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Cited by 78Neurotransmitter Receptor Influence on BehaviorMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

The role of acetylcholine in negative encoding bias: Too much of a good thing?

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Mineur, Yann S., Picciotto, Marina R.·2021·European Journal of Neuroscience
DOI 10.1111/ejn.14641PMC PMC7282966
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Abstract

Optimal acetylcholine (ACh) signaling is important for sustained attention and facilitates learning and memory. At the same time, human and animal studies have demonstrated increased levels of ACh in the brain during depressive episodes and increased symptoms of anxiety, depression, and reactivity to stress when ACh breakdown is impaired. While it is possible that the neuromodulatory roles of ACh in cognitive and affective processes are distinct, one possibility is that homeostatic levels of ACh signaling are necessary for appropriate learning, but overly high levels of cholinergic signaling promote encoding of stressful events, leading to the negative encoding bias that is a core symptom of depression. In this review, we outline this hypothesis and suggest potential neural pathways and underlying mechanisms that may support a role for ACh signaling in negative encoding bias.

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  • Optimal levels of ACh contribute to encoding of both rewarding and aversive stimuli, while suprathreshold increases in ACh signaling favor encoding of aversive stimuli and lead to the negative encoding bias observed in anxiety and depressive disorders.

    “One possibility is that whereas optimal levels of ACh con-tribute to encoding of both rewarding and aversive stimuli, suprathreshold increases in ACh signaling, mediated by chronic stress or other stimuli that can lead to depression, favor encoding of aversive stimuli and lead to the type of negative encoding bias observed in human subjects with anxiety and depressive disorders (Mineur and Picciot”

    From Mechanisms of Nicotine Addiction (2021) · cites this paper as Mineur and Picciotto 2019

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Cited by

Sorted by citations

Authors
Mineur, Y. S., & Picciotto, M. R.
Affiliations
Yale University (US)
Corresponding author
Picciotto, Marina R.
ORCID
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2019-12-24
Volume
53
Issue
1
Pages
114-125
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1111/ejn.14641
PMC
PMC7282966
OpenAlex
W2994638190
Cited by
78
References
26
Citations by year
2026: 11 · 2025: 22 · 2024: 15 · 2023: 9 · 2022: 9 · 2021: 7 · 2020: 4 · 2018: 1
FWCI
0.66
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (AA027473)
  • National Institute of Mental Health (MH077681)
  • National Institute on Drug Abuse (DA036151, DA050986, DA14241)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
acetylcholine, depression, cholinergic neurotransmission, sustained attention, anxiety, neuromodulation, neural pathways
MeSH terms
Acetylcholine, Animals, Brain, Humans, Learning, Memory, Neural Pathways

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