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The effect of acute exercise on blood concentrations of brain-derived neurotrophic factor in healthy adults. A meta-analysis.
Abstract
It has been hypothesized that one mechanism through which physical activity provides benefits to cognition and mood is via increasing brain‐derived neurotrophic factor (BDNF) concentrations. Some studies have reported immediate benefits to mood and various cognitive domains after a single session of exercise. This meta‐analysis sought to determine the effect of a single exercise session on concentrations of BDNF in peripheral blood, in order to evaluate the potential role of BDNF in mediating the beneficial effects of exercise on brain health. MEDLINE, Embase, PsycINFO, SPORTDiscus, Rehabilitation & Sports Medicine Source, and CINAHL databases were searched for original, peer‐reviewed reports of peripheral blood BDNF concentrations before and after acute exercise interventions. Risk of bias within studies was assessed using standardized criteria. Standardized mean differences (SMD s) were generated from random effects models. Risk of publication bias was assessed using a funnel plot and Egger's test. Potential sources of heterogeneity were explored in subgroup analyses. In 55 studies that met inclusion criteria, concentrations of peripheral blood BDNF were higher after exercise (SMD = 0.59, 95% CI: 0.46–0.72, P < 0.001). In meta‐regression analysis, greater duration of exercise was associated with greater increases in BDNF. Subgroup analyses revealed an effect in males but not in females, and a greater BDNF increase in plasma than serum. Acute exercise increased BDNF concentrations in the peripheral blood of healthy adults. This effect was influenced by exercise duration and may be different across genders.
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“Since dose is an essential factor for triggering neurobiological processes (e.g., release of neurotrophins such as BDNF; Dinoff et al., 2017), which in turn lead to neuroplastic”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Dinoff et al., 2017
In the citing paper
“for triggering neurobiological processes (e.g., release of neurotrophins such as BDNF; Dinoff et al., 2017), which in turn lead to neuroplastic and cognitive changes (Cotman et al., 2007; Voss et al., 2011, 2013a; Lucas et al., 2015; Zimmer et al., 2015; Basso and Suzuki, 2017; Stimpson et al., 2018)”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Dinoff et al., 2017
In the citing paper
“Findings further indicated that increased BDNF concentrations were observed following longer bout durations (>30 min relative to <30 min) in those who had higher cardiorespiratory fitness (i.e., > VO2 peak), and that the findings were selective to males (although 75% of participants across studies were male) (74).”
From Physical Activity, Cognition, and Brain Outcomes: A Review of the 2018 Physical Activity Guidelines (2019) · cites this paper as [74]
In the citing paper
“However, a meta-analysis examining a blood-based biomarker has indicated higher concentrations of peripheral blood BDNF following an acute bout of PA (both aerobic and resistance bouts).”
From Physical Activity, Cognition, and Brain Outcomes: A Review of the 2018 Physical Activity Guidelines (2019) · cites this paper as [74]
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Metadata
- Authors
- Dinoff, A., Herrmann, N., Swardfager, W., & Lanctôt, K. L.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Lanctôt, Krista L.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2017-06-19
- Volume
- 46
- Issue
- 1
- Pages
- 1635-1646
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2612535417
- Cited by
- 323
- References
- 151
- Citations by year
- 2026: 27 · 2025: 44 · 2024: 43 · 2023: 28 · 2022: 39 · 2021: 45 · 2020: 36 · 2019: 28 · 2018: 27 · 2017: 6
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- acute exercise, brain-derived neurotrophic factor, exercise duration, sex differences, exercise and cognition, exercise and mood, healthy adults
- MeSH terms
- Humans, Exercise, Brain-Derived Neurotrophic Factor
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