Sweat gland organoids contribute to cutaneous wound healing and sweat gland regeneration
Open accessAbstract
Sweat glands perform a vital thermoregulatory function in mammals. Like other skin components, they originate from epidermal progenitors. However, they have low regenerative potential in response to injury. We have established a sweat gland culture and expansion method using 3D organoids cultures. The epithelial cells derived from sweat glands in dermis of adult mouse paw pads were embedded into Matrigel and formed sweat gland organoids (SGOs). These organoids maintained remarkable stem cell features and demonstrated differentiation capacity to give rise to either sweat gland cells (SGCs) or epidermal cells. Moreover, the bipotent SGO-derived cells could be induced into stratified epidermis structures at the air−liquid interface culture in a medium tailored for skin epidermal cells in vitro. The SGCs embedded in Matrigel tailored for sweat glands formed epithelial organoids, which expressed sweat-gland-specific markers, such as cytokeratin (CK) 18 and CK19, aquaporin (AQP) 5 and αATP. More importantly, they had potential of regeneration of epidermis and sweat gland when they were transplanted into the mouse back wound and claw pad with sweat gland injury, respectively. In summary, we established and optimized culture conditions for effective generation of mouse SGOs. These cells are candidates to restore impaired sweat gland tissue as well as to improve cutaneous skin regeneration.
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Human SwG organoids derived from SwG epithelial cells contributed to regeneration of epidermis and SwGs in vivo.
“Human SwG organoids derived from SwG epithelial cells contributed to the regeneration of epidermis and SwGs in vivo.[ 22 ]”
From Sweat Gland Organoids Originating from Reprogrammed Epidermal Keratinocytes Functionally Recapitulated Damaged Skin (2021) · cites this paper as [22]
The Results section reports that transplanted sweat-gland-organoid-derived cells participated in epidermal and sweat gland regeneration in vivo. However, the organoids were generated from mouse sweat gland epithelial cells and transplanted into mice; the paper does not report this result for human organoids. (LLM, conf=0.92)
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- Authors
- Diao, J., Liu, J., Wang, S., Chang, M., Wang, X., Guo, B., Yu, Q., Yan, F., Su, Y., & Wang, Y.
- Affiliations
- Institute of Health Service and Transfusion Medicine (CN)
- Corresponding author
- Wang, Yunfang
- Venue
- Cell Death & Disease
- Published
- 2019-03-11
- Volume
- 10
- Issue
- 3
- Pages
- 238-238
- ISSN
- 2041-4889 (ISSN-L)
- PMC
- PMC6411741
- OpenAlex
- W2920810540
- Cited by
- 92
- References
- 47
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 24 · 2023: 17 · 2022: 10 · 2021: 11 · 2020: 4 · 2019: 3
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cell Death and Disease (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (No. 81730052)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- sweat gland regeneration, skin wound healing, 3D organoid culture, epidermal progenitors, sweat gland cells, epidermal differentiation, air-liquid interface culture, Matrigel, aquaporin 5, cytokeratin, skin regeneration
- MeSH terms
- Epidermal Cells, Animals, Cell Differentiation, Cells, Cultured, Collagen, Drug Combinations, Epidermis, Epithelial Cells, Laminin, Organoids, Proteoglycans, Regeneration, Stem Cells, Sweat Glands, Wound Healing, Skin Transplantation, Cell Culture Techniques, Tissue Engineering, Mice, Aquaporin 5, Keratin-18
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