OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons
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The vast diversity of GABAergic interneurons is believed to endow hippocampal microcircuits with the required flexibility for memory encoding and retrieval. However, dissection of the functional roles of defined interneuron types has been hampered by the lack of cell-specific tools. We identified a precise molecular marker for a population of hippocampal GABAergic interneurons known as oriens lacunosum-moleculare (OLM) cells. By combining transgenic mice and optogenetic tools, we found that OLM cells are important for gating the information flow in CA1, facilitating the transmission of intrahippocampal information (from CA3) while reducing the influence of extrahippocampal inputs (from the entorhinal cortex). Furthermore, we found that OLM cells were interconnected by gap junctions, received direct cholinergic inputs from subcortical afferents and accounted for the effect of nicotine on synaptic plasticity of the Schaffer collateral pathway. Our results suggest that acetylcholine acting through OLM cells can control the mnemonic processes executed by the hippocampus.
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Since isocortical Sst Myh8 and Etv1 cells are L5 Martinotti cells, the HPF Myh8 and Etv1 cells are likely the Martinotti-like oriens lacunosum-moleculare (OLM) cells.
“Since isocortical Sst Myh8 and Etv1 cells are L5 Martinotti cells (Gouwens et al., 2020) (Fig. S1B), the HPF Myh8 and Etv1 cells are likely the Martinotti-like oriens lacunosum-moleculare (OLM) cells (Leao et al., 2012).”
From A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation (2021) · cites this paper as Leao et al., 2012
The restriction of horizontally oriented O-LM soma and spiny dendrites within s.o. and the alveus dictates that the dominant source of excitatory recruitment is from CA1 pyramidal cell collaterals while the preferential axonal targeting to s.l.m. then distributes inhibition back to the distal apical dendritic tufts of CA1 pyramidal cells to gate excitatory input from the entorhinal cortex and reni
“Indeed, the restriction of horizontally oriented O-LM soma and spiny dendrites within s.o. and the alveus dictates that the dominant source of excitatory recruitment is from CA1 pyramidal cell collaterals while the preferential axonal targeting to s.l.m. then distributes inhibition back to the distal apical dendritic tufts of CA1 pyramidal cells to gate excitatory input from the entorhinal cortex”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [649]
In the hippocampus, preferential targeting for O-LMs has been reported using a driver line based on nicotinic acetylcholine receptor α2 subunit promoter activity (Chrna2-Cre mice).
“In the hippocampus, preferential targeting for O-LMs has been reported using a driver line based on nicotinic acetylcholine receptor α2 subunit promoter activity (Chrna2-Cre mice) (649, 787).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [649]
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- Authors
- Leão, R. N., Mikulovic, S., Leão, K. E., Munguba, H., Gezelius, H., Enjin, A., Patra, K., Eriksson, A., Loew, L. M., Tort, A. B. L., & Kullander, K.
- Affiliations
- Uppsala University (SE)
- Universidade Federal do Rio Grande do Norte (BR)
- UConn Health (US)
- Corresponding author
- Leão, Richardson N
- Kullander, Klas
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2012-10-07
- Volume
- 15
- Issue
- 11
- Pages
- 1524-1530
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3483451
- OpenAlex
- W2084079308
- Cited by
- 359
- References
- 54
- Citations by year
- 2026: 21 · 2025: 24 · 2024: 28 · 2023: 31 · 2022: 27 · 2021: 30 · 2020: 26 · 2019: 21 · 2018: 28 · 2017: 28 · 2016: 22 · 2015: 28 · 2014: 26 · 2013: 17 · 2012: 1
- FWCI
- 11.80
- Type
- journal article
- Language
- en
- Open access
- green
- repositorio.ufrn.br
- Licence
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p41rr000954-34)
- National Institute of Biomedical Imaging and Bioengineering (R01EB001963)
- National Center for Research Resources (P41-RR000954)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- oriens-lacunosum moleculare interneurons, GABAergic interneurons, hippocampal CA1, CA3, entorhinal cortex, gap junctions, cholinergic input, nicotine, Schaffer collateral pathway, synaptic plasticity, memory encoding and retrieval
- MeSH terms
- Animals, Animals, Newborn, Electric Stimulation, gamma-Aminobutyric Acid, Interneurons, Luminescent Proteins, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neurons, Nicotine, Picrotoxin, Receptors, Nicotinic, RNA, Messenger, Valine, Long-Term Potentiation, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, Nicotinic Agonists, 6-Cyano-7-nitroquinoxaline-2,3-dione, GABA Antagonists, Excitatory Postsynaptic Potentials, Plant Lectins, Green Fluorescent Proteins, Mice, CA1 Region, Hippocampal, CA3 Region, Hippocampal, Voltage-Sensitive Dye Imaging, In Vitro Techniques
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