The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Antibiotics in agriculture and the risk to human health: how worried should we be?
Open accessAbstract
The use of antibiotics in agriculture is routinely described as a major contributor to the clinical problem of resistant disease in human medicine. While a link is plausible, there are no data conclusively showing the magnitude of the threat emerging from agriculture. Here, we define the potential mechanisms by which agricultural antibiotic use could lead to human disease and use case studies to critically assess the potential risk from each. The three mechanisms considered are as follows 1: direct infection with resistant bacteria from an animal source, 2: breaches in the species barrier followed by sustained transmission in humans of resistant strains arising in livestock, and 3: transfer of resistance genes from agriculture into human pathogens. Of these, mechanism 1 is the most readily estimated, while significant is small in comparison with the overall burden of resistant disease. Several cases of mechanism 2 are known, and we discuss the likely livestock origins of resistant clones of Staphylococcus aureus and Enterococcus faecium, but while it is easy to show relatedness the direction of transmission is hard to assess in robust fashion. More difficult yet to study is the contribution of mechanism 3, which may be the most important of all.
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Foodborne illness acquired in the United States—Major pathogens
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Antimicrobial Resistance: Implications and Costs
Dadgostar, P. (2019) · Infection and Drug Resistance · doi:10.2147/idr.s234610 · Cited by 2,024
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Environmental antimicrobial resistance and its drivers: a potential threat to public health
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Antibiotic use in food animals worldwide, with a focus on Africa: Pluses and minuses
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A structural analysis of the FDA green book-approved veterinary drugs and roles in human medicine
Scott, K. A., Qureshi, M. H., Cox, P. B., Marshall, C. M., Bellaire, B. C., Wilcox, M., Stuart, B. A. R., & Njardarson, J. T. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01502 · Cited by 56
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Antibiotic resistance genes in an urban stream before and after a state fair
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Metadata
- Authors
- Chang, Q., Wang, W., Regev‐Yochay, G., Lipsitch, M., & Hanage, W. P.
- Venue
- Evolutionary Applications
- Publisher
- Wiley
- Published
- 2014-08-02
- Volume
- 8
- Issue
- 3
- Pages
- 240-247
- ISSN
- 1752-4563 (ISSN-L)
- 1752-4571
- OpenAlex
- W2132993428
- Cited by
- 562
- References
- 3
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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