Physical activity and the 15-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye study
Open accessAbstract
BACKGROUND: Cardiovascular disease and age-related macular degeneration (AMD) may share common risk factors. Physical activity improves the cardiovascular risk profile; however, there have been few studies investigating a relationship between physical activity and the long-term incidence of AMD. METHODS: The 15-year cumulative incidence of AMD was determined through four examination phases at 5-year intervals of a population-based study conducted in Beaver Dam, Wisconsin, USA, initiated in 1988-90 (n = 3874 men and women between ages 43 and 86 years). Early AMD (pigment abnormalities or soft indistinct drusen), exudative AMD and geographic atrophy were determined by grading stereoscopic colour fundus photographs. Measures of physical activity were obtained through a questionnaire administered at the baseline examination. RESULTS: After controlling for age, sex, history of arthritis, systolic blood pressure, body mass index, smoking and education, people with an active lifestyle (defined as regular activity > or =3 times/week) at baseline were less likely to develop exudative AMD (odds ratio (OR) 0.3, 95% confidence interval (CI) 0.1 to 0.7) compared with people without an active lifestyle. After multivariate adjustment, increased categories of number of blocks walked per day decreased the risk of exudative AMD (OR 0.7, 95% CI 0.6 to 0.97). Physical activity was not related to the incidence of early AMD or pure geographic atrophy. CONCLUSIONS: These data show a protective effect of physical activity for incident exudative AMD, independent of body mass index and other confounders. They also suggest a possible modifiable behaviour that might be protective against developing AMD.
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PA has been shown to be protective against development of age-related macular degeneration, but very little research exists in type 2 diabetes.
“While PA has been shown to be protective against development of age-related macular degeneration ( 150 ), very little research exists in type 2 diabetes.”
From Exercise and Type 2 Diabetes (2010) · cites this paper as [150]
The Results and Discussion (page not provided) report that physical activity was associated with a lower incidence of exudative AMD over 15 years. They found no independent association with early AMD or pure geographic atrophy, so the unqualified claim that PA protects against development of AMD is broader than the finding. The type 2 diabetes clause is not attributed to this citation. (LLM, conf=0.88)
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A Study of Correlates of Age-Related Macular Degeneration in Patients Attending a Tertiary Hospital
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The effects of physical activity on pediatric eyes: A systematic review and meta-analysis
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Dégénérescence maculaire liée à l’âge et risque d’accident vasculaire cérébral
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Eye and its health from the viewpoint of Traditional Iranian Medicine
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Lifestyle and age-related macular degeneration
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An Unexpected Role for GPR143 in Retinal HomeostasisPreprint
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Atividade física e qualidade de vida em adultos mais velhos em Copacabana
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- Authors
- Knudtson, M. D., Klein, R., & Klein, B. E. K.
- Affiliations
- Wisconsin Alumni Research Foundation (US)
- Corresponding author
- Knudtson, M D
- Venue
- British Journal of Ophthalmology
- Publisher
- BMJ
- Published
- 2006-08-17
- Volume
- 90
- Issue
- 12
- Pages
- 1461-1463
- ISSN
- 0007-1161 (ISSN-L)
- PMC
- PMC1857544
- OpenAlex
- W2117164797
- Cited by
- 115
- References
- 13
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 8
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Ophthalmology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Research to Prevent Blindness (EY06594)
- National Institutes of Health (EY 06594)
- National Eye Institute (EY0-6594, U10EY006594)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- physical activity, age-related macular degeneration, exudative AMD, geographic atrophy, early AMD, cumulative incidence, walking, cardiovascular risk factors, Beaver Dam Eye Study, modifiable risk factors
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Life Style, Macular Degeneration, Male, Middle Aged, Motor Activity, Risk Factors, Wisconsin, Exercise, Incidence, Walking
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