The anterior insula bidirectionally modulates cost-benefit decision-making on a rodent gambling task
Open accessAbstract
Deficits in cost-benefit decision-making, as assessed in the Iowa Gambling Task (IGT), are commonly observed in neuropsychiatric disorders such as addiction. There is considerable variation in the maximization of rewards on such tasks, both in the general population and in rodent models, suggesting individual differences in decision-making may represent a key endophenotype for vulnerability to neuropsychiatric disorders. Increasing evidence suggests that the insular cortex, which is involved in interoception and emotional processes in humans, may be a key neural locus in the control of decision-making processes. However, the extent to which the insula contributes to individual differences in cost-benefit decision-making remains unknown. Using male Sprague Dawley rats, we first assessed individual differences in the performance over the course of a single session on a rodent analogue of the IGT (rGT). Rats were matched for their ability to maximize reward and received bilateral excitotoxic or sham lesions of the anterior insula cortex (AIC). Animals were subsequently challenged on a second rGT session with altered contingencies. Finally, animals were also assessed for instrumental conditioning and reversal learning. AIC lesions produced bidirectional alterations on rGT performance; rats that had performed optimally prior to surgery subsequently showed impairments, and animals that had performed poorly showed improvements in comparison with sham-operated controls. These bidirectional effects were not attributable to alterations in behavioural flexibility or in motivation. These data suggest that the recruitment of the AIC during decision-making may be state-dependent and help guide response selection towards subjectively favourable options.
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Insula lesions lead to reductions in performance on an adaptation of the Iowa Gambling Task in rats who previously performed optimally.
“Similarly, insula lesions have been found to lead to reductions in performance on an adaptation of the Iowa Gambling Task in rats who previously performed optimally (Daniel et al., 2017).”
From Atypical interoception as a common risk factor for psychopathology: A review (2021) · cites this paper as Daniel et al., 2017
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- Authors
- Daniel, M. L., Cocker, P. J., Lacoste, J., Mar, A. C., Houeto, J. L., Belin‐Rauscent, A., & Belin, D.
- Affiliations
- University of Cambridge (GB)
- Centre Hospitalier Universitaire de Martinique (MQ)
- New York University (US)
- Service de Neurologie CIC‐INSERM 1402 CHU de Poitiers Poitiers Cedex France
- Corresponding author
- Cocker, P. J.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2017-10-06
- Volume
- 46
- Issue
- 10
- Pages
- 2620-2628
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- PMC
- PMC5725664
- OpenAlex
- W2752203438
- Cited by
- 35
- References
- 45
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 2 · 2019: 6 · 2018: 1
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- European Journal of Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Apollo (cc-by)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- AXA Research Fund
- Medical Research Council (RG82507)
- Leverhulme Trust (RG83473)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- anterior insula, cost-benefit decision making, gambling task, individual differences, reward maximization, excitotoxic lesions, reversal learning, operant conditioning, behavioral flexibility, motivation, addiction vulnerability, endophenotypes
- MeSH terms
- Animals, Cerebral Cortex, Conditioning, Operant, Decision Making, Games, Experimental, Male, Reward, Rats, Sprague-Dawley
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