Complementing the inflammasome
Open accessAbstract
Summary: The innate immune system is an ancient surveillance system able to sense microbial invaders as well as aberrations in normal cell function. No longer viewed as a static and non‐specific part of immunity, the innate immune system employs a plethora of specialized pattern recognition sensors to monitor and achieve homeostasis; these include the Toll‐like receptors, the retinoic acid‐inducible gene‐like receptors, the nucleotide‐binding oligomerization domain receptors (NLR s), the C‐type lectins and the complement system. In order to increase specificity and diversity, innate immunity uses homotypic and heterotypic associations among these different components. Multi‐molecular assemblies are formed both on the cell surface and in the cytosol to respond to pathogen and danger signals. Diverse, but tailored, responses to a changing environment are orchestrated depending on the the nature of the challenge and the repertoire of interacting receptors and components available in the sensing cell. It is now emerging that innate immunity operates a system of ‘checks and balances’ where interaction among the sensors is key in maintaining normal cell function. Complement sits at the heart of this alarm system and it is becoming apparent that it is capable of interacting with all the other pathways to effect a tailored immune response. In this review, we will focus on complement interactions with NLR s, the so‐called ‘inflammasomes’, describing the molecular mechanisms that have been revealed so far and discussing the circumstantial evidence that exists for these interactions in disease states.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
C5a has well-known pro-inflammatory functions mediated through its C5aR receptors and activation of the NLRP3 inflammasome.
“While it has well-known pro-inflammatory functions mediated through its C5aR receptors and activation of the NLRP3 inflammasome (as previously reviewed [185,186])”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [186]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631 · see citing works
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066 · see citing works
Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475 · see citing works
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026 · see citing works
Complement: a key system for immune surveillance and homeostasis
Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654 · see citing works
A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
Lennon, V. A., Wingerchuk, D. M., Kryzer, T. J., Pittock, S. J., Lucchinetti, C. F., Fujihara, K., Nakashima, I., & Weinshenker, B. G. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17551-x · Cited by 3,239 · see citing works
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080 · see citing works
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065 · see citing works
Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,006 · see citing works
Activation and regulation of the inflammasomes
Latz, E., Xiao, T. S., & Stutz, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3452 · Cited by 2,884 · see citing works
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Coll, R. C., Robertson, A. A. B., Chae, J. J., Higgins, S. C., Muñoz-Planillo, R., Inserra, M. C., Vetter, I., Dungan, L. S., Monks, B. G., Stutz, A., et al. (2015) · Nature Medicine · doi:10.1038/nm.3806 · Cited by 2,849 · see citing works
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658 · see citing works
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655 · see citing works
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441 · see citing works
The Inflammasomes: Guardians of the Body
Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436 · see citing works
Mechanisms for Insulin Resistance: Common Threads and Missing Links
Samuel, V. T., & Shulman, G. I. (2012) · Cell · doi:10.1016/j.cell.2012.02.017 · Cited by 2,294 · see citing works
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
Youm, Y.-H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3804 · Cited by 2,172 · see citing works
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,822 · see citing works
Ruiter, A. M., Meilof, J. F., Somanje-Bolweg, R. R. J., van Gorsel, E., & Kalkers, N. F. (2017) · Case Reports in Neurology · doi:10.1159/000455942 · Cited by 1,762 · see citing works
The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
Davis, B. K., Wen, H., & Ting, J. P.-Y. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101405 · Cited by 1,618 · see citing works
Is Type II diabetes mellitus a disease of the innate immune system?
Pickup, J. C., & Crook, M. A. (1998) · Diabetologia · doi:10.1007/s001250051058 · Cited by 1,040 · see citing works
Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome
Yan, Y., Jiang, W., Liu, L., Wang, X., Ding, C., Tian, Z., & Zhou, R. (2015) · Cell · doi:10.1016/j.cell.2014.11.047 · Cited by 1,014 · see citing works
Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease
Meyer-Luehmann, M., Spires-Jones, T. L., Prada, C., Garcia-Alloza, M., de Calignon, A., Rozkalne, A., Koenigsknecht-Talboo, J., Holtzman, D. M., Bacskai, B. J., & Hyman, B. T. (2008) · Nature · doi:10.1038/nature06616 · Cited by 987 · see citing works
Sutterwala, F. S., Ogura, Y., Szczepanik, M., Lara-Tejero, M., Lichtenberger, G. S., Grant, E. P., Bertin, J., Coyle, A. J., Galán, J. E., Askenase, P. W., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.004 · Cited by 980 · see citing works
Critical role for calcium mobilization in activation of the NLRP3 inflammasome
Murakami, T., Öckinger, J., Yu, J., Byles, V., McColl, A., Hofer, A. M., & Horng, T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117765109 · Cited by 926 · see citing works
The role of the anaphylatoxins in health and disease
Klos, A., Tenner, A. J., Johswich, K.-O., Ager, R. R., Reis, E. S., & Köhl, J. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.04.027 · Cited by 730 · see citing works
Stienstra, R., Joosten, L. A. B., Koenen, T. B., van Tits, B. L. J. H., van Diepen, J. A., van den Berg, S. A. A., Rensen, P. C. N., Voshol, P. J., Fantuzzi, G., Hijmans, A., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.011 · Cited by 681 · see citing works
Korb, L. C., & Ahearn, J. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.10.4525 · Cited by 659 · see citing works
Influenza virus activates inflammasomes via its intracellular M2 ion channel
Ichinohe, T., Pang, I. K., & Iwasaki, A. (2010) · Nature Immunology · doi:10.1038/ni.1861 · Cited by 632 · see citing works
Luther, K., Torosantucci, A., Brakhage, A. A., Heesemann, J., & Ebel, F. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00796.x · Cited by 582 · see citing works
Role of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease
Walter, S., Letiembre, M., Liu, Y., Heine, H., Penke, B., Hao, W., Bode, B., Manietta, N., Walter, J., Schulz-Schüffer, W., et al. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000110455 · Cited by 543 · see citing works
Kanneganti, T., Lamkanfi, M., Kim, Y., Chen, G., Park, J., Franchi, L., Vandenabeele, P., & Núñez, G. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.008 · Cited by 526 · see citing works
Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase
Bokisch, V. A., & Müller‐Eberhard, H. J. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106462 · Cited by 517 · see citing works
Ribas, C., Penela, P., Murga, C., Salcedo, A., García‐Hoz, C., Jurado-Pueyo, M., Aymerich, I., & Mayor, F. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.09.019 · Cited by 409 · see citing works
Functional roles for C5a receptors in sepsis
Rittirsch, D., Flierl, M. A., Nadeau, B. A., Day, D. E., Huber-Lang, M. S., Mackay, C. R., Zetoune, F. S., Gerard, N. P., Cianflone, K., Köhl, J., et al. (2008) · Nature Medicine · doi:10.1038/nm1753 · Cited by 386 · see citing works
Complement membrane attack on nucleated cells: resistance, recovery and non-lethal effects
Morgan, B. P. (1989) · Biochemical Journal · doi:10.1042/bj2640001 · Cited by 383 · see citing works
Self-citationRegulation of Toll-like receptor–mediated inflammatory response by complement in vivo
Zhang, X., Kimura, Y., Fang, C., Zhou, L., Sfyroera, G., Lambris, J. D., Wetsel, R. A., Miwa, T., & Song, W. (2007) · Blood · doi:10.1182/blood-2006-12-063636 · Cited by 373 · see citing works
Triantafilou, K., Hughes, T. R., Triantafilou, M., & Morgan, B. P. (2013) · Journal of Cell Science · doi:10.1242/jcs.124388 · Cited by 361 · see citing works
Self-citationCritical review of acylation-stimulating protein physiology in humans and rodents
Cianflone, K., Xia, Z., & Chen, L. Y. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00686-7 · Cited by 358 · see citing works
Inflammasomes: too big to miss
Stutz, A., Golenbock, D. T., & Latz, E. (2009) · Journal of Clinical Investigation · doi:10.1172/jci40599 · Cited by 345 · see citing works
Immunology and immunotherapy of Alzheimer's disease
Weiner, H. L., & Frenkel, D. (2006) · Nature Reviews Immunology · doi:10.1038/nri1843 · Cited by 335 · see citing works
Toll-like receptors: linking inflammation to metabolism
Könner, A. C., & Brüning, J. C. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.007 · Cited by 327 · see citing works
Asgari, E., Friec, G. L., Yamamoto, H., Perucha, E., Sacks, S. H., Köhl, J., Cook, H. T., & Kemper, C. (2013) · Blood · doi:10.1182/blood-2013-05-502229 · Cited by 311 · see citing works
Microbial manipulation of receptor crosstalk in innate immunity
Hajishengallis, G., & Lambris, J. D. (2011) · Nature reviews. Immunology · doi:10.1038/nri2918 · Cited by 307 · see citing works
Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release
Samstad, E. O., Niyonzima, N., Nymo, S. H., Aune, M. H., Ryan, L., Bakke, S. S., Lappegård, K. T., Brekke, O., Lambris, J. D., Damås, J. K., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302484 · Cited by 286 · see citing works
Spitzer, D., Mitchell, L. M., Atkinson, J. P., & Hourcade, D. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2600 · Cited by 281 · see citing works
Crosstalk pathways between Toll-like receptors and the complement system
Hajishengallis, G., & Lambris, J. D. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.01.002 · Cited by 277 · see citing works
Fonseca, M. I., Ager, R. R., Chu, S.-H., Yazan, O., Sanderson, S. D., LaFerla, F. M., Taylor, S. M., Woodruff, T. M., & Tenner, A. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901005 · Cited by 268 · see citing works
Navratil, J. S., Watkins, S. C., Wisnieski, J. J., & Ahearn, J. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.5.3231 · Cited by 262 · see citing works
Complement Receptor Type 1 (CR1, CD35) Is a Receptor for C1q
Klickstein, L. B., Barbashov, S. F., Liu, T., Jack, R. M., & Nicholson-Weller, A. (1997) · Immunity · doi:10.1016/s1074-7613(00)80356-8 · Cited by 257 · see citing works
Mastellos, D. C., Papadimitriou, J. C., Franchini, S., Tsonis, P. A., & Lambris, J. D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2479 · Cited by 253 · see citing works
Pazár, B., Ea, H., Narayan, S., Kolly, L., Bagnoud, N., Chobaz, V., Roger, T., Lioté, F., So, A. K.-L., & Busso, N. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001284 · Cited by 252 · see citing works
Structure and activation of the C1 complex of complement: unraveling the puzzle
Gaboriaud, C., Thielens, N. M., Gregory, L., Rossi, V., Fontecilla-Camps, J. C., & Arlaud, G. J. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.04.008 · Cited by 248 · see citing works
Benoit, M. E., Clarke, E. V., Morgado, P., Fraser, D. A., & Tenner, A. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103760 · Cited by 245 · see citing works
C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a
Chen, N., Mirtsos, C., Suh, D., Lu, Y., Lin, W., McKerlie, C., Lee, T. W., Baribault, H., Tian, H., & Yeh, W. (2007) · Nature · doi:10.1038/nature05559 · Cited by 243 · see citing works
Arulkumaran, N., Unwin, R. J., & Tam, F. W. K. (2011) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2011.578068 · Cited by 241 · see citing works
Complement C3a and C5a Induce Different Signal Transduction Cascades in Endothelial Cells
Schraufstätter, I. U., Trieu, K., Sikora, L., Sriramarao, P., & DiScipio, R. G. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.2102 · Cited by 233 · see citing works
Microbial Hijacking of Complement–Toll-Like Receptor Crosstalk
Wang, M., Krauss, J. L., Domon, H., Hosur, K. B., Liang, S., Magotti, P., Triantafilou, M., Triantafilou, K., Lambris, J. D., & Hajishengallis, G. (2010) · Science Signaling · doi:10.1126/scisignal.2000697 · Cited by 229 · see citing works
Self-citationInflammation, anti-inflammatory agents and Alzheimer disease: The last 12 years
McGeer, P. L., Rogers, J., & McGeer, E. G. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9s330 · Cited by 222 · see citing works
Nuki, G., Bresnihan, B., Bear, M. B., & McCabe, D. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10578 · Cited by 222 · see citing works
Update on colchicine and its mechanism of action
Molad, Y. (2002) · Current Rheumatology Reports · doi:10.1007/s11926-002-0073-2 · Cited by 213 · see citing works
Cutting Edge: The NLRP3 Inflammasome Links Complement-Mediated Inflammation and IL-1β Release
Laudisi, F., Spreafico, R., Evrard, M., Hughes, T. R., Mandriani, B., Kandasamy, M., Morgan, B. P., Sivasankar, B., & Mortellaro, A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300489 · Cited by 198 · see citing works
Self-citationBeyond lysis: how complement influences cell fate
Cole, D., & Morgan, B. P. (2003) · Clinical Science · doi:10.1042/cs20020362 · Cited by 195 · see citing works
Self-citationSpecific interactions of chemoattractant factor receptors with G-proteins
AMATRUDA, T. T., Gerard, N. P., Gerard, C. J., & Simon, M. I. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82183-4 · Cited by 194 · see citing works
Carboxypeptidase N: a pleiotropic regulator of inflammation
Matthews, K. R. W., Mueller‐Ortiz, S. L., & Wetsel, R. A. (2003) · Molecular Immunology · doi:10.1016/j.molimm.2003.10.002 · Cited by 185 · see citing works
IMMUNOCYTOCHEMICAL LOCALIZATION OF THE TERMINAL COMPLEMENT COMPLEX IN MULTIPLE SCLEROSIS
Compston, D. A. S., Morgan, B. P., Campbell, A. K., Wilkins, P. R., Cole, G., Thomas, N. D., & Jasani, B. (1989) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1989.tb01231.x · Cited by 185 · see citing works
Self-citationC3a(C3adesArg) induces production and release of interleukin 1 by cultured human monocytes.
Haeffner‐Cavaillon, N., Cavaillon, J., Laude, M., & Kazatchkine, M. D. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.3.794 · Cited by 177 · see citing works
C5L2 Is a Functional Receptor for Acylation-stimulating Protein
Kalant, D., MacLaren, R., Cui, W., Samanta, R., Monk, P. N., Laporte, S. A., & Cianflone, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m406921200 · Cited by 177 · see citing works
Complement activation in multiple sclerosis plaques: an immunohistochemical analysis
Ingram, G., Loveless, S., Howell, O. W., Hakobyan, S., Dancey, B., Harris, C. L., Robertson, N. P., Neal, J., & Morgan, B. P. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-53 · Cited by 177 · see citing works
Self-citationThe Chemoattractant Receptor-like Protein C5L2 Binds the C3a des-Arg77/Acylation-stimulating Protein
Kalant, D., Cain, S. A., Maslowska, M., Sniderman, A. D., Cianflone, K., & Monk, P. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206169200 · Cited by 175 · see citing works
Inflammasomes and Metabolic Disease
Henao‐Mejia, J., Elinav, E., Thaiss, C. A., & Flavell, R. A. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170324 · Cited by 175 · see citing works
Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U‐937 cells
Crass, T., Raffetseder, U., Martin, U., Grove, M., Klos, A., Köhl, J., & Bautsch, W. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260840 · Cited by 174 · see citing works
The immunogenesis of the multiple sclerosis plaque
LUMSDEN, C. E. (1971) · Brain Research · doi:10.1016/0006-8993(71)90052-7 · Cited by 171 · see citing works
Anaphylatoxins and infectious and non-infectious inflammatory diseases
Köhl, J. (2001) · Molecular Immunology · doi:10.1016/s0161-5890(01)00041-4 · Cited by 166 · see citing works
Triantafilou, K., Kar, S., Vakakis, E., Kotecha, S., & Triantafilou, M. (2012) · Thorax · doi:10.1136/thoraxjnl-2012-202182 · Cited by 161 · see citing works
Self-citationInhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria
Xu, L., Xiao, N., Liu, F., Ren, H., & Gu, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811029106 · Cited by 159 · see citing works
Compstatin: A Complement Inhibitor on its Way to Clinical Application
Ricklin, D., & Lambris, J. D. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-78952-1_20 · Cited by 157 · see citing works
Sarkar, A., Hall, M. W., Exline, M. C., Hart, J., Knatz, N. L., Gatson, N. T., & Wewers, M. D. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200604-546oc · Cited by 150 · see citing works
Phuan, P.-W., Ratelade, J., Rossi, A., Tradtrantip, L., & Verkman, A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.344325 · Cited by 146 · see citing works
C1q and MBL, components of the innate immune system, influence monocyte cytokine expression
Fraser, D. A., Bohlson, S. S., Jasinskiene, N., Rawal, N., Palmarini, G., Ruiz, S., Rochford, R. A., & Tenner, A. J. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1105683 · Cited by 143 · see citing works
Rhinovirus-Induced Calcium Flux Triggers NLRP3 and NLRC5 Activation in Bronchial Cells
Triantafilou, K., Kar, S., van Kuppeveld, F. J. M., & Triantafilou, M. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0032oc · Cited by 141 · see citing works
Self-citationCharacterization of Complement Anaphylatoxins and Their Biological Responses
Ember, J. A., Jagels, M. A., & Hugli, T. E. (1998) · CRC Press eBooks · doi:10.1201/b14212-12 · Cited by 141 · see citing works
Pertussis Toxin-sensitive Activation of Phospholipase C by the C5a and fMet-Leu-Phe Receptors
Jiang, H., Kuang, Y., Wu, Y., Smrcka, A. V., Simon, M. I., & Wu, D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.23.13430 · Cited by 137 · see citing works
Kim, H. J., Lee, D. W., Ravichandran, K., Keys, D. O., Akçay, A., Nguyen, Q., He, Z., Jani, A. H., Ljubanović, D. G., & Edelstein, C. L. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.205732 · Cited by 134 · see citing works
Venkatesha, R. T., Thangam, E. R. R. B., Zaidi, A. K., & Ali, H. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.09.009 · Cited by 131 · see citing works
Chen, C.-B., & Wallis, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401318200 · Cited by 130 · see citing works
Wu, G., Hu, W., Shahsafaei, A., Song, W., Dobarro, M., Sukhova, G. K., Bronson, R. R., Shi, G., Rother, R. P., Halperin, J. A., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.191361 · Cited by 130 · see citing works
Huang, W., Huang, P., & Hillert, J. A. (2004) · Multiple Sclerosis Journal · doi:10.1191/1352458504ms1071oa · Cited by 128 · see citing works
Jones, H. D., Crother, T. R., González-Villalobos, R. A., Jupelli, M., Chen, S., Dagvadorj, J., Arditi, M., & Shimada, K. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0087oc · Cited by 125 · see citing works
Mapping of the C5a receptor signal transduction network in human neutrophils.
Buhl, A. M., Avdi, N. J., Worthen, G. S., & Johnson, G. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.9190 · Cited by 123 · see citing works
C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathway
Perianayagam, M. C., Balakrishnan, V. S., King, A. J., Pereira, B. J. G., & Jaber, B. L. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00139.x · Cited by 121 · see citing works
Skokowa, J., Ali, S. R., Felda, O., Kumar, V. V., Konrad, S., Shushakova, N., Schmidt, R. E., Piekorz, R. P., Nürnberg, B., Spicher, K., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.3041 · Cited by 119 · see citing works
Phieler, J., Chung, K., Chatzigeorgiou, A., Ameln, A. K., García-Martín, R., Sprott, D., Moisidou, M., Tzanavari, T., Ludwig, B., Baraban, E., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300038 · Cited by 114 · see citing works
Norgauer, J., Dobos, G., Kownatzki, E., Dahinden, C. A., Bürger, R., KUPPER, R., & Gierschik, P. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18245.x · Cited by 109 · see citing works
Recent developments in low molecular weight complement inhibitors
Qu, H., Ricklin, D., & Lambris, J. D. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.08.032 · Cited by 109 · see citing works
la Sala, A., Gadina, M., & Kelsall, B. L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.2994 · Cited by 106 · see citing works
The Role of the Complement System in Acute Kidney Injury
McCullough, J. W., Renner, B., & Thurman, J. M. (2013) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2013.08.005 · Cited by 106 · see citing works
Hu, R., Zf, C., Yan, J., Li, Q.-F., Huang, Y., Xu, H., Zhang, X., & Jiang, H. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.274 · Cited by 103 · see citing works
Caspase-1 expression in multiple sclerosis plaques and cultured glial cells
Ming, X., Li, W., Maeda, Y., Blumberg, B. M., Raval, S., Cook, S. D., & Dowling, P. C. (2002) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(02)00030-8 · Cited by 103 · see citing works
Sahu, A., Kozel, T. R., & Pangburn, M. K. (1994) · Biochemical Journal · doi:10.1042/bj3020429 · Cited by 102 · see citing works
Intracellular Ca2+ and cell injury: A paradoxical role of Ca2+ in complement membrane attack
Morgan, B. P., Luzio, J. P., & Campbell, A. K. (1986) · Cell Calcium · doi:10.1016/0143-4160(86)90042-4 · Cited by 102 · see citing works
Self-citationIdentification of four novel human G protein-coupled receptors expressed in the brain
Lee, D.-K., George, S. R., Cheng, R., Nguyen, T., Liu, Y., Brown, M., Lynch, K. R., & O’Dowd, B. F. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00242-4 · Cited by 101 · see citing works
Mullmann, T. J., Siegel, M. I., Egan, R. W., & Billah, M. M. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.5.1901 · Cited by 99 · see citing works
Inflammatory Caspases: Targets for Novel Therapies
Cornelis, S., Kersse, K., Festjens, N., Lamkanfi, M., & Vandenabeele, P. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207780163006 · Cited by 99 · see citing works
Tramontini, N. L., Huber, C. M., Liu‐Bryan, R., Terkeltaub, R. A., & Kilgore, K. S. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20386 · Cited by 89 · see citing works
Chemotaxis by mouse macrophage cell lines.
Aksamit, R. R., Falk, W., & Leonard, E. J. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.126.6.2194 · Cited by 85 · see citing works
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins
Chami, M., Oulès, B., & Paterlini-Bréchot, P. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.09.025 · Cited by 82 · see citing works
Two different transduction pathways are activated by C3a and C5a anaphylatoxins on astrocytes
Sayah, S., Jauneau, A.-C., Patte‐Mensah, C., Tonon, M., Vaudry, H., & Fontaine, M. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(03)00046-9 · Cited by 82 · see citing works
Hammerschmidt, D. E., Greenberg, C. S., Yamada, O., Craddock, P. R., & Jacob, H. S. (1981) · PubMed · Cited by 82 · see citing works
Raby, A., Holst, B., Davies, J. A., Colmont, C. S., Laumonnier, Y., Coles, B., Shah, S., Hall, J. E., Topley, N., Köhl, J., et al. (2011) · European Journal of Immunology · doi:10.1002/eji.201041350 · Cited by 77 · see citing works
Self-citationBraun, L., Christophe, T., & Boulay, F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210120200 · Cited by 75 · see citing works
Furlan, R., Filippi, M., Bergami, A., Rocca, M. A., Martinelli, V., Poliani, P. L., Grimaldi, L. M. E., Desina, G., Comı, G., & Martino, G. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.67.6.785 · Cited by 72 · see citing works
Complement C5a potentiates uric acid crystal‐induced IL‐1β production
An, L., Mehta, P., Xu, L., Turman, S., Reimer, T., Naiman, B. M., Connor, J. R., Sanjuán, M. A. F., Kolbeck, R., & Fung, M. S. C. (2014) · European Journal of Immunology · doi:10.1002/eji.201444560 · Cited by 71 · see citing works
Critical Role of Aquaporins in Interleukin 1β (IL-1β)-induced Inflammation
Rabolli, V., Wallemme, L., Re, S. L., Uwambayinema, F., Palmai‐Pallag, M., Thomassen, L. C. J., Tyteca, D., Octave, J., Marbaix, É., Lison, D., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.534594 · Cited by 71 · see citing works
Complement C1q regulates LPS‐induced cytokine production in bone marrow‐derived dendritic cells
Yamada, M., Oritani, K., Kaisho, T., Ishikawa, J., Yoshida, H., Takahashi, I., Kawamoto, S., Ishida, N., Ujiie, H., Masaie, H., et al. (2003) · European Journal of Immunology · doi:10.1002/eji.200324026 · Cited by 68 · see citing works
Lewis, R. D., Jackson, C. L., Morgan, B. P., & Hughes, T. R. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.10.035 · Cited by 63 · see citing works
Self-citationCastellano, G., Trouw, L. A., Fiore, N., Daha, M. R., Schena, F., & van Kooten, C. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2010.02.006 · Cited by 57 · see citing works
Petry, F., Reid, K. B. M., & Loos, M. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3988 · Cited by 56 · see citing works
Seifert, P. S., & Kazatchkine, M. D. (1987) · Molecular Immunology · doi:10.1016/0161-5890(87)90125-8 · Cited by 50 · see citing works
Ion flux in the lung: virus-induced inflammasome activation
Triantafilou, K., & Triantafilou, M. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2014.06.002 · Cited by 47 · see citing works
Self-citationMechanisms of complement activation by crystalline cholesterol
Vogt, W., von Zabern, I., Damerau, B., Hesse, D., Lühmann, B., & Nolte, R. (1985) · Molecular Immunology · doi:10.1016/s0161-5890(85)80003-1 · Cited by 46 · see citing works
Doherty, M., Whicher, J. T., & Dieppe, P. A. (1983) · Annals of the Rheumatic Diseases · doi:10.1136/ard.42.3.285 · Cited by 46 · see citing works
Interleukin 1 and tumor necrosis factor in obese alcoholics compared with normal-weight patients
Bunout, D. C., Muñoz, C., Lopez, M., de la Maza, M., Liana Schlesinger, F., Hirsch, S., & Pettermann, M. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.3.373 · Cited by 45 · see citing works
Yun, S., Leung, V. W. Y., Botto, M., Boyle, J. J., & Haskard, D. O. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.169912 · Cited by 39 · see citing works
Daly, J. J., & Kotwal, G. J. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00100-6 · Cited by 39 · see citing works
Monk, P. N., & Partridge, L. (1993) · Biochemical Journal · doi:10.1042/bj2950679 · Cited by 39 · see citing works
Papadimitriou, J. C., Phelps, P. C., Shin, M. L., Smith, M. W., & Trump, B. F. (1994) · Cell Calcium · doi:10.1016/0143-4160(94)90061-2 · Cited by 38 · see citing works
Kawana, N., Yamamoto, Y., Ishida, T., Saito, Y., Konno, H., Arima, K., & Satoh, J. (2013) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12068 · Cited by 34 · see citing works
Mannan binding lectin attenuates double‐stranded RNA‐mediated TLR3 activation and innate immunity
Liu, H., Zhou, J., Ma, D., Lu, X., Ming, S., Shan, G., Zhang, X., Hou, J., Chen, Z., & Zuo, D. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.01.064 · Cited by 27 · see citing works
Eculizumab opens a new era of treatment for paroxysmal nocturnal hemoglobinuria
Schrezenmeier, H., & Höchsmann, B. (2009) · Expert Review of Hematology · doi:10.1586/17474086.2.1.7 · Cited by 20 · see citing works
Lee, M., Narayanan, S., McGeer, E. G., & McGeer, P. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087316 · Cited by 15 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Langkabel P, Zwirner J, Oppermann M. Ligand-induced phosphorylation of anaphyla- toxin receptors C3aR and C5aR is mediated by G-protein-coupled receptor kinases. Eur J Immunol 1999; 29:3035-46.
- Monk P, Partridge L. Characterisation of a complement-fragement C5a stimulated cal- cium influx mechanism in U937 monocytic cells. Biochem J 1993; 295:679-84.
- Samuel V, Shulman G. Mechanisms of insulin resistance: common threads and miss- ing links. Cell 2012; 148:852-71.
- Kalant D, Cain S, Maslowska M, Sniderman A, Cianflone K, Monk P. The chemoat- tractant receptor-like protein C5L2 binds the C3ades-Arg77/Acylation-stimulating pro- tein. J Biol Chem 2003; 278:11123-9.
- Kawana N, Yamamoto Y, Ishida T, Saito Y, Konno H, Arima K et al. Reactive astro- cytes and perivascular macrophages express NLRP3 inflammasome in active demyeli- nating lesions of multiple sclerosis and necrotic lesions of neuromyelitis optica and cerebral infarction. Clin Exp Neuroimmunol 2013; 4:296-304. 122
Cited by
Sorted by citations
Liver Macrophages in Tissue Homeostasis and Disease
Krenkel, O., & Tacke, F. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.11 · Cited by 1,424 · see citing works
Complement in disease: a defence system turning offensive
Ricklin, D., Reis, E. S., & Lambris, J. D. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.70 · Cited by 558 · see citing works
TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease
Yang, J., Wise, L., & Fukuchi, K.-I. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00724 · Cited by 387 · see citing works
Complement and the Regulation of T Cell Responses
West, E. E., Kolev, M. V., & Kemper, C. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053245 · Cited by 271 · see citing works
Complement-Mediated Regulation of Metabolism and Basic Cellular Processes
Hess, C., & Kemper, C. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.003 · Cited by 176 · see citing works
COVID-19: Complement, Coagulation, and Collateral Damage
Lo, M. W., Kemper, C., & Woodruff, T. M. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000644 · Cited by 158 · see citing works
Arbore, G., & Kemper, C. (2016) · European Journal of Immunology · doi:10.1002/eji.201546131 · Cited by 141 · see citing works
Complement: Bridging the innate and adaptive immune systems in sterile inflammation
Lo, M. W., & Woodruff, T. M. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mir0220-270r · Cited by 106 · see citing works
Role of the inflammasome in insulin resistance and type 2 diabetes mellitus
Lu, S., Li, Y., Qian, Z., Zhao, T., Feng, Z., Weng, X., & Yu, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1052756 · Cited by 83 · see citing works
Inflammasomes: Pandora’s box for sepsis
Kumar, V. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s178084 · Cited by 85 · see citing works
Complement cascade inhibition in geographic atrophy: a review
Desai, D., & Dugel, P. U. (2022) · Eye · doi:10.1038/s41433-021-01765-x · Cited by 76 · see citing works
Vilariño‐Güell, C., Zimprich, A. A., Boneschi, F. M., Herculano, B., Wang, Z., Matesanz, F., Urcelay, E., Vandenbroeck, K., Leyva, L., Gris, D., et al. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008180 · Cited by 76 · see citing works
Briard, B., Karki, R., Malireddi, R. K. S., Bhattacharya, A., Place, D. E., Mavuluri, J., Peters, J. L., Vogel, P., Yamamoto, M., & Kanneganti, T. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0298-0 · Cited by 71 · see citing works
Soluble Membrane Attack Complex: Biochemistry and Immunobiology
Barnum, S. R., Bubeck, D., & Schein, T. N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.585108 · Cited by 72 · see citing works
Molecular and genetic inflammation networks in major human diseases
Zhao, Y., Forst, C. V., Sayegh, C. E., Wang, I., Yang, X., & Zhang, B. (2016) · Molecular BioSystems · doi:10.1039/c6mb00240d · Cited by 71 · see citing works
Macrophages in nonalcoholic fatty liver disease: a role model of pathogenic immunometabolism
Krenkel, O., & Tacke, F. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1604480 · Cited by 66 · see citing works
Complement dysregulation is a prevalent and therapeutically amenable feature of long COVID
Baillie, K. L., Davies, H. E., Keat, S., Ladell, K., Miners, K. L., Jones, S., Melou, E., Toonen, E. J. M., Price, D. A., Morgan, B. P., et al. (2024) · Med · doi:10.1016/j.medj.2024.01.011 · Cited by 62 · see citing works
Self-citationTerminal complexes of the complement system: New structural insights and their relevance to function
Morgan, B. P., Walters, D., Serna, M., & Bubeck, D. (2016) · Immunological Reviews · doi:10.1111/imr.12461 · Cited by 58 · see citing works
Self-citationThe complex functioning of the complement system in xenotransplantation
Zhou, H., Hara, H., & Cooper, D. K. C. (2019) · Xenotransplantation · doi:10.1111/xen.12517 · Cited by 59 · see citing works
Michailidou, I., Jongejan, A., Vreijling, J. P., Georgakopoulou, T., de Wissel, M. B., Wolterman, R. A., Ruizendaal, P., Klar‐Mohamad, N., Grootemaat, A. E., Picavet, D. I., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0536-y · Cited by 54 · see citing works
Self-citationMechanisms of SARS-CoV-2-induced lung vascular disease: potential role of complement
Stenmark, K., Frid, M., Gerasimovskaya, E., Zhang, H., McCarthy, M., Thurman, J., & Morrison, T. (2021) · Pulmonary Circulation · doi:10.1177/20458940211015799 · Cited by 43 · see citing works
Extra-Pulmonary Complications in SARS-CoV-2 Infection: A Comprehensive Multi Organ-System Review
Louis, T. J., Qasem, A., Abdelli, L. S., & Naser, S. A. (2022) · Microorganisms · doi:10.3390/microorganisms10010153 · Cited by 50 · see citing works
NLRP3 inflammasome activation contributes to aldosterone-induced podocyte injury
Bai, M., Chen, Y., Zhao, M., Zhang, Y., He, J. C., Huang, S., Jia, Z., & Zhang, A. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00332.2016 · Cited by 51 · see citing works
A double edged-sword - The Complement System during SARS-CoV-2 infection
Santiesteban-Lores, L. E., Amamura, T. A., da Silva, T. F., Midon, L. M., Carneiro, M. C., Isaac, L., & Bavia, L. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119245 · Cited by 47 · see citing works
Hammadi, S., Tzoumas, N., Ferrara, M., Meschede, I. P., Lo, K., Harris, C., Lako, M., & Steel, D. H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082870 · Cited by 44 · see citing works
Declercq, J., Leeuw, E. D., & Lambrecht, B. N. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155934 · Cited by 40 · see citing works
Bjånes, E., & Nizet, V. (2021) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00177-20 · Cited by 36 · see citing works
Minimizing Ischemia Reperfusion Injury in Xenotransplantation
Patel, P. M., Connolly, M. R., Coe, T. M., Calhoun, A., Pollok, F., Markmann, J. F., Burdorf, L., Azimzadeh, A. M., Madsen, J. C., & Pierson, R. N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.681504 · Cited by 33 · see citing works
Colchicine for the treatment of cardiovascular diseases: old drug, new targets
Andreis, A., Imazio, M., & Ferrari, G. M. D. (2020) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000001079 · Cited by 31 · see citing works
Colchicine in Stable Coronary Artery Disease
Fiolet, A. T. L., Nidorf, S. M., Mosterd, A., & Cornel, J. H. (2018) · Clinical Therapeutics · doi:10.1016/j.clinthera.2018.09.011 · Cited by 29 · see citing works
Pedicino, D., Giglio, A. F., Ruggio, A., Massaro, G., d’Aiello, A., Trotta, F., Lucci, C., Graziani, F., Biasucci, L. M., Crea, F., et al. (2018) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1666860 · Cited by 28 · see citing works
Ge, T.-Q., Guan, P.-P., & Wang, P. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105868 · Cited by 27 · see citing works
The dual role of complement in cancers, from destroying tumors to promoting tumor development
Lü, P., Ma, Y., Wei, S., & Liang, X. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155522 · Cited by 25 · see citing works
Unexpected Roles for Intracellular Complement in the Regulation of Th1 Responses
West, E. E., Afzali, B., & Kemper, C. (2018) · Advances in immunology · doi:10.1016/bs.ai.2018.02.001 · Cited by 25 · see citing works
Hokstad, I., Deyab, G., Fagerland, M. W., Lyberg, T., Hjeltnes, G., Førre, Ø. T., Agewall, S., Mollnes, T. E., & Hollan, I. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220079 · Cited by 23 · see citing works
Complement System and Alarmin HMGB1 Crosstalk: For Better or Worse
Gaboriaud, C., Lorvellec, M., Rossi, V., Dumestre‐Pérard, C., & Thielens, N. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.869720 · Cited by 23 · see citing works
Evaluation of complement system proteins C3a, C5a and C6 in patients of endometriosis
Karadadaş, E., Hortu, İ., Ak, H., Ergenoğlu, A. M., Karadadaş, N., & Aydın, H. H. (2020) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2020.04.005 · Cited by 22 · see citing works
Neural–Cardiac Inflammasome Axis after Traumatic Brain Injury
Keane, R. W., Hadad, R., Scott, X. O., Ranaldi, E. D. L. R. M. C., Pérez‐Bárcena, J., & Vaccari, J. P. D. R. (2023) · Pharmaceuticals · doi:10.3390/ph16101382 · Cited by 21 · see citing works
Yang, Z., Nicholson, S. E., Cancio, T. S., Cancio, L. C., & Li, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1100461 · Cited by 21 · see citing works
Sexual Dimorphism, Age, and Fat Mass Are Key Phenotypic Drivers of Proteomic Signatures
Curran, A. M., Draper, C. F., Scott‐Boyer, M., Valsesia, A., Roche, H. M., Ryan, M. F., Gibney, M. J., Kutmon, M., Evelo, C. T., Coort, S. L., et al. (2017) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00501 · Cited by 20 · see citing works
Preeclampsia: Platelet procoagulant membrane dynamics and critical biomarkers
Agbani, E. O., Skeith, L., & Lee, A. (2023) · Research and Practice in Thrombosis and Haemostasis · doi:10.1016/j.rpth.2023.100075 · Cited by 17 · see citing works
Wu, X., Yao, D., Bao, L., Liu, D., Xu, X., An, Y., Zhang, X., & Cao, B. (2020) · Immunology and Cell Biology · doi:10.1111/imcb.12344 · Cited by 17 · see citing works
Ahmed, C. M. I., Johnson, H. M., & Lewin, A. S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1416181 · Cited by 15 · see citing works
Yang, Z., Nunn, M. A., Le, T. D., Simovic, M. O., Edsall, P. R., Liu, B., Barr, J. L., Lund, B. J., Hill-Pryor, C., Pusateri, A. E., et al. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15970 · Cited by 15 · see citing works
The Inflammatory Response in Tissue Repair
Frangogiannis, N. G. (2017) · Wiley-VCH eBooks · doi:10.1002/9783527692156.ch60 · Cited by 14 · see citing works
Wang, S., Wang, Z., Gu, Y., Li, Z., Li, Z.-Y., Wei, F., & Liu, Q. (2016) · Microbes and Infection · doi:10.1016/j.micinf.2016.07.004 · Cited by 12 · see citing works
Troise, D. E., Allegra, C., Cirolla, L. A., Mercuri, S., Infante, B., Castellano, G., & Stallone, G. (2025) · Antioxidants · doi:10.3390/antiox14010066 · Cited by 10 · see citing works
Comprehensive review: Frailty in pancreas transplant candidates and recipients
Parsons, R. F., Tantisattamo, E., Cheungpasitporn, W., Basu, A., Lu, Y., Lentine, K. L., Woodside, K. J., Singh, N., Scalea, J. R., Alhamad, T., et al. (2023) · Clinical Transplantation · doi:10.1111/ctr.14899 · Cited by 9 · see citing works
The Roles of Long Noncoding RNA in Depression
Wang, S., Tang, L., Huang, N., & Wang, H. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2811321 · Cited by 8 · see citing works
Colchicine in atrial fibrillation: are old trees in bloom?
Zhan, Y., Yue, H., Zhao, X., Tang, J., & Wu, Z. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1260774 · Cited by 7 · see citing works
Recent advances into the role of pattern recognition receptors in transplantation
Kulkarni, H. S., Scozzi, D., & Gelman, A. E. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104088 · Cited by 7 · see citing works
Complement dysregulation is a predictive and therapeutically amenable feature of long COVIDPreprint
Baillie, K. L., Davies, H. E., Keat, S., Ladell, K., Miners, K. L., Jones, S., Mellou, E., Toonen, E. J. M., Price, D. A., Morgan, B. P., et al. (2023) · medRxiv · doi:10.1101/2023.10.26.23297597 · Cited by 7 · see citing works
Self-citationComplement and inflammasome crosstalk in chronic inflammation
Janžič, L., & Kouter, K. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1778759 · Cited by 5 · see citing works
Cooke, R. S., Spicer, B. A., Harrison, R. A., Dunstone, M. A., Morgan, B. P., & Zelek, W. M. (2025) · Immunology · doi:10.1111/imm.70008 · Cited by 5 · see citing works
Self-citationGene Expression Profile in the Liver of Sheep Infected with Cystic Echinococcosis
Hui, W., Jiang, S., Liu, X., Ban, Q., Chen, S., & Jia, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160000 · Cited by 5 · see citing works
Catecholamine-Induced Inflammasome Activation in the Heart Following Photothrombotic Stroke
Scott, X. O., Kerr, N. A., Sanchez‐Molano, J., Vaccari, J. P. D. R., Hadad, R., de la Cruz, A., Larsson, H. P., Dietrich, W. D., & Keane, R. W. (2024) · Translational Stroke Research · doi:10.1007/s12975-024-01311-3 · Cited by 4 · see citing works
The grand escape – how pathogens outsmart the human complement system
Nowacka, A. A., Vieira, L. S., Petr, V., Fageräng, B., Würzner, R., & Ohms, M. (2025) · Immunobiology · doi:10.1016/j.imbio.2025.153126 · Cited by 4 · see citing works
Complement in acute kidney injury: a convergent pathogenic pathway in multifactorial renal damage
Yi, D., Yang, R., Guo, Y., Zhou, H., & Luan, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1840335 · Cited by 2 · see citing works
Boaru, D. L., Castro-Martinez, P. D., García-Montero, C., Fraile‐Μartinez, O., Alhaddadin, M. N. M., Barrena-Blázquez, S., López-González, L., Tasende, C., Hurtado, R. A., Giménez, T. R., et al. (2026) · MedComm · doi:10.1002/mco2.70844 · Cited by 2 · see citing works
Qingfei Paidu Decoction Inhibits LPS-induced Acute Lung Injury by Targeting the Complement Pathway
Shi, D., Ge, L., Yan, L., Zhang, Y., Wang, T., Geng, Y., Fan, H., Zhang, R., Shao, Z., Hu, L., et al. (2023) · Exploratory Research and Hypothesis in Medicine · doi:10.14218/erhm.2022.00127 · Cited by 2 · see citing works
Eker, S. G., Yengin, G. I., Tatar, C., & Öktem, G. (2024) · Advances in experimental medicine and biology · doi:10.1007/5584_2024_838 · Cited by 2 · see citing works
Humoral Innate Immune Effector Responses
Land, W. G. (2018) · Springer eBooks · doi:10.1007/978-3-319-78655-1_23 · Cited by 2 · see citing works
Korhonen, E. (2024) · Acta Ophthalmologica · doi:10.1111/aos.16646 · Cited by 2 · see citing works
The Immunotoxicology of Nanotechnology-Derived Materials and Therapeutics
House, R. V. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00068-1 · Cited by 1 · see citing works
Establishment of a Time-Resolved Fluoroimmunoassay for sC5b-9 and Validation in Lupus Nephritis
Wu, B., Zhu, L., Kao, S., Bao, H., Zheng, T., Qin, Y., Shao, X., Huang, B., & Zhao, H. (2025) · Journal of Fluorescence · doi:10.1007/s10895-025-04620-4 · Cited by 1 · see citing works
Roles of the Complement System in Peripheral Nerve Injury and Repair
Azar, C., Pan, K., Jain, P., Sánchez‐López, E., & Shah, S. B. (2026) · Bioengineering · doi:10.3390/bioengineering13020251 · Cited by 1 · see citing works
The Immunotoxicology of Nanotechnology-Derived Materials and Therapeutics
House, R. V. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64243-5
Limulus Ancient Innate Responses
Gustchina, E., & Williams, K. L. (2019) · Springer eBooks · doi:10.1007/978-3-030-17148-3_18
Pathogenesis of age-related macular degeneration
Li, W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822061-0.00002-5
Yu, J., Nie, Z.-Y., Feng, D.-D., Zhang, L., Bai, Y., Zhang, H., Zhao, J., & Pan, W. (2023) · Research Square · doi:10.21203/rs.3.rs-2912890/v1
Role of Kupffer cells and other immune cells
Puengel, T., & Tacke, F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95262-0.00024-3
Liver Steatosis: From Lipotoxicity to Cellular Damage
Puengel, T., & Tacke, F. (2024) · Springer eBooks · doi:10.1007/978-981-97-9519-2_4 · Cited by 1 · see citing works
Khau, S., Treps, L., Ilango, G., Riteau, N., Couillin, I., Togbe, D., Bigot, J., Balloy, V., David, C., Blan, M. C. L., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.20.707105
Qi, M., Derby, C. A., Rader, D. J., Janssen, İ., Barinas-Mitchell, E. J. W., Brooks, M. M., Chang, C.-C. H., Karlamangla, A. S., McConnell, D. S., Crawford, S., et al. (2026) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000002874
Neumann, C. M., Hickl, F., Kemnitzer, J., Leitner, M., Giamarellos‐Bourboulis, E. J., & Rubio, I. (2026) · Critical Care · doi:10.1186/s13054-026-06315-z
- Authors
- Triantafilou, M., Hughes, T. R., Morgan, B. P., & Triantafilou, K.
- Affiliations
- University Hospital of Wales (GB)
- Corresponding author
- Triantafilou, Kathy
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 2016-01-19
- Volume
- 147
- Issue
- 2
- Pages
- 152-164
- ISSN
- 0019-2805 (ISSN-L)
- 1365-2567
- PMC
- PMC4717242
- OpenAlex
- W2174642786
- Cited by
- 76
- References
- 134
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 10 · 2023: 11 · 2022: 5 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 8 · 2017: 6 · 2016: 7
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Keywords
- complement system, inflammasome, innate immunity, pattern recognition receptors, Toll-like receptors, C-type lectin, immune homeostasis, disease
- MeSH terms
- Animals, Anti-Inflammatory Agents, Complement System Proteins, Complement Activation, Humans, Immunity, Innate, Inflammation, Ligands, Receptors, Immunologic, Signal Transduction, Inflammation Mediators, Inflammasomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review