NF‐κB: roles and regulation in different CD 4+ T‐cell subsets
Open accessAbstract
Summary: The nuclear factor‐κB (NF‐κB) family of transcription factors plays important roles in various biological processes including apoptosis, stress response, immunity, and inflammation. NF‐κB signaling is involved in both immune cell development and function, and it is critical in modulation of the immune response through the transcriptional regulation of cytokine and chemokine expression. An area of great interest in T‐cell‐mediated adaptive immunity is the ability of naive CD 4+ T cells generated in the thymus to differentiate into various subsets including T‐helper 1 (Th1), Th2, Th17, Th9, follicular helper T (Tfh), Th22, and regulatory T (Treg) cells, upon encountering different pathogens and microenvironments. In this review, we discuss the role of NF‐κB pathway in the development and functional divergence of the different helper T‐cell subsets as well as in regulatory T cells.
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The identified TFs (FOXK2 and NR4A1) have important roles in naive CD4+ T cell response upon TCR stimulation.
“Other studies have also shown that FOXK2 affects the activation of T lymphocytes77,78 and revealed the essential roles of NR4A1 in regulatory T cell differentiation79,80, suggesting that the identified TFs have important roles in naive CD4+ T cell response upon TCR stimulation.”
From Inferring gene regulatory networks from single-cell multiome data using atlas-scale external data (2025) · cites this paper as [78]
The Introduction discusses TCR-stimulated T-cell activation, and the section on natural regulatory T-cell development discusses NF-κB and FoxP3. Searches for NR4A1 and FOXK2 returned no passages linking either factor to regulatory T-cell differentiation or naive CD4+ T-cell responses. Our copy therefore does not address the claim about these two factors. (LLM, conf=0.76)
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BackgroundEarly, S., Huyett, P. A., Brown-Steinke, K., Borish, L., & Steinke, J. W. (2009) · Genes and Immunity · doi:10.1038/gene.2009.28 · Cited by 13 · cited 1× · see citing works
“Finally, it has been suggested that IL-9 expression in T cells is regulated by NF-jB, thereby implicating the pathway in the function of these cells (41).”
Background
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- [1]Hayden MS Ghosh S NF-kappaB in immunobiology Cell Res 2011 21 223 244 21243012 PMC3193440
- [59]Crotty S Follicular helper CD4 T cells (Tfh) Annu Rev Immunol 2011 29 621 663 21314428
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Sorted by citations
NF-κB signaling in inflammation
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JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression
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NF-κB in inflammation and cancer
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Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development
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Pathogenesis of allergic diseases and implications for therapeutic interventions
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NF-κB in inflammation and renal diseases
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NF ‐κB and HIF crosstalk in immune responses
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NF-kappaB: Two Sides of the Same Coin
Pires, B. R. B., Silva, R. C. M. C., Ferreira, G. M., & Abdelhay, E. S. F. W. (2018) · Genes · doi:10.3390/genes9010024 · Cited by 235 · see citing works
“Functions: Supports the activity of different T CD4+ cell sub-types, such as T helper 1 (Th1) and T regulatory cells (Tregs) [43].”
BackgroundNF-κB control of T cell development
Gerondakis, S., Fulford, T. S., Messina, N. L., & Grumont, R. J. (2013) · Nature Immunology · doi:10.1038/ni.2785 · Cited by 235 · see citing works
Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma
Seumois, G., Ramírez-Suástegui, C., Schmiedel, B. J., Liang, S. Y., Peters, B., Sette, A., & Vijayanand, P. (2020) · Science Immunology · doi:10.1126/sciimmunol.aba6087 · Cited by 208 · see citing works
“Prosurvival factors included several in the nuclear factor B signaling pathway, including NFKBID, NIPAI, MAP3K8, FOSL2, NEDD9 (89), ZEB2, BCL2A1 (90), BIRC3 (91), DUSP4/MKP-2 (92, 93), and CFLAR (cFLIP/CASPER) (94).”
BackgroundNotch in T Cell Differentiation: All Things Considered
Amsen, D., Helbig, C., & Backer, R. A. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.10.007 · Cited by 182 · see citing works
NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development
Ratnam, N. M., Peterson, J. M., Talbert, E. E., Ladner, K. J., Rajasekera, P. V., Schmidt, C. R., Dillhoff, M. E., Swanson, B. J., Haverick, E. N., Kladney, R. D., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci91561 · Cited by 176 · see citing works
Interleukin-17 in human inflammatory diseases
Shabgah, A. G., Fattahi, E., & Shahneh, F. Z. (2014) · Advances in Dermatology and Allergology · doi:10.5114/pdia.2014.40954 · Cited by 173 · see citing works
NF-κB pathways in hematological malignancies
Gasparini, C., Celeghini, C., Monasta, L., & Zauli, G. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1545-4 · Cited by 166 · see citing works
Klemann, C., Camacho-Ordóñez, N., Yang, L., Eskandarian, Z., Rojas‐Restrepo, J., Frede, N., Bulashevska, A., Heeg, M., Al-Ddafari, M. S., Premm, J., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00297 · Cited by 150 · see citing works
Identification of environmental factors that promote intestinal inflammation
Sanmarco, L. M., Chao, C., Wang, Y., Kenison, J. E., Li, Z., Rone, J. M., Rejano-Gordillo, C. M., Polonio, C. M., Gutiérrez‐Vázquez, C., Piester, G., et al. (2022) · Nature · doi:10.1038/s41586-022-05308-6 · Cited by 151 · see citing works
NF-κB: master regulator of cellular responses in health and disease
Hoffmann, A., Cheng, G., & Baltimore, D. (2025) · Immunity & Inflammation · doi:10.1007/s44466-025-00014-0 · Cited by 169 · see citing works
Immune system adaptation during gender-affirming testosterone treatment
Lakshmikanth, T., Consiglio, C. R., Sardh, F., Forlin, R., Wang, J., Tan, Z., Barcenilla, H., Rodriguez, L., Sugrue, J. A., Noori, P., et al. (2024) · Nature · doi:10.1038/s41586-024-07789-z · Cited by 148 · see citing works
“…binding sites (data not shown), indicating that the canonical NFκB pathway is induced epigenetically in T/NK cells following testosterone treatment, possibly as a consequence of elevated TNF responses by myeloid cells, with broad functional implications for T/NK cell function and proliferation 32 .”
BackgroundLaurindo, L. F., Dias, J. A., Araújo, A. C., Pomini, K. T., Galhardi, C. M., Detregiachi, C. R. P., Haber, L. S. D. A., Roque, D. D., Bechara, M. D., de Castro, M. V. M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1305933 · Cited by 149 · see citing works
Hypoxia‐Inducible Exosomes Facilitate Liver‐Tropic Premetastatic Niche in Colorectal Cancer
Sun, H., Meng, Q., Shi, C., Yang, H., Li, X., Wu, S., Familiari, G., Relucenti, M., Aschner, M., Wang, X., et al. (2021) · Hepatology · doi:10.1002/hep.32009 · Cited by 143 · see citing works
Lactate oxidase nanocapsules boost T cell immunity and efficacy of cancer immunotherapy
Cao, Z., Xu, D., Harding, J., Chen, W., Liu, X., Wang, Z., Wang, L., Qi, T., Chen, S., Guo, X., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.add2712 · Cited by 141 · see citing works
Gut microbiota in pre-clinical rheumatoid arthritis: From pathogenesis to preventing progression
Lin, L., Zhang, K., Xiong, Q., Zhang, J., Cai, B., Huang, Z., Yang, B., Wei, B., Chen, J., & Niu, Q. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103001 · Cited by 138 · see citing works
A population-level digital histologic biomarker for enhanced prognosis of invasive breast cancer
Amgad, M., Hodge, J. M., Elsebaie, M. A. T., Bodelon, C., Puvanesarajah, S., Gutman, D. A., Siziopikou, K. P., Goldstein, J. A., Gaudet, M. M., Teras, L. R., et al. (2024) · Nature Medicine · doi:10.1038/s41591-023-02643-7 · Cited by 137 · see citing works
“In addition, GSEA using the Hallmarks set showed that chromatin clumping of TILs was positively associated with protein secretion, probably because of B cells and plasma cells, and inversely associated with TNF-α signaling via NF-kB, a critical pathway in T cell activation 69,70,74,75 .”
Song, N., Thaiss, F., & Guo, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00815 · Cited by 123 · see citing works
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
Mikami, N., Kawakami, R., Chen, K. Y., Sugimoto, A., Ohkura, N., & Sakaguchi, S. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922600117 · Cited by 119 · see citing works
“With our observation of a lower level of NF-κ B signaling-related genes expressed in both stimulated CD28( − ) iTregs and nTregs, it remains to be investigated whether excessive NF-κ B signaling may preferentially polarize Tconvs toward effector T cell differentiation and away from pTregs (48, 49).”
Inferring gene regulatory networks from single-cell multiome data using atlas-scale external data
Yuan, Q., & Duren, Z. (2025) · Nature Biotechnology · doi:10.1038/s41587-024-02182-7 · Cited by 118 · see citing works
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Small molecules in the treatment of COVID-19
Lei, S., Chen, X., Wu, J., Duan, X., & Men, K. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01249-8 · Cited by 117 · see citing works
Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease
Davies, D. A., Adlimoghaddam, A., & Albensi, B. C. (2021) · Cells · doi:10.3390/cells10081884 · Cited by 111 · see citing works
NF-κB signaling pathway and its potential as a target for therapy in lymphoid neoplasms
Yu, L., Li, L., Medeiros, L. J., & Young, K. H. (2017) · Blood Reviews · doi:10.1016/j.blre.2016.10.001 · Cited by 105 · see citing works
NF-κB and Its Role in Checkpoint Control
Betzler, A. C., Theodoraki, M., Schuler, P. J., Döscher, J., Laban, S. A., Hoffmann, T. K., & Brunner, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113949 · Cited by 102 · see citing works
Masenga, S. K., Mweene, B. C., Luwaya, E. L., Muchaili, L., Chona, M., & Kirabo, A. (2023) · Cells · doi:10.3390/cells12101351 · Cited by 106 · see citing works
Harusato, A., Abo, H., Ngo, V. L., Yi, S. W., Mitsutake, K., Osuka, S., Kohlmeier, J. E., Li, J., Gewirtz, A. T., Nusrat, A., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.21 · Cited by 99 · see citing works
Morris, G., Bortolasci, C. C., Puri, B. K., Marx, W., O'Neil, A. E., Athan, E., Walder, K. R., Berk, M., OLIVE, L. S., Carvalho, A. F., et al. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155593 · Cited by 97 · see citing works
NF-κB Signaling and Inflammation—Drug Repurposing to Treat Inflammatory Disorders?
Roberti, A., Chaffey, L., & Greaves, D. R. (2022) · Biology · doi:10.3390/biology11030372 · Cited by 103 · see citing works
Nicolay, J., Müller-Decker, K., Schroeder, A. E., Brechmann, M., Möbs, M., Géraud, C., Assaf, C., Goerdt, S., Krammer, P., & Gülow, K. (2016) · Blood · doi:10.1182/blood-2016-01-694117 · Cited by 98 · see citing works
“As opposed to restingT cells (D0), activatedTcells (D6) dependonNF-kB.(37)Upon DMF treatment, activated, but not resting, healthy T cells were shown to undergo cell death, reflecting selective cell death induction by DMF in cells with high NF-kB activity(18,21,37) (supplemental Figure 1C).”
BackgroundNuclear Factor-kappaB in Autoimmunity: Man and Mouse
Miraghazadeh, B., & Cook, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00613 · Cited by 96 · see citing works
Targeting the NF-κB pathway as a potential regulator of immune checkpoints in cancer immunotherapy
Ebrahimi, N., Abdulwahid, A. R. R., Mansouri, A., Karimi, N., Bostani, R. J., Beiranvand, S., Adelian, S., Khorram, R., Vafadar, R., Hamblin, M. R., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05098-8 · Cited by 98 · see citing works
Nazerian, Y., Ghasemi, M., Yassaghi, Y., Nazerian, A., & Hashemi, S. M. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109428 · Cited by 96 · see citing works
“Activation of the NF-κB pathway is also involved in regulating CD4 T-cell differentiation following TCR activation and also via regulating the cytokine production in innate immune response [72].”
BackgroundInflammation and pancreatic cancer: An updated review
Shadhu, K., & Xi, C. (2018) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_390_18 · Cited by 94 · see citing works
“[9,10] NF‐κB is a transcription factor known to participate in the communication between tumor and immune cells.[11] The NF‐κB subunit p65 is ubiquitously expressed in mammalian cells, and when constitutively activated, it is associated with cellular transformation.”
BackgroundLkb1 maintains Treg cell lineage identity
Wu, D., Luo, Y., Guo, W., Niu, Q., Xue, T., Yang, F., Sun, X., Chen, S., Liu, Y., Liu, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms15876 · Cited by 90 · see citing works
Shi, Y., Zhao, T., Yang, X., Sun, B., Li, Y., Duan, J., & Sun, Z. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.09.085 · Cited by 92 · see citing works
Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma
Seumois, G., Zapardiel‐Gonzalo, J., White, B. M., Singh, D. K., Schulten, V. M. J., Dillon, M., Hinz, D., Broide, D. H., Sette, A., Peters, B., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600397 · Cited by 92 · see citing works
STIM- and Orai-mediated calcium entry controls NF-κB activity and function in lymphocytes
Berry, C. T., May, M. J., & Freedman, B. D. (2018) · Cell Calcium · doi:10.1016/j.ceca.2018.07.003 · Cited by 90 · see citing works
A timer for analyzing temporally dynamic changes in transcription during differentiation in vivo
Bending, D., Martín, P. P., Paduraru, A., Ducker, C. B., Marzaganov, E., Laviron, M., Kitano, S., Miyachi, H., Crompton, T., & Ono, M. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201711048 · Cited by 89 · see citing works
“A timer for analyzing temporally dynamic changes in transcription during differentiation in vivo Journal of Cell Biology https://doi.org/10.1083/jcb.201711048 2 (Oh and Ghosh, 2013), but their effects on T cell differentiation over the timescale of hours and days are obscure.”
MethodInfluentialTargeting Undruggable Transcription Factors with PROTACs: Advances and Perspectives
Li, Y., Song, J. H., Zhou, P., Zhou, J., & Xie, S. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00691 · Cited by 88 · see citing works
Selenium and Selenoproteins in Gut Inflammation—A Review
Nettleford, S. K., & Prabhu, K. S. (2018) · Antioxidants · doi:10.3390/antiox7030036 · Cited by 87 · see citing works
Yoon, S., Mitra, S., Wyse, C. A., Alnabulsi, A., Zou, J., Weerdenburg, E. M., van der Sar, A. M., Wang, D., Secombes, C. J., & Bird, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126378 · Cited by 87 · see citing works
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“Toll-like receptor (TLR) agonists, which stimulate immune signaling pathways in T cells, leading to transcriptional modifications and NF-κB activation [9, 10].”
BackgroundRole and mechanisms of the NF-ĸB signaling pathway in various developmental processes
Liu, P., Li, Y., Wang, W., Bai, Y., Jia, H., Yuan, Z., & Zhonghua, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113513 · Cited by 85 · see citing works
Targeting ubiquitin signaling for cancer immunotherapy
Zhou, X., & Sun, S. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00421-2 · Cited by 84 · see citing works
GWAS analysis implicates NF-κB-mediated induction of inflammatory T cells in multiple sclerosis
Hussman, J. P., Beecham, A. H., Schmidt, M. A., Martin, E. R., McCauley, J. L., Vance, J. M., Haines, J. L., & Pericak‐Vance, M. A. (2016) · Genes and Immunity · doi:10.1038/gene.2016.23 · Cited by 80 · see citing works
Wang, T., Husain, M., Hong, S., & Holland, J. W. (2014) · European Journal of Immunology · doi:10.1002/eji.201344273 · Cited by 77 · see citing works
Liu, J., Wang, S., Zhang, Q., Li, X., & Xu, S. (2019) · Metallomics · doi:10.1039/c9mt00216b · Cited by 75 · see citing works
Escape from X chromosome inactivation and female bias of autoimmune diseases
Mousavi, M. J., Mahmoudi, M., & Ghotloo, S. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00256-1 · Cited by 76 · see citing works
NF-κB, a culprit of both inflamm-ageing and declining immunity?
Songkiatisak, P., Rahman, S. M. T., Aqdas, M., & Sung, M. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00277-w · Cited by 74 · see citing works
NF-κB signaling in rheumatoid arthritis with focus on fibroblast-like synoviocytes
Samimi, L. N., Farhadi, E., Tahmasebi, M., Jamshidi, A., Vaziri, A. S., & Mahmoudi, M. (2020) · Autoimmunity Highlights · doi:10.1186/s13317-020-00135-z · Cited by 70 · see citing works
Zayed, A., Al-Saedi, D. A., Mensah, E. O., Kanwugu, O. N., Adadi, P., & Ulber, R. (2023) · Marine Drugs · doi:10.3390/md22010029 · Cited by 77 · see citing works
Lesovaya, E. A., Yemelyanov, A. Y., Swart, A. C., Swart, P., Haegeman, G., & Budunova, I. V. (2015) · Oncotarget · doi:10.18632/oncotarget.5078 · Cited by 72 · see citing works
The gut microbiota promotes the pathogenesis of schizophrenia via multiple pathways
Yuan, X., Kang, Y., Zhuo, C., Huang, X., & Song, X. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.02.152 · Cited by 73 · see citing works
Liu, X., Berry, C. T., Ruthel, G. T., Madara, J. J., Macgillivray, K., Gray, C. M., Madge, L. A., McCorkell, K. A., Beiting, D. P., Hershberg, U., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.713008 · Cited by 69 · see citing works
CCR6 signaling inhibits suppressor function of induced-Treg during gut inflammation
Kulkarni, N., Meitei, H. T., Sonar, S. A., Sharma, P., Mujeeb, V. R., Srivastava, S., Boppana, R., & Lal, G. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.10.013 · Cited by 71 · see citing works
Digital signaling decouples activation probability and population heterogeneity
Kellogg, R., Tian, C., Lipniacki, T., Quake, S. R., & Tay, S. (2015) · eLife · doi:10.7554/elife.08931 · Cited by 67 · see citing works
“T- and B-cell receptor binding with antigen-MHC triggers digital activation and cell fate control via NF-κB (Kingeter et al., 2010; Oh and Ghosh, 2013; Gerondakis et al., 2014; Shinohara et al., 2014).”
BackgroundMacrophages in pancreatic cancer: An immunometabolic perspective
Yang, J. M., Li, Y., Sun, Z., & Zhan, H. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.10.029 · Cited by 71 · see citing works
A complex issue on CD 4+ T‐cell subsets
Jiang, S., & Dong, C. (2013) · Immunological Reviews · doi:10.1111/imr.12041 · Cited by 68 · see citing works
Samotij, D., Nedoszytko, B., Bartosińska, J., Batycka-Baran, A., Czajkowski, R., Dobrucki, I. T., Dobrucki, L. W., Górecka-Sokołowska, M., Janaszak‐Jasiecka, A., Krasowska, D., et al. (2020) · Advances in Dermatology and Allergology · doi:10.5114/ada.2020.94832 · Cited by 68 · see citing works
Inflammation: A bridge between diabetes and COVID-19, and possible management with sitagliptin
Mozafari, N., Azadi, S., Mehdi-Alamdarlou, S., Ashrafi, H., & Azadi, A. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110111 · Cited by 66 · see citing works
Schmidt, C., Berger, T., Groettrup, M., & Basler, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02386 · Cited by 65 · see citing works
Combined exposure to formaldehyde and PM2.5: Hematopoietic toxicity and molecular mechanism in mice
Ge, J., Yang, H., Lu, X., Wang, S., Zhao, Y. S., Huang, J., Xi, Z., Zhang, L., & Li, R. (2020) · Environment International · doi:10.1016/j.envint.2020.106050 · Cited by 64 · see citing works
“Some recent studies have found that NF-κB has a crucial role in the development of Th2 and Th17 cells, mainly in the regulation of IL-4 and IL-17A secretion (Oh and Ghosh, 2013).”
BackgroundLi, Y., Wang, H., Zhou, X., Xie, X., Chen, X. '., Jie, Z., Zou, Q., Hu, H., Zhu, L., Cheng, X., et al. (2016) · Scientific Reports · doi:10.1038/srep22115 · Cited by 63 · see citing works
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FKBP51 modulates steroid sensitivity and NFκB signalling: A novel anti‐inflammatory drug target
Kästle, M., Kistler, B., Lamla, T., Bretschneider, T., Lamb, D. J., Nicklin, P. L., & Wyatt, D. (2018) · European Journal of Immunology · doi:10.1002/eji.201847699 · Cited by 62 · see citing works
García‐Díaz, N., Piris, M. A., Ortiz-Romero, P. L., & Vaque, J. P. (2021) · Cancers · doi:10.3390/cancers13081931 · Cited by 61 · see citing works
“Then, p52 heterodimerizes with RelB and translocates to the nucleus (reviewed in [71]).”
BackgroundThe Role of Nuclear Factor Kappa B (NF-κB) in Development and Treatment of COVID-19: Review
Gudowska-Sawczuk, M., & Mroczko, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095283 · Cited by 59 · see citing works
“Therefore, dysregulation of NF-κB can lead to an uncontrolled and pathogenic inflammatory response [12,15].”
BackgroundMannino, M. P., & Hart, G. W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.828648 · Cited by 63 · see citing works
Gammaherpesviruses and Pulmonary Fibrosis
Williams, K. J. (2014) · Veterinary Pathology · doi:10.1177/0300985814521838 · Cited by 57 · see citing works
Li, S. X., Barrett, B. S., Heilman, K. J., Messer, R. J., Liberatore, R. A., Bieniasz, P. D., Kassiotis, G., Hasenkrug, K. J., & Santiago, M. L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400490 · Cited by 57 · see citing works
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Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases
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Immunometabolism: signaling pathways, homeostasis, and therapeutic targets
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NF-κB dynamics in the language of immune cells
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- Authors
- Oh, H., & Ghosh, S.
- Affiliations
- Department of Microbiology and Immunology Columbia University New York NY
- Columbia University (US)
- Corresponding author
- Ghosh, Sankar
- ORCID
- Ghosh, Sankar
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2013-02-13
- Volume
- 252
- Issue
- 1
- Pages
- 41-51
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- PMC
- PMC3576882
- OpenAlex
- W2070085523
- Cited by
- 408
- References
- 71
- Citations by year
- 2026: 16 · 2025: 36 · 2024: 43 · 2023: 46 · 2022: 43 · 2021: 39 · 2020: 28 · 2019: 25 · 2018: 27 · 2017: 26 · 2016: 26 · 2015: 24 · 2014: 21 · 2013: 7
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (R37-33443, R01-68977)
- National Institute of Allergy and Infectious Diseases (R01AI068977, R37AI033443)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- NF-κB signaling, CD4+ T cells, T helper cell differentiation, Th1 cells, Th2 cells, Th17 cells, Th9 cells, Th22 cells, T follicular helper cells, regulatory T cells, transcriptional regulation, cytokine and chemokine expression, adaptive immunity, inflammation
- MeSH terms
- Animals, Cell Differentiation, Gene Expression Regulation, Humans, Lymphocyte Activation, Transcription Factors, Transcription, Genetic, Signal Transduction, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, Cytokines, NF-kappa B, Mice, Adaptive Immunity
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