Cited by 761Gut microbiota and healthClostridium difficile and Clostridium perfringens researchAntibiotic Resistance in Bacteria

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The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens

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Kim, Sohn, Covington, April, Pamer, Eric G.·2017·Immunological Reviews

DOI 10.1111/imr.12563PMC PMC6026851

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Abstract

Summary: The human gastrointestinal tract hosts a diverse network of microorganisms, collectively known as the microbiota that plays an important role in health and disease. For instance, the intestinal microbiota can prevent invading microbes from colonizing the gastrointestinal tract, a phenomenon known as colonization resistance. Perturbations to the microbiota, such as antibiotic administration, can alter microbial composition and result in the loss of colonization resistance. Consequently, the host may be rendered susceptible to colonization by a pathogen. This is a particularly relevant concern in the hospital setting, where antibiotic use and antibiotic‐resistant pathogen exposure are more frequent. Many nosocomial infections arise from gastrointestinal colonization. Due to their resistance to antibiotics, treatment is often very challenging. However, recent studies have demonstrated that manipulating the commensal microbiota can prevent and treat various infections in the intestine. In this review, we discuss the members of the microbiota, as well as the mechanisms, that govern colonization resistance against specific pathogens. We also review the effects of antibiotics on the microbiota, as well as the unique epidemiology of immunocompromised patients that renders them a particularly high‐risk population to intestinal nosocomial infections.

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Authors: Kim, S., Covington, A., & Pamer, E. G.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
Corresponding author: Pamer, Eric G.
ORCID: Kim, Sohn
Pamer, Eric G.
Venue: Immunological Reviews
Publisher: Wiley
Published: 2017-08-30
Volume: 279
Issue: 1
Pages: 90-105
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/imr.12563
PMC: PMC6026851
OpenAlex: W2753747201
Cited by: 741
References: 147
Citations by year: 2026: 49 · 2025: 67 · 2024: 112 · 2023: 95 · 2022: 136 · 2021: 117 · 2020: 69 · 2019: 68 · 2018: 27 · 2017: 1
FWCI: 4.22
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P01CA023766, P30CA008748)
National Institute of General Medical Sciences (T32GM007739)
National Institute of Allergy and Infectious Diseases (R01AI095706, U01AI124275, R01AI042135)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Keywords: gut microbiota, colonization resistance, antibiotics, enteric pathogens, nosocomial infections, antibiotic resistance, immunocompromised patients, commensal microbiota, intestinal colonization
MeSH terms: Gastrointestinal Microbiome, Animals, Anti-Bacterial Agents, Bacterial Infections, Cross Infection, Drug Resistance, Humans, Immunocompromised Host, Host-Pathogen Interactions, Dysbiosis

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The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens

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