Insular neural system controls decision-making in healthy and methamphetamine-treated rats
Open accessAbstract
Patients suffering from neuropsychiatric disorders such as substance-related and addictive disorders exhibit altered decision-making patterns, which may be associated with their behavioral abnormalities. However, the neuronal mechanisms underlying such impairments are largely unknown. Using a gambling test, we demonstrated that methamphetamine (METH)-treated rats chose a high-risk/high-reward option more frequently and assigned higher value to high returns than control rats, suggestive of changes in decision-making choice strategy. Immunohistochemical analysis following the gambling test revealed aberrant activation of the insular cortex (INS) and nucleus accumbens in METH-treated animals. Pharmacological studies, together with in vivo microdialysis, showed that the insular neural system played a crucial role in decision-making. Moreover, manipulation of INS activation using designer receptor exclusively activated by designer drug technology resulted in alterations to decision-making. Our findings suggest that the INS is a critical region involved in decision-making and that insular neural dysfunction results in risk-taking behaviors associated with altered decision-making.
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In vivo microdialysis of the aAgIC has shown decreased depolarization-evoked GABA release in rats previously chronically exposed to methamphetamine.
“In vivo microdialysis of the aAgIC has also shown decreased depolarization-evoked GABA release in rats previously chronically exposed to methamphetamine”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Mizoguchi et al., 2015
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The Insula: A Brain Stimulation Target for the Treatment of Addiction
Ibrahim, C., Rubin-Kahana, D. S., Pushparaj, A., Musiol, M., Blumberger, D. M., Daskalakis, Z. J., Zangen, A., & Le Foll, B. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00720 · Cited by 133 · see citing works
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The anterior insula bidirectionally modulates cost-benefit decision-making on a rodent gambling task
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- Authors
- Mizoguchi, H., Katahira, K., Inutsuka, A., Fukumoto, K., Nakamura, A., Wang, T., Nagai, T., Sato, J., Sawada, M., Ohira, H., Yamanaka, A., & Yamada, K.
- Affiliations
- Research Institute of Environmental Medicine, Nagoya University (JP)
- Nagoya University (JP)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-07-06
- Volume
- 112
- Issue
- 29
- Pages
- E3930-9
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4517258
- OpenAlex
- W1776113396
- Cited by
- 49
- References
- 56
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 13 · 2018: 5 · 2017: 5 · 2016: 5
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Takeda Science Foundation
- Uehara Memorial Foundation
- Ministry of Education, Culture, Sports, Science and Technology (24111518, 25460094, 25116515)
- Ministry of Health, Labour and Welfare
- Smoking Research Foundation
- National Institute of Biomedical Innovation
- Japan Society for the Promotion of Science (24111518, 26118506, 25460094, 24243068, 15H01428, 25284003, 26293046, 26640041, 25116515)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- insula, decision-making, methamphetamine, gambling behavior, risk-taking, nucleus accumbens, substance-related and addictive disorders, DREADD, reward valuation, microdialysis
- MeSH terms
- Animals, Behavior, Animal, Cerebral Cortex, Choice Behavior, Decision Making, gamma-Aminobutyric Acid, Gambling, Male, Methamphetamine, Motivation, Synaptic Transmission, Reinforcement, Psychology, Reward, Risk-Taking, Proto-Oncogene Proteins c-fos, Rats, Wistar, Maze Learning
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