Dissociable effects of lesions to orbitofrontal cortex subregions on impulsive choice in the rat
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The orbitofrontal cortex (OFC) is implicated in a variety of adaptive decision-making processes. Human studies suggest that there is a functional dissociation between medial and lateral OFC (mOFC and lOFC, respectively) subregions when performing certain choice procedures. However, little work has examined the functional consequences of manipulations of OFC subregions on decision making in rodents. In the present experiments, impulsive choice was assessed by evaluating intolerance to delayed, but economically optimal, reward options using a delay-discounting paradigm. Following initial delay-discounting training, rats received bilateral neurotoxic or sham lesions targeting whole OFC (wOFC) or restricted to either mOFC or lOFC subregions. A transient flattening of delay-discounting curves was observed in wOFC-lesioned animals relative to shams—differences that disappeared with further training. Stable, dissociable effects were found when lesions were restricted to OFC subregions; mOFC-lesioned rats showed increased, whereas lOFC-lesioned rats showed decreased, preference for the larger-delayed reward relative to sham-controls—a pattern that remained significant during retraining after all delays were removed. When locations of levers leading to small–immediate versus large–delayed rewards were reversed, wOFC- and lOFC-lesioned rats showed retarded, whereas mOFC-lesioned rats showed accelerated, trajectories for reversal of lever preference. These results provide the first direct evidence for dissociable functional roles of the mOFC and lOFC for impulsive choice in rodents. The findings are consistent with recent human functional imaging studies and suggest that functions of mOFC and lOFC subregions may be evolutionarily conserved and contribute differentially to decision-making processes.
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NAc core lesions cause rats to make risk-averse choices and prefer smaller rewards at shorter delays.
“NAc core lesions cause rats to make risk-averse choices (Cardinal and Howes, 2005) and prefer smaller rewards at shorter delays (Cardinal et al., 2001; Mar et al., 2011)”
From A framework for understanding the emerging role of corticolimbic-ventral striatal networks in OCD-associated repetitive behaviors (2015) · cites this paper as Mar et al., 2011
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- Authors
- Mar, A. C., Walker, A. L. J., Theobald, D. E., Eagle, D. M., & Robbins, T. W.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Mar, Adam C.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-04-27
- Volume
- 31
- Issue
- 17
- Pages
- 6398-6404
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3183455
- OpenAlex
- W2035946861
- Cited by
- 206
- References
- 39
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 10 · 2023: 13 · 2022: 13 · 2021: 11 · 2020: 17 · 2019: 14 · 2018: 11 · 2017: 16 · 2016: 17 · 2015: 17 · 2014: 19 · 2013: 17 · 2012: 15
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (089589/Z/09/Z, 089589, 093875)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- orbitofrontal cortex, medial orbitofrontal cortex, lateral orbitofrontal cortex, impulsive choice, delay discounting, decision-making, neurotoxic lesion, reversal learning, reward preference, rats
- MeSH terms
- Animals, Behavior, Animal, Choice Behavior, Conditioning, Operant, Impulsive Behavior, Functional Laterality, Male, Reward, Time Factors, Prefrontal Cortex, Rats
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