Eccrine sweat gland development and sweat secretion

Cui, Chang‐Yi; Schlessinger, David

doi:10.1111/exd.12773

Cited by 213Hair Growth and DisordersIon Transport and Channel RegulationCancer and Skin Lesions

Eccrine sweat gland development and sweat secretion

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Cui, Chang‐Yi, Schlessinger, David·2015·Experimental Dermatology

DOI 10.1111/exd.12773PMC PMC5508982

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Abstract

Eccrine sweat glands help to maintain homoeostasis, primarily by stabilizing body temperature. Derived from embryonic ectoderm, millions of eccrine glands are distributed across human skin and secrete litres of sweat per day. Their easy accessibility has facilitated the start of analyses of their development and function. Mouse genetic models find sweat gland development regulated sequentially by Wnt, Eda and Shh pathways, although precise subpathways and additional regulators require further elucidation. Mature glands have two secretory cell types, clear and dark cells, whose comparative development and functional interactions remain largely unknown. Clear cells have long been known as the major secretory cells, but recent studies suggest that dark cells are also indispensable for sweat secretion. Dark cell‐specific Foxa1 expression was shown to regulate a Ca 2+‐dependent Best2 anion channel that is the candidate driver for the required ion currents. Overall, it was shown that cholinergic impulses trigger sweat secretion in mature glands through second messengers – for example InsP3 and Ca 2+ – and downstream ion channels/transporters in the framework of a Na+‐K+‐Cl− cotransporter model. Notably, the microenvironment surrounding secretory cells, including acid–base balance, was implicated to be important for proper sweat secretion, which requires further clarification. Furthermore, multiple ion channels have been shown to be expressed in clear and dark cells, but the degree to which various ion channels function redundantly or indispensably also remains to be determined.

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Eccrine sweat glands are widely distributed in human skin but are rare in fur-covered mammals such as mice.
“eccrine sweat glands are widely distributed in human skin, they are rare in fur-covered mammals such as mice55.”
From Candida auris skin tropism and antifungal resistance are mediated by carbonic anhydrase Nce103 (2025) · cites this paper as [55]

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[25]Heller DS Haefner HK Hameed M J Reprod Med 2002 47 695 700 12380447
[63]Boulant JA Fed Proc 1981 40 2843 2850 6273235

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Authors: Cui, C., & Schlessinger, D.
Affiliations: National Institutes of Health (US)
Corresponding author: Cui, Chang‐Yi
ORCID: Cui, Chang‐Yi
Schlessinger, David
Venue: Experimental Dermatology
Publisher: Wiley
Published: 2015-07-14
Volume: 24
Issue: 9
Pages: 644-650
ISSN: 0906-6705 (ISSN-L)
1600-0625
DOI: 10.1111/exd.12773
PMC: PMC5508982
OpenAlex: W1646243120
Cited by: 213
References: 124
Citations by year: 2026: 20 · 2025: 25 · 2024: 25 · 2023: 31 · 2022: 21 · 2021: 17 · 2020: 18 · 2019: 19 · 2018: 10 · 2017: 17 · 2016: 8 · 2015: 1
FWCI: 2.55
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Experimental Dermatology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (ZIAAG000643)
Topics: Health Sciences › Medicine › Urology › Hair Growth and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Health Sciences › Medicine › Dermatology › Cancer and Skin Lesions
Keywords: eccrine sweat glands, sweat gland development, sweat secretion, Wnt signaling, Sonic hedgehog signaling, clear cells, dark cells, FOXA1, cholinergic neurotransmission, IP3 receptor, calcium signaling, Na+-K+-2Cl- cotransporter, ion channels, acid-base balance, thermoregulation, mouse model
MeSH terms: Bestrophins, Animals, Calcium, Eccrine Glands, Humans, Sweat, Chloride Channels, Sodium-Potassium-Chloride Symporters, Mice, Wnt Signaling Pathway

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Eccrine sweat gland development and sweat secretion

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