A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor

Szuhany, Kristin L.; Bugatti, Matteo; Otto, Michael W.

doi:10.1016/j.jpsychires.2014.10.003

Cited by 909Nerve injury and regenerationPhysical Activity and HealthExercise and Physiological Responses

A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor

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Szuhany, Kristin L., Bugatti, Matteo, Otto, Michael W.·2015·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2014.10.003PMC PMC4314337

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Abstract

Consistent evidence indicates that exercise improves cognition and mood, with preliminary evidence suggesting that brain-derived neurotrophic factor (BDNF) may mediate these effects. The aim of the current meta-analysis was to provide an estimate of the strength of the association between exercise and increased BDNF levels in humans across multiple exercise paradigms. We conducted a meta-analysis of 29 studies (N = 1111 participants) examining the effect of exercise on BDNF levels in three exercise paradigms: (1) a single session of exercise, (2) a session of exercise following a program of regular exercise, and (3) resting BDNF levels following a program of regular exercise. Moderators of this effect were also examined. Results demonstrated a moderate effect size for increases in BDNF following a single session of exercise (Hedges' g = 0.46, p < 0.001). Further, regular exercise intensified the effect of a session of exercise on BDNF levels (Hedges' g = 0.59, p = 0.02). Finally, results indicated a small effect of regular exercise on resting BDNF levels (Hedges' g = 0.27, p = 0.005). When analyzing results across paradigms, sex significantly moderated the effect of exercise on BDNF levels, such that studies with more women showed less BDNF change resulting from exercise. Effect size analysis supports the role of exercise as a strategy for enhancing BDNF activity in humans, but indicates that the magnitude of these effects may be lower in females relative to males.

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An acute bout of aerobic exercise transiently increases both serum and plasma BDNF in an intensity-dependent manner.
“It has repeatedly been demonstrated that an acute bout of aerobic exercise transiently increases both serum and plasma BDNF in an intensity-dependent manner [10,11].”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [11]
The Results section (“Effect of Acute Exercise on BDNF Levels”; page unavailable) reports a moderate increase in BDNF after a single exercise session. The moderators analysis includes serum and plasma measurements, but the paper does not establish that the increase depends on exercise intensity. Its measurements extend only to 60 minutes after exercise, so they do not establish when the increase subsides. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Physical exercise is one particularly effective strategy for increasing circulating levels of BDNF and improving brain function.
“Physical exercise is one particularly effective strategy for increasing circulating levels of BDNF [10,11] and improving brain function [12,13,14].”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [11]
Regular exercise in moderate amounts increases the magnitude of BDNF expression following individual sessions of exercise.
“Furthermore, regular exercise in moderate amounts has been shown to increase the magnitude of BDNF expression following individual sessions of exercise (Szuhany et al., 2015).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Szuhany et al., 2015
Considerable evidence from the meta-analysis suggests that humans experience a dose-response relationship in which each session of exercise corresponds to a dose of increased BDNF expression.
“Interestingly, considerable evidence from this meta-analysis suggests that humans also experience a dose-response relationship in which each session of exercise corresponds to a dose of increased BDNF expression.”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Szuhany et al., 2015
A meta-analysis of 29 studies spanning 1,111 human participants analyzed BDNF expression levels across various exercise paradigms.
“Consistent with these findings is a meta-analysis of 29 studies spanning 1,111 human participants that analyzed BDNF expression levels across various exercise paradigms.”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Szuhany et al., 2015

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Hyun-Chul, C., Kim, J., Kim, S.-Y., Son, Y. H., Lee, N., & Jung, S. H. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.05.025 · Cited by 128 · see citing works
No exercise-induced increase in serum BDNF after cycling near a major traffic road
Bos, I., Jacobs, L., Nawrot, T. S., de Geus, B., Torfs, R., Panis, L. I., Degraeuwe, B., & MEEUSEN, R. R. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.06.019 · Cited by 124 · see citing works
Training in MS: influence of two different endurance training protocols (aquatic versus overland) on cytokine and neurotrophin concentrations during three week randomized controlled trial
Bansi, J., Bloch, W., Gamper, U. N., & Kesselring, J. (2012) · Multiple Sclerosis Journal · doi:10.1177/1352458512458605 · Cited by 122 · see citing works
The acute response of plasma brain-derived neurotrophic factor as a result of exercise in major depressive disorder.
Gustafsson, G., Lira, C. M., Johansson, J., Wisén, A., Wohlfart, B., Ekman, R., & Westrin, Å. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.06.030 · Cited by 118 · see citing works
Interaction between serum BDNF and aerobic fitness predicts recognition memory in healthy young adults
Whiteman, A., Young, D. E., He, X., Chen, T. C., WAGENAAR, R. C., Stern, C. E., & Schön, K. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.11.023 · Cited by 104 · see citing works
Exercising our brains: how physical activity impacts synaptic plasticity in the dentate gyrus.
Christie, B. R., Eadie, B. D., Kannangara, T. S., Robillard, J. M., Shin, J., & Titterness, A. K. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8033-2 · Cited by 99 · see citing works
Kinetics of serum brain-derived neurotrophic factor following low-intensity versus high-intensity exercise in men and women
Schmidt‐Kassow, M., Schädle, S., Otterbein, S., Thiel, C., Doehring, A., Lötsch, J., & Kaiser, J. (2012) · Neuroreport · doi:10.1097/wnr.0b013e32835946ca · Cited by 94 · see citing works
Comment: Assumptions and Procedures in the File Drawer Problem
Rosenthal, R., & Rubin, D. (1988) · Statistical Science · doi:10.1214/ss/1177013014 · Cited by 93 · see citing works
Acute Exercise Modulates BDNF and pro-BDNF Protein Content in Immune Cells
BRUNELLI, A., Dimauro, I., Sgrò, P., Emerenziani, G. P., Magi, F., Baldari, C., Guidetti, L., Luigi, L. D., Parisi, P., & Caporossi, D. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31825ab69b · Cited by 86 · see citing works
Effects of serum brain derived neurotrophic factor on exercise augmentation treatment of depression.
Toups, M. S. P., Greer, T. L., Kurian, B. T., Grannemann, B. D., Carmody, T. J., Huebinger, R., Rethorst, C., & Trivedi, M. H. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.05.002 · Cited by 85 · cited 2× · see citing works
“Of these studies, three examined the effect of acute exercise (Gustafsson et al., 2009; Laske et al., 2010; Strohle et al., 2010), whereas one (targeting depression) examined the effect of programmed exercise on resting BDNF levels (Toups et al., 2011).”
Background
Acute strength exercise and the involvement of small or large muscle mass on plasma brain-derived neurotrophic factor levels
Correia, P. R., Pansani, A. P., Machado, F., Andrade, M. S., da Silva, A. C., Scorza, F. A., Cavalheiro, É. A., & Arida, R. M. (2010) · Clinics · doi:10.1590/s1807-59322010001100012 · Cited by 79 · see citing works
Age-specific effects of voluntary exercise on memory and the older brain
Siette, J., Westbrook, R. F., Cotman, C., Sidhu, K., Zhu, W., Sachdev, P., & Valenzuela, M. J. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.034 · Cited by 78 · see citing works
Subclinical Effects of Aerobic Training in Urban Environment
Bos, I., Boever, P. D., Vanparijs, J., Pattyn, N., Panis, L. I., & MEEUSEN, R. R. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31827767fc · Cited by 64 · see citing works
The Effect of Exercise Training Modality on Serum Brain Derived Neurotrophic Factor Levels in Individuals with Type 2 Diabetes
Swift, D. L., Johannsen, N. M., Myers, V. H., Earnest, C. P., Smits, J. A. J., Blair, S. N., & Church, T. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042785 · Cited by 63 · see citing works
No Influence of Noradrenaline Manipulation on Acute Exercise-Induced Increase of Brain-Derived Neurotrophic Factor
Goekint, M., Heyman, E., Roelands, B., Njemini, R., Bautmans, I., Mets, T. F., & MEEUSEN, R. R. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31817eee85 · Cited by 62 · see citing works
Responses of serum neurotrophic factors to exercise in pregnant and postpartum women
Vega, S. R., Kleinert, J., Sulprizio, M., Hollmann, W., Bloch, W., & Strüder, H. K. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.07.012 · Cited by 51 · see citing works
Use it and boost it with physical and mental activity.
Korol, D. L., Gold, P. E., & Scavuzzo, C. J. (2013) · Hippocampus · doi:10.1002/hipo.22197 · Cited by 45 · see citing works
Regular treadmill exercise prevents sleep deprivation-induced disruption of synaptic plasticity and associated signaling cascade in the dentate gyrus
Zagaar, M. A., Dao, A. T., Alhaider, I. A., & Alkadhi, K. A. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.07.011 · Cited by 45 · see citing works
Plasma brain‐derived neurotrophic factor in prepubertal obese children: results from a 2‐year lifestyle intervention programme
Corripio, R., González-Clemente, J. M., Pérez, J., Näf, S., Gallart, L., Joan, V., & Caixàs, A. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04431.x · Cited by 37 · see citing works
Effect of Exercise on Circulating Levels of Brain-derived Neurotrophic Factor (BDNF) in Overweight and Obese Subjects
Araya, A., Orellana, X., Godoy, D., Soto, L., & Fiedler, J. L. (2013) · Hormone and Metabolic Research · doi:10.1055/s-0032-1333237 · Cited by 36 · see citing works
The aging hippocampus: Interactions between exercise, depression, and BDNF
Erickson, K., Miller, D., & Roecklein, K. (2012) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 35 · see citing works
BDNF concentrations are decreased in serum and parietal cortex in immunotoxin 192 IgG-Saporin rat model of cholinergic degeneration
Angelucci, F., Gelfo, F., Bartolo, P. D., Caltagirone, C., & Petrosini, L. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.04.010 · Cited by 32 · see citing works
What men should know about the impact of physical activity on their health
Alford, L. (2010) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2010.02478.x · Cited by 23 · see citing works

Flagged first, then by citations

2 of the 96 references couldn’t be matched to a known paper.

Sorted by citations

Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies
Schuch, F. B., Vancampfort, D., Firth, J., Rosenbaum, S., Ward, P. B., Silva, E. S., Hallgren, M., Ponce De Leon, A., Dunn, A. L., Deslandes, A. C., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17111194 · Cited by 1,763 · see citing works
Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain
Miranda, M., Morici, J. F., Zanoni, M. B., & Bekinschtein, P. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00363 · Cited by 1,416 · see citing works
Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer
Colucci-D’Amato, L., Speranza, L., & Volpicelli, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207777 · Cited by 991 · see citing works
Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders
Malhi, G. S., Bassett, D., Boyce, P., Bryant, R., Fitzgerald, P. B., Fritz, K., Hopwood, M., Lyndon, B., Mulder, R., Murray, G., et al. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415617657 · Cited by 842 · see citing works
“A possible mechanism appears to involve brain-derived neurotrophic factor (BDNF) (Szuhany et al., 2015).”
Background
The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level
Barton, W., Penney, N. C., Cronin, O., Garcia-Perez, I., Molloy, M. G., Holmes, E., Shanahan, F., Cotter, P. D., & O'Sullivan, O. (2018) · Gut · doi:10.1136/gutjnl-2016-313627 · Cited by 647 · see citing works
Acute effects of moderate aerobic exercise on specific aspects of executive function in different age and fitness groups: A meta‐analysis
Ludyga, S., Gerber, M., Brand, S., Holsboer‐Trachsler, E., & Pühse, U. (2016) · Psychophysiology · doi:10.1111/psyp.12736 · Cited by 589 · see citing works
Exercise-Mediated Neurogenesis in the Hippocampus via BDNF
Liu, P. Z., & Nusslock, R. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00052 · Cited by 533 · see citing works
Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis
Firth, J., Stubbs, B., Vancampfort, D., Schuch, F., Lagopoulos, J., Rosenbaum, S., & Ward, P. B. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2017.11.007 · Cited by 526 · see citing works
Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?
Hillard, C. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.130 · Cited by 449 · see citing works
Physical activity protects from incident anxiety: A meta‐analysis of prospective cohort studies
Schuch, F. B., Stubbs, B., Meyer, J., Heissel, A., Zech, P., Vancampfort, D., Rosenbaum, S., Deenik, J., Firth, J., Ward, P. B., et al. (2019) · Depression and Anxiety · doi:10.1002/da.22915 · Cited by 427 · see citing works
Sex differences in exercise efficacy to improve cognition: a systematic review and meta-analysis of randomized controlled trials in older humans
Barha, C. K., Davis, J. C., Falck, R. S., Nagamatsu, L. S., & Liu-Ambrose, T. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.04.002 · Cited by 432 · see citing works
Neuromodulation of Aerobic Exercise—A Review
Heijnen, S., Hommel, B., Kibele, A., & Colzato, L. S. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01890 · Cited by 372 · see citing works
The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis
Dinoff, A., Herrmann, N., Swardfager, W., Liu, C. S., Sherman, C., Chan, S. W., & Lanctôt, K. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163037 · Cited by 343 · see citing works
The effect of acute exercise on blood concentrations of brain-derived neurotrophic factor in healthy adults. A meta-analysis.
Dinoff, A., Herrmann, N., Swardfager, W., & Lanctôt, K. L. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13603 · Cited by 323 · see citing works
Exercise-Induced Neuroplasticity: A Mechanistic Model and Prospects for Promoting Plasticity
El‐Sayes, J., Harasym, D., Turco, C. V., Locke, M. B., & Nelson, A. J. (2018) · The Neuroscientist · doi:10.1177/1073858418771538 · Cited by 303 · see citing works
Thinking While Moving or Moving While Thinking – Concepts of Motor-Cognitive Training for Cognitive Performance Enhancement
Herold, F., Hamacher, D., Schega, L., & Müller, N. G. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00228 · Cited by 295 · see citing works
Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions
Benedetto, S. D., Müller, L., Wenger, E., Düzel, S., & Pawelec, G. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.044 · Cited by 280 · see citing works
Special Issue – Therapeutic Benefits of Physical Activity for Mood: A Systematic Review on the Effects of Exercise Intensity, Duration, and Modality
Chan, J. S. Y., Liu, G., Liang, D., Deng, K., Wu, J., & Yan, J. H. (2018) · The Journal of Psychology · doi:10.1080/00223980.2018.1470487 · Cited by 283 · see citing works
Exercise and circulating BDNF: Mechanisms of release and implications for the design of exercise interventions
Walsh, J. J., & Tschakovsky, M. E. (2018) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2018-0192 · Cited by 256 · see citing works
6th and 7th International consensus guidelines for the management of advanced breast cancer (ABC guidelines 6 and 7)
Cardoso, F., Paluch–Shimon, S., Schumacher-Wulf, E., de Matos, L. V., Gelmon, K. A., Aapro, M., Bajpai, J., Barrios, C. H., Bergh, J. C. S., Bergsten-Nordström, E., et al. (2024) · The Breast · doi:10.1016/j.breast.2024.103756 · Cited by 260 · see citing works
Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?
Müller, P., Duderstadt, Y., Lessmann, V., & Müller, N. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041136 · Cited by 241 · see citing works
Exercise and Hippocampal Memory Systems
Voss, M. W., Soto, C., Yoo, S., Sodoma, M., Vivar, C., & van Praag, H. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.01.006 · Cited by 235 · see citing works
Dynamic Brains and the Changing Rules of Neuroplasticity: Implications for Learning and Recovery
Voss, P., Thomas, M. E., Cisneros-Franco, J. M., & de Villers‐Sidani, E. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01657 · Cited by 245 · see citing works
The Neuroprotective Effects of Exercise: Maintaining a Healthy Brain Throughout Aging
Vecchio, L. M., Meng, Y., Xhima, K., Lipsman, N., Hamani, C., & Aubert, I. (2018) · Brain Plasticity · doi:10.3233/bpl-180069 · Cited by 230 · see citing works
BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with Working Memory Function
Håkansson, K., Ledreux, A., Daffner, K. R., Terjestam, Y., Bergman, P., Carlsson, R., Kivipelto, M., Winblad, B. G., Granholm, A., & Mohammed, A. K. H. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160593 · Cited by 216 · see citing works
Obesity Reduces Cognitive and Motor Functions across the Lifespan
Wang, C., Chan, J. S. Y., Ren, L., & Yan, J. H. (2016) · Neural Plasticity · doi:10.1155/2016/2473081 · Cited by 199 · see citing works
The exercise-glucocorticoid paradox: How exercise is beneficial to cognition, mood, and the brain while increasing glucocorticoid levels
Chen, C., Nakagawa, S., An, Y., Ito, K., Kitaichi, Y., & Kusumi, I. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.001 · Cited by 191 · see citing works
The Aerobic and Cognitive Exercise Study (ACES) for Community-Dwelling Older Adults With or At-Risk for Mild Cognitive Impairment (MCI): Neuropsychological, Neurobiological and Neuroimaging Outcomes of a Randomized Clinical Trial
Anderson‐Hanley, C., Barcelos, N. M., Zimmerman, E. A., Gillen, R. W., Dunnam, M., Cohen, B. D., Yerokhin, V., Miller, K. E., Hayes, D. J., Arciero, P. J., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00076 · Cited by 188 · see citing works
Brain-derived Neurotrophic Factor in Megakaryocytes
Chacón-Fernández, P., Säuberli, K., Colzani, M., Moreau, T., Ghevaert, C., & Barde, Y.-A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.720029 · Cited by 186 · see citing works
How Does Exercise Reduce the Rate of Age-Associated Cognitive Decline? A Review of Potential Mechanisms
Kennedy, G., Hardman, R. J., Macpherson, H., Scholey, A. B., & Pipingas, A. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160665 · Cited by 187 · see citing works
The Role of BDNF in Peripheral Nerve Regeneration: Activity-Dependent Treatments and Val66Met
McGregor, C., & ENGLISH, A. W. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00522 · Cited by 176 · see citing works
Yoga- and meditation-based lifestyle intervention increases neuroplasticity and reduces severity of major depressive disorder: A randomized controlled trial
Tolahunase, M. R., Sagar, R., Faiq, M., & Dada, R. (2018) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-170810 · Cited by 167 · see citing works
Structural Neuroimaging of Anorexia Nervosa: Future Directions in the Quest for Mechanisms Underlying Dynamic Alterations
King, J. A., Frank, G., Thompson, P. M., & Ehrlich, S. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.011 · Cited by 164 · see citing works
Examining the impact of physical activity on sleep quality and executive functions in children with autism spectrum disorder: A randomized controlled trial
Tse, A. C. Y., Lee, P. H., Chan, K. K. S., Edgar, V. B., Wilkinson-Smith, A., & Lai, W. H. E. (2019) · Autism · doi:10.1177/1362361318823910 · Cited by 164 · see citing works
Towards an understanding of the physical activity-BDNF-cognition triumvirate: A review of associations and dosage
Walsh, E., Smith, L. M., Northey, J. M., Rattray, B., & Cherbuin, N. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101044 · Cited by 163 · see citing works
Exercise as a buffer against difficulties with emotion regulation: A pathway to emotional wellbeing
Bernstein, E. E., & McNally, R. J. (2018) · Behaviour Research and Therapy · doi:10.1016/j.brat.2018.07.010 · Cited by 167 · see citing works
Roles of myokines in exercise-induced improvement of neuropsychiatric function
Kim, S., Choi, J., Moon, S., Park, D., Kwak, H., & Kang, J. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-019-02253-8 · Cited by 168 · see citing works
Effects of Exercise Interventions and Physical Activity Behavior on Cancer Related Cognitive Impairments: A Systematic Review
Zimmer, P., Baumann, F. T., Oberste, M., Wright, P., Garthe, A., Schenk, A., Elter, T., Galvao, D. A., Bloch, W., Hübner, S. T., et al. (2016) · BioMed Research International · doi:10.1155/2016/1820954 · Cited by 156 · see citing works
Measuring and Validating the Levels of Brain-Derived Neurotrophic Factor in Human Serum
Naegelin, Y., Dingsdale, H., Säuberli, K., Schädelin, S., Kappos, L., & Barde, Y. (2018) · eNeuro · doi:10.1523/eneuro.0419-17.2018 · Cited by 155 · see citing works
Physical activity for cognitive health promotion: An overview of the underlying neurobiological mechanisms
Chen, C., & Nakagawa, S. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101868 · Cited by 156 · see citing works
Aerobic Exercise: Evidence for a Direct Brain Effect to Slow Parkinson Disease Progression
Ahlskog, J. E. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.12.015 · Cited by 145 · see citing works
Blood Brain-Derived Neurotrophic Factor (BDNF) and Major Depression: Do We Have a Translational Perspective?
Arosio, B., Guerini, F. R., Voshaar, R. C. O., & Aprahamian, I. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.626906 · Cited by 151 · see citing works
Effects of physical exercise on plasma brain-derived neurotrophic factor in neurodegenerative disorders: A systematic review and meta-analysis of randomized controlled trials
Ruiz‐González, D., Hernández‐Martínez, A., Valenzuela, P. L., Morales, J. S., & Soriano‐Maldonado, A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.025 · Cited by 144 · see citing works
Effects of Exercise on Cognitive Performance in Children and Adolescents with ADHD: Potential Mechanisms and Evidence-based Recommendations
Christiansen, L., Beck, M. M., Bilenberg, N., Wienecke, J., Astrup, A. V., & Lundbye‐Jensen, J. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060841 · Cited by 148 · see citing works
Physical Exercise Enhances Neuroplasticity and Delays Alzheimer’s Disease
Lin, T.-W., Tsai, S., & Kuo, Y. (2018) · Brain Plasticity · doi:10.3233/bpl-180073 · Cited by 146 · see citing works
Physical Exercise for Treatment of Mood Disorders: A Critical Review
Hearing, C. M., Chang, W. C., Szuhany, K. L., Deckersbach, T., Nierenberg, A. A., & Sylvia, L. G. (2016) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-016-0089-y · Cited by 137 · see citing works
Self-citation
Joggin’ the Noggin: Towards a Physiological Understanding of Exercise-Induced Cognitive Benefits
Stimpson, N. J., Davison, G., & Javadi, A.-H. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.018 · Cited by 134 · see citing works
Exercise-induced increase in brain-derived neurotrophic factor in human Parkinson's disease: a systematic review and meta-analysis
Hirsch, M. A., van Wegen, E. E. H., Newman, M. A., & Heyn, P. C. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0112-1 · Cited by 134 · see citing works
Depression and Objectively Measured Physical Activity: A Systematic Review and Meta-Analysis
Gianfredi, V., Blandi, L., Cacitti, S., Minelli, M., Signorelli, C., Amerio, A., & Odone, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17103738 · Cited by 134 · see citing works
The T herapeutic P otential of E xercise to I mprove M ood, C ognition, and S l eep in P arkinson's D isease
Reynolds, G., Otto, M. W., Ellis, T. D., & Cronin‐Golomb, A. (2015) · Movement Disorders · doi:10.1002/mds.26484 · Cited by 132 · see citing works
Self-citation
BDNF Impact on Biological Markers of Depression—Role of Physical Exercise and Training
Murawska‐Ciałowicz, E., Wiatr, M., Ciałowicz, M., de Assis, G. G., Borowicz, W., Rocha‐Rodrigues, S., Paprocka‐Borowicz, M., & Marques, A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18147553 · Cited by 140 · see citing works
Brain‐derived neurotrophic factor and post‐stroke depression
Zhang, E., & Liao, P. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24510 · Cited by 125 · see citing works
The Effect of Aerobic Exercise on Brain-Derived Neurotrophic Factor in People with Neurological Disorders: A Systematic Review and Meta-Analysis
Mackay, C. P., Kuys, S. S., & Brauer, S. G. (2017) · Neural Plasticity · doi:10.1155/2017/4716197 · Cited by 125 · see citing works
A Review of the Cognitive Effects Observed in Humans Following Acute Supplementation with Flavonoids, and Their Associated Mechanisms of Action
Bell, L., Lamport, D. J., Butler, L. T., & Williams, C. M. (2015) · Nutrients · doi:10.3390/nu7125538 · Cited by 124 · see citing works
The effects of aerobic exercise intensity on memory in older adults
Kovačević, A., Fenesi, B., Paolucci, E. M., & Heisz, J. J. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0495 · Cited by 122 · see citing works
Randomized, Controlled Trial of Exercise on Objective and Subjective Sleep in Parkinson's Disease
Amara, A. W., Wood, K. H., Joop, A., Memon, R. A., Pilkington, J., Tuggle, S. C., Reams, J., Barrett, M. J., Edwards, D. A., WELTMAN, A. L., et al. (2020) · Movement Disorders · doi:10.1002/mds.28009 · Cited by 123 · see citing works
Effects of exercise on Irisin, BDNF and IL-6 serum levels in patients with progressive multiple sclerosis
Briken, S., Rosenkranz, S. C., Keminer, O., Patra, S., Ketels, G., Heesen, C., Hellweg, R., Pleß, O., Schulz, K., & Gold, S. M. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.08.007 · Cited by 118 · see citing works
Implications of exercise-induced adipo-myokines in bone metabolism
Lombardi, G., Sanchis‐Gomar, F., Perego, S., Sansoni, V., & Banfi, G. (2015) · Endocrine · doi:10.1007/s12020-015-0834-0 · Cited by 117 · see citing works
Novel Blood-Based Biomarkers of Cognition, Stress, and Physical or Cognitive Training in Older Adults at Risk of Dementia: Preliminary Evidence for a Role of BDNF, Irisin, and the Kynurenine Pathway
Küster, O. C., Laptinskaya, D., Fissler, P., Schnack, C., Zügel, M., Nold, V., Thurm, F., Pleiner, S., Karabatsiakis, A., von Einem, B., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170447 · Cited by 114 · see citing works
Exercise increases serum brain-derived neurotrophic factor in patients with major depressive disorder
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Authors: Szuhany, K. L., Bugatti, M., & Otto, M. W.
Affiliations: Boston University (US)
Corresponding author: Szuhany, Kristin L.
ORCID: Szuhany, Kristin L.
Bugatti, Matteo
Otto, Michael W.
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2015-01
Volume: 60
Pages: 56-64
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2014.10.003
PMC: PMC4314337
OpenAlex: W2047262956
Cited by: 909
References: 96
Citations by year: 2026: 113 · 2025: 104 · 2024: 83 · 2023: 90 · 2022: 77 · 2021: 99 · 2020: 75 · 2019: 76 · 2018: 64 · 2017: 63 · 2016: 49 · 2015: 15 · 2012: 1
FWCI: 4.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (F31 MH100773)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Physiology › Physical Activity and Health
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords: physical activity, brain-derived neurotrophic factor, single-session exercise, regular exercise, sex differences, cognitive function, mood, neuroplasticity
MeSH terms: Adult, Age Factors, Female, Humans, Male, Motor Activity, Sex Factors, Time Factors, Exercise, Brain-Derived Neurotrophic Factor

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A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor

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