New Insights on NOX Enzymes in the Central Nervous System

Nayernia, Zeynab; Jaquet, Vincent; Krause, Karl-Heinz

doi:10.1089/ars.2013.5703

Cited by 279Redox biology and oxidative stressNitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

New Insights on NOX Enzymes in the Central Nervous System

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Nayernia, Zeynab, Jaquet, Vincent, Krause, Karl-Heinz·2014·Antioxidants & Redox Signaling

DOI 10.1089/ars.2013.5703PMC PMC4026375

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Abstract

SIGNIFICANCE: There is increasing evidence that the generation of reactive oxygen species (ROS) in the central nervous system (CNS) involves the NOX family of nicotinamide adenine dinucleotide phosphate oxidases. Controlled ROS generation appears necessary for optimal functioning of the CNS through fine-tuning of redox-sensitive signaling pathways, while overshooting ROS generation will lead to oxidative stress and CNS disease. RECENT ADVANCES: NOX enzymes are not only restricted to microglia (i.e. brain phagocytes) but also expressed in neurons, astrocytes, and the neurovascular system. NOX enzymes are involved in CNS development, neural stem cell biology, and the function of mature neurons. While NOX2 appears to be a major source of pathological oxidative stress in the CNS, other NOX isoforms might also be of importance, for example, NOX4 in stroke. Globally speaking, there is now convincing evidence for a role of NOX enzymes in various neurodegenerative diseases, cerebrovascular diseases, and psychosis-related disorders. CRITICAL ISSUES: The relative importance of specific ROS sources (e.g., NOX enzymes vs. mitochondria; NOX2 vs. NOX4) in different pathological processes needs further investigation. The absence of specific inhibitors limits the possibility to investigate specific therapeutic strategies. The uncritical use of non-specific inhibitors (e.g., apocynin, diphenylene iodonium) and poorly validated antibodies may lead to misleading conclusions. FUTURE DIRECTIONS: Physiological and pathophysiological studies with cell-type-specific knock-out mice will be necessary to delineate the precise functions of NOX enzymes and their implications in pathomechanisms. The development of CNS-permeant, specific NOX inhibitors will be necessary to advance toward therapeutic applications.

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Among NOX isoforms, NOX4 is a major isoform in astrocytes.
“Among NOX isoforms, NOX4 is a major isoform in astrocytes [36].”
From NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer’s diseases (2021) · cites this paper as [36]

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Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease
Valencia, A., Sapp, E., Kimm, J. S., McClory, H., Reeves, P., Alexander, J. S., Ansong, K. A., Masso, N., Frosch, M. P., Kegel, K. B., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds516 · Cited by 93 · see citing works
Retracted
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989 · see citing works
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175 · see citing works
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734 · see citing works
Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality
Miller, E. R., Pastor-Barriuso, R., Dalal, D., Riemersma, R. A., Appel, L. J., & Guallar, E. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-1-200501040-00110 · Cited by 2,577 · see citing works
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
Kierdorf, K., Erny, D., Goldmann, T., Sander, V., Schulz, C., Perdiguero, E. G., Wieghofer, P., Heinrich, A., Riemke, P., Hölscher, C., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3318 · Cited by 1,468 · see citing works
Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.
Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A., & Markesbery, W. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10540 · Cited by 1,296 · see citing works
Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease
Girouard, H., & Iadecola, C. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00966.2005 · Cited by 1,268 · see citing works
Interneuron dysfunction in psychiatric disorders
Marín, O. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3155 · Cited by 1,190 · see citing works
Inflammatory mechanisms in ischemic stroke: therapeutic approaches
Lakhan, S. E., Kirchgessner, A. L., & Hofer, M. (2009) · Journal of Translational Medicine · doi:10.1186/1479-5876-7-97 · Cited by 1,075 · see citing works
Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
Ilieva, H., Polymenidou, M., & Cleveland, D. W. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200908164 · Cited by 1,008 · see citing works
Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain
Alliot, F., Godin, I., & Pessac, B. (1999) · Developmental Brain Research · doi:10.1016/s0165-3806(99)00113-3 · Cited by 884 · see citing works
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
Kim, C., Ho, D.-H., Suk, J.-E., You, S., Michael, S., Kang, J., Joong Lee, S., Masliah, E., Hwang, D., Lee, H.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms2534 · Cited by 856 · see citing works
Microglia: Scapegoat, saboteur, or something else?
Aguzzi, A., Barres, B. A., & Bennett, M. L. (2013) · Science · doi:10.1126/science.1227901 · Cited by 836 · see citing works
Homologs of gp91 phox : cloning and tissue expression of Nox3, Nox4, and Nox5
Cheng, G., Cao, Z., Xu, X., Meir, E. G. V., & Lambeth, J. D. (2001) · Gene · doi:10.1016/s0378-1119(01)00449-8 · Cited by 820 · see citing works
Mitochondria, oxidative stress and neurodegeneration
Federico, A., Cardaioli, E., Pozzo, P. D., Formichi, P., Gallus, G. N., & Radi, E. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.05.030 · Cited by 790 · see citing works
Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner
Le Belle, J. E., Orozco, N. M., Paucar, A. A., Saxe, J. P., Mottahedeh, J., Pyle, A. D., Wu, H., & Kornblum, H. I. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2010.11.028 · Cited by 789 · see citing works
Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System
Lassegue, B. P., Martín, A. S., & Griendling, K. K. (2012) · Circulation Research · doi:10.1161/circresaha.111.243972 · Cited by 768 · see citing works
Microglia Promote the Death of Developing Purkinje Cells
Marı́n-Teva, J. L., Dusart, I., Colin, C., Gervais, A., van Rooijen, N., & Mallat, M. (2004) · Neuron · doi:10.1016/s0896-6273(04)00069-8 · Cited by 757 · see citing works
Oxidative damage in multiple sclerosis lesions
Haider, L., Fischer, M. T., Frischer, J., Bauer, J., Höftberger, R., Botond, G., Esterbauer, H., Binder, C., Witztum, J., & Lassmann, H. (2011) · Brain : a journal of neurology · doi:10.1093/brain/awr128 · Cited by 754 · see citing works
Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant
Heumüller, S., Wind, S., Barbosa-Sicard, E., Schmidt, H. H. H. W., Busse, R., Schröder, K., & Brandes, R. P. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.100214 · Cited by 735 · see citing works
Toll‐like receptor 4 is required for α‐synuclein dependent activation of microglia and astroglia
Fellner, L., Irschick, R., Schanda, K., Reindl, M., Klimaschewski, L., Poewe, W., Wenning, G. K., & Stefanova, N. (2013) · Glia · doi:10.1002/glia.22437 · Cited by 697 · see citing works
NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation
Serrander, L., Cartier, L., Bedard, K., Banfi, B., Lardy, B., Plastre, O., Sienkiewicz, A., Fórró, L., Schlegel, W., & Krause, K.-H. (2007) · Biochemical Journal · doi:10.1042/bj20061903 · Cited by 627 · see citing works
Self-citation
Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection
Zhang, M., An, C., Gao, Y., Leak, R. K., Chen, J., & Zhang, F. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.09.003 · Cited by 618 · see citing works
Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase
O’Donnell, V. B., Tew, D. G., Jones, O. T. G., & ENGLAND, P. J. (1993) · Biochemical Journal · doi:10.1042/bj2900041 · Cited by 590 · see citing works
Ketamine-Induced Loss of Phenotype of Fast-Spiking Interneurons Is Mediated by NADPH-Oxidase
Behrens, M. M., Ali, S. S., Dao, D. N., Lucero, J., Shekhtman, G., Quick, K. L., & Dugan, L. L. (2007) · Science · doi:10.1126/science.1148045 · Cited by 585 · see citing works
Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group.
Yamaguchi, T., Sano, K., Takakura, K., Saito, I., Shinohara, Y., Asano, T., & Yasuhara, H. (1998) · Stroke · doi:10.1161/01.str.29.1.12 · Cited by 558 · see citing works
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
Trifunovic, A., Hansson, A., Wredenberg, A., Rovio, A. T., Dufour, E., Khvorostov, I., Spelbrink, J. N., Wibom, R., Jacobs, H. T., & Larsson, N.-G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508886102 · Cited by 555 · see citing works
N-Acetyl Cysteine as a Glutathione Precursor for Schizophrenia—A Double-Blind, Randomized, Placebo-Controlled Trial
Berk, M., Copolov, D., Dean, O., Lu, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., Judd, F., Katz, F., Katz, P., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.004 · Cited by 552 · see citing works
Functional Mimics of Glutathione Peroxidase: Bioinspired Synthetic Antioxidants
Bhabak, K. P., & Mugesh, G. (2010) · Accounts of Chemical Research · doi:10.1021/ar100059g · Cited by 544 · see citing works
NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation
Brennan, A. M., Suh, S. W., Won, S. J., Narasimhan, P., Kauppinen, T. M., Lee, H., Edling, Y., Chan, P. H., & Swanson, R. A. (2009) · Nature Neuroscience · doi:10.1038/nn.2334 · Cited by 538 · see citing works
The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4
Takac, I., Schröder, K., Zhang, L., Lardy, B., Anilkumar, N. P., Lambeth, J. D., Shah, A. M., Morel, F., & Brandes, R. P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.192138 · Cited by 524 · see citing works
NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury
Fischer, M. T., Sharma, R., Lim, J. L., Haider, L., Frischer, J. M., Drexhage, J., Mahad, D., Bradl, M., van Horssen, J., & Lassmann, H. (2012) · Brain · doi:10.1093/brain/aws012 · Cited by 507 · see citing works
Chronic traumatic encephalopathy: Neurodegeneration following repetitive concussive and subconcussive brain trauma
Baugh, C. M., Stamm, J. M., Riley, D. O., Gavett, B. E., Shenton, M. E., Lin, A., Nowinski, C. J., Cantu, R. C., McKee, A. C., & Stern, R. A. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-012-9164-5 · Cited by 486 · see citing works
Redox Signaling in Cardiac Physiology and Pathology
Burgoyne, J. R., Mongue‐Din, H., Eaton, P., & Shah, A. M. (2012) · Circulation Research · doi:10.1161/circresaha.111.255216 · Cited by 483 · see citing works
NOX Enzymes in the Central Nervous System: From Signaling to Disease
Sorce, S., & Krause, K. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2578 · Cited by 472 · see citing works
Regulation of ROS signal transduction by NADPH oxidase 4 localization
Chen, K., Kirber, M. T., Xiao, H. Q., Yang, Y., & Keaney, J. F. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709049 · Cited by 468 · see citing works
Deciphering the mechanism underlying late-onset Alzheimer disease
Krstic, D., & Knuesel, I. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.236 · Cited by 457 · see citing works
The microglial "activation" continuum: from innate to adaptive responses
Town, T., Nikolic, V., & Tan, J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-24 · Cited by 456 · see citing works
Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration
Kleinschnitz, C., Grund, H., Wingler, K., Armitage, M. E., Jones, E., Mittal, M., Barit, D., Schwarz, T., Geis, C., Kraft, P., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000479 · Cited by 447 · see citing works
Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS
Liao, B., Zhao, W., Beers, D. R., Henkel-Tigges, J., & Appel, S. H. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.06.011 · Cited by 438 · see citing works
Animal models of neuropathic pain
Jaggi, A. S., Jain, V., & Singh, N. (2010) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2009.00801.x · Cited by 391 · see citing works
The NOX toolbox: validating the role of NADPH oxidases in physiology and disease
Altenhöfer, S., Kleikers, P. W. M., Radermacher, K. A., Scheurer, P., Rob Hermans, J. J., Schiffers, P., Ho, H., Wingler, K., & Schmidt, H. H. H. W. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1010-9 · Cited by 371 · see citing works
Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis
Getts, D. R., Terry, R. L., Getts, M. T., Müller, M., Rana, S., Shrestha, B., Radford, J., Van Rooijen, N., Campbell, I. L., & King, N. J. C. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080421 · Cited by 360 · see citing works
SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model
Harraz, M. M., Marden, J. J., Zhou, W., Zhang, Y., Williams, A. J., Sharov, V. S., Nelson, K., Luo, M., Paulson, H. L., Schöneich, C., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34060 · Cited by 357 · see citing works
Severe Life Stress and Oxidative Stress in the Brain: From Animal Models to Human Pathology
Schiavone, S., Jaquet, V., Trabace, L., & Krause, K. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4720 · Cited by 350 · see citing works
Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase
Walder, C. E., Green, S. P., Darbonne, W. C., Mathias, J., Rae, J., Dinauer, M. C., Curnutte, J. T., & Thomas, G. R. (1997) · Stroke · doi:10.1161/01.str.28.11.2252 · Cited by 349 · see citing works
The clinical spectrum of sport-related traumatic brain injury
Jordan, B. D. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.33 · Cited by 347 · see citing works
Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene
Hultqvist, M. H., Olofsson, P., Holmberg, J., Bäckström, B. T., Tordsson, J. M., & Holmdahl, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403831101 · Cited by 346 · see citing works
Targeting and Regulation of Reactive Oxygen Species Generation by Nox Family NADPH Oxidases
Leto, T. L., Morand, S. C., Hurt, D. E., & Ueyama, T. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2637 · Cited by 345 · see citing works
Induction and Activation by Zinc of NADPH Oxidase in Cultured Cortical Neurons and Astrocytes
Noh, K., & Koh, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-j0001.2000 · Cited by 335 · see citing works
Mechanisms of chronic central neuropathic pain after spinal cord injury
Hulsebosch, C. E., Hains, B. C., Crown, E. D., & Carlton, S. M. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.010 · Cited by 313 · see citing works
Aiding and abetting roles of NOX oxidases in cellular transformation
Block, K. L., & Gorin, Y. C. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3339 · Cited by 301 · see citing works
Schizophrenia: A New Approach. II. Result of a Year's Research
Hoffer, A., Osmond, H., & Smythies, J. (1954) · Journal of Mental Science · doi:10.1192/bjp.100.418.29 · Cited by 300 · see citing works
Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy
Carrano, A., Hoozemans, J. J. M., van der Vies, S. M., Rozemuller, A. J. M., van Horssen, J., & de Vries, H. E. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.3895 · Cited by 293 · see citing works
Nox2 redox signaling maintains essential cell populations in the brain
Dickinson, B. C., Peltier, J., Stone, D., Schaffer, D. V., & Chang, C. J. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.497 · Cited by 273 · see citing works
Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons
Stefanova, N., Fellner, L., Reindl, M., Masliah, E., Poewe, W., & Wenning, G. K. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.04.013 · Cited by 272 · see citing works
NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration
Qin, L., Liu, Y., Hong, J., & Crews, F. T. (2013) · Glia · doi:10.1002/glia.22479 · Cited by 271 · see citing works
The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice
Wu, D., Ré, D. B., Nagai, M., Ischiropoulos, H., & Przedborski, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603670103 · Cited by 253 · see citing works
The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke
Wu, L.-J., Wu, G., Sharif, M. R. A., Baker, A., Jia, Y., Fahey, F. H., Luo, H. R., Feener, E. P., & Clapham, D. E. (2012) · Nature Neuroscience · doi:10.1038/nn.3059 · Cited by 252 · see citing works
NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain
Kim, D., You, B., Jo, E., Han, S., Simon, M. I., & Lee, S. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009926107 · Cited by 251 · see citing works
Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states
Kumar, A., Stoica, B. A., Sabirzhanov, B., Burns, M. P., Faden, A. I., & Loane, D. J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.013 · Cited by 244 · see citing works
Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets
Jaquet, V., Scapozza, L., Clark, R. A., Krause, K. H., & Lambeth, J. D. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2585 · Cited by 243 · see citing works
Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation
Diaz, B., Shani, G., Pass, I., Anderson, D., Quintavalle, M., & Courtneidge, S. A. (2009) · Science Signaling · doi:10.1126/scisignal.2000368 · Cited by 242 · see citing works
Interleukin-6 Mediates the Increase in NADPH-Oxidase in the Ketamine Model of Schizophrenia
Behrens, M. M., Ali, S. S., & Dugan, L. L. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4457-08.2008 · Cited by 241 · see citing works
Brain renin-angiotensin—A new look at an old system
Wright, J. W., & Harding, J. W. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.07.001 · Cited by 233 · see citing works
Harnessing monocyte‐derived macrophages to control central nervous system pathologies: no longer ‘if’ but ‘how’
Shechter, R., & Schwartz, M. (2012) · The Journal of Pathology · doi:10.1002/path.4106 · Cited by 225 · see citing works
Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase
Chéret, C., Gervais, A., Lelli, A., Colin, C., Amar, L., Ravassard, P., Mallet, J., Cumano, A., Krause, K.-H., & Mallat, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3568-08.2008 · Cited by 225 · see citing works
Self-citation
Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative‐induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy
Marchesi, V. T. (2011) · The FASEB Journal · doi:10.1096/fj.11-0102ufm · Cited by 223 · see citing works
Inhibition of NADPH oxidase promotes alternative and anti‐inflammatory microglial activation during neuroinflammation
Choi, S., Aïd, S., Kim, H., Jackson, S. H., & Bosetti, F. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07572.x · Cited by 222 · see citing works
Nox4-Derived H2O2 Mediates Endoplasmic Reticulum Signaling through Local Ras Activation
Wu, R. F., Ma, Z., Liu, Z., & Terada, L. S. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01445-09 · Cited by 219 · see citing works
NADPH oxidase immunoreactivity in the mouse brain
Serrano, F., Kolluri, N., Wientjes, F. B., Card, J. P., & Klann, E. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03364-x · Cited by 216 · see citing works
Traumatic brain injury and Alzheimer's disease: a review
van den Heuvel, C., Thornton, E., & Vink, R. (2007) · Progress in brain research · doi:10.1016/s0079-6123(06)61021-2 · Cited by 213 · see citing works
Critical Role of NADPH Oxidase in Neuronal Oxidative Damage and Microglia Activation following Traumatic Brain Injury
Zhang, Q.-G., Laird, M. D., Han, D., Nguyen, K., Scott, E., Dong, Y., Dhandapani, K. M., & Brann, D. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034504 · Cited by 211 · see citing works
Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3
Rappold, P. M., Cui, M., Chesser, A. S., Tibbett, J., Grima, J. C., Duan, L., Sen, N., Javitch, J. A., & Tieu, K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115141108 · Cited by 209 · see citing works
Involvement of NOX2 in the Development of Behavioral and Pathologic Alterations in Isolated Rats
Schiavone, S., Sorce, S., Dubois-Dauphin, M., Jaquet, V., Colaianna, M., Zotti, M., Cuomo, V., Trabace, L., & Krause, K.-H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.033 · Cited by 208 · see citing works
Self-citation
Free radical pathology in schizophrenia: a review
Reddy, R. D., & YAO, J. K. (1996) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(96)90143-x · Cited by 201 · see citing works
NOX2 Complex–Derived ROS as Immune Regulators
Sareila, O., Kelkka, T., Pizzolla, A., Hultqvist, M. H., & Holmdahl, R. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3635 · Cited by 200 · see citing works
VCAM1 Is Essential to Maintain the Structure of the SVZ Niche and Acts as an Environmental Sensor to Regulate SVZ Lineage Progression
Kokovay, E., Wang, Y., Kusek, G., Wurster, R., Lederman, P. L., Lowry, N. A., Shen, Q., & Temple, S. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.06.016 · Cited by 199 · see citing works
Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation
van Horssen, J., Singh, S., van der Pol, S. M. A., Kipp, M., Lim, J. L., Peferoen, L. A. N., Gerritsen, W. H., Kooi, E., Witte, M. E., Geurts, J. J. G., et al. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-156 · Cited by 197 · see citing works
Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury
Dohi, K., Ohtaki, H., Nakamachi, T., Yofu, S., Satoh, K., Miyamoto, K., Song, D., Tsunawaki, S., Shioda, S., & Aruga, T. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-41 · Cited by 188 · see citing works
The acute effects of NMDA antagonism: from the rodent to the human brain.
Gunduz-Bruce, H. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.07.006 · Cited by 182 · see citing works
Regulation of p53 stability and activity in response to genotoxic stress
Colman, M. S., Afshari, C. A., & Barrett, J. C. (2000) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(00)00035-1 · Cited by 181 · see citing works
NADPH Oxidase 1-Mediated Oxidative Stress Leads to Dopamine Neuron Death in Parkinson's Disease
Choi, D.-H., Cristóvão, A. C., Guhathakurta, S., Lee, J., JOH, T. H., Beal, M. F., & Kim, Y.-S. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3960 · Cited by 180 · see citing works
Neuroinflammation in Huntington’s disease
Möller, T. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0430-7 · Cited by 174 · see citing works
Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells
Vejražka, M., MICEK, R., & Štípek, S. (2005) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2004.12.008 · Cited by 173 · see citing works
Reactive Oxygen Species in Myocardial Reperfusion Injury: From Physiopathology to Therapeutic Approaches
Braunersreuther, V., & Jaquet, V. (2011) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112798868782 · Cited by 172 · see citing works
Intermittent Hypoxia-Induced Cognitive Deficits Are Mediated by NADPH Oxidase Activity in a Murine Model of Sleep Apnea
Nair, D., Dayyat, E. A., Zhang, S. X. L., Wang, Y., & Gozal, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019847 · Cited by 168 · see citing works
Evidence of Oxidant Damage in Huntington's Disease: Translational Strategies Using Antioxidants
Stack, E. C., Matson, W. R., & Ferrante, R. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.008 · Cited by 167 · see citing works
IL-6 Mediated Degeneration of Forebrain GABAergic Interneurons and Cognitive Impairment in Aged Mice through Activation of Neuronal NADPH Oxidase
Dugan, L. L., Ali, S. S., Shekhtman, G., Roberts, A. J., Lucero, J., Quick, K. L., & Behrens, M. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005518 · Cited by 165 · see citing works
The Role of NADPH Oxidase 1–Derived Reactive Oxygen Species in Paraquat-Mediated Dopaminergic Cell Death
Cristóvão, A. C., Choi, D.-H., Baltazar, G., Beal, M. F., & Kim, Y.-S. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2459 · Cited by 165 · see citing works
TRPM2 Cation Channels, Oxidative Stress and Neurological Diseases: Where Are We Now?
Nazıroğlu, M. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0347-4 · Cited by 163 · see citing works
Synaptic Plasticity Deficits and Mild Memory Impairments in Mouse Models of Chronic Granulomatous Disease
Kishida, K. T., Hoeffer, C. A., Hu, D., Pao, M., Holland, S. M., & Klann, E. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00269-06 · Cited by 162 · see citing works
Oxidative Stress and Microglial Cells in Parkinson's Disease
Peterson, L. J., & Flood, P. M. (2012) · Mediators of Inflammation · doi:10.1155/2012/401264 · Cited by 161 · see citing works
Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase
Schäppi, M. G., Jaquet, V., Belli, D. C., & Krause, K. (2008) · Seminars in Immunopathology · doi:10.1007/s00281-008-0119-2 · Cited by 156 · see citing works
Nox5 and the Regulation of Cellular Function
Fulton, D. J. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2587 · Cited by 151 · see citing works
Detection of reactive oxygen species derived from the family of NOX NADPH oxidases
Maghzal, G. J., Krause, K., Stocker, R., & Jaquet, V. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.09.002 · Cited by 151 · see citing works
ReviewPTPs versus PTKs: The redox side of the coin
Chiarugi, P. (2005) · Free Radical Research · doi:10.1080/10715760400027987 · Cited by 149 · see citing works
Where Vascular Meets Neurodegenerative Disease
Schneider, J. A., & Bennett, D. A. (2010) · Stroke · doi:10.1161/strokeaha.110.598326 · Cited by 148 · see citing works
Neuroprotection After Stroke by Targeting NOX4 As a Source of Oxidative Stress
Radermacher, K. A., Wingler, K., Langhauser, F., Altenhöfer, S., Kleikers, P. W. M., Hermans, J. J. R., de Angelis, M. H., Kleinschnitz, C., & Schmidt, H. H. H. W. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4797 · Cited by 147 · see citing works
Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues
Juhasz, A. N., Ge, Y., Markel, S., Chiu, A., Matsumoto, L., van Balgooy, J. N. A., Roy, K., & Doroshow, J. H. (2009) · Free Radical Research · doi:10.1080/10715760902918683 · Cited by 147 · see citing works
Redox modifier genes in amyotrophic lateral sclerosis in mice
Marden, J. J., Harraz, M. M., Williams, A. J., Nelson, K., Luo, M., Paulson, H., & Engelhardt, J. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31265 · Cited by 145 · see citing works
The Nox Family of NADPH Oxidases: Friend or Foe of the Vascular System?
Takac, I., Schröder, K., & Brandes, R. P. (2011) · Current Hypertension Reports · doi:10.1007/s11906-011-0238-3 · Cited by 143 · see citing works
NOX1 Deficiency Protects From Aortic Dissection in Response to Angiotensin II
Gavazzi, G., Deffert, C., Trocme, C., Schäppi, M., Herrmann, F. R., & Krause, K.-H. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.089706 · Cited by 135 · see citing works
Self-citation
Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4
Kozieł, R., Pircher, H., Kratochwil, M., Lener, B., Hermann, M., Dencher, N. A., & Jansen‐Dürr, P. (2013) · Biochemical Journal · doi:10.1042/bj20121778 · Cited by 135 · see citing works
Targeting microglia-mediated neurotoxicity: the potential of NOX2 inhibitors
Surace, M. J., & Block, M. L. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1015-4 · Cited by 131 · see citing works
NADPH-oxidase activation and cognition in Alzheimer disease progression
Ansari, M. A., & Scheff, S. W. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.025 · Cited by 131 · see citing works
IQGAP1 Regulates Reactive Oxygen Species–Dependent Endothelial Cell Migration Through Interacting With Nox2
Ikeda, S., Yamaoka‐Tojo, M., Hilenski, L. L., Patrushev, N. A., Anwar, G. M., Quinn, M. T., & Ushio‐Fukai, M. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000187472.55437.af · Cited by 129 · see citing works
Obstructive Sleep Apnea, Oxidative Stress and Cardiovascular Disease: Lessons from Animal Studies
Dumitrascu, R., Heitmann, J., Seeger, W., Weißmann, N., & Schulz, R. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/234631 · Cited by 127 · see citing works
Rodent models of TDP-43: Recent advances
Tsao, W., Jeong, Y. H., Lin, S. Z., Ling, J. P., Price, D. L., Chiang, P., & Wong, P. C. (2012) · Brain Research · doi:10.1016/j.brainres.2012.04.031 · Cited by 126 · see citing works
The brain’s best friend: microglial neurotoxicity revisited
Hellwig, S., Heinrich, A., & Biber, K. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00071 · Cited by 126 · see citing works
Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE2 activation
Chiu, W., Shen, S., Chow, J., Lin, C., Shia, L.-T., & Chen, Y.-C. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.09.015 · Cited by 126 · see citing works
Which NADPH Oxidase Isoform Is Relevant for Ischemic Stroke? The Case for Nox 2
Kahles, T., & Brandes, R. P. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4721 · Cited by 125 · see citing works
The Role of Reactive Oxygen Species in Integrin and Matrix Metalloproteinase Expression and Function
Svineng, G., Ravuri, C. S., Rikardsen, O., Huseby, N., & Winberg, J. (2008) · Connective Tissue Research · doi:10.1080/03008200802143166 · Cited by 122 · see citing works
Reactive oxygen species and the brain in sleep apnea
Wang, Y., Zhang, S. X. L., & Gozal, D. (2010) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2010.09.001 · Cited by 120 · see citing works
NOX5: from basic biology to signaling and disease
Bedard, K., Jaquet, V., & Krause, K. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.023 · Cited by 119 · see citing works
Activation of Neuronal NMDA Receptors Induces Superoxide-Mediated Oxidative Stress in Neighboring Neurons and Astrocytes
Reyes, R. C., Brennan, A. M., Shen, Y., Baldwin, Y., & Swanson, R. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1597-12.2012 · Cited by 117 · see citing works
NADPH oxidase is involved in post-ischemic brain inflammation
Chen, H., Kim, G. S., Okami, N., Narasimhan, P., & Chan, P. H. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.027 · Cited by 116 · see citing works
Ebselen and Congeners Inhibit NADPH Oxidase 2-Dependent Superoxide Generation by Interrupting the Binding of Regulatory Subunits
Smith, S. M. E., Min, J., Ganesh, T., Diebold, B. A., Kawahara, T., Zhu, Y., McCoy, J. W., Sun, A., Snyder, J. P., Fu, H., et al. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.04.015 · Cited by 116 · see citing works
From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis
Lincecum, J. M., Vieira, F. G., Wang, M. Z., Thompson, K., Zutter, G. S. D., Kidd, J. D., Moreno, A., Sànchez, R., Carrion, I. J., Levine, B. A., et al. (2010) · Nature Genetics · doi:10.1038/ng.557 · Cited by 114 · see citing works
NADPH Oxidase-4 Maintains Neuropathic Pain after Peripheral Nerve Injury
Kallenborn-Gerhardt, W., Schröder, K., Turco, D. D., Lu, R., Kynast, K. L., Kosowski, J., Niederberger, E., Shah, A. M., Brandes, R. P., Geißlinger, G., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6227-11.2012 · Cited by 114 · see citing works
c-Src–Mediated Phosphorylation of NoxA1 and Tks4 Induces the Reactive Oxygen Species (ROS)–Dependent Formation of Functional Invadopodia in Human Colon Cancer Cells
Gianni, D., Taulet, N., DerMardirossian, C. M., & Bokoch, G. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-08-0685 · Cited by 112 · see citing works
NADPH Oxidase Subunit 4-Mediated Reactive Oxygen Species Contribute to Cycling Hypoxia-Promoted Tumor Progression in Glioblastoma Multiforme
Hsieh, C., Shyu, W., Chiang, C.-Y., Kuo, J.-W., Shen, W., & Liu, R.-S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023945 · Cited by 111 · see citing works
The Antioxidant Ebselen Prevents Neurotoxicity and Clinical Symptoms in a Primate Model of Parkinson's Disease
Moussaoui, S. M., Obinu, M. C., Daniel, N., Reibaud, M., Blanchard, V., & Impérato, A. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7516 · Cited by 110 · see citing works
Novel p47 phox -Related Organizers Regulate Localized NADPH Oxidase 1 (Nox1) Activity
Gianni, D., Díaz, B., Taulet, N., Fowler, B. J., Courtneidge, S. A., & Bokoch, G. (2009) · Science Signaling · doi:10.1126/scisignal.2000370 · Cited by 109 · see citing works
Nox2, Ca 2+ , and Protein Kinase C Play a Role in Angiotensin II-Induced Free Radical Production in Nucleus Tractus Solitarius
Wang, G., Anrather, J., Glass, M. J., Tarsitano, M., Zhou, P., Frys, K. A., Pickel, V. M., & Iadecola, C. (2006) · Hypertension · doi:10.1161/01.hyp.0000236647.55200.07 · Cited by 109 · see citing works
Role of the NADPH Oxidases in the Subfornical Organ in Angiotensin II–Induced Hypertension
Lob, H. E., Schultz, D. W., Marvar, P. J., Davisson, R. L., & Harrison, D. G. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.00546 · Cited by 108 · see citing works
Protein disulfide isomerases in neurodegeneration: From disease mechanisms to biomedical applications
Andreu, C. I., Woehlbier, U., Torres, M., & Hetz, C. A. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.07.023 · Cited by 106 · see citing works
Amyotrophic lateral sclerosis
Ludolph, A. C., Brettschneider, J., & Weishaupt, J. H. (2012) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328356d328 · Cited by 103 · see citing works
Chimerization of astroglial population in the lumbar spinal cord after mesenchymal stem cell transplantation prolongs survival in a rat model of amyotrophic lateral sclerosis
Boucherie, C., Schäfer, S., Lavand'homme, P. M., Maloteaux, J., & Hermans, E. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22038 · Cited by 100 · see citing works
NADPH Oxidases as Regulators of Tumor Angiogenesis: Current and Emerging Concepts
Coso, S., Harrison, I., Harrison, C. B., Vinh, A., Sobey, C. G., Drummond, G. R., Williams, E. D., & Selemidis, S. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4489 · Cited by 99 · see citing works
Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival
Shono, T., Yokoyama, N., Uesaka, T., Kuroda, J., Takeya, R., Yamasaki, T., Amano, T., Mizoguchi, M., Suzuki, S. O., Niiro, H., et al. (2008) · International Journal of Cancer · doi:10.1002/ijc.23569 · Cited by 99 · see citing works
NADPH Oxidase 1 Mediates α-Synucleinopathy in Parkinson's Disease
Cristóvão, A. C., Guhathakurta, S., Bok, E., Je, G., Yoo, S. D., Choi, D., & Kim, Y. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2246-12.2012 · Cited by 99 · see citing works
The role of the central renin-angiotensin system in Parkinson’s disease
Mertens, B., Vanderheyden, P., Michotte, Y. M., & Sarre, S. (2009) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320309347789 · Cited by 99 · see citing works
Genetic Silencing of Nox2 and Nox4 Reveals Differential Roles of These NADPH Oxidase Homologues in the Vasopressor and Dipsogenic Effects of Brain Angiotensin II
Peterson, J. R., Burmeister, M. A., Tian, X., Zhou, Y., Guruju, M. R., Stupinski, J. A., Sharma, R. V., & Davisson, R. L. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.140087 · Cited by 98 · see citing works
Chapter 24 NF‐KappaB Dimers in the Regulation of Neuronal Survival
Sarnico, I., Lanzillotta, A., Benarese, M., Alghisi, M., Baiguera, C., Battistin, L., Spano, P., & Pizzi, M. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)85024-1 · Cited by 97 · see citing works
Cognitive impairment in humanized APP×PS1 mice is linked to Aβ1–42 and NOX activation
Bruce-Keller, A. J., Gupta, S., Knight, A. G., Beckett, T. L., McMullen, J. M., Davis, P. R., Murphy, M. P., Van Eldik, L. J., St Clair, D., & Keller, J. N. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.07.012 · Cited by 96 · see citing works
Endogenous reactive oxygen species are essential for proliferation of neural stem/progenitor cells
Yoneyama, M., Kawada, K., Gotoh, Y., Shiba, T., & Ogita, K. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.11.018 · Cited by 96 · see citing works
Mitochondrial-localized NADPH oxidase 4 is a source of superoxide in angiotensin II-stimulated neurons
Case, A. J., Li, S., Basu, U., Tian, J., & Zimmerman, M. C. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00974.2012 · Cited by 96 · see citing works
Alsin and SOD1G93A Proteins Regulate Endosomal Reactive Oxygen Species Production by Glial Cells and Proinflammatory Pathways Responsible for Neurotoxicity
Li, Q., Spencer, N. Y., Pantazis, N. J., & Engelhardt, J. F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.279711 · Cited by 95 · see citing works
A key role for the microglial NADPH oxidase in APP-dependent killing of neurons
Qin, B., Cartier, L., Dubois‐Dauphin, M., Li, B., Serrander, L., & Krause, K. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.036 · Cited by 95 · see citing works
TDP-43-Based Animal Models of Neurodegeneration: New Insights into ALS Pathology and Pathophysiology
Wegorzewska, I., & Baloh, R. H. (2010) · Neurodegenerative Diseases · doi:10.1159/000321547 · Cited by 93 · see citing works
The NADPH Oxidase NOX2 Controls Glutamate Release: A Novel Mechanism Involved in Psychosis-Like Ketamine Responses
Sorce, S., Schiavone, S., Tucci, P., Colaianna, M., Jaquet, V., Cuomo, V., Dubois‐Dauphin, M., Trabace, L., & Krause, K. H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1491-10.2010 · Cited by 92 · see citing works
The Adult Neural Stem Cell Niche: Lessons for Future Neural Cell Replacement Strategies
Lim, D. A., Huang, Y.-C., & Álvarez-Buylla, A. (2007) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2006.10.002 · Cited by 90 · see citing works
Molecular targeting of NOX4 for neuropathic pain after traumatic injury of the spinal cord
Im, Y. B., Jee, M. K., Choi, J.-Y., Cho, H. T., Kwon, O. H., & Kang, S. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.168 · Cited by 83 · see citing works
Ebselen inhibits iron-induced tau phosphorylation by attenuating DMT1 up-regulation and cellular iron uptake
Xie, L., Zheng, W. H., Xin, N., Xie, J., Wang, T., & Wang, Z. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.05.016 · Cited by 79 · see citing works
Targeting NOX enzymes in the central nervous system: therapeutic opportunities
Sorce, S., Krause, K., & Jaquet, V. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1014-5 · Cited by 78 · see citing works
Toxic effects of oxygen and of hydrogen peroxide on brain metabolism
Mann, P. J., & Quastel, J. H. (1946) · Biochemical Journal · doi:10.1042/bj0400139 · Cited by 77 · see citing works
NOX4 Expression in Human Microglia Leads to Constitutive Generation of Reactive Oxygen Species and to Constitutive IL-6 Expression
Li, B., Bedard, K., Sorce, S., Hinz, B., Dubois‐Dauphin, M., & Krause, K. (2009) · Journal of Innate Immunity · doi:10.1159/000235563 · Cited by 77 · see citing works
NADPH oxidase elevations in pyramidal neurons drive psychosocial stress-induced neuropathology
Schiavone, S., Jaquet, V., Sorce, S., Dubois‐Dauphin, M., Hultqvist, M. H., Bäckdahl, L., Holmdahl, R., Colaianna, M., Cuomo, V., Trabace, L., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.36 · Cited by 75 · see citing works
Mitochondria as sources and targets of damage in cellular aging
Gómez‐Cabrera, M. C., Sanchis‐Gomar, F., Garcia-Valles, R., Pareja-Galeano, H., Gambini, J., Borrás, C., & Viña, J. (2012) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2011-0795 · Cited by 72 · see citing works
Cognitive Function in Patients With Chronic Granulomatous Disease: A Preliminary Report
Pao, M., Wiggs, E. A., Anastacio, M. M., Hyun, J. K., DeCarlo, E. S., Miller, J. T., Anderson, V., Malech, H. L., Gallin, J. I., & Holland, S. M. (2004) · Psychosomatics · doi:10.1176/appi.psy.45.3.230 · Cited by 72 · see citing works
Immunohistochemical study of p47Phox and gp91Phox distributions in rat brain
Kim, M. J., Shin, K.-S., Chung, Y.-B., Jung, K. W., Ik, C., & Shin, D. H. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.066 · Cited by 72 · see citing works
Vascular cognitive impairment and Alzheimer’s disease: role of cerebral hypoperfusion and oxidative stress
Kim, H. A., Miller, A. A., Drummond, G. R., Thrift, A. G., Arumugam, T. V., Phan, T. G., Srikanth, V. K., & Sobey, C. G. (2012) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-012-0790-7 · Cited by 68 · see citing works
NOX activity in brain aging: Exacerbation by high fat diet
Bruce‐Keller, A. J., White, C. L., Gupta, S., Knight, A. G., Pistell, P. J., Ingram, D. K., Morrison, C. D., & Keller, J. N. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.006 · Cited by 67 · see citing works
Oxidative stress in synapse development and function
Milton, V. J., & Sweeney, S. T. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20957 · Cited by 67 · see citing works
Cognitive Function in Prepubertal Children with Obstructive Sleep Apnea: A Modifying Role for NADPH Oxidase p22 Subunit Gene Polymorphisms?
Gozal, D., Khalyfa, A., Capdevila, Ó. S., Gozal, D., Khalyfa, A. A., & Kim, J. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4189 · Cited by 67 · see citing works
VAS2870 is a pan-NADPH oxidase inhibitor
Wingler, K., Altenhöfer, S., Kleikers, P. W. M., Radermacher, K. A., Kleinschnitz, C., & Schmidt, H. H. H. W. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1107-1 · Cited by 66 · see citing works
Early and Late Events Induced by PolyQ-expanded Proteins
Bertoni, A., Giuliano, P., Galgani, M., Rotoli, D., Ulianich, L., Adornetto, A., Santillo, M. R., Porcellini, A., & Avvedimento, V. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.156521 · Cited by 66 · see citing works
NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in glioblastoma multiforme
Hsieh, C., Wu, C., Lee, H., Liang, J., Yu, C.-Y., & Lin, Y. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.06.009 · Cited by 66 · see citing works
Three common polymorphisms in theCYBAgene form a haplotype associated with decreased ROS generation
Bedard, K., Attar, H., Bonnefont, J., Jaquet, V., Borel, C., Plastre, O., Stasia, M. J., Antonarakis, S. E., & Krause, K. (2009) · Human Mutation · doi:10.1002/humu.21029 · Cited by 66 · see citing works
Pesticides, Microglial NOX2, and Parkinson's Disease
Taetzsch, T., & Block, M. L. (2013) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21464 · Cited by 63 · see citing works
Attenuation of brain edema and spatial learning deficits by the inhibition of NADPH oxidase activity using apocynin following diffuse traumatic brain injury in rats
Song, S., Gao, J., Wang, R. C., Li, R., Tian, Y., Wei, J.-Q., & Cui, J. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2012.1147 · Cited by 63 · see citing works
Involvement of NOX1/NADPH Oxidase in Morphine-Induced Analgesia and Tolerance
Ibi, M., Matsuno, K., Matsumoto, M., Sasaki, M., Nakagawa, T., Katsuyama, M., Iwata, K., Zhang, J., Kaneko, S., & Yabe‐Nishimura, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4136-11.2011 · Cited by 59 · see citing works
Characterization of NADPH oxidase 5 expression in human tumors and tumor cell lines with a novel mouse monoclonal antibody
Antony, S., Wu, Y., Hewitt, S. M., Anver, M. R., Butcher, D. O., Jiang, G., Meitzler, J. L., Liu, H., Juhasz, A. N., Lu, J., et al. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.005 · Cited by 58 · see citing works
Angiotensin II slow-pressor hypertension enhances NMDA currents and NOX2-dependent superoxide production in hypothalamic paraventricular neurons
Wang, G., Coleman, C. G., Chan, J., Faraco, G., Marques-Lopes, J., Milner, T. A., Guruju, M. R., Anrather, J., Davisson, R. L., Iadecola, C., et al. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00367.2012 · Cited by 58 · see citing works
Reversal of aging‐associated hippocampal synaptic plasticity deficits by reductants via regulation of thiol redox and NMDA receptor function
Yang, Y., Wu, P., Long, L., Yu, D., Wu, W., Hu, Z., Fu, H. Q., Xie, N., Jin, Y., Ni, L., et al. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00595.x · Cited by 57 · see citing works
Angiotensin-Generated Reactive Oxygen Species in Brain and Pathogenesis of Cardiovascular Diseases
Chan, S. H. H., & Chan, J. Y. H. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4585 · Cited by 57 · see citing works
Allosteric Modulation of Retinal GABA Receptors by Ascorbic Acid
Calero, C. I., Vickers, E. D., Moraga‐Cid, G., Aguayo, L. G., von Gersdorff, H., & Calvo, D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5157-10.2011 · Cited by 57 · see citing works
Diapocynin and apocynin administration fails to significantly extend survival in G93A SOD1 ALS mice
Trumbull, K. A., McAllister, D. M., Gandelman, M., Fung, W. Y., Lew, T. K., Brennan, L. D., Lopez, N. I., Morré, J. T., Kalyanaraman, B., & Beckman, J. S. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.07.015 · Cited by 56 · see citing works
The NADPH oxidase Nox2 regulates VEGFR1/CSF‐1R‐mediated microglial chemotaxis and promotes early postnatal infiltration of phagocytes in the subventricular zone of the mouse cerebral cortex
Lelli, A., Gervais, A., Colin, C., Chéret, C., de Almodóvar, C. R., Carmeliet, P., Krause, K., Boillée, S., & Mallat, M. (2013) · Glia · doi:10.1002/glia.22540 · Cited by 55 · see citing works
Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1
Berger, J. V., Deumens, R., Goursaud, S., Schäfer, S., Lavand'homme, P. M., Joosten, E. A. J., & Hermans, E. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-33 · Cited by 55 · see citing works
NAD(P)H oxidase contributes to neurotoxicity in an excitotoxic/prooxidant model of Huntington's disease in rats: Protective role of apocynin
Maldonado, P. D., Molina‐Jijón, E., Villeda‐Hernández, J., Galván‐Arzate, S., Santamarı́a, A., & Pedraza‐Chaverrí, J. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22240 · Cited by 55 · see citing works
Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox
Zhou, H., Zhang, F., Chen, S., Zhang, D., Wilson, B. C., Hong, J., & Gao, H. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.488 · Cited by 54 · see citing works
TRPM2 Channels Are Required for NMDA-Induced Burst Firing and Contribute to H2O2-Dependent Modulation in Substantia Nigra Pars Reticulata GABAergic Neurons
Lee, C. R., Machold, R. P., Witkovsky, P., & Rice, M. E. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2832-12.2013 · Cited by 51 · see citing works
Advanced Intercross Line Mapping of Eae5 Reveals Ncf-1 and CLDN4 as Candidate Genes for Experimental Autoimmune Encephalomyelitis
Bečanović, K., Jagodic, M., Sheng, J. R., Dahlman, I. A., Aboul‐Enein, F., Wallström, E., Olofsson, P., Holmdahl, R., Lassmann, H., & Olsson, T. P. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.10.6055 · Cited by 51 · see citing works
Hydrogen Peroxide As an Immunological Transmitter Regulating Autoreactive T Cells
Holmdahl, R., Sareila, O., Pizzolla, A., Winter, S., Hagert, C., Jaakkola, N., Kelkka, T., Olsson, L. M., Wing, K., & Bäckdahl, L. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4734 · Cited by 50 · see citing works
Chronic Apocynin Treatment Attenuates Beta Amyloid Plaque Size and Microglial Number in hAPP(751)SL Mice
Lull, M. E., Levesque, S., Surace, M. J., & Block, M. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020153 · Cited by 50 · see citing works
Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats
Choi, S., Roh, D., Yoon, S. Y., Kang, S.-Y., Moon, J.-Y., Kwon, S. G., Choi, H., Han, H. J., Beitz, A. J., Oh, S. B., et al. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.05.004 · Cited by 50 · see citing works
Targeting NADPH Oxidase and Phospholipases A2 in Alzheimer’s Disease
Simonyi, Á., He, Y., Sheng, W., Sun, A. Y., Wood, W. G., Weisman, G. A., & Sun, G. Y. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8107-7 · Cited by 49 · see citing works
Nitric Oxide and Zinc-Mediated Protein Assemblies Involved in Mu Opioid Receptor Signaling
Rodríguez-Muñoz, M., & Garzón, J. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8465-z · Cited by 47 · see citing works
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Wang, X., Pinto-Duarte, A., Sejnowski, T. J., & Behrens, M. M. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4907 · Cited by 46 · see citing works
Role of reactive oxygen species and NADPH-oxidase in the development of rat cerebellum
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Neuronal nitric oxide synthase and NADPH oxidase interact to affect cognitive, affective, and social behaviors in mice
Walton, J. C., Selvakumar, B., Weil, Z. M., Snyder, S. H., & Nelson, R. J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.08.003 · Cited by 44 · see citing works
Redox signaling at invasive microdomains in cancer cells
Díaz, B., & Courtneidge, S. A. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.016 · Cited by 37 · see citing works
Brain angiotensin and dopaminergic degeneration: relevance to Parkinson's disease.
Labandeira-García, J. L., Rodríguez‐Pallares, J., Rodriguez-Perez, A. I., Garrido‐Gil, P., Villar‐Cheda, B., Valenzuela, R., & Guerra, M. J. (2012) · Europe PMC (PubMed Central) · Cited by 36 · see citing works
Protein disulfide isomerase in ALS mouse glia links protein misfolding with NADPH oxidase-catalyzed superoxide production
Jaronen, M., Vehviläinen, P., Malm, T., Keksa-Goldsteine, V., Pollari, E., Valonen, P. K., Koıstınaho, J., & Goldsteins, G. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds472 · Cited by 36 · see citing works
Initial evidence linking synaptic superoxide production with poor short-term memory in aged mice
Ali, S. S., Young, J. W., Wallace, C. K., Gresack, J. E., Jeste, D. V., Geyer, M. A., Dugan, L. L., & Risbrough, V. B. (2010) · Brain Research · doi:10.1016/j.brainres.2010.11.009 · Cited by 32 · see citing works
Identifying new small molecule anti-invasive compounds for glioma treatment
Munson, J. M., Bonner, M. Y., Fried, L. E., Hofmekler, J., Arbiser, J. L., & Bellamkonda, R. V. (2013) · Cell Cycle · doi:10.4161/cc.25334 · Cited by 26 · see citing works
Apocynin administration does not improve behavioral and neuropathological deficits in a transgenic mouse model of Alzheimer's disease
Dumont, M., Stack, C., Elipenhali, C., Calingasan, N. Y., Wille, E. J., & Beal, M. F. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.01.077 · Cited by 20 · see citing works
Adverse cognitive effects of high-fat diet in a murine model of sleep apnea are mediated by NADPH oxidase activity
Nair, D., Ramesh, V., & Gozal, D. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.068 · Cited by 19 · see citing works
Cognitive Ability in Children with Chronic Granulomatous Disease: A Comparison of Those Managed Conservatively with Those Who Have Undergone Hematopoietic Stem Cell Transplant
McKendrick, F., Cant, A. J., Pearce, M. S., Cale, C. M., Goldblatt, D., Gennery, A. R., Titman, P., & Cole, T. S. (2013) · Neuropediatrics · doi:10.1055/s-0033-1333875 · Cited by 12 · see citing works
Knock, Nox—ROS there?
Carroll, K. S. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.515 · Cited by 5 · see citing works

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Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
Sies, H., & Jones, D. P. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0230-3 · Cited by 5,335 · see citing works
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Zielonka, J., Joseph, J., Sikora, A., Hardy, M., Ouari, O., Vasquez-Vivar, J., Cheng, G., Lopez, M., & Kalyanaraman, B. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00042 · Cited by 1,683 · see citing works
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Lushchak, V. I. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.10.016 · Cited by 1,665 · see citing works
13 reasons why the brain is susceptible to oxidative stress
Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215 · see citing works
ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease
Simpson, D. S. A., & Oliver, P. L. (2020) · Antioxidants · doi:10.3390/antiox9080743 · Cited by 1,044 · see citing works
“The cellular expression of NOX enzymes throughout the CNS has been thoroughly reviewed, however, the precise localisation of different NOX isoforms requires further examination [63].”
Background
Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications
Pajares, M., I. Rojo, A., Manda, G., Boscá, L., & Cuadrado, A. (2020) · Cells · doi:10.3390/cells9071687 · Cited by 779 · see citing works
NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer’s diseases
Park, M. W., Cha, H. W., Kim, J., Kim, J. H., Yang, H., Yoon, S., Boonpraman, N., Yi, S. S., Yoo, I. D., & Moon, J.-S. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101947 · Cited by 683 · see citing works
“Among NOX isoforms, NOX4 is a major isoform in astrocytes [36].”
Background
The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review
Atashi, F., Modarressi, A., & Pepper, M. S. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0484 · Cited by 655 · see citing works
Microglial cell dysregulation in brain aging and neurodegeneration
von Bernhardi, R., Eugenín-von Bernhardi, L., & Eugenín, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00124 · Cited by 556 · see citing works
NADPH oxidase in brain injury and neurodegenerative disorders
Ma, M. W., Wang, J., Zhang, Q., Wang, R., Dhandapani, K. M., Vadlamudi, R. K., & Brann, D. W. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0150-7 · Cited by 432 · see citing works
Neurodegenerative disorders: Mechanisms of degeneration and therapeutic approaches with their clinical relevance
Gadhave, D. G., Sugandhi, V. V., Jha, S. K., Nangare, S., Gupta, G., Singh, S. K., Dua, K., Cho, H., Hansbro, P. M., & Paudel, K. R. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102357 · Cited by 391 · see citing works
The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders
Tarafdar, A., & Pula, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123824 · Cited by 373 · see citing works
Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance
Rojo, A. I., McBean, G. J., Cindrić, M., Egea, J., López, M. G., Rada, P., Žarković, N., & Cuadrado, A. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5745 · Cited by 313 · see citing works
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Egea, J., Fabregat, I., Frapart, Y., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K. I., Knaus, U. G., López, M. G., González, G. O., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.05.007 · Cited by 311 · see citing works
The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis
Wang, Y., Chang, S.-Y., Wu, Q., Gou, Y.-J., Jia, L., Cui, Y.-M., Yu, P., Shi, Z.-H., Wu, W.-S., Gao, G., et al. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00308 · Cited by 309 · see citing works
The role of astrocytes in oxidative stress of central nervous system: A mixed blessing
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Astrocytic mitochondrial ROS modulate brain metabolism and mouse behaviour
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Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor
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NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease
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Computer Aided Drug Design and its Application to the Development of Potential Drugs for Neurodegenerative Disorders
Baig, M. H., Ahmad, K., Rabbani, G., Danishuddin, M., & Choi, I. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666171016163510 · Cited by 176 · see citing works
Therapeutic potential of nadph oxidase 1/4 inhibitors
Teixeira, G., Szyndralewiez, C., Molango, S., Carnesecchi, S., Heitz, F., Wiesel, P., & Wood, J. M. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13532 · Cited by 163 · see citing works
Genetic disorders coupled to ROS deficiency
O’Neill, S., Brault, J., Stasia, M.-J., & Knaus, U. G. (2015) · Redox Biology · doi:10.1016/j.redox.2015.07.009 · Cited by 164 · see citing works
Sex-specific differences in mitochondria biogenesis, morphology, respiratory function, and ros homeostasis in young mouse heart and brain
Khalifa, A. R. M., Abdel‐Rahman, E. A., Mahmoud, A. M., Ali, M. H., Noureldin, M., Saber, S. H., Mohsen, M., & Ali, S. S. (2017) · Physiological Reports · doi:10.14814/phy2.13125 · Cited by 154 · see citing works
HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy
Thangaraj, A., Periyasamy, P., Liao, K., Bendi, V. S., Callen, S. E., Pendyala, G., & Buch, S. J. (2018) · Autophagy · doi:10.1080/15548627.2018.1476810 · Cited by 147 · see citing works
Connecting the “Dots”: From Free Radical Lipid Autoxidation to Cell Pathology and Disease
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Oxidative Stress, Neuroinflammation, and NADPH Oxidase: Implications in the Pathogenesis and Treatment of Alzheimer’s Disease
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Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities
Sbodio, J. I., Snyder, S. H., & Paul, B. D. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7321 · Cited by 143 · see citing works
Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury
Eastman, C. L., D’Ambrosio, R., & Ganesh, T. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107907 · Cited by 137 · see citing works
Microglia antioxidant systems and redox signalling
Vilhardt, F., Haslund-Vinding, J. L., Jaquet, V., & McBean, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13426 · Cited by 133 · see citing works
Mammalian NADPH Oxidases
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From Flies to Men: ROS and the NADPH Oxidase in Phagocytes
Moghadam, Z. M., Henneke, P., & Kolter, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.628991 · Cited by 136 · see citing works
Crosstalk Between the Oxidative Stress and Glia Cells After Stroke: From Mechanism to Therapies
Zhu, G., Wang, X., Chen, L., Lenahan, C., Fu, Z., Fang, Y., & Yu, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.852416 · Cited by 135 · see citing works
Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice
Langley, M. R., Ghosh, A., Charli, A., Sarkar, S., Ay, M., Luo, J. D., Zielonka, J., Brenza, T. M., Bennett, B., Jin, H., et al. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6905 · Cited by 130 · see citing works
From birth to death: A role for reactive oxygen species in neuronal development
Wilson, C., Muñoz-Palma, E., & González-Billault, C. E. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.09.012 · Cited by 129 · see citing works
Nitroxidative signaling mechanisms in pathological pain
Grace, P. M., Gaudet, A. D., Staikopoulos, V., Maier, S. F., Hutchinson, M. R., Salvemini, D., & Watkins, L. R. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.10.003 · Cited by 128 · see citing works
Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy—Mitochondria, Calcium Dynamics and Reactive Oxygen Species
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Which NADPH Oxidase Isoform Is Relevant for Ischemic Stroke? The Case for Nox 2
Kahles, T., & Brandes, R. P. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4721 · Cited by 125 · see citing works
Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway
Wei, C., Kong, Y., Li, G., Guan, Y., Wang, P., & Miao, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-00851-z · Cited by 126 · see citing works
NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: What is the evidence?
Sorce, S., Stocker, R., Seredenina, T. S., Holmdahl, R., Aguzzi, A., Chiò, A., Depaulis, A., Heitz, F., Olofsson, P., Olsson, T. P., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.08.006 · Cited by 116 · see citing works
NADPH oxidases in traumatic brain injury – Promising therapeutic targets?
Ma, M. W., Wang, J., Dhandapani, K. M., Wang, R., & Brann, D. W. (2018) · Redox Biology · doi:10.1016/j.redox.2018.03.005 · Cited by 114 · see citing works
ROS as Regulators of Mitochondrial Dynamics in Neurons
Cid‐Castro, C., Hernández-Espinosa, D. R., & Morán, J. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0584-7 · Cited by 111 · see citing works
Inflammation and Oxidative Stress: Potential Targets for Improving Prognosis After Subarachnoid Hemorrhage
Wu, F., Liu, Z., Li, G., Zhou, L., Huang, K., Wu, Z., Zhan, R., & Shen, J. F. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.739506 · Cited by 110 · see citing works
Microglia morphology and proinflammatory signaling in the nucleus accumbens during nicotine withdrawal
Adeluyi, A., Guerin, L. N., Fisher, M. L., Galloway, A. L., Cole, R. D., Chan, S. S. L., Wyatt, M. D., Davis, S. W., Freeman, L. R., Ortinski, P. I., et al. (2019) · Science Advances · doi:10.1126/sciadv.aax7031 · Cited by 107 · see citing works
RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage
Piras, S., Furfaro, A. L., Domenicotti, C., Traverso, N., Marinari, U. M., Pronzato, M. A., & Nitti, M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9348651 · Cited by 104 · see citing works
Crosstalk between Neuron and Glial Cells in Oxidative Injury and Neuroprotection
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Neuroinflammation, oxidative stress and their interplay in neuropathic pain: Focus on specialized pro-resolving mediators and NADPH oxidase inhibitors as potential therapeutic strategies
Teixeira-Santos, L., Albino‐Teixeira, A., & Pinho, D. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105280 · Cited by 103 · see citing works
NADPH oxidases: redox regulation of cell homeostasis and disease
Kračun, D., Lopes, L. R., Cifuentes-Pagano, E., & Pagano, P. J. (2025) · Physiological Reviews · doi:10.1152/physrev.00034.2023 · Cited by 104 · see citing works
Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases
Xiang, Y., Song, X., & Long, D. (2024) · Archives of Toxicology · doi:10.1007/s00204-023-03660-8 · Cited by 109 · see citing works
Innate Immunity: A Common Denominator between Neurodegenerative and Neuropsychiatric Diseases
Novellino, F., Saccà, V., Donato, A., Zaffino, P., Spadea, M. F., Vismara, M. F. M., Arcidiacono, B., Malara, N., Presta, I., & Donato, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031115 · Cited by 104 · see citing works
Characteristics and roles of the volume-sensitive outwardly rectifying (VSOR) anion channel in the central nervous system
Akita, T., & Okada, Y. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.015 · Cited by 99 · see citing works
Alpha-synuclein and beta-amyloid – different targets, same players: calcium, free radicals and mitochondria in the mechanism of neurodegeneration
Angelova, P. R., & Abramov, A. Y. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.07.103 · Cited by 98 · see citing works
The role of autophagy in pro‐inflammatory responses of microglia activation via mitochondrial reactive oxygen species in vitro
Ye, J., Jiang, Z., Chen, X., Liu, M., Li, J., & Liu, N. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14042 · Cited by 92 · see citing works
NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease
Boonpraman, N., Yoon, S., Kim, C. Y., Moon, J., & Yi, S. S. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102698 · Cited by 94 · see citing works
Unlocking the power of NOX2: A comprehensive review on its role in immune regulation
Bode, K., Hauri-Hohl, M. M., Jaquet, V., & Weyd, H. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102795 · Cited by 94 · see citing works
Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation
Mossakowski, A. A., Pohlan, J., Bremer, D., Lindquist, R. L., Millward, J. M., Bock, M., Pollok, K., Mothes, R., Viohl, L., Radbruch, M., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1497-x · Cited by 93 · see citing works
The Plasma Membrane: A Platform for Intra- and Intercellular Redox Signaling
Nordzieke, D. E., & Medraño-Fernandez, I. (2018) · Antioxidants · doi:10.3390/antiox7110168 · Cited by 90 · see citing works
Actin filaments—A target for redox regulation
Wilson, C., Terman, J. R., González-Billault, C. E., & Ahmed, G. (2016) · Cytoskeleton · doi:10.1002/cm.21315 · Cited by 90 · see citing works
Neuroprotection by glucose‐6‐phosphate dehydrogenase and the pentose phosphate pathway
Tang, B. L. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29004 · Cited by 89 · see citing works
Reactive oxygen species in status epilepticus
Shekh‐Ahmad, T., Kovac, S., Abramov, A. Y., & Walker, M. C. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.07.011 · Cited by 89 · see citing works
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Dhakal, S., Kushairi, N., Phan, C., Adhikari, B., Sabaratnam, V., & Macreadie, I. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205090 · Cited by 89 · see citing works
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Bórquez, D. A., Urrutia, P. J., Wilson, C., van Zundert, B., Núñez, M. T., & González-Billault, C. E. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13581 · Cited by 86 · see citing works
Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer’s disease
Gameiro‐Ros, I., Michalska, P., Tenti, G., Cores, Á., Buendía, I., Rojo, A. I., Georgakopoulos, N., Hernández-Guijo, J. M., Ramos, M. T., Wells, G., et al. (2017) · Scientific Reports · doi:10.1038/srep45701 · Cited by 82 · see citing works
The impact of glutathione metabolism in autism spectrum disorder
Bjørklund, G., Doşa, M. D., Maes, M. H. J., Dadar, M., Frye, R. E., Peana, M., & Chirumbolo, S. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105437 · Cited by 77 · see citing works
Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration
Chen, S.-H., Oyarzabal, E. A., & Hong, J.-S. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.10.001 · Cited by 76 · see citing works
Redox‐based therapeutics in neurodegenerative disease
McBean, G. J., López, M. G., & Wallner, F. K. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13551 · Cited by 75 · see citing works
The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease
Narciso, L., Parlanti, E., Racaniello, M., Simonelli, V., Cardinale, A., Merlo, D., & Dogliotti, E. (2016) · Neural Plasticity · doi:10.1155/2016/3619274 · Cited by 75 · see citing works
How Oxidative Stress Induces Depression?
Ji, N., Lei, M., Chen, Y., Tian, S., Li, C., & Zhang, B. (2023) · ASN NEURO · doi:10.1177/17590914231181037 · Cited by 82 · see citing works
What has passed is prolog: new cellular and physiological roles of G6PD
Yang, H., Wu, Y.-H., Liu, H.-Y., Stern, A., & Chiu, D. T.-Y. (2016) · Free Radical Research · doi:10.1080/10715762.2016.1223296 · Cited by 74 · see citing works
Mechanisms Underlying Interferon-γ-Induced Priming of Microglial Reactive Oxygen Species Production
Spencer, N. G., Schilling, T., Miralles, F., & Eder, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162497 · Cited by 72 · see citing works
Contribution of NADPH-oxidase to the establishment of hippocampal neuronal polarity in culture
Wilson, C., Núñez, M. T., & González-Billault, C. E. (2015) · Journal of Cell Science · doi:10.1242/jcs.168567 · Cited by 70 · see citing works
Sodium butyrate inhibits high cholesterol-induced neuronal amyloidogenesis by modulating NRF2 stabilization-mediated ROS levels: involvement of NOX2 and SOD1
Kim, S. Y., Chae, C. W., Lee, H. J., Jung, Y. H., Choi, G. E., Kim, J. S., Lim, J. R., Lee, J., Cho, J. H., Park, H., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2663-1 · Cited by 68 · see citing works
The Neurobiology of Bipolar Disorder: An Integrated Approach
Muneer, A. (2016) · Chonnam Medical Journal · doi:10.4068/cmj.2016.52.1.18 · Cited by 68 · see citing works
Reactive Oxygen Species: Angels and Demons in the Life of a Neuron
Biswas, K., Alexander, K. D., & Francis, M. M. (2022) · NeuroSci · doi:10.3390/neurosci3010011 · Cited by 69 · see citing works
Superoxide Radical Dismutation as New Therapeutic Strategy in Parkinson’s Disease
Lazzari, F. D., Bubacco, L., Whitworth, A. J., & Bisaglia, M. (2018) · Aging and Disease · doi:10.14336/ad.2017.1018 · Cited by 66 · see citing works
The role of NADPH oxidases in neuronal development
Terzi, A., & Suter, D. M. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.04.027 · Cited by 65 · see citing works
Reactive Oxygen Species in the Regulation of the GABA Mediated Inhibitory Neurotransmission
González, A. N. B., Pazos, M. I. L., & Calvo, D. J. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.05.064 · Cited by 65 · see citing works
TSPO Finds NOX2 in Microglia for Redox Homeostasis
Guilarte, T. R., Loth, M. K., & Guariglia, S. R. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.02.008 · Cited by 65 · see citing works
Activation of neuronal NADPH oxidase NOX2 promotes inflammatory neurodegeneration
Tu, D., Velagapudi, R., Gao, Y., Hong, J., Zhou, H., & Gao, H. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.03.001 · Cited by 64 · see citing works
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Sorce, S., Nuvolone, M., Keller, A., Falsig, J., Varol, A., Schwarz, P., Bieri, M., Budka, H., & Aguzzi, A. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004531 · Cited by 62 · see citing works
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Li, X., & Jiang, L. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0270-1 · Cited by 62 · see citing works
Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia
Siddiqui, T. A., Lively, S. S., & Schlichter, L. C. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0531-9 · Cited by 59 · see citing works
Involvement of NADPH oxidases in alkali burn-induced corneal injury
GU, X.-J., Liu, X., Chen, Y., Zhao, Y., Xu, M., Han, X., Liu, Q., Yi, J., & Li, J. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2594 · Cited by 59 · see citing works
Reactive oxygen species (ROS) generation is stimulated by κ opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation
Schattauer, S. S., Bedini, A., Summers, F., Reilly-Treat, A., Andrews, M. M., Land, B. B., & Chavkin, C. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009592 · Cited by 58 · see citing works
Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis
Seredenina, T. S., Nayernia, Z., Sorce, S., Maghzal, G. J., Филиппова, А., Ling, S., Basset, O., Plastre, O., Daali, Y., Rushing, E. J., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.05.016 · Cited by 58 · see citing works
Redox Signaling Mechanisms in Nervous System Development
Olguín‐Albuerne, M., & Morán, J. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7284 · Cited by 58 · see citing works
Oxidative stress and DNA damage in the mechanism of fetal alcohol spectrum disorders
Bhatia, S., Drake, D. M., Miller, L., & Wells, P. G. (2019) · Birth Defects Research · doi:10.1002/bdr2.1509 · Cited by 57 · see citing works
The role of reactive oxygen species in angiogenesis and preventing tissue injury after brain ischemia
Yang, J. (2018) · Microvascular Research · doi:10.1016/j.mvr.2018.12.005 · Cited by 57 · see citing works
Oxidative stress response and NRF2 signaling pathway in autism spectrum disorder
Davinelli, S., Medoro, A., Siracusano, M., Savino, R., Saso, L., Scapagnini, G., & Mazzone, L. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103661 · Cited by 56 · see citing works
Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors
Cifuentes-Pagano, E., Meijles, D. N., & Pagano, P. J. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666151029112013 · Cited by 55 · see citing works
NADPH Oxidases: Redox Regulators of Stem Cell Fate and Function
Maraldi, T., Angeloni, C., Prata, C., & Hrelia, S. (2021) · Antioxidants · doi:10.3390/antiox10060973 · Cited by 55 · see citing works
Ginsenoside Rg1 ameliorates aging‑induced liver fibrosis by inhibiting the NOX4/NLRP3 inflammasome in SAMP8 mice
Li, Y., Zhang, D., Li, L., Han, Y., Dong, X., Liu, Y., Li, X., Li, W., & Li, W. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12441 · Cited by 53 · see citing works
The TRPM2 channel nexus from oxidative damage to Alzheimer’s pathologies: An emerging novel intervention target for age-related dementia
Jiang, L., Li, X., Mortadza, S. A. S., Lovatt, M., & Yang, W. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.002 · Cited by 53 · see citing works
Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species
Campos, P. B., Paulsen, B. S., & Rehen, S. K. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00292 · Cited by 52 · see citing works
Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
Schattauer, S. S., Land, B. B., Reichard, K. L., Abraham, A. D., Burgeno, L. M., Kuhar, J. R., Phillips, P. E. M., Ong, S. E., & Chavkin, C. (2017) · Nature Communications · doi:10.1038/s41467-017-00791-2 · Cited by 51 · see citing works
Nox, Nox, Are You There? The Role of NADPH Oxidases in the Peripheral Nervous System
Eid, S., Savelieff, M. G., Eid, A. A., & Feldman, E. L. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0135 · Cited by 50 · see citing works
PERK pathway is involved in oxygen-glucose-serum deprivation-induced NF-kB activation via ROS generation in spinal cord astrocytes
Liu, J., & Du, L. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.10.007 · Cited by 49 · see citing works
ROS regulation of axonal mitochondrial transport is mediated by Ca2+ and JNK in Drosophila
Liao, P., Tandarich, L. C., & Hollenbeck, P. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178105 · Cited by 49 · see citing works
Lung Ischaemia–Reperfusion Injury: The Role of Reactive Oxygen Species
Pak, O., Sydykov, A. S., Kosanovic, D., SCHERMULY, R. T., Dietrich, A., Schröder, K., Brandes, R. P., Gudermann, T. W., Sommer, N., & Weißmann, N. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-63245-2_12 · Cited by 51 · see citing works
Brightness and shadows of mitochondrial ROS in the brain
Jiménez-Blasco, D., Almeida, Á., & Bolaños, J. P. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106199 · Cited by 48 · see citing works

NADPH Oxidases in the Central Nervous System: Regional and Cellular Localization and the Possible Link to Brain Diseases
Fang, J., Sheng, R., & Qin, Z. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0040 · Cited by 39 · see citing works
NOX Enzymes in the Central Nervous System: From Signaling to Disease
Sorce, S., & Krause, K. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2578 · Cited by 472 · see citing works
Targeting NOX enzymes in the central nervous system: therapeutic opportunities
Sorce, S., Krause, K., & Jaquet, V. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1014-5 · Cited by 78 · see citing works
NADPH Oxidases in Neurodegenerative Disorders: Mechanisms and Therapeutic Opportunities
Fiadeiro, M. B., Diogo, J. C., Silva, A., Kim, Y., & Cristóvão, A. C. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0002 · Cited by 24 · see citing works
NADPH Oxidase: A Potential Target for Treatment of Stroke
Zhang, L., Wu, J., Duan, X., Tian, X., Shen, H., Sun, Q., & Chen, G. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5026984 · Cited by 67 · see citing works

Authors: Nayernia, Z., Jaquet, V., & Krause, K.-H.
Affiliations: University of Geneva (CH)
Corresponding author: Krause, Karl-Heinz
ORCID: Jaquet, Vincent
Krause, Karl-Heinz
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2014-06
Volume: 20
Issue: 17
Pages: 2815-2837
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2013.5703
PMC: PMC4026375
OpenAlex: W2061260053
Cited by: 279
References: 194
Citations by year: 2026: 13 · 2025: 17 · 2024: 18 · 2023: 19 · 2022: 21 · 2021: 24 · 2020: 31 · 2019: 20 · 2018: 23 · 2017: 30 · 2016: 34 · 2015: 18 · 2014: 9 · 2012: 1
FWCI: 1.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Antioxidants and Redox Signaling (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (FP7/2007-2013)
European Commission (278611)
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (FP7/2007-2013, 141182, 310030B)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: NADPH oxidase, reactive oxygen species, central nervous system, oxidative stress, NOX2, NOX4, microglia, neurons, astrocytes, neurovascular system, neurodegenerative diseases, cerebrovascular disease, psychosis, stroke, redox signaling, NOX inhibitors
MeSH terms: Animals, Central Nervous System, Enzyme Inhibitors, Humans, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, NADPH Oxidases, Neurodegenerative Diseases, Mice

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