Effects of excitotoxic lesions in the ventral striatopallidal-thalamocortical pathway on odor reversal learning: inability to extinguish an incorrect response
Abstract
The role of the ventral striatopallidal pathway and related cortical areas in stimulus-reward association reversal behavior was studied by inducing bilateral lesions with the excitotoxin, N-methyl-D-aspartate (NMDA) at restricted sites in the system. The areas lesioned were the ventral pallidum (VP), the ventral striatum (VS), the medial prefrontal cortex (mPFC) [i.e., the prelimbic (PL) and infralimbic (IL) cortexes], and the orbital cortex [i.e., the dorsolateral orbital (DLO), ventral lateral orbital (VLO), and lateral orbital (LO) cortexes]. Rats with lesions of the dorsal caudate nucleus and putamen (CPu) served as a positive control in this study. Water-deprived rats were trained on a go, no-go two-odor olfactory discrimination task to respond to one odor (S+) with water as a reward and to suppress responding to the other odor (S-). The rats were then tested for their ability to reverse the associated stimuli. The number of errors made before successfully learning the stimulus-reward association were measured in relation to a sham lesion control group which did not receive injections of NMDA. In experimental rats, the lesions did not affect their ability to learn stimulus-reward associations for novel odors, but did result in an increase in the number of false alarms after the significance of the associated stimuli were reversed. That is, the lesioned animals persisted in responding to the formerly rewarded but now unrewarded stimulus. Rats with damage to the CPu did no…
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Lesions of the ventral striatum and pallidum, MD, or the OMPFC cause perseverative deficits in stimulus-reward reversal tasks in rats and monkeys.
“In support of this hypothesis, lesions of the ventral striatum and pallidum, MD, or the OMPFC have been shown to cause perseverative deficits in stimulus-reward reversal tasks in rats and monkeys, such that the animals have difficulty switching away from previously rewarded, but now unrewarded stimuli (Roberts et al, 1990;McBride and Slotnick, 1997;Ferry et al, 2000a;Kazama and Bachevalier, 2009).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Ferry et al, 2000a
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(2000) · doi:10.1002/1096-9861(20000925)425:3
Self-citation
- Authors
- Ferry, A. T., Lu, X.-C. M., & Price, J. L.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Experimental Brain Research
- Published
- 2000-03-17
- Volume
- 131
- Issue
- 3
- Pages
- 320-335
- ISSN
- 0014-4819 (ISSN-L)
- OpenAlex
- W2029499396
- Cited by
- 109
- References
- 53
- Citations by year
- 2023: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 2 · 2012: 2
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Experimental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders (DC00093)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- thalamocortical circuits, ventral pallidum, ventral striatum, medial prefrontal cortex, orbital cortex, stimulus-reward associations, odor discrimination, false alarm errors, caudate nucleus, putamen
- MeSH terms
- Animals, Brain, Brain Mapping, Caudate Nucleus, Conditioning, Operant, Corpus Striatum, Globus Pallidus, Learning, Male, Models, Neurological, Neurotoxins, Odorants, Olfactory Pathways, Organ Specificity, Putamen, Visual Cortex, N-Methylaspartate, Rats, Sprague-Dawley, Prefrontal Cortex, Rats
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