Cited by 76Inflammasome and immune disordersImmune Response and InflammationComplement system in diseases

Complementing the inflammasome

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Triantafilou, Martha, Hughes, Timothy R., Morgan, Bryan Paul, Triantafilou, Kathy·2016·Immunology

Abstract

Summary: The innate immune system is an ancient surveillance system able to sense microbial invaders as well as aberrations in normal cell function. No longer viewed as a static and non‐specific part of immunity, the innate immune system employs a plethora of specialized pattern recognition sensors to monitor and achieve homeostasis; these include the Toll‐like receptors, the retinoic acid‐inducible gene‐like receptors, the nucleotide‐binding oligomerization domain receptors (NLR s), the C‐type lectins and the complement system. In order to increase specificity and diversity, innate immunity uses homotypic and heterotypic associations among these different components. Multi‐molecular assemblies are formed both on the cell surface and in the cytosol to respond to pathogen and danger signals. Diverse, but tailored, responses to a changing environment are orchestrated depending on the the nature of the challenge and the repertoire of interacting receptors and components available in the sensing cell. It is now emerging that innate immunity operates a system of ‘checks and balances’ where interaction among the sensors is key in maintaining normal cell function. Complement sits at the heart of this alarm system and it is becoming apparent that it is capable of interacting with all the other pathways to effect a tailored immune response. In this review, we will focus on complement interactions with NLR s, the so‐called ‘inflammasomes’, describing the molecular mechanisms that have been revealed so far and discussing the circumstantial evidence that exists for these interactions in disease states.

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Authors
Triantafilou, M., Hughes, T. R., Morgan, B. P., & Triantafilou, K.
Affiliations
University Hospital of Wales (GB)
Corresponding author
Triantafilou, Kathy
Venue
Immunology
Publisher
Wiley
Published
2016-01-19
Volume
147
Issue
2
Pages
152-164
ISSN
  • 0019-2805 (ISSN-L)
  • 1365-2567
OpenAlex
W2174642786
Cited by
76
References
134
Citations by year
2026: 7 · 2025: 4 · 2024: 10 · 2023: 11 · 2022: 5 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 8 · 2017: 6 · 2016: 7
FWCI
0.68
Type
journal article
Language
en
Open access
Locations
  • Immunology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
Keywords
complement system, inflammasome, innate immunity, pattern recognition receptors, Toll-like receptors, C-type lectin, immune homeostasis, disease
MeSH terms
Animals, Anti-Inflammatory Agents, Complement System Proteins, Complement Activation, Humans, Immunity, Innate, Inflammation, Ligands, Receptors, Immunologic, Signal Transduction, Inflammation Mediators, Inflammasomes

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