Circadian Clocks Are Resounding in Peripheral Tissues
Open accessAbstract
Circadian rhythms are prevalent in most organisms. Even the smallest disturbances in the orchestration of circadian gene expression patterns among different tissues can result in functional asynchrony, at the organism level, and may to contribute to a wide range of physiologic disorders. It has been reported that as many as 5%-10% of transcribed genes in peripheral tissues follow a circadian expression pattern. We have conducted a comprehensive study of circadian gene expression on a large dataset representing three different peripheral tissues. The data have been produced in a large-scale microarray experiment covering replicate daily cycles in murine white and brown adipose tissues as well as in liver. We have applied three alternative algorithmic approaches to identify circadian oscillation in time series expression profiles. Analyses of our own data indicate that the expression of at least 7% to 21% of active genes in mouse liver, and in white and brown adipose tissues follow a daily oscillatory pattern. Indeed, analysis of data from other laboratories suggests that the percentage of genes with an oscillatory pattern may approach 50% in the liver. For the rest of the genes, oscillation appears to be obscured by stochastic noise. Our phase classification and computer simulation studies based on multiple datasets indicate no detectable boundary between oscillating and non-oscillating fractions of genes. We conclude that greater attention should be given to the potential influence of circadian mechanisms on any biological pathway related to metabolism and obesity.
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Food consumption patterns have changed markedly over the past decades: more meals are skipped, consumed outside the family context, on-the-go, later in the day and more irregularly.
“This is reflected in food consumption patterns, which have changed markedly over the past decades: more meals are skipped, consumed outside the family context, on-the-go, later in the day and more irregularly (1,2) .”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [2]
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- Authors
- Ptitsyn, A. A., Zvonic, S., Conrad, S. A., Scott, L. K., Mynatt, R. L., & Gimble, J. M.
- Affiliations
- Pennington Biomedical Research Center (US)
- Louisiana State University Health Sciences Center Shreveport (US)
- Corresponding author
- Gimble, Jeffrey M
- Venue
- PLoS Computational Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2006-03-10
- Volume
- 2
- Issue
- 3
- Pages
- e16
- ISSN
- 1553-734X (ISSN-L)
- 1553-7358
- PMC
- PMC1391918
- OpenAlex
- W2037122954
- Cited by
- 145
- References
- 25
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 22 · 2019: 3 · 2018: 3 · 2017: 7 · 2016: 4 · 2015: 8 · 2014: 9 · 2013: 9 · 2012: 11
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Computational Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian rhythm, circadian gene expression, peripheral tissues, white adipose tissue, brown adipose tissue, liver, temporal gene expression, stochastic noise, phase classification, metabolism, obesity, mice
- MeSH terms
- Adipose Tissue, Algorithms, Animals, Circadian Rhythm, Gene Expression Regulation, Liver, Obesity, Oscillometry, Stochastic Processes, Transcription, Genetic, Models, Statistical, Computational Biology, Oligonucleotide Array Sequence Analysis, Mice
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