Cited by 79Memory and Neural MechanismsTranscranial Magnetic Stimulation StudiesNeuroscience and Neuropharmacology Research

Enhanced Extinction of Aversive Memories by High-Frequency Stimulation of the Rat Infralimbic Cortex

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Maroun, Mouna, Kavushansky, Alexandra, Holmes, Andrew, Wellman, Cara, Motanis, Helen·2012·PLoS ONE

Abstract

Electrical stimulation of the rodent medial prefrontal cortex (mPFC), including the infralimbic cortex (IL), immediately prior to or during fear extinction training facilitates extinction memory. Here we examined the effects of high-frequency stimulation (HFS) of the rat IL either prior to conditioning or following retrieval of the conditioned memory, on extinction of Pavlovian fear and conditioned taste aversion (CTA). IL-HFS applied immediately after fear memory retrieval, but not three hours after retrieval or prior to conditioning, subsequently reduced freezing during fear extinction. Similarly, IL-HFS given immediately, but not three hours after, retrieval of a CTA memory reduced aversion during extinction. These data indicate that HFS of the IL may be an effective method for reducing both learned fear and learned aversion.

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  • Electrical stimulation of infralimbic cortex reduces freezing to the conditioned stimulus even in animals that are resistant to extinction training.

    “electrical stimulation of infralimbic cortex reduces freezing to the CS even in animals that are resistant to extinction training108,112.”

    From Resolving the neural circuits of anxiety (2015) · cites this paper as [112]

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  1. [53]Milad MR Vidal-Gonzalez I Quirk GJ 2004 Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner. Behav Neurosci, 118 2 389 94 15113265

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Authors
Maroun, M., Kavushansky, A., Holmes, A., Wellman, C., & Motanis, H.
Affiliations
  • University of Haifa (IL)
  • National Institutes of Health (US)
  • Indiana University Bloomington (US)
Corresponding author
Maroun, Mouna
Venue
PLoS ONE
Published
2012-05-07
Volume
7
Issue
5
Pages
e35853
ISSN
1932-6203 (ISSN-L)
OpenAlex
W1982818912
Cited by
79
References
58
Citations by year
2026: 1 · 2025: 4 · 2024: 8 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 8 · 2015: 13 · 2014: 5 · 2013: 6 · 2012: 5
FWCI
4.74
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, public-domain)
  • PubMed Central (publishedVersion, public-domain)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
United States-Israel Binational Science Foundation
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
fear extinction, conditioned taste aversion, infralimbic cortex, high-frequency stimulation, medial prefrontal cortex, memory retrieval, freezing behavior, aversive memory
MeSH terms
Animals, Brain Mapping, Conditioning, Psychological, Conditioning, Classical, Electric Stimulation, Extinction, Psychological, Fear, Male, Memory, Rats, Sprague-Dawley, Rats, Wistar, Prefrontal Cortex, Rats

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