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Cited by 168Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

Behavioral flexibility in rats and mice: contributions of distinct frontocortical regions

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Hamilton, D. A., Brigman, J. L.·2015·Genes, Brain and Behavior
DOI 10.1111/gbb.12191PMC PMC4482359
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Abstract

Research examining the contribution of genetics to behavior is increasingly focused on higher order behavioral and cognitive processes including the ability to modify behaviors when environmental demands change. The frontal cortices of mammals, including rodents, subserve a diverse set of behavioral and cognitive functions including motor planning, social behavior, evaluation of expected outcomes and working memory, which may be particularly sensitive to genetic factors and interactions with experience (e.g. stress). Behavioral flexibility is a core attribute of these functions. This review orients readers to the current landscape of the literature on the frontocortical bases of behavioral flexibility in rodent laboratory experiments. Studies are divided into three broad categories: reversal learning, inhibitory learning and set‐shifting. Functional dissociations within the broader scope of behavioral flexibility are reviewed, followed by discussion of the associations between specific components of frontal cortex and specific aspects of relevant behavioral processes. Finally, the authors identify open questions that need to be addressed to better establish the constituents of frontal cortex underlying behavioral flexibility.

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  • Extensive research in rodents and non-human primates emphasises major roles of fronto-striatal circuits in the ability to respond flexibly.

    “Extensive research in rodents and non-human primates emphasises the major roles of fronto-striatal circuits in the ability to respond flexibly [34–42].”

    From Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility (2024) · cites this paper as [39]

    The Introduction says that rodent and non-human-primate research has investigated neural circuits underlying behavioral flexibility. The section on extradimensional set-shifting reports that disconnecting rat medial frontal cortex from the nucleus accumbens impaired flexible responding, supporting a fronto-striatal role in rodents. The review focuses on frontocortical regions, however, and the passages do not establish a major fronto-striatal role in non-human primates. Our copy provides section labels but no page numbers. (LLM, conf=0.82)

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Authors
Hamilton, D. A., & Brigman, J. L.
Affiliations
University of New Mexico (US)
Corresponding author
Brigman, J. L.
ORCID
Venue
Genes, Brain and Behavior
Publisher
Wiley
Published
2015-01
Volume
14
Issue
1
Pages
4-21
ISSN
  • 1601-183X (ISSN-L)
  • 1601-1848
DOI
10.1111/gbb.12191
PMC
PMC4482359
OpenAlex
W1832907532
Cited by
168
References
14
Citations by year
2026: 7 · 2025: 9 · 2024: 17 · 2023: 16 · 2022: 9 · 2021: 20 · 2020: 11 · 2019: 22 · 2018: 14 · 2017: 14 · 2016: 20 · 2015: 9
FWCI
1.85
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 27 d)
Locations
  • Genes Brain & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (1K22-AA020303-01, 4R01-AA019462)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
behavioral flexibility, frontal cortex, reversal learning, inhibitory learning, set-shifting, rodent behavior, behavioral genetics, stress, working memory, functional dissociation
MeSH terms
Animals, Frontal Lobe, Learning, Mice, Rats

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