Cited by 166Redox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative MechanismsNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 222 of the 224 references it cites were found in a registry or an index.

Therapeutic potential of NADPH oxidase 1/4 inhibitors

Open access

Teixeira, G, Szyndralewiez, C, Molango, S, Carnesecchi, S, Heitz, F, Wiesel, P, Wood, J M·2017·British Journal of Pharmacology

DOI 10.1111/bph.13532PMC PMC5446584

Open this paper in CoChat — free account Open PDF

Abstract

The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is becoming recognized as key modulators of signal transduction pathways with a physiological role under acute stress and a pathological role after excessive activation under chronic stress. The seven isoforms differ in their regulation, tissue and subcellular localization and ROS products. The most studied are NOX1, 2 and 4. Genetic deletion of NOX1 and 4, in contrast to NOX2, has revealed no significant spontaneous pathologies and a pathogenic relevance of both NOX1 and 4 across multiple organs in a wide range of diseases and in particular inflammatory and fibrotic diseases. This has stimulated interest in NOX inhibitors for therapeutic application. GKT136901 and GKT137831 are two structurally related compounds demonstrating a preferential inhibition of NOX1 and 4 that have suitable properties for in vivo studies and have consequently been evaluated across a range of disease models and compared with gene deletion. In contrast to gene deletion, these inhibitors do not completely suppress ROS production, maintaining some basal level of ROS. Despite this and consistent with most gene deletion studies, these inhibitors are well tolerated and slow or prevent disease progression in a range of models of chronic inflammatory and fibrotic diseases by modulating common signal transduction pathways. Clinical trials in patients with GKT137831 have demonstrated excellent tolerability and reduction of various markers of chronic inflammation. NOX1/4 inhibition may provide a safe and effective therapeutic strategy for a range of inflammatory and fibrotic diseases. Linked Articles: This article is part of a themed section on Redox Biology and Oxidative Stress in Health and Disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.12/issuetoc

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/bph.13532

Cites

222 of 222 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Inflammation and cancer
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
NOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125
Non-Transgenic Mouse Models of Kidney Disease
Rabe, M., & Schaefer, F. S. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000445171 · Cited by 1,927
Inflammation and Cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation
Itzkowitz, S. H., & Yio, X. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00079.2004 · Cited by 1,272
The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands
Southan, C., Sharman, J., Benson, H., Faccenda, E., Pawson, A. J., Alexander, S. P. H., Buneman, O., Davenport, A., McGrath, J., Peters, J., et al. (2015) · Nucleic Acids Res. · doi:10.1093/nar/gkv1037 · Cited by 1,121
Mouse model of x-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
Pollock, J. D., Williams, D. A., Gifford, M. A. C., Li, L. L., Du, X., Fisherman, J., Orkin, S. H., Doerschuk, C. M., & Dinauer, M. C. (1995) · Nature Genetics · doi:10.1038/ng0295-202 · Cited by 921
NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury
Hecker, L., Vittal, R., Jones, T., Jagirdar, R., Luckhardt, T. R., Horowitz, J. C., Pennathur, S., Martinez, F. J., & Thannickal, V. J. (2009) · Nature Medicine · doi:10.1038/nm.2005 · Cited by 852
Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis
Sorescu, D., Weiss, D., Lassègue, B., Clempus, R. E., Szöcs, K., Sorescu, G. P., Valppu, L., Quinn, M. T., Lambeth, J. D., Vega, J. D., et al. (2002) · Circulation · doi:10.1161/01.cir.0000012917.74432.66 · Cited by 847
Nox proteins in signal transduction
Brown, D., & Griendling, K. K. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.07.023 · Cited by 837
NAD(P)H Oxidase 4 Mediates Transforming Growth Factor-β1–Induced Differentiation of Cardiac Fibroblasts Into Myofibroblasts
Cucoranu, I., Clempus, R., Dikalova, A., Phelan, P. J., Ariyan, S., Dikalov, S., & Sorescu, D. (2005) · Circulation Research · doi:10.1161/01.res.0000187457.24338.3d · Cited by 786
Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System
Lassegue, B. P., Martín, A. S., & Griendling, K. K. (2012) · Circulation Research · doi:10.1161/circresaha.111.243972 · Cited by 780
NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart
Kuroda, J., Ago, T., Matsushima, S., Zhai, P., Schneider, M. D., & Sadoshima, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002178107 · Cited by 772
Nox enzymes, ROS, and chronic disease: An example of antagonistic pleiotropy
Lambeth, J. D. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.027 · Cited by 687
Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance
Hecker, L., Logsdon, N. J., Kurundkar, D., Kurundkar, A., Bernard, K., Hock, T., Meldrum, E., Sanders, Y. Y., & Thannickal, V. J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008182 · Cited by 686
Methods for Detection of Mitochondrial and Cellular Reactive Oxygen Species
Dikalov, S., & Harrison, D. G. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4886 · Cited by 639
Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-κB
Park, H. S., Jung, H. Y., Park, E. Y., Kim, J., Lee, W. J., & Bae, Y. S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3589 · Cited by 635
NADPH Oxidases in Cardiovascular Health and Disease
Cave, A. C., Brewer, A. C., Narayanapanicker, A., Ray, R., Grieve, D. J., Walker, S., & Shah, A. M. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.691 · Cited by 630
Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase
Schröder, K., Zhang, M., Benkhoff, S., Mieth, A., Pliquett, R., Kosowski, J., Kruse, C., Luedike, P., Michaelis, U. R., Weissmann, N., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.267054 · Cited by 622
The Concise Guide to PHARMACOLOGY 2015/16: Enzymes
Alexander, S. P. H., Fabbro, D., Kelly, E., Marrion, N. V., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13354 · Cited by 604
NADPH Oxidases: Functions and Pathologies in the Vasculature
Lassègue, B., & Griendling, K. K. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.181610 · Cited by 592
The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4
Takac, I., Schröder, K., Zhang, L., Lardy, B., Anilkumar, N. P., Lambeth, J. D., Shah, A. M., Morel, F., & Brandes, R. P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.192138 · Cited by 539
Evolution of nadph oxidase inhibitors: Selectivity and mechanisms for target engagement
Altenhöfer, S., Radermacher, K. A., Kleikers, P. W. M., Wingler, K., & Schmidt, H. H. H. W. (2015) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5814 · Cited by 521
NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury
Fischer, M. T., Sharma, R., Lim, J. L., Haider, L., Frischer, J. M., Drexhage, J., Mahad, D., Bradl, M., van Horssen, J., & Lassmann, H. (2012) · Brain · doi:10.1093/brain/aws012 · Cited by 507
Reactive oxygen generated by Nox1 triggers the angiogenic switch
Arbiser, J. L., Petros, J. A., Klafter, R., Govindajaran, B., McLaughlin, E. R., Brown, L. F., Cohen, C., Moses, M. A., Kilroy, S. M., Arnold, R. S., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022630199 · Cited by 489
Nox1 Is Involved in Angiotensin II–Mediated Hypertension: A Study in Nox1-Deficient Mice
Matsuno, K., Yamada, H., Iwata, K., Jin, D., Katsuyama, M., Matsuki, M., Takai, S., Yamanishi, K., Miyazaki, M., Matsubara, H., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.573709 · Cited by 470
Multiple Hits, Including Oxidative Stress, as Pathogenesis and Treatment Target in Non-Alcoholic Steatohepatitis (NASH)
Takaki, A., Kawai, D., & Yamamoto, K. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141020704 · Cited by 460
NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis
Zhang, M., Brewer, A. C., Schröder, K., Santos, C. X. C., Grieve, D., Wang, M., Anilkumar, N. P., Yu, B., Dong, X., Walker, S. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009700107 · Cited by 452
Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration
Kleinschnitz, C., Grund, H., Wingler, K., Armitage, M. E., Jones, E., Mittal, M., Barit, D., Schwarz, T., Geis, C., Kraft, P., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000479 · Cited by 447
Upregulation of Nox-Based NAD(P)H Oxidases in Restenosis After Carotid Injury
Szöcs, K., Lassegue, B. P., Sorescu, D., Hilenski, L. L., Valppu, L., Couse, T. L., Wilcox, J. N., Quinn, M. T., Lambeth, J. D., & Griendling, K. K. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0102.102189 · Cited by 443
Nox1 Overexpression Potentiates Angiotensin II-Induced Hypertension and Vascular Smooth Muscle Hypertrophy in Transgenic Mice
Dikalova, A., Clempus, R., Lassègue, B., Cheng, G., McCoy, J., Dikalov, S., Martin, A. S., Lyle, A., Weber, D. S., Weiss, D., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.538934 · Cited by 438
Contrasting Roles of NADPH Oxidase Isoforms in Pressure-Overload Versus Angiotensin II–Induced Cardiac Hypertrophy
Byrne, J., Grieve, D., Bendall, J. K., Li, J., Gove, C. D., Lambeth, J. D., Cave, A. C., & Shah, A. M. (2003) · Circulation Research · doi:10.1161/01.res.0000099504.30207.f5 · Cited by 412
Two cytosolic neutrophil oxidase components absent in autosomal chronic granulomatous disease
Volpp, B. D., Nauseef, W. M., & Clark, R. A. (1988) · Science · doi:10.1126/science.2848318 · Cited by 407
The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex
Dinauer, M. C., Orkin, S. H., Brown, R., Jesaitis, A. J., & Parkos, C. A. (1987) · Nature · doi:10.1038/327717a0 · Cited by 407
Critical role of nox4-based nadph oxidase in glucose-induced oxidative stress in the kidney: Implications in type 2 diabetic nephropathy
Sedeek, M., Callera, G., Montezano, A., Gutsol, A., Heitz, F., Szyndralewiez, C., Page, P., Kennedy, C. R. J., Burns, K. D., Touyz, R. M., et al. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00028.2010 · Cited by 396
Self-citation
NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis
Gray, S. P., Di Marco, E., Okabe, J., Szyndralewiez, C., Heitz, F., Montezano, A. C., de Haan, J. B., Koulis, C., El-Osta, A., Andrews, K. L., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.132159 · Cited by 386
Self-citation
Bone Morphogenic Protein 4 Produced in Endothelial Cells by Oscillatory Shear Stress Induces Monocyte Adhesion by Stimulating Reactive Oxygen Species Production From a Nox1-Based NADPH Oxidase
Sorescu, G. P., Song, H. W., Tressel, S. L., Hwang, J., Dikalov, S., Smith, D. A., Boyd, N. L., Platt, M. O., Lassegue, B. P., Griendling, K. K., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000145728.22878.45 · Cited by 383
The NOX toolbox: validating the role of NADPH oxidases in physiology and disease
Altenhöfer, S., Kleikers, P. W. M., Radermacher, K. A., Scheurer, P., Rob Hermans, J. J., Schiffers, P., Ho, H., Wingler, K., & Schmidt, H. H. H. W. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1010-9 · Cited by 371
Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease.
McKenzie, S. J., Baker, M. S., Buffinton, G. D., & Doe, W. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118757 · Cited by 352
Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy
Jha, J. C., Gray, S. P., Barit, D., Okabe, J., El-Osta, A., Namikoshi, T., Thallas-Bonke, V., Wingler, K., Szyndralewiez, C., Heitz, F., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013070810 · Cited by 352
Self-citation
Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients
Rice, L. M., Padilla, C. M., McLaughlin, S. R., Mathes, A., Ziemek, J., Goummih, S., Nakerakanti, S., York, M., Farina, G., Whitfield, M. L., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77958 · Cited by 351
NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGF 1-induced fibroblast differentiation into myofibroblasts
Amara, N., Goven, D., Prost, F., Muloway, R., Crestani, B., & Boczkowski, J. (2010) · Thorax · doi:10.1136/thx.2009.113456 · Cited by 345
Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent
Aoyama, T., Paik, Y.-H., Watanabe, S., Laleu, B., Gaggini, F., Fioraso-Cartier, L., Molango, S., Heitz, F., Merlot, C., Szyndralewiez, C., et al. (2012) · Hepatology · doi:10.1002/hep.25938 · Cited by 336
Self-citation
Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo
Ray, R., Murdoch, C. E., Wang, M., Santos, C. X. C., Zhang, M., Alom-Ruiz, S. P., Anilkumar, N. P., Ouattara, A., Cave, A. C., Walker, S. J., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.219238 · Cited by 332
Decreased blood pressure in NOX1‐deficient mice
Gavazzi, G., Banfi, B., Deffert, C., Fiette, L., Schappi, M., Herrmann, F., & Krause, K.-H. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.049 · Cited by 321
Aiding and abetting roles of NOX oxidases in cellular transformation
Block, K. L., & Gorin, Y. C. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3339 · Cited by 308
Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair
Leoni, G., Alam, A. M., Neumann, P.-A., Lambeth, J. D., Cheng, G., McCoy, J. W., Hilgarth, R., Kundu, K., Murthy, N., Kusters, D. H. M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci65831 · Cited by 303
Oscillatory Shear Stress Stimulates Endothelial Production of O2- from p47 -dependent NAD(P)H Oxidases, Leading to Monocyte Adhesion
Hwang, J., Saha, A., Boo, Y. C., Sorescu, G. P., McNally, J. S., Holland, S. M., Dikalov, S., Giddens, D. P., Griendling, K. K., Harrison, D. G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305150200 · Cited by 299
Impact of genetic background on nephropathy in diabetic mice
Gurley, S. B., Clare, S. E., Snow, K. P., Hu, A., Meyer, T. W., & Coffman, T. M. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00204.2005 · Cited by 293
A key role for nox4 in epithelial cell death during development of lung fibrosis
Carnesecchi, S., Deffert, C., Donati, Y., Basset, O., Hinz, B., Preynat-Seauve, O., Guichard, C., Arbiser, J. L., Banfi, B., Pache, J.-C., et al. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3829 · Cited by 290
ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence
Weyemi, U., Lagente-Chevallier, O., Boufraqech, M., Prenois, F., Courtin, F., Caillou, B., Talbot, M., Dardalhon, M., Al Ghuzlan, A., Bidart, J.-M., et al. (2012) · Oncogene · doi:10.1038/onc.2011.327 · Cited by 285
Mining the Thiol Proteome for Sulfenic Acid Modifications Reveals New Targets for Oxidation in Cells
Leonard, S. E., Reddie, K. G., & Carroll, K. S. (2009) · ACS Chemical Biology · doi:10.1021/cb900105q · Cited by 282
New Insights on NOX Enzymes in the Central Nervous System
Nayernia, Z., Jaquet, V., & Krause, K.-H. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5703 · Cited by 279
NADPH oxidases in cardiovascular disease
Brandes, R. P., Weißmann, N., & Schröder, K. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.030 · Cited by 273
Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo
Wingler, K., Wünsch, S., Kreutz, R. H., Rothermund, L., Paul, M., & Schmidt, H. H. H. W. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00727-4 · Cited by 273
The Concise Guide to PHARMACOLOGY 2015/16: Transporters
Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., Davies, J. A., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13355 · Cited by 267
Essential role for RGS9 in opiate action
Zachariou, V., Georgescu, D., Sanchez, N., Rahman, Z. U., Dileone, R., Berton, O., Neve, R. L., Sim‐Selley, L. J., Selley, D. E., Gold, S. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232594100 · Cited by 253
Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo
Jiang, J. X., Chen, X., Serizawa, N., Szyndralewiez, C., Page, P., Schröder, K., Brandes, R. P., Devaraj, S., & Török, N. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.007 · Cited by 251
Self-citation
NADPH Oxidase 4 Induces Cardiac Fibrosis and Hypertrophy Through Activating Akt/mTOR and NFκB Signaling Pathways
Zhao, Q. D., Viswanadhapalli, S., Williams, P., Shi, Q., Tan, C., Yi, X., Bhandari, B., & Abboud, H. E. (2015) · Circulation · doi:10.1161/circulationaha.114.011079 · Cited by 248
Genetic Variants of Chronic Granulomatous Disease: Prevalence of Deficiencies of Two Cytosolic Components of the NADPH Oxidase System
Clark, R. A., Malech, H. L., Gallin, J. I., Nunoi, H., Volpp, B. D., Pearson, D. W., Nauseef, W. M., & Curnutte, J. T. (1989) · New England Journal of Medicine · doi:10.1056/nejm198909073211005 · Cited by 244
First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
Laleu, B., Gaggini, F., Orchard, M., Fioraso-Cartier, L., Cagnon, L., Houngninou-Molango, S., Gradia, A., Duboux, G., Merlot, C., Heitz, F., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100773e · Cited by 243
Self-citation
Mechanisms of Vascular Smooth Muscle NADPH Oxidase 1 (Nox1) Contribution to Injury-Induced Neointimal Formation
Lee, M. Y., Martín, A. S., Mehta, P. K., Dikalova, A., Garrido, A. M., Datla, S. R., Lyons, E., Krause, K., Bánfi, B., Lambeth, J. D., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.181925 · Cited by 239
Cancer Stem–like Cell Marker CD44 Promotes Bone Metastases by Enhancing Tumorigenicity, Cell Motility, and Hyaluronan Production
Hiraga, T., Ito, S., & Nakamura, H. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3801 · Cited by 233
Site-specific mapping and quantification of protein S-sulphenylation in cells
Yang, J. H., Gupta, V., Carroll, K. S., & Liebler, D. C. (2014) · Nature Communications · doi:10.1038/ncomms5776 · Cited by 232
NADPH oxidases and cancer
Roy, K., Wu, Y., Meitzler, J. L., Juhasz, A. N., Liu, H., Jiang, G., Lu, J., Antony, S., & Doroshow, J. H. (2015) · Clinical Science · doi:10.1042/cs20140542 · Cited by 230
The Concise Guide to PHARMACOLOGY 2015/16: Overview
Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., Buneman, O. P., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13347 · Cited by 230
Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase
Chéret, C., Gervais, A., Lelli, A., Colin, C., Amar, L., Ravassard, P., Mallet, J., Cumano, A., Krause, K.-H., & Mallat, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3568-08.2008 · Cited by 225
Role of NADPH Oxidases in Liver Fibrosis
Paik, Y., Kim, J., Aoyama, T., Minicis, S. D., Bataller, R. A., & Brenner, D. A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5619 · Cited by 223
Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation
Lan, T., Kisseleva, T., & Brenner, D. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129743 · Cited by 214
Activation of Dual Oxidases Duox1 and Duox2
Rigutto, S., Hoste, C., Grasberger, H., Milenkovic, M., Communi, D., Dumont, J. E., Corvilain, B., Miot, F., & De Deken, X. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806893200 · Cited by 213
Novel Mechanism of Activation of NADPH Oxidase 5
Jagnandan, D., Church, J. E., Banfi, B., Stuehr, D. J., Marrero, M. B., & Fulton, D. J. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608966200 · Cited by 210
Expression of NOX1 , a superoxide‐generating NADPH oxidase, in colon cancer and inflammatory bowel disease
Szántó, I., Rubbia‐Brandt, L., Kiss, P. J., Steger, K., Bánfi, B., Kövari, E., Herrmann, F. R., Hadengue, A., & Krause, K. (2005) · The Journal of Pathology · doi:10.1002/path.1824 · Cited by 210
Role of NADPH oxidase 4 in lipopolysaccharide-induced proinflammatory responses by human aortic endothelial cells
Park, H., CHUN, J., Jung, H., CHOI, C., & Bae, Y. H. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.09.012 · Cited by 209
NAD(P)H Oxidase 1, a Product of Differentiated Colon Epithelial Cells, Can Partially Replace Glycoprotein 91 phox in the Regulated Production of Superoxide by Phagocytes
Geiszt, M., Lekstrom, K. J., Brenner, S., Hewitt, S. M., Dana, R., Malech, H. L., & Leto, T. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.299 · Cited by 207
The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91phox mediate hepatic fibrosis in mice
Paik, Y., Iwaisako, K., Seki, E., Inokuchi, S., Schnabl, B., Österreicher, C. H., Kisseleva, T., & Brenner, D. A. (2011) · Hepatology · doi:10.1002/hep.24281 · Cited by 207
Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor
Hirano, K., Chen, W. S., Chueng, A. L. W., Dunne, A. A., Seredenina, T., Filippova, A., Ramachandran, S., Bridges, A., Chaudry, L., Pettman, G., et al. (2015) · Antioxidants & Redox Signaling · doi:10.1089/ars.2014.6202 · Cited by 205
Inhibition of Reactive Oxygen Species by Lovastatin Downregulates Vascular Endothelial Growth Factor Expression and Ameliorates Blood-Retinal Barrier Breakdown in db/db Mice
Li, J., Wang, J. J., Yu, Q., Chen, K., Mahadev, K., & Zhang, S. X. (2010) · Diabetes · doi:10.2337/db09-1057 · Cited by 199
NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon
Coant, N., Mkaddem, S. B., Pédruzzi, E., Guichard, C., Tréton, X., Ducroc, R. A., Freund, J., Cazals-Hatem, D. L., Bouhnik, Y., Woerther, P., et al. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01194-09 · Cited by 197
The Concise Guide to PHARMACOLOGY 2015/16: Voltage‐gated ion channels
Alexander, S. P. H., Catterall, W. A., Kelly, E., Marrion, N. V., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13349 · Cited by 196
Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease
You, Y.-H., Quach, T., Saito, R., Pham, J., & Sharma, K. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015030302 · Cited by 191
NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies
Sirker, A. A., Zhang, M., & Shah, A. M. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0190-z · Cited by 184
Targeting nadph oxidase with a novel dual nox1/nox4 inhibitor attenuates renal pathology in type 1 diabetes
Gorin, Y., Cavaglieri, R. C., Khazim, K., Lee, D.-Y., Bruno, F., Thakur, S., Fanti, P., Szyndralewiez, C., Barnes, J. L., Block, K., et al. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00396.2014 · Cited by 183
Self-citation
NADPH Oxidase 1-Mediated Oxidative Stress Leads to Dopamine Neuron Death in Parkinson's Disease
Choi, D.-H., Cristóvão, A. C., Guhathakurta, S., Lee, J., JOH, T. H., Beal, M. F., & Kim, Y.-S. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3960 · Cited by 183
Hepatocyte NAD(P)H Oxidases as an Endogenous Source of Reactive Oxygen Species During Hepatitis C Virus Infection
de Mochel, N. S. R., Seronello, S., Wang, S. H., Ito, C., Zheng, J. X., Liang, J. T., Lambeth, D. J., & Choi, J. (2010) · Hepatology · doi:10.1002/hep.23671 · Cited by 183
Role of Nox4 and Nox2 in Hyperoxia-Induced Reactive Oxygen Species Generation and Migration of Human Lung Endothelial Cells
Pendyala, S., Gorshkova, I. A., Usatyuk, P. V., He, D., Pennathur, A., Lambeth, J. D., Thannickal, V. J., & Natarajan, V. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2203 · Cited by 182
Type IHelicobacter pyloriLipopolysaccharide Stimulates Toll-Like Receptor 4 and Activates Mitogen Oxidase 1 in Gastric Pit Cells
Kawahara, T., Teshima, S., Oka, A., Sugiyama, T., Kishi, K., & Rokutan, K. (2001) · Infection and Immunity · doi:10.1128/iai.69.7.4382-4389.2001 · Cited by 181
The NADPH oxidase Nox4 has anti-atherosclerotic functions
Schürmann, C., Rezende, F., Kruse, C., Yasar, Y., Löwe, O., Fork, C., van de Sluis, B., Bremer, R., Weißmann, N., Shah, A. M., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv460 · Cited by 178
From fatty liver to fibrosis: A tale of “second hit”
Başaranoğlu, M. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i8.1158 · Cited by 177
Measurement of Long-Range Angular Correlation and Quadrupole Anisotropy of Pions and (Anti)Protons in Central d + Au Collisions at s N N = 200 GeV
Adare, A. M., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Bataineh, H., Al-Ta’ani, H., Alexander, J., Andrews, K. R., Angerami, A., et al. (2015) · Physical Review Letters · doi:10.1103/physrevlett.114.192301 · Cited by 172
Nox4 is a Novel Inducible Source of Reactive Oxygen Species in Monocytes and Macrophages and Mediates Oxidized Low Density Lipoprotein–Induced Macrophage Death
Lee, C. F., Qiao, M., Schröder, K., Zhao, Q. D., & Asmis, R. (2010) · Circulation Research · doi:10.1161/circresaha.109.215392 · Cited by 171
The Concise Guide to PHARMACOLOGY 2015/16: Nuclear hormone receptors
Alexander, S. P. H., Cidlowski, J. A., Kelly, E., Marrion, N. V., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13352 · Cited by 169
NADPH Oxidase NOX4 Mediates Stellate Cell Activation and Hepatocyte Cell Death during Liver Fibrosis Development
Sancho, P., Mainez, J., Crosas‐Molist, E., Roncero, C., Fernández‐Rodríguez, C., Pinedo, F., Huber, H., Eferl, R., Mikulits, W., & Fabregat, I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045285 · Cited by 168
Hepatocyte nicotinamide adenine dinucleotide phosphate reduced oxidase 4 regulates stress signaling, fibrosis, and insulin sensitivity during development of steatohepatitis in mice
Bettaieb, A., Jiang, J. X., Sasaki, Y., Chao, T.-I., Kiss, Z., Chen, X., Tian, J., Katsuyama, M., Yabe-Nishimura, C., Xi, Y., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.009 · Cited by 167
Self-citation
The Role of NADPH Oxidase 1–Derived Reactive Oxygen Species in Paraquat-Mediated Dopaminergic Cell Death
Cristóvão, A. C., Choi, D.-H., Baltazar, G., Beal, M. F., & Kim, Y.-S. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2459 · Cited by 167
NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis
Goettsch, C., Bábelová, A., Trummer, O., Erben, R. G., Rauner, M., Rammelt, S., Weißmann, N., Weinberger, V., Benkhoff, S., Kampschulte, M., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67603 · Cited by 165
Genetic disorders coupled to ROS deficiency
O’Neill, S., Brault, J., Stasia, M.-J., & Knaus, U. G. (2015) · Redox Biology · doi:10.1016/j.redox.2015.07.009 · Cited by 164
Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes
Sedeek, M. H., Gutsol, A. A., Montezano, A. C. I., Burger, D. E., Cat, A. N. D., Kennedy, C., Burns, K. D., Cooper, M. E., Jandeleit-Dahm, K. A. M., Page, P., et al. (2012) · Clinical Science · doi:10.1042/cs20120330 · Cited by 164
Self-citation
NADPH oxidase subunit, gp91phox homologue, preferentially expressed in human colon epithelial cells
Kikuchi, H., Hikage, M., Miyashita, H., & Fukumoto, M. (2000) · Gene · doi:10.1016/s0378-1119(00)00258-4 · Cited by 161
Role of NADPH Oxidase and Stat3 in Statin-Mediated Protection against Diabetic Retinopathy
Al‐Shabrawey, M., Bartoli, M., El‐Remessy, A. B., Ma, G., Matragoon, S., Lemtalsi, T., Caldwell, R. W., & Caldwell, R. B. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1754 · Cited by 161
Nadph oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice
Carnesecchi, S., Deffert, C., Pagano, A., Garrido-Urbani, S., Métrailler-Ruchonnet, I., Schäppi, M., Donati, Y., Matthay, M. A., Krause, K.-H., & Barazzone Argiroffo, C. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200902-0296oc · Cited by 160
Defects in Nicotinamide-adenine Dinucleotide Phosphate Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease
Hayes, P., Dhillon, S., O’Neill, K., Thoeni, C. E., Hui, K. Y., Elkadri, A. A., Guo, C., Kovačič, L., Aviello, G., Álvarez, L., et al. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.06.005 · Cited by 159
Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase
Schäppi, M. G., Jaquet, V., Belli, D. C., & Krause, K. (2008) · Seminars in Immunopathology · doi:10.1007/s00281-008-0119-2 · Cited by 159
The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors
Alexander, S. P. H., Fabbro, D., Kelly, E., Marrion, N. V., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13353 · Cited by 159
Broad Suppression of NADPH Oxidase Activity Exacerbates Ischemia/Reperfusion Injury Through Inadvertent Downregulation of Hypoxia-inducible Factor-1α and Upregulation of Peroxisome Proliferator–activated Receptor-α
Matsushima, S., Kuroda, J., Ago, T., Zhai, P., Ikeda, Y., Oka, S., Fong, G., Tian, R., & Sadoshima, J. (2013) · Circulation Research · doi:10.1161/circresaha.111.300171 · Cited by 157
Reactive Oxygen Species Derived from NOX1/NADPH Oxidase Enhance Inflammatory Pain
Ibi, M., Matsuno, K., Shiba, D., Katsuyama, M., Iwata, K., Kakehi, T., Nakagawa, T., Sango, K., Shirai, Y., Yokoyama, T., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1857-08.2008 · Cited by 156
Increased NADPH-Oxidase Activity and Nox4 Expression During Chronic Hypertension Is Associated With Enhanced Cerebral Vasodilatation to NADPH In Vivo
Paravicini, T. M., Chrissobolis, S., Drummond, G. R., & Sobey, C. G. (2004) · Stroke · doi:10.1161/01.str.0000112974.37028.58 · Cited by 156
Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy
Lu, W., Hu, Y., Chen, G., Chen, Z., Zhang, H., Wang, F., Feng, L., Pelicano, H., Wang, H., Keating, M. J., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001326 · Cited by 152
Role of Nox4 in murine models of kidney disease
Bábelová, A., Avaniadi, D., Jung, O., Fork, C., Beckmann, J., Kosowski, J., Weißmann, N., Anilkumar, N. P., Shah, A. M., Schaefer, L., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.06.027 · Cited by 152
Role for Nox1 NADPH oxidase in atherosclerosis
Sheehan, A. L., Carrell, S., Johnson, B., Stanić, B., Bánfi, B., & Miller, F. J. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.02.028 · Cited by 148
NADPH-Oxidase 4 Protects against Kidney Fibrosis during Chronic Renal Injury
Khodo, S. N., Dizin, É., Sossauer, G., Szántó, I., Martin, P., Féraille, E., Krause, K. H., & de Seigneux, S. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012040373 · Cited by 148
The nox4 inhibitor gkt137831 attenuates hypoxia-induced pulmonary vascular cell proliferation
Green, D. E., Murphy, T. C., Kang, B.-Y., Kleinhenz, J. M., Szyndralewiez, C., Page, P., Sutliff, R. L., & Hart, C. M. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0418oc · Cited by 146
Self-citation
Redox modifier genes in amyotrophic lateral sclerosis in mice
Marden, J. J., Harraz, M. M., Williams, A. J., Nelson, K., Luo, M., Paulson, H., & Engelhardt, J. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31265 · Cited by 145
Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cells
Kawahara, T., Kohjima, M., Kuwano, Y., Mino, H., Teshima-Kondo, S., Takeya, R., Tsunawaki, S., Wada, A., Sumimoto, H., & Rokutan, K. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00319.2004 · Cited by 145
Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism
Garrido-Urbani, S., Jemelin, S., Deffert, C., Carnesecchi, S., Basset, O., Szyndralewiez, C., Heitz, F., Page, P., Montet, X., Michalik, L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014665 · Cited by 143
Self-citation
Reactive oxygen species, Nox and angiotensin II in angiogenesis: implications for retinopathy
Wilkinson‐Berka, J. L., Rana, I., Armani, R., & Agrotis, A. (2013) · Clinical Science · doi:10.1042/cs20120212 · Cited by 141
Involvement of UVB-induced reactive oxygen species in TGF-β biosynthesis and activation in keratinocytes
Wang, H., & Kochevar, I. E. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.12.005 · Cited by 141
PPARγ regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-κB
Lu, X., Murphy, T. C., Nanes, M. S., & Hart, C. M. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00090.2010 · Cited by 138
A chemical approach for detecting sulfenic acid-modified proteins in living cells
Reddie, K. G., Seo, Y. H., Muse, W. B., Leonard, S. E., & Carroll, K. S. (2008) · Molecular BioSystems · doi:10.1039/b719986d · Cited by 136
Physiological and pathological functions of NADPH oxidases during myocardial ischemia–reperfusion
Matsushima, S., Tsutsui, H., & Sadoshima, J. (2014) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2014.03.003 · Cited by 132
Hepatitis C Virus (HCV) Proteins Induce NADPH Oxidase 4 Expression in a Transforming Growth Factor β-Dependent Manner: a New Contributor to HCV-Induced Oxidative Stress
Boudreau, H. E., Emerson, S. U., Korzeniowska, A., Jendrysik, M. A., & Leto, T. L. (2009) · Journal of Virology · doi:10.1128/jvi.01059-09 · Cited by 132
TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury
Peters, D. M., Vadász, I., Wujak, L. A., Wygrecka, M., Olschewski, A., Becker, C., Herold, S., Papp, R., Mayer, K., Rummel, S., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306798111 · Cited by 131
Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6
Adachi, Y., Shibai, Y., Mitsushita, J., Shang, W. H., Hirose, K., & Kamata, T. (2008) · Oncogene · doi:10.1038/onc.2008.133 · Cited by 125
NADPH Oxidase 4 Is Expressed in Pulmonary Artery Adventitia and Contributes to Hypertensive Vascular Remodeling
Barman, S. A., Chen, F., Su, Y., Dimitropoulou, C., Wang, Y., Catravas, J. D., Han, W., Őrfi, L., Szántai-Kis, C., Kéri, G., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303848 · Cited by 124
NADPH Oxidase, NOX1, Mediates Vascular Injury in Ischemic Retinopathy
Wilkinson‐Berka, J. L., Deliyanti, D., Rana, I., Miller, A. G., Agrotis, A., Armani, R., Szyndralewiez, C., Wingler, K., Touyz, R. M., Cooper, M. E., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5357 · Cited by 123
Self-citation
Pivotal Role of gp91 phox -Containing NADH Oxidase in Lipopolysaccharide-Induced Tumor Necrosis Factor-α Expression and Myocardial Depression
Peng, T., Lu, X., & Feng, Q. (2005) · Circulation · doi:10.1161/01.cir.0000160366.50210.e9 · Cited by 123
Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4
Wendt, M. C., Daiber, A., Kleschyov, A. L., Mülsch, A., Sydow, K., Schulz, E., Chen, K., Keaney, J. F., Lassègue, B., Walter, U., et al. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.03.020 · Cited by 122
Updates of reactive oxygen species in melanoma etiology and progression
Liu, F., Dellinger, R. W., & Meyskens, F. L. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.04.007 · Cited by 119
NADPH Oxidase Subunit 4-Mediated Reactive Oxygen Species Contribute to Cycling Hypoxia-Promoted Tumor Progression in Glioblastoma Multiforme
Hsieh, C., Shyu, W., Chiang, C.-Y., Kuo, J.-W., Shen, W., & Liu, R.-S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023945 · Cited by 117
Ethanol and Arachidonic Acid Increase α2(I) Collagen Expression in Rat Hepatic Stellate Cells Overexpressing Cytochrome P450 2E1
Nieto, N., Greenwel, P., Friedman, S. L., Zhang, F., Dannenberg, A. J., & Cederbaum, A. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001422200 · Cited by 117
Nox Activator 1
Niu, X.-L., Madamanchi, N. R., Vendrov, A. E., Tchivilev, I., Rojas, M., Madamanchi, C., Brandes, R. P., Krause, K. H., Humphries, J., Smith, A., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.908319 · Cited by 116
NADPH Oxidase-4 Maintains Neuropathic Pain after Peripheral Nerve Injury
Kallenborn-Gerhardt, W., Schröder, K., Turco, D. D., Lu, R., Kynast, K. L., Kosowski, J., Niederberger, E., Shah, A. M., Brandes, R. P., Geißlinger, G., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6227-11.2012 · Cited by 116
Nox4 Is Critical for Hypoxia-Inducible Factor 2-α Transcriptional Activity in von Hippel-Lindau–Deficient Renal Cell Carcinoma
Maranchie, J. K., & Zhan, Y. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2105 · Cited by 115
The human Nox4: gene, structure, physiological function and pathological significance
Guo, S., & Chen, X. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1036276 · Cited by 114
An Inhibitor of NADPH Oxidase-4 Attenuates Established Pulmonary Fibrosis in a Rodent Disease Model
Jarman, E. R., Khambata, V. S., Cope, C. L., Jones, P. L., Roger, J., Ye, L. Y., Duggan, N., Head, D., Pearce, A. C., Press, N. J., et al. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0174oc · Cited by 114
Increased Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Expression Mediates Intrinsic Airway Smooth Muscle Hypercontractility in Asthma
Sutcliffe, A., Hollins, F., Gomez, E., Saunders, R., Doe, C., Cooke, M. S., Challiss, R. A. J., & Brightling, C. E. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201107-1281oc · Cited by 111
ROS ‐generating oxidases N ox1 and N ox4 contribute to oncogenic R as‐induced premature senescence
Kodama, R., Kato, M., Furuta, S., Ueno, S., Zhang, Y., Matsuno, K., Yabe‐Nishimura, C., Tanaka, E., & Kamata, T. (2012) · Genes to Cells · doi:10.1111/gtc.12015 · Cited by 110
Role of NADPH Oxidases in Disturbed Flow- and BMP4- Induced Inflammation and Atherosclerosis
Jo, H., Song, H. W., & Mowbray, A. L. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1609 · Cited by 108
NADPH oxidase and cyclooxygenase mediate the ultraviolet B-induced generation of reactive oxygen species and activation of nuclear factor-κB in HaCaT human keratinocytes
Beak, S.-M., Lee, Y. S., & Kim, J. (2004) · Biochimie · doi:10.1016/j.biochi.2004.06.010 · Cited by 103
Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells
Boudreau, H. E., Casterline, B. W., Burke, D. J., & Leto, T. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.165 · Cited by 102
Overexpression of a novel superoxide-producing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon
Fukuyama, M., Rokutan, K., Sano, T., Miyake, H., Shimada, M., & Tashiro, S. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.08.031 · Cited by 102
NADPH Oxidase-generated Hydrogen Peroxide Induces DNA Damage in Mutant FLT3-expressing Leukemia Cells
Stanicka, J., Russell, E. G., Woolley, J. F., & Cotter, T. G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.510495 · Cited by 101
NADPH Oxidase 1 Mediates α-Synucleinopathy in Parkinson's Disease
Cristóvão, A. C., Guhathakurta, S., Bok, E., Je, G., Yoo, S. D., Choi, D., & Kim, Y. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2246-12.2012 · Cited by 100
Nox4 Mediates Renal Cell Carcinoma Cell Invasion through Hypoxia-Induced Interleukin 6- and 8- Production
Fitzgerald, J. P., Nayak, B., Shanmugasundaram, K., Friedrichs, W. E., Sudarshan, S., Eid, A. A., DeNapoli, T. S., Parekh, D. J., Gorin, Y. C., & Block, K. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030712 · Cited by 98
A Constitutive NADPH Oxidase-Like System Containing gp91phox Homologs in Human Keratinocytes
Chamulitrat, W., Stremmel, W., Kawahara, T., Rokutan, K., Fujii, H. G., Wingler, K., Schmidt, H. H. H. W., & Schmidt, R. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22410.x · Cited by 96
The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice
Anvari, E., Wikström, P., Walum, E., & Welsh, N. (2015) · Free Radical Research · doi:10.3109/10715762.2015.1067697 · Cited by 95
NADPH Oxidase Is Involved in Prostaglandin F2α-induced Hypertrophy of Vascular Smooth Muscle Cells
Katsuyama, M., Fan, C., & Yabe-Nishimura, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111634200 · Cited by 95
Link between PI3K/AKT/PTEN Pathway and NOX Proteinin Diseases
Nakanishi, A. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500203 · Cited by 95
NOXious signaling in pain processing
Kallenborn-Gerhardt, W., Schröder, K., Geißlinger, G., & Schmidtko, A. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.11.001 · Cited by 93
NADPH Oxidases Regulate CD44 and Hyaluronic Acid Expression in Thrombin-treated Vascular Smooth Muscle Cells and in Atherosclerosis
Vendrov, A. E., Madamanchi, N. R., Niu, X.-L., Molnar, K., Runge, M., Szyndralewiez, C., Page, P., & Runge, M. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.143917 · Cited by 93
Self-citation
Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis
Bates, M. D., Erwin, C. R., Sanford, L. P., Wiginton, D. A., Bezerra, J. A., Schatzman, L. C., Jegga, A. G., Ebert, C., Williams, S. S., Steinbrecher, K. A., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.32975 · Cited by 91
NADPH Oxidase 4 Mediates Insulin-Stimulated HIF-1α and VEGF Expression, and Angiogenesis In Vitro
Meng, D., Mei, A., Liu, J., Kang, X., Shi, X., Qian, R., & Chen, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048393 · Cited by 91
Targeting NOX enzymes in pulmonary fibrosis
Hecker, L., Cheng, J., & Thannickal, V. J. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1012-7 · Cited by 90
The NADPH oxidase NOX4 inhibits hepatocyte proliferation and liver cancer progression
Crosas‐Molist, E., Bertrán, E., Sancho, P., López‐Luque, J., Fernando, J., Sánchez, A., Fernández, M., Navarro, E., & Fabregat, I. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.01.040 · Cited by 90
Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR
Briones, A. M., Tabet, F., Callera, G. E., Montezano, A. C. I., Yogi, Á., He, Y., Quinn, M. T., Salaíces, M., & Touyz, R. M. (2011) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2011.02.001 · Cited by 89
Mucosal reactive oxygen species are required for antiviral response: Role of duox in influenza a virus infection
Strengert, M., Jennings, R., Davanture, S., Hayes, P., Gabriel, G., & Knaus, U. G. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5353 · Cited by 88
Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells.
Bokoch, G., & Prossnitz, V. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115599 · Cited by 86
NAD(P)H Oxidase Activity of Nox4 in Chondrocytes Is Both Inducible and Involved in Collagenase Expression
Grange, L., Nguyen, M. V. C., Lardy, B., Derouazi, M., Campion, Y., Trocmé, C., Paclet, M., Gaudin, P., & Morel, F. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1485 · Cited by 85
Induction of Cancer Stem Cell Properties in Colon Cancer Cells by Defined Factors
Oshima, N., Yamada, Y., Nagayama, S., Kawada, K., Hasegawa, S., Okabe, H., Sakai, Y., & Aoi, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101735 · Cited by 84
A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms
Hironori Nakagami, A., Jensen, K. S., & Liao, J. K. (2003) · Annals of Medicine · doi:10.1080/07853890310001294 · Cited by 83
ROS signalling, NADPH oxidases and cancer
Landry, W. D., & Cotter, T. G. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140060 · Cited by 83
Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual nox4/nox1 inhibitors
Gaggini, F., Laleu, B., Orchard, M., Fioraso-Cartier, L., Cagnon, L., Houngninou-Molango, S., Gradia, A., Duboux, G., Merlot, C., Heitz, F., et al. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.10.016 · Cited by 79
Self-citation
Targeting NADPH oxidases for the treatment of cancer and inflammation
Bonner, M. Y., & Arbiser, J. L. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1017-2 · Cited by 78
Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina
Deliyanti, D., & Wilkinson‐Berka, J. L. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0363-z · Cited by 78
A combination of Lox-1 and Nox1 regulates TLR9-mediated foam cell formation
Lee, J., Lim, E., Park, D., Lee, S.-H., Kim, J.-R., & Baek, S. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.08.022 · Cited by 76
The ROS-NOX Connection in Cancer and Angiogenesis
Blanchetot, C., & Boonstra, J. (2008) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v18.i1.30 · Cited by 76
NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation
Gatto, G. J. J., Ao, Z., Kearse, M. G., Zhou, M., Morales, C. R., Daniels, E., Bradley, B. T., Goserud, M. T., Goodman, K. B., Douglas, S. A., et al. (2011) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2011.636360 · Cited by 76
Evidence for cancer-associated expression of NADPH oxidase 1 (Nox1)-based oxidase system in the human stomach
Tominaga, K., Kawahara, T., Sano, T., Toida, K., Kuwano, Y., Sasaki, H., Kawai, T., Teshima-Kondo, S., & Rokutan, K. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.029 · Cited by 75
NADPH oxidase 1-dependent ROS is crucial for TLR4 signaling to promote tumor metastasis of non-small cell lung cancer
Liu, X., Pei, C., Yan, S., Liu, G., Liu, G., Chen, W., Cui, Y., & Liu, Y. (2015) · Tumor Biology · doi:10.1007/s13277-014-2639-9 · Cited by 74
NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells
Jayavelu, A. K., Müller, J. P., Bauer, R., Böhmer, S.-A., Lässig, J., Cerny‐Reiterer, S., Sperr, W. R., Valent, P., Maurer, B., Moriggl, R., et al. (2015) · Leukemia · doi:10.1038/leu.2015.234 · Cited by 70
Increased Expression of gp91phox Homologues of NAD(P)H Oxidase in the Aortic Media during Chronic Hypertension: Involvement of the Renin-Angiotensin System
Akasaki, T., Ohya, Y., Kuroda, J., Eto, K., Abe, I., Sumimoto, H., & Iida, M. (2006) · Hypertension Research · doi:10.1291/hypres.29.813 · Cited by 70
Signalling pathways from NADPH oxidase-4 to idiopathic pulmonary fibrosis
Crestani, B., Besnard, V., & Boczkowski, J. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.04.003 · Cited by 70
Protein redox chemistry: post-translational cysteine modifications that regulate signal transduction and drug pharmacology
Wani, R., Nagata, A., & Murray, B. W. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00224 · Cited by 70
Selective Rac-1 Inhibition Protects From Diabetes-Induced Vascular Injury
Vecchione, C., Aretini, A., Marino, G., Bettarini, U., Poulet, R., Maffei, A., Sbroggió, M., Pastore, L., Gentile, M. T., Notte, A., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000200440.18768.30 · Cited by 70
NADPH Oxidase NOX4 Supports Renal Tumorigenesis by Promoting the Expression and Nuclear Accumulation of HIF2α
Gregg, J. L., Turner, R. M., Chang, G., Joshi, D., Zhan, Y., Chen, L., & Maranchie, J. K. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2979 · Cited by 68
Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts
Felice, B. D., Garbi, C., Santoriello, M., Santillo, A., & Wilson, R. R. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0057-x · Cited by 67
MALONDIALDEHYDE STIMULATES COLLAGEN PRODUCTION BY HEPATIC LIPOCYTES ONLY UPON ACTIVATION IN PRIMARY CULTURE
Maher, J. J., Tzagarakis, C., & Giménez, A. (1994) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a045590 · Cited by 67
A Reactive Oxygen Species–Mediated Loop Maintains Increased Expression of NADPH Oxidases 2 and 4 in Skin Fibroblasts From Patients With Systemic Sclerosis
Spadoni, T., Svegliati, S., Amico, D., Albani, L., Moroncini, G., Avvedimento, E. V., & Gabrielli, A. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39084 · Cited by 64
Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance
Doyle, T. M., Bryant, L., Muscoli, C., Cuzzocrea, S., Esposito, E., Chen, Z., & Salvemini, D. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.07.013 · Cited by 64
Regulation of growth and apoptosis of cultured guinea pig gastric mucosal cells by mitogenic oxidase 1
Teshima, S., Kutsumi, H., Kawahara, T., Kishi, K., & Rokutan, K. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.6.g1169 · Cited by 63
Combined NADPH Oxidase 1 and Interleukin 10 Deficiency Induces Chronic Endoplasmic Reticulum Stress and Causes Ulcerative Colitis-Like Disease in Mice
Tréton, X., Pédruzzi, E., Guichard, C., Ladeiro, Y., Sedghi, S., Vallée, M., Fernandez, N., Bruyère, E., Woerther, P., Ducroc, R. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101669 · Cited by 61
Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune–inflammatory responses in diabetic Apoe −/− mice
Marco, E. D., Gray, S. P., Chew, P., Koulis, C., Ziegler, A. I., Szyndralewiez, C., Touyz, R. M., Schmidt, H. H. H. W., Cooper, M. E., Slattery, R. M., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-3118-3 · Cited by 60
Self-citation
Involvement of NOX1/NADPH Oxidase in Morphine-Induced Analgesia and Tolerance
Ibi, M., Matsuno, K., Matsumoto, M., Sasaki, M., Nakagawa, T., Katsuyama, M., Iwata, K., Zhang, J., Kaneko, S., & Yabe‐Nishimura, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4136-11.2011 · Cited by 59
XPC silencing in normal human keratinocytes triggers metabolic alterations through NOX-1 activation-mediated reactive oxygen species
Rezvani, H. R., Rossignol, R., Ali, N., Bénard, G., Tang, X., Yang, H. S., Jouary, T., de Verneuil, H., Taı̈eb, A., Kim, A. L., et al. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.12.006 · Cited by 59
NADPH Oxidase 4-Derived H 2 O 2 Promotes Aberrant Retinal Neovascularization via Activation of VEGF Receptor 2 Pathway in Oxygen-Induced Retinopathy
Li, J., Wang, J. J., & Zhang, S. X. (2015) · Journal of Diabetes Research · doi:10.1155/2015/963289 · Cited by 58
Oxidative Damage and Antioxidative Therapy in Systemic Sclerosis
Grygiel‐Górniak, B., & Puszczewicz, M. (2014) · Mediators of Inflammation · doi:10.1155/2014/389582 · Cited by 58
Hyperinflammation of chronic granulomatous disease is abolished by NOX2 reconstitution in macrophages and dendritic cells
Deffert, C., Carnésecchi, S., Yuan, H., Rougemont, A., Kelkka, T., Holmdahl, R., Krause, K., & Schäppi, M. G. (2012) · The Journal of Pathology · doi:10.1002/path.4061 · Cited by 57
Role of Neuronal NADPH Oxidase 1 in the Peri-Infarct Regions after Stroke
Choi, D.-H., Kim, J.-H., Lee, K.-H., Kim, H.-Y., Kim, Y.-S., Choi, W. S., & Lee, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116814 · Cited by 56
Unchanged NADPH Oxidase Activity in Nox1-Nox2-Nox4 Triple Knockout Mice: What Do NADPH-Stimulated Chemiluminescence Assays Really Detect?
Rezende, F., Löwe, O., Helfinger, V., Prior, K.-K., Walter, M., Zukunft, S., Fleming, I., Weißmann, N., Brandes, R. P., & Schröder, K. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6314 · Cited by 55
The NOX1/4 Inhibitor GKT136901 as Selective and Direct Scavenger of Peroxynitrite
Schildknecht, S., Weber, A., Gerding, H., Pape, R., Robotta, M., Drescher, M., Marquardt, A., Daiber, A., Ferger, B., & Leist, M. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990179 · Cited by 55
Nicotine mediates oxidative stress and apoptosis through cross talk between NOX1 and Bcl-2 in lung epithelial cells
Zanetti, F., Giacomello, M., Donati, Y. R. A., Carnésecchi, S., Frieden, M., & Barazzone‐Argiroffo, C. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.08.002 · Cited by 54
Small-Molecule Inhibitors of NADPH Oxidase 4
Borbély, G., Szabadkai, I., Horváth, Z., Markó, P., Varga, Z. V., Breza, N., Baska, F., Vántus, T., Huszár, M., Geiszt, M., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm1004368 · Cited by 53
Increased Expression of NAPDH Oxidase 4 in Systemic Sclerosis Dermal Fibroblasts: Regulation by Transforming Growth Factor β
Piera-Velázquez, S., Makul, A., & Jiménez, S. A. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39242 · Cited by 51
NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia
Sánchez-Sánchez, B., Gutiérrez-Herrero, S., López-Ruano, G., Prieto-Bermejo, R., Romo-González, M., Llanillo, M., Pandiella, A., Guerrero, C., Miguel, J. F. S., Sanchez-Guijo, F. M., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3044 · Cited by 51
NOX4 in Mitochondria: Yeast Two-Hybrid-Based Interaction with Complex I Without Relevance for Basal Reactive Oxygen Species?
Hirschhäuser, C., Bornbaum, J., Reis, A., Böhme, S., Kaludercic, N., Menabò, R., Lisa, F. D., Boengler, K., Shah, A. M., Schulz, R., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6238 · Cited by 50
NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents
Babalola, O., Mamalis, A., Lev‐Tov, H. A., & Jagdeo, J. R. (2013) · Archives of Dermatological Research · doi:10.1007/s00403-013-1416-8 · Cited by 48
A subset of N-substituted phenothiazines inhibits NADPH oxidases
Seredenina, T., Chiriano, G., Filippova, A., Nayernia, Z., Mahiout, Z., Fioraso-Cartier, L., Plastre, O., Scapozza, L., Krause, K.-H., & Jaquet, V. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.023 · Cited by 45
Modulation of Fibrosis in Systemic Sclerosis by Nitric Oxide and Antioxidants
Dooley, A., Bruckdorfer, K. R., & Abraham, D. (2011) · Cardiology Research and Practice · doi:10.1155/2012/521958 · Cited by 45
Matrix Metalloproteinase-3 Causes Dopaminergic Neuronal Death through Nox1-Regenerated Oxidative Stress
Choi, D.-H., Kim, J.-H., Seo, J.-H., Lee, J., Choi, W. S., & Kim, Y.-S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115954 · Cited by 45
Nox4 supports proper capillary growth in exercise and retina neo‐vascularization
Vogel, J., Kruse, C., Zhang, M., & Schröder, K. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.284901 · Cited by 43

Flagged first, then by citations

2 of the 224 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Wiesel PHL, 2012, American Society of Nephrology Kidney Week

Sorted by citations

Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy
Forman, H. J., & Zhang, H. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00233-1 · Cited by 2,900
Reactive Oxygen Species in Metabolic and Inflammatory Signaling
Forrester, S. J., Kikuchi, D. S., Hernandes, M. S., Xu, Q., & Griendling, K. K. (2018) · Circulation Research · doi:10.1161/circresaha.117.311401 · Cited by 2,081
Oxidative stress in chronic kidney disease
Daenen, K., Andries, A., Mekahli, D., Schepdael, A. V., Jouret, F., & Bammens, B. (2018) · Pediatric Nephrology · doi:10.1007/s00467-018-4005-4 · Cited by 927
Functions of ROS in Macrophages and Antimicrobial Immunity
Herb, M., & Schramm, M. (2021) · Antioxidants · doi:10.3390/antiox10020313 · Cited by 633
Endothelial Cell Metabolism
Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P. (2017) · Physiological Reviews · doi:10.1152/physrev.00001.2017 · Cited by 614

See all 166

Authors: Teixeira, G., Szyndralewiez, C., Molango, S., Carnesecchi, S., Heitz, F., Wiesel, P., & Wood, J. M.
Affiliations: Evotec (Germany) (DE)
Genkyotex (Switzerland) (CH)
Genkyotex SA Plan les Ouates Switzerland
Inovaid Biel‐Benken Switzerland
Corresponding author: Wood, J M
ORCID: Wiesel, P
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 2016-07-14
Volume: 174
Issue: 12
Pages: 1647-1669
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1111/bph.13532
PMC: PMC5446584
OpenAlex: W2414686680
Semantic Scholar: 3495831cf5de9bc9c88751dc4734fc06fde77667
Cited by: 163
References: 224
Citations by year: 2026: 10 · 2025: 13 · 2024: 9 · 2023: 12 · 2022: 15 · 2021: 15 · 2020: 28 · 2019: 17 · 2018: 22 · 2017: 16 · 2016: 5
FWCI: 1.81
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: British Journal of Pharmacology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: NADPH oxidase, NOX1, NOX4, NOX2, reactive oxygen species, NADPH oxidase inhibitors, GKT137831, chronic inflammation, fibrotic diseases, redox signaling, signal transduction, oxidative stress
MeSH terms: NADPH Oxidase 1, NADPH Oxidase 2, Animals, Anti-Inflammatory Agents, Enzyme Inhibitors, Fibrosis, Humans, Inflammation, Pyrazoles, Pyridines, Pyridones, Pyrazolones

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Therapeutic potential of NADPH oxidase 1/4 inhibitors

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks