Cited by 86Physical Activity and HealthDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and Research

The influence of physical activity on vascular complications and mortality in patients with type 2 diabetes mellitus

Blomster, J. I., Chow, C. K., Zoungas, S., Woodward, M., Patel, A., Poulter, N. R., Marre, M., Harrap, S. +2 more·2013·Diabetes, Obesity and Metabolism

Abstract

Aims: There is limited evidence regarding the association between physical activity and vascular complications, particularly microvascular disease, in patients with type 2 diabetes. Methods: From the 11 140 patients in the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron modified release Controlled Evaluation) trial, the effect of physical activity, categorized as none, mild, moderate or vigorous, and the number of sessions within a week, was examined in multivariable regression models adjusted for potential confounders. The study end‐points were major cardiovascular events, microvascular complications and all‐cause mortality. Results: Forty‐six percent of participants reported undertaking moderate to vigorous physical activity for >15 min at least once in the previous week. During a median of 5 years of follow‐up, 1031 patients died, 1147 experienced a major cardiovascular event and 1136 a microvascular event. Compared to patients who undertook no or mild physical activity, those reporting moderate to vigorous activity had a decreased risk of cardiovascular events ( HR : 0.78, 95% CI : 0.69–0.88, p < 0.0001), microvascular events ( HR : 0.85, 95% CI : 0.76–0.96, p = 0.010) and all‐cause mortality ( HR : 0.83, 95% CI : 0.73–0.94, p = 0.0044). Conclusions: Moderate to vigorous, but not mild, physical activity is associated with a reduced incidence of cardiovascular events, microvascular complications and all‐cause mortality in patients with type 2 diabetes.

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Crossref · 10.1111/dom.12122

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Authors
Blomster, J. I., Chow, C. K., Zoungas, S., Woodward, M., Patel, A., Poulter, N. R., Marre, M., Harrap, S., Chalmers, J., & Hillis, G. S.
Affiliations
  • The University of Sydney (AU)
  • Imperial College London (GB)
  • Hôpital Bichat-Claude-Bernard (FR)
  • The Royal Melbourne Hospital (AU)
Corresponding author
Blomster, J. I.
Venue
Diabetes, Obesity and Metabolism
Publisher
Wiley
Published
2013-06-11
Volume
15
Issue
11
Pages
1008-1012
ISSN
  • 1462-8902 (ISSN-L)
  • 1463-1326
OpenAlex
W2006992645
Cited by
86
References
24
Citations by year
2026: 3 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 8 · 2017: 4 · 2016: 9 · 2015: 6 · 2014: 7
FWCI
5.09
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Obesity and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
physical activity, type 2 diabetes, vascular complications, microvascular complications, cardiovascular events, all-cause mortality, moderate-to-vigorous physical activity, ADVANCE trial
MeSH terms
Aged, Cardiovascular Diseases, Combined Modality Therapy, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Female, Follow-Up Studies, Humans, Hypoglycemic Agents, Male, Microcirculation, Middle Aged, Mortality, Motor Activity, Risk, Severity of Illness Index, Vascular Diseases, Cohort Studies, Exercise, Incidence, Proportional Hazards Models, Sedentary Behavior

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