:10.18632/aging.100624 · Cited by 147 · see citing works

Influences of dopaminergic lesion on epidermal growth factor‐ErbB signals in Parkinson's disease and its model: neurotrophic implication in nigrostriatal neurons

Iwakura, Y., Piao, Y., Mizuno, M., Takei, N., Kakita, A., Takahashi, H., & Nawa, H. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03073.x · Cited by 136 · see citing works

LncRNA SNHG14 promotes inflammatory response induced by cerebral ischemia/reperfusion injury through regulating miR-136-5p /ROCK1

Zhong, Y., Yu, C., & Qin, W. (2018) · Cancer Gene Therapy · doi:10.1038/s41417-018-0067-5 · Cited by 135 · see citing works

Essential function of HIPK2 in TGFβ-dependent survival of midbrain dopamine neurons

Zhang, J., Pho, V., Bonasera, S. J., Holtzman, J., Tang, A. T., Hellmuth, J. M., Tang, S., Janak, P. H., Tecott, L. H., & Huang, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1816 · Cited by 134 · see citing works

A53T-Alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old Mice

Kurz, A., Double, K. L., Lastres‐Becker, I., Tozzi, A., Tantucci, M., Bockhart, V., von Bonin, M., Garcı́a-Arencibia, M., Nuber, S., Schlaudraff, F., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011464 · Cited by 134 · see citing works

miRNA-based signatures in cerebrospinal fluid as potential diagnostic tools for early stage Parkinson’s disease

dos Santos, M. C. T., Barreto-Sanz, M. A., Correia, B. R. S., Bell, R., Widnall, C., Perez, L. T., Berteau, C., Schulte, C., Scheller, D., Berg, D., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24736 · Cited by 125 · see citing works

FOXO in Neural Cells and Diseases of the Nervous System

Santo, E. E., & Paik, J. (2018) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.10.002 · Cited by 113 · see citing works

MicroRNA abundance is altered in synaptoneurosomes during prion disease

Boese, A. S., Saba, R., Campbell, K., Majer, A., Medina, S. J., Burton, L., Booth, T. F., Chong, P. M., Westmacott, G., Dutta, S. M., et al. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.12.001 · Cited by 112 · see citing works

Plasma levels of miR-137 and miR-124 are associated with Parkinson’s disease but not with Parkinson’s disease with depression

Li, N., Pan, X., Zhang, J., Ma, A., Yang, S., Ma, J., & Xie, A. (2017) · Neurological Sciences · doi:10.1007/s10072-017-2841-9 · Cited by 107 · see citing works

Clinical Assessments in Parkinson's Disease

Bhidayasiri, R., & Martínez‐Martín, P. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.01.001 · Cited by 102 · see citing works

FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra

Pino, E., Amamoto, R., Zheng, L., Cacquevel, M., Sarria, J. ‐. F., Knott, G. W., & Schneider, B. L. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt530 · Cited by 101 · see citing works

Transforming Growth Factor β Is Required for Differentiation of Mouse Mesencephalic Progenitors into Dopaminergic Neurons In Vitro and In Vivo: Ectopic Induction in Dorsal Mesencephalon

Roussa, E., Wiehle, M., Dünker, N., Becker‐Katins, S., Oehlke, O., & KRIEGLSTEIN, K. G. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0514 · Cited by 96 · see citing works

Gene Expression Profiles in Parkinson Disease Prefrontal Cortex Implicate FOXO1 and Genes under Its Transcriptional Regulation

Dumitriu, A., Latourelle, J. C., Hadzi, T. C., Pankratz, N., Garza, D., Miller, J. P., Vance, J. M., Foroud, T., Beach, T. G., & Myers, R. H. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002794 · Cited by 91 · see citing works

Deficiency in Neuronal TGF-β Signaling Leads to Nigrostriatal Degeneration and Activation of TGF-β Signaling Protects against MPTP Neurotoxicity in Mice

Tesseur, I. C., Nguyen, A., Chang, B., Li, L., Woodling, N. S., Wyss‐Coray, T., & Luo, J. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2952-16.2017 · Cited by 88 · see citing works

The GBAP1 pseudogene acts as a ceRNA for the glucocerebrosidase gene GBA by sponging miR-22-3p

Straniero, L., Rimoldi, V., Samarani, M., Goldwurm, S., Fonzo, A. D., Krüger, R., Deleidi, M., Aureli, M., Soldà, G., Duga, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12973-5 · Cited by 88 · see citing works

CCAAT/Enhancer-Binding Protein Phosphorylation Biases Cortical Precursors to Generate Neurons Rather Than AstrocytesIn Vivo

Paquin, A., Barnabé‐Heider, F., Kageyama, R., & Miller, F. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2662-05.2005 · Cited by 81 · see citing works

Effect of the ubiquitous transcription factors, SP1 and MAZ, on NMDA receptor subunit type 1 (NR1) expression during neuronal differentiation

Okamoto, S., Sherman, K., Bai, G., & Lipton, S. A. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00440-0 · Cited by 77 · see citing works

Chronic Oral Nicotine Normalizes Dopaminergic Function and Synaptic Plasticity in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Primates

Quik, M., Chen, L., Parameswaran, N., Xie, X., Langston, J. W., & McCallum, S. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0215-06.2006 · Cited by 77 · see citing works

MicroRNA Targeting of CoREST Controls Polarization of Migrating Cortical Neurons

Volvert, M.-L., Prévôt, P.-P., Close, P., Laguesse, S., Pirotte, S., Hemphill, J., Rogister, F., Kruzy, N., Sacheli, R., Moonen, G., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.075 · Cited by 74 · see citing works

(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse

Chou, J.-S., Chen, C., Chen, Y., Weng, Y.-H., Yeh, T., Lu, C.-S., Chang, Y.-M., & Wang, H. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.04.021 · Cited by 72 · see citing works

A recurrent 14q32.2 microdeletion mediated by expanded TGG repeats

Béna, F., Gimelli, S., Migliavacca, E., Brun-Druc, N., Buiting, K., Antonarakis, S. E., & Sharp, A. J. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq075 · Cited by 72 · see citing works

MicroRNA-22 Gates Long-Term Heterosynaptic Plasticity in Aplysia through Presynaptic Regulation of CPEB and Downstream Targets

Fiumara, F., Rajasethupathy, P., Antonov, I., Kosmidis, S., Sossin, W. S., & Kandel, E. R. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.034 · Cited by 70 · see citing works

ErbB4 signaling in dopaminergic axonal projections increases extracellular dopamine levels and regulates spatial/working memory behaviors

Skirzewski, M., Karavanova, I. D., Shamir, A., Erben, L., García‐Olivares, J., Shin, J. H., Vullhorst, D., Alvarez, V. A., Amara, S. G., & Buonanno, A. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.132 · Cited by 61 · see citing works

In silico identification and in vivo validation of miR-495 as a novel regulator of motivation for cocaine that targets multiple addiction-related networks in the nucleus accumbens

Bastle, R. M., Oliver, R. J., Gardiner, A. S., Pentkowski, N. S., Bolognani, F., Allan, A. M., Chaudhury, T., Peter, M. S., Galles, N., Smith, C. L., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.238 · Cited by 59 · see citing works

Circulating Brain‐Enriched MicroRNAs for Detection and Discrimination of Idiopathic and Genetic Parkinson's Disease

Ravanidis, S., Bougea, A. M., Papagiannakis, N., Maniati, M., Koros, C., Simitsi, A., Bozi, M., Pachi, I., Stamelou, M., Paraskevas, G. P., et al. (2019) · Movement Disorders · doi:10.1002/mds.27928 · Cited by 54 · see citing works

Neuroprotective Role of MicroRNA-22 in a 6-Hydroxydopamine-Induced Cell Model of Parkinson’s Disease via Regulation of Its Target Gene TRPM7

Yang, C., Zhang, Z. H., Zhang, L. H., & Rui, H. C. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0828-2 · Cited by 53 · see citing works

Systematic identification of 3′-UTR regulatory elements in activity-dependent mRNA stability in hippocampal neurons

Cohen, J. E., Lee, P. R., & Fields, R. D. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0509 · Cited by 51 · see citing works

Neuroplasticity, axonal guidance and micro‐ RNA genes are associated with morphine self‐administration behavior

Tapocik, J. D., Luu, T. V., Mayo, C. L., Wang, B., Doyle, E., Lee, A. D., Lee, N. H., & Elmer, G. I. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00470.x · Cited by 50 · see citing works

Post-translational modifications of Parkinson's disease-related proteins: Phosphorylation, SUMOylation and Ubiquitination

Junqueira, S. C., Centeno, E. G. Z., Wilkinson, K. A., & Cimarosti, H. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.10.025 · Cited by 50 · see citing works

The role of posttranslational modifications of α-synuclein and LRRK2 in Parkinson's disease: Potential contributions of environmental factors

Pajarillo, E. A. B., Rizor, A., Lee, J., Aschner, M., & Lee, E.-S. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.11.017 · Cited by 39 · see citing works

Transforming growth factor beta2 haploinsufficient mice develop age-related nigrostriatal dopamine deficits

Andrews, Z. B., Zhao, H., Frugier, T., Meguro, R., Grattan, D. R., Koishi, K., & McLennan, I. S. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.09.001 · Cited by 35 · see citing works

Global MicroRNA Expression Profiling Reveals Differential Expression of Target Genes in 6-Hydroxydopamine-injured MN9D Cells

Li, L., Chen, H., Chen, F., Li, F., Wang, M., Wang, L., Li, Y.-Q., & Gao, D. (2013) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8244-z · Cited by 32 · see citing works

Roles for the TGFβ Superfamily in the Development and Survival of Midbrain Dopaminergic Neurons

Hegarty, S. V., Sullivan, A. M., & O’Keeffe, G. W. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8639-3 · Cited by 32 · see citing works

Roles of differential expression of microRNA-21-3p and microRNA-433 in FSH regulation in rat anterior pituitary cells

Han, D., Sun, X.-L., Xu, M.-Q., Chen, C., Jiang, H., Gao, Y., Yuan, B., & Zhang, J. (2017) · Oncotarget · doi:10.18632/oncotarget.16615 · Cited by 30 · see citing works

Principles of miRNA-Target Regulation in Metazoan Models

Doxakis, E. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140816280 · Cited by 27 · see citing works

Cell-free microRNAs in Parkinson’s disease: potential biomarkers that provide new insights into disease pathogenesis

Doxakis, E. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101023 · Cited by 25 · see citing works

MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis

Liu, B., Ma, A., Zhang, F., Wang, Y., Li, Z., Li, Q., Xu, Z., & Zheng, Y.-F. (2016) · Scientific Reports · doi:10.1038/srep21534 · Cited by 23 · see citing works

MicroRNA-433 Inhibits the Proliferation and Migration of HUVECs and Neurons by Targeting Hypoxia-Inducible Factor 1 Alpha

Zhang, L., Zhang, Y., Zhang, X., Zhang, Y., Jiang, Y., Xiao, X., Tan, J. Y., Yuan, W., & Liu, Y. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0853-1 · Cited by 22 · see citing works

Intracranial Self-Stimulation Modulates Levels of SIRT1 Protein and Neural Plasticity-Related microRNAs

Puig-Parnau, I., García‐Brito, S., Faghihi, N., Gubern, C., Aldavert-Vera, L., Segura-Torres, P., Huguet, G., & Kádár, E. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01901-w · Cited by 21 · see citing works

The 14q32 maternally imprinted locus is a major source of longitudinally stable circulating microRNAs as measured by small RNA sequencing

Valbuena, G. N., Apostolidou, S., Roberts, R., Barnes, J., ALDERTON, W. K., Harper, L., Jacobs, I. J., Menon, U., & Keun, H. C. (2019) · Scientific Reports · doi:10.1038/s41598-019-51948-6 · Cited by 15 · see citing works

A Rare, Recurrent,De Novo14q32.2q32.31 Microdeletion of 1.1 Mb in a 20-Year-Old Female Patient with a Maternal UPD(14)-Like Phenotype and Intellectual Disability

Zada, A., Mundhofir, F. E., Pfundt, R., Leijsten, N., Nillesen, W. M., Faradz, S. M., & de Leeuw, N. (2014) · Case Reports in Genetics · doi:10.1155/2014/530134 · Cited by 9 · see citing works

The role of noncoding RNAs in Parkinson’s disease: biomarkers and associations with pathogenic pathways

Kuo, M., Liu, S. C.-H., Hsu, Y.-F., & Wu, R. (2021) · Journal of Biomedical Science · doi:10.1186/s12929-021-00775-x · Cited by 96 · see citing works

miR-323a regulates ERBB4 and is involved in depression

Fiori, L. M., Kos, A., Lin, R., Théroux, J.-F., Lopez, J. P., Kühne, C., Eggert, C., Holzapfel, M., Huettl, R.-E., Mechawar, N., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00953-7 · Cited by 88 · see citing works

Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases

Gentile, G., Morello, G., Cognata, V. L., Guarnaccia, M., Conforti, F. L., & Cavallaro, S. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12050770 · Cited by 69 · see citing works

MicroRNA-124: A Key Player in Microglia-Mediated Inflammation in Neurological Diseases

Zhao, J., He, Z., & Wang, J. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.771898 · Cited by 66 · see citing works

Opportunities and challenges for microRNA-targeting therapeutics for epilepsy

Morris, G., O’Brien, D., & Henshall, D. C. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.04.007 · Cited by 65 · see citing works

Deep sequencing of sncRNAs reveals hallmarks and regulatory modules of the transcriptome during Parkinson’s disease progression

Kern, F., Fehlmann, T., Violich, I., Alsop, E. B., Hutchins, E. D., Kahraman, M., Grammes, N. L., Guimarães, P., Backes, C., Poston, K. L., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00042-6 · Cited by 63 · see citing works

Differentially Expressed Circular <scp>RNAs</scp> in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease

Ravanidis, S., Bougea, A., Karampatsi, D., Papagiannakis, N., Maniati, M., Stefanis, L., & Doxakis, E. (2021) · Movement Disorders · doi:10.1002/mds.28467 · Cited by 63 · see citing works

Recent Evidence in Epigenomics and Proteomics Biomarkers for Early and Minimally Invasive Diagnosis of Alzheimer’s and Parkinson’s Diseases

Mayo, S., Benito‐León, J., Peña‐Bautista, C., Baquero, M., & Cháfer‐Pericás, C. (2020) · Current Neuropharmacology · doi:10.2174/1570159x19666201223154009 · Cited by 60 · see citing works

MicroRNAs in Parkinson’s disease: a systematic review and diagnostic accuracy meta-analysis

Guévremont, D., Roy, J., Cutfield, N. J., & Williams, J. M. (2023) · Scientific Reports · doi:10.1038/s41598-023-43096-9 · Cited by 48 · see citing works

The Role of Non-Coding RNAs in the Pathogenesis of Parkinson’s Disease: Recent Advancement

Zhang, H., Yao, L., Zheng, Z., Koç, S., & Lu, G. (2022) · Pharmaceuticals · doi:10.3390/ph15070811 · Cited by 43 · see citing works

Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury

Gupta, S. D., Ciszek, R., Heiskanen, M., Lapinlampi, N., Kukkonen, J., Leinonen, V., Puhakka, N., & Pitkänen, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041563 · Cited by 39 · see citing works

Synaptic plasticity and depression: the role of miRNAs dysregulation

Rahmani, S., Kadkhoda, S., & Ghafouri‐Fard, S. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07461-7 · Cited by 36 · see citing works

Aberrant Expression of Circulating MicroRNA Leads to the Dysregulation of Alpha-Synuclein and Other Pathogenic Genes in Parkinson’s Disease

Cai, M., Chai, S., Xiong, T., Wei, J., Mao, W., Zhu, Y., Li, X., Wei, W., Dai, X., Yang, B., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.695007 · Cited by 35 · see citing works

The SATB1‐MIR22‐GBA axis mediates glucocerebroside accumulation inducing a cellular senescence‐like phenotype in dopaminergic neurons

Russo, T., Kolisnyk, B., Aswathy, B. S., Kim, T. W., Martin, J., Plessis‐Belair, J., Ni, J., Pearson, J. A., Park, E. J., Sher, R. B., et al. (2024) · Aging Cell · doi:10.1111/acel.14077 · Cited by 29 · see citing works

Exosomes from Inflamed Macrophages Promote the Progression of Parkinson’s Disease by Inducing Neuroinflammation

Jin, Y., Wu, R., Li, L., Shen, L., Gu, Y., & Sun, C. (2023) · Molecular Neurobiology · doi:10.1007/s12035-022-03179-6 · Cited by 29 · see citing works

Discovery and Validation of Circulating microRNAs as Biomarkers for Epileptogenesis after Experimental Traumatic Brain Injury–The EPITARGET Cohort

Heiskanen, M., Gupta, S. D., Mills, J. D., van Vliet, E. A., Manninen, E., Ciszek, R., Andrade, P., Puhakka, N., Aronica, E., & Pitkänen, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032823 · Cited by 25 · see citing works

Lipid accumulation drives cellular senescence in dopaminergic neurons

Russo, T., & Rießland, M. (2024) · Aging · doi:10.18632/aging.206030 · Cited by 23 · see citing works

circRNA from APP Gene Changes in Alzheimer’s Disease Human Brain

Urdánoz‐Casado, A., de Gordoa, J. S., Robles, M., Roldán, M., Macías, M., Acha, B., Blanco‐Luquin, I., & Mendióroz, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054308 · Cited by 23 · see citing works

NLRP3/miR-223-3p axis attenuates neuroinflammation induced by chronic intermittent hypoxia

Wu, C., Xing, W., Zhang, Y., Wang, J., Zuo, N., Sun, F., Liu, Q., & Liu, S. (2023) · Functional & Integrative Genomics · doi:10.1007/s10142-023-01268-w · Cited by 23 · see citing works

The pyroptosis mediated biomarker pattern: an emerging diagnostic approach for Parkinson’s disease

Liang, J., Wan, Z., Qian, C., Rasheed, M., Cao, C., Sun, J., Wang, X., Chen, Z., & Deng, Y. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00516-y · Cited by 22 · see citing works

Extracellular Vesicle-Enriched miRNA-Biomarkers Show Improved Utility for Detecting Alzheimer’s Disease Dementia and Medial Temporal Atrophy

Chai, Y. L., Strohm, L., Zhu, Y., Chia, R. S. L., Chong, J. R., Suresh, D. D., Zhou, L. H., Too, H., Hilal, S., Radivoyevitch, T., et al. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230572 · Cited by 19 · see citing works

Involvement of extracellular vesicle microRNA clusters in developing healthy and Rett syndrome brain organoids

Sangani, N. B., Koetsier, J., Gomes, A. R., Diogo, M. M., Fernandes, T. G., Bouwman, F. G., Mariman, E. C. M., Ghazvini, M., Gribnau, J. H., Curfs, L., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05409-7 · Cited by 17 · see citing works

MicroRNA as Candidate Biomarkers in Atypical Parkinsonian Syndromes: Systematic Literature Review

Bougea, A. M. (2022) · Medicina · doi:10.3390/medicina58040483 · Cited by 17 · see citing works

MicroRNAs Modulating Neuroinflammation in Parkinson's disease

Saadh, M. J., Muhammad, F. A., Singh, A., Mustafa, M. A., Zuhairi, R. A. H. A., Ghildiyal, P., Hashim, G. M., Alsaikhan, F., Khalilollah, S., & Akhavan‐Sigari, R. (2024) · Inflammation · doi:10.1007/s10753-024-02125-z · Cited by 16 · see citing works

Fasting-mediated metabolic and toxicity reprogramming impacts circulating microRNA levels in humans

Ravanidis, S., Grundler, F., de Toledo, F. W., Dimitriou, E., Tekos, F., Skaperda, Z., Kouretas, D., & Doxakis, E. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112187 · Cited by 16 · see citing works

TGF-β1 Inhibition of ACE2 Mediated by miRNA Uncovers Novel Mechanism of SARS-CoV-2 Pathogenesis

Hejenkowska, E. D., Mitash, N., Donovan, J., Chandra, A., Bertrand, C. A., Santi, C. D., Greene, C. M., Mu, F., & Swiatecka‐Urban, A. (2023) · Journal of Innate Immunity · doi:10.1159/000533606 · Cited by 14 · see citing works

Apilarnil exerts neuroprotective effects and alleviates motor dysfunction by rebalancing M1/M2 microglia polarization, regulating miR-155 and miR-124 expression in a rotenone-induced Parkinson’s disease rat model

Salama, R. M., Darwish, S. F., Yehia, R., Eissa, N., Elmongy, N. F., Abdel-Galil, M., Schaalan, M. F., & Wakeel, S. A. E. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112536 · Cited by 13 · see citing works

MicroRNAs in Parkinson’s disease: From pathogenesis to diagnostics and therapeutic strategies

Zheng, D., & Chen, J. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.01.038 · Cited by 13 · see citing works

Evolutionary Changes in the Interaction of miRNA With mRNA of Candidate Genes for Parkinson’s Disease

Kamenova, S. U., Aralbayeva, А., Kondybayeva, А., Akimniyazova, A., Pyrkova, A., & At, I. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.647288 · Cited by 13 · see citing works

C/EBPβ Regulates TFAM Expression, Mitochondrial Function and Autophagy in Cellular Models of Parkinson’s Disease

Sierra‐Magro, A., Bartolomé, F. B., Lozano-Muñoz, D., Alarcón-Gil, J., Giné, E., Sanz-SanCristóbal, M., Alonso‐Gil, S., Cortés‐Canteli, M., Carro, E., Pérez‐Castillo, A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021459 · Cited by 13 · see citing works

miR-154-5p Is a Novel Endogenous Ligand for TLR7 Inducing Microglial Activation and Neuronal Injury

McGurran, H., Kumbol, V. W.-A., Krüger, C., Wallach, T., & Lehnardt, S. (2024) · Cells · doi:10.3390/cells13050407 · Cited by 12 · see citing works

Exercise training-induced extracellular miR-136-3p modulates glucose uptake and myogenesis through targeting of NRDC in human skeletal muscle

Katayama, M., Caria, E., Simaeys, D. V., Sanz, A. Y., Barrès, R., Caidahl, K., Wiklander, O. P. B., Andaloussi, S. E., Berggren, P., Zierath, J. R., et al. (2025) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2025.101091 · Cited by 12 · see citing works

Exosomal microRNAs in Parkinson’s disease: insights into biomarker potential and disease pathology

Chandran, D., Krishnan, S., Urulangodi, M., & Gopala, S. (2024) · Neurological Sciences · doi:10.1007/s10072-024-07439-2 · Cited by 12 · see citing works

Converging peripheral blood microRNA profiles in Parkinson's disease and progressive supranuclear palsy

Pavelka, L., Rauschenberger, A., Hemedan, A. A., Ostaszewski, M., Glaab, E., Krüger, R., Acharya, G., Aguayo, G., Alexandre, M., Ali, M., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae187 · Cited by 11 · see citing works

microRNA and circRNA in Parkinson’s Disease and atypical parkinsonian syndromes

Bougea, A. M., & Stefanis, L. (2023) · Advances in clinical chemistry · doi:10.1016/bs.acc.2023.03.002 · Cited by 9 · see citing works

Plasma miR-203a-3p as a Novel Predictor of Dementia in Patients with Parkinson’s Disease

Hsu, Y.-F., Lin, S., Chu, Y., Tsai, Y., Huang, J., Phoa, F. K. H., & Wu, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063554 · Cited by 9 · see citing works

Unlocking Parkinson’s disease: the role of microRNAs in regulation, diagnosis, and therapy

Li, X., Fu, Q., Guo, M., Du, Y., & Cheng, Y. (2025) · APOPTOSIS · doi:10.1007/s10495-025-02117-w · Cited by 8 · see citing works

Cohort-specific boolean models highlight different regulatory modules during Parkinson’s disease progression

Hemedan, A. A., Satagopam, V., Schneider, R., & Ostaszewski, M. (2024) · iScience · doi:10.1016/j.isci.2024.110956 · Cited by 7 · see citing works

SOS1-IT1 silencing alleviates MPP+-induced neuronal cell injury through regulating the miR-124-3p/PTEN/AKT/mTOR pathway

Fan, J., Wu, D., Guo, Y., & Yang, Z. (2022) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2022.01.003 · Cited by 7 · see citing works

Plasma miRNA Biomarker Signatures in Parkinsonian Syndromes

Ravanidis, S., Bougea, A. M., Koros, C., Simitsi, A., Kokotis, P., Stefanis, L., & Doxakis, E. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04890-w · Cited by 6 · see citing works

Activation of toll‑like receptors by non‑coding RNAs and their fragments (Review)

Garrido, R. R.-E., & Velázquez-Flores, M. Á. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13650 · Cited by 4 · see citing works

The Role of miRNAs in Parkinson’s Disease: A Systematic Review

Chrysanthou, M., Christodoulou, C. C., & Papanicolaou, E. Z. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262412164 · Cited by 4 · see citing works

Plasma hsa‐mir‐19b is a potential LevoDopa therapy marker

Chiş, A. R., Moatăr, A. I., Dijmarescu, C., Roşca, E. C., Vorovenci, R. J., Krabbendam, I. E., Dolga, A. M., Bejinar, C., Marian, C., Sîrbu, I. O., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16827 · Cited by 4 · see citing works

Evaluation role of miR-124 in neurodegenerative diseases: literature review and in silico analysisPreprint

Amini, J., Bibak, B., Afshar, A. R., & Sahebkar, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.17.464692 · Cited by 4 · see citing works

Effects of the LINC00641/miR-323a-3p/EIF4G2 axis on behaviors and brain monoamine neurotransmitters in chronic unpredictable mild stress mice

Lin, Z., Qi, D., & Zhang, Y. (2025) · Cell Biology and Toxicology · doi:10.1007/s10565-025-10015-9 · Cited by 3 · see citing works

Decoding Parkinson's disease: A multifaceted approach to diagnosis and biomarker discovery

Ragab, M. H., Soliman, A.-H., Shaltout, A. E.-R., El-Ramly, T. A., Morris, M., Mohamed, O. A. A., Ibrahim, R., & Dakhlaah, D. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15702-8.00015-4 · Cited by 3 · see citing works

miR‐330‐5p Attenuates Isoflurane‐Induced Neuroinflammation and Cognitive Dysfunction by Regulating EPHB3

Yang, W. W., Wang, N., Zhang, Q. Y., Guan, Y. F., Wang, S. L., & Ma, R. C. (2025) · Synapse · doi:10.1002/syn.70020 · Cited by 3 · see citing works

Dysregulated miRNAs mark Parkinson’s disease progression

Rosenthal, L. S., Yang, J., & Mao, X. (2021) · Nature Aging · doi:10.1038/s43587-021-00046-2 · Cited by 3 · see citing works

A Disease in Search for a Biomarker: MicroRNAs in Parkinson’s Disease

Chiş, A. R., Moatăr, A. I., & Sîrbu, I.-O. (2021) · Timişoara Medical Journal · doi:10.35995/tmj20210102 · Cited by 1 · see citing works

Circulating miR-323–3p as a novel potential plasma biomarker for multimorbidity burden and cognitive decline in middle-aged and older adults: Results from the national institute for longevity sciences–longitudinal study of aging in Japan

Chu, W., Goto, M., Kabetani, K., Nishita, Y., Zhang, S., Shimokata, H., Lee, M., Satoh, A., & Otsuka, R. (2024) · Archives of Gerontology and Geriatrics Plus · doi:10.1016/j.aggp.2024.100099 · Cited by 1 · see citing works

The role of retroelements in Parkinson’s disease development

Mustafin, R. N. (2025) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vjgb-25-32 · Cited by 1 · see citing works

Independent validation of circulating microRNAs as biomarkers in a case-control study of adolescents with type 1 diabetes for more than 8 years

Swolin‐Eide, D., Lyckå, A. P., Forsander, G., Novák, D., Grillari, J., Diendorfer, A. B., Hackl, M. J., & Magnusson, P. (2026) · PLoS ONE · doi:10.1371/journal.pone.0343117 · Cited by 1 · see citing works

Role of microRNAs in cognitive decline related to COVID‑19 (Review)

Bougea, A. M., Georgakopoulou, V., Lempesis, I. G., Fotakopoulos, G., Papalexis, P., Sklapani, P., Τράκας, Ν., Spandidos, D. A., & Angelopoulou, E. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12427 · Cited by 1 · see citing works

Regulated cell death: Discovery, features, and implications for neurodegenerative diseases

Pandey, S. K., Nanda, A., Singh, S., & Singh, R. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-32852-7.00001-2

Additional file 3 of The pyroptosis mediated biomarker pattern: an emerging diagnostic approach for Parkinson’s disease

Liang, J., Wan, Z., Qian, C., Rasheed, M., Cao, C., Sun, J., Wang, X., Chen, Z., & Deng, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26660272

Additional file 1 of The pyroptosis mediated biomarker pattern: an emerging diagnostic approach for Parkinson’s disease

Liang, J., Wan, Z., Qian, C., Rasheed, M., Cao, C., Sun, J., Wang, X., Chen, Z., & Deng, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26660266

Additional file 5 of The pyroptosis mediated biomarker pattern: an emerging diagnostic approach for Parkinson’s disease

Liang, J., Wan, Z., Qian, C., Rasheed, M., Cao, C., Sun, J., Wang, X., Chen, Z., & Deng, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26660278

Additional file 4 of The pyroptosis mediated biomarker pattern: an emerging diagnostic approach for Parkinson’s disease

Liang, J., Wan, Z., Qian, C., Rasheed, M., Cao, C., Sun, J., Wang, X., Chen, Z., & Deng, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26660275

Additional file 2 of The pyroptosis mediated biomarker pattern: an emerging diagnostic approach for Parkinson’s disease

Liang, J., Wan, Z., Qian, C., Rasheed, M., Cao, C., Sun, J., Wang, X., Chen, Z., & Deng, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26660269

Additional file 6 of The pyroptosis mediated biomarker pattern: an emerging diagnostic approach for Parkinson’s disease

Liang, J., Wan, Z., Qian, C., Rasheed, M., Cao, C., Sun, J., Wang, X., Chen, Z., & Deng, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26660281

The Diagnostic and Therapeutic Value of Micro-RNA in Parkinson’s Disease

Lin, G.-L., Wang, Y., & Cheng, B.-H. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01767-x

Inhibition of miR-206 Ameliorates Seizures and Cognitive Deficits via BDNF/TrkB Signaling in Pilocarpine-Induced TLE Mice

Zhang, H., & Cai, Z.-X. (2026) · Brain Sciences · doi:10.3390/brainsci16101048

Validation of Differentially Expressed Brain-Enriched microRNAs in the Plasma of Parkinson’s Disease PatientsPreprint

Ravanidis, S., Bougea, A. M., Papagiannakis, N., Koros, C., Simitsi, A., Pachi, I., Breza, M., Stefanis, L., & Doxakis, E. (2020) · doi:10.21203/rs.3.rs-33785/v1 · Cited by 4 · see citing works

Circulating Brain‐Enriched MicroRNAs for Detection and Discrimination of Idiopathic and Genetic Parkinson's Disease

Ravanidis, S., Bougea, A. M., Papagiannakis, N., Maniati, M., Koros, C., Simitsi, A., Bozi, M., Pachi, I., Stamelou, M., Paraskevas, G. P., et al. (2019) · Movement Disorders · doi:10.1002/mds.27928 · Cited by 54 · see citing works

Identification and Characterization of MicroRNAs Involved in Parkinson’s Disease: Potential Role as Diagnostic Biomarkers.

Serafin, A. (2016) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/7354

MicroRNAs regulation in Parkinson’s disease, and their potential role as diagnostic and therapeutic targets

Shaheen, N., Shaheen, A., Osama, M., Nashwan, A. J., Bharmauria, V., & Flouty, O. E. (2024) · npj Parkinson s Disease · doi:10.1038/s41531-024-00791-2 · Cited by 77 · see citing works

Elevated plasma miR-133b and miR-221-3p as biomarkers for early Parkinson’s disease

Chen, Q., Deng, N., Lu, K., Liao, Q., Long, X., Gou, D., Bi, F., & Zhou, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-94734-z · Cited by 57 · see citing works