Cited by 323Nerve injury and regenerationPhysical Activity and HealthExercise and Physiological Responses

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The effect of acute exercise on blood concentrations of brain-derived neurotrophic factor in healthy adults. A meta-analysis.

Dinoff, Adam, Herrmann, Nathan, Swardfager, Walter, Lanctôt, Krista L.·2017·European Journal of Neuroscience

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Abstract

It has been hypothesized that one mechanism through which physical activity provides benefits to cognition and mood is via increasing brain‐derived neurotrophic factor (BDNF) concentrations. Some studies have reported immediate benefits to mood and various cognitive domains after a single session of exercise. This meta‐analysis sought to determine the effect of a single exercise session on concentrations of BDNF in peripheral blood, in order to evaluate the potential role of BDNF in mediating the beneficial effects of exercise on brain health. MEDLINE, Embase, PsycINFO, SPORTDiscus, Rehabilitation & Sports Medicine Source, and CINAHL databases were searched for original, peer‐reviewed reports of peripheral blood BDNF concentrations before and after acute exercise interventions. Risk of bias within studies was assessed using standardized criteria. Standardized mean differences (SMD s) were generated from random effects models. Risk of publication bias was assessed using a funnel plot and Egger's test. Potential sources of heterogeneity were explored in subgroup analyses. In 55 studies that met inclusion criteria, concentrations of peripheral blood BDNF were higher after exercise (SMD = 0.59, 95% CI: 0.46–0.72, P < 0.001). In meta‐regression analysis, greater duration of exercise was associated with greater increases in BDNF. Subgroup analyses revealed an effect in males but not in females, and a greater BDNF increase in plasma than serum. Acute exercise increased BDNF concentrations in the peripheral blood of healthy adults. This effect was influenced by exercise duration and may be different across genders.

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Authors: Dinoff, A., Herrmann, N., Swardfager, W., & Lanctôt, K. L.
Affiliations: University of Toronto (CA)
Corresponding author: Lanctôt, Krista L.
ORCID: Herrmann, Nathan
Swardfager, Walter
Lanctôt, Krista L.
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 2017-06-19
Volume: 46
Issue: 1
Pages: 1635-1646
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1111/ejn.13603
OpenAlex: W2612535417
Cited by: 323
References: 151
Citations by year: 2026: 27 · 2025: 44 · 2024: 43 · 2023: 28 · 2022: 39 · 2021: 45 · 2020: 36 · 2019: 28 · 2018: 27 · 2017: 6
FWCI: 3.26
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: acute exercise, brain-derived neurotrophic factor, exercise duration, sex differences, exercise and cognition, exercise and mood, healthy adults
MeSH terms: Humans, Exercise, Brain-Derived Neurotrophic Factor

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The effect of acute exercise on blood concentrations of brain-derived neurotrophic factor in healthy adults. A meta-analysis.

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