Cited by 193Dermatology and Skin DiseasesAntimicrobial Peptides and ActivitiesContact Dermatitis and Allergies

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Interleukin-10 Downregulates Anti-Microbial Peptide Expression in Atopic Dermatitis

Open access

Howell, Michael D., Novak, Natalija, Bieber, Thomas, Pastore, Saveria, Girolomoni, Giampiero, Boguniewicz, Mark, Streib, Joanne, Wong, Cathy, Gallo, Richard L., Leung, Donald Y.M.·2005·Journal of Investigative Dermatology

DOI 10.1111/j.0022-202x.2005.23776.x

Open this paper in CoChat — free account

Abstract

Recurrent skin infections in extrinsic atopic dermatitis (EAD) may be because of the suppression of anti-microbial peptide (AMP) expression by interleukin (IL)-4 and IL-13. Twenty to thirty percent of AD, however, are classified as intrinsic atopic dermatitis (IAD). They exhibit normal serum IgE levels, no allergen-specific sensitization, and lower levels of IL-4 and IL-13 than EAD. Both forms of AD have increased propensity to skin infection, suggesting a novel mechanism for infection in IAD. In this study, we observed significantly decreased human beta-defensin (HBD)-2 gene expression in the skin of both IAD (p = 0.010) and EAD (p = 0.004), as compared with psoriasis patients. Conversely, IAD (p = 0.019) and EAD (p = 0.002) skin lesions exhibited elevated IL-10 gene expression when compared with psoriasis. Using primary keratinocytes, we found that the deficiency in AMP expression is an acquired rather than a constitutive defect. Interestingly, neutralizing antibodies to IL-10 augmented the production of tumor necrosis factor-alpha and interferon-gamma by peripheral blood mononuclear cell from AD patients. Additionally, treatment of AD skin explants with anti-IL-10 augmented the expression of both HBD-2 and LL-37. Thus, increased levels of IL-10 may contribute to the AMP deficiency in both IAD and EAD by reducing cytokines that induce AMP.

Integrity signals

Registry

Crossref · 10.1111/j.0022-202x.2005.23776.x

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Diagnostic features of atopic dermatitis
Hanifin, J. M., & Rajka, G. (1980) · Acta Dermato-Venereologica · doi:10.2340/00015555924447 · Cited by 5,086
Atopic Dermatitis
Williams, H. C., Leung, D. Y. M., Thestrup‐Pedersen, K., & David, T. J. (2000) · Cited by 4,597
Self-citation
Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.
de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762
IL-10 inhibits cytokine production by activated macrophages
Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888
Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003
Johansson, S. G. O., Bieber, T., Dahl, R., Friedmann, P. S., Lanier, B. Q., Lockey, R. F., Motala, C., Ortega Martell, J. A., Platts-Mills, T. A. E., Ring, J., et al. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.12.591 · Cited by 2,391
Self-citation
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960
Self-citation
New insights into atopic dermatitis
Leung, D. Y. M., Boguniewicz, M., Howell, M. D., Nomura, I., & Hamid, Q. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21060 · Cited by 1,435
Self-citation
Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.
D’Andrea, A., Aste-Amézaga, M., Valiante, N. M., Ma, X., Kubin, M. Z., & Trinchieri, G. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.3.1041 · Cited by 1,367
A peptide antibiotic from human skin
Harder, J., Bartels, J., Christophers, E., & Schröder, J. ‐. (1997) · Nature · doi:10.1038/43088 · Cited by 1,365
Innate antimicrobial peptide protects the skin from invasive bacterial infection
Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K., & Gallo, R. L. (2001) · Nature · doi:10.1038/35106587 · Cited by 1,198
Self-citation

Show all 34 references

Sorted by citations

Items 101–193 of 193

Expression and distribution of antimicrobial peptides in the skin of healthy beagles
Santoro, D., Bunick, D., Graves, T. K., & CAMPBELL, K. L. (2010) · Veterinary Dermatology · doi:10.1111/j.1365-3164.2010.00911.x · Cited by 25
Antimicrobial Peptides
Park, A. J., Okhovat, J., & Kim, J. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-29785-9_6 · Cited by 27
Evaluation of antimicrobial peptides and cytokine production in primary keratinocyte cell culture from healthy and atopic beagles
Santoro, D., Ahrens, K. P., Marsella, R., & Segre, M. (2015) · Experimental Dermatology · doi:10.1111/exd.12660 · Cited by 24
IL-10 inhibits while calcitriol reestablishes placental antimicrobial peptides gene expression
Olmos‐Ortiz, A., Noyola-Martínez, N., Barrera, D., Zaga‐Clavellina, V., Avila, E., Halhali, A., Biruete, B., Larrea, F., & Dı́az, L. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.07.012 · Cited by 23
Expression of the antimicrobial peptide α-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice
Inaba, Y., Ashida, T., Ito, T., Ishikawa, C., Tanabe, H., Maemoto, A., Watari, J., Ayabe, T., Mizukami, Y., Fujiya, M., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21253 · Cited by 23
Advantage of a Narrow Spectrum Host Defense (Antimicrobial) Peptide Over a Broad Spectrum Analog in Preclinical Drug Development
Ostorházi, E., Hoffmann, R., Herth, N., Wade, J. D., Kraus, C. N., & Otvos, L. J. (2018) · Frontiers in Chemistry · doi:10.3389/fchem.2018.00359 · Cited by 23
Expression of Antimicrobial Peptides Such as LL-37 and hBD-2 in Nonlesional Skin of Atopic Individuals
Goo, J., Ji, J. H., Jeon, H., Kim, M. J., Jeon, S.-Y., Cho, M.-Y., Lee, S. H., & Choi, E. H. (2010) · Pediatric Dermatology · doi:10.1111/j.1525-1470.2010.01122.x · Cited by 23
Vitamin D Status and Expression of Vitamin D Receptor and LL-37 in Patients with Spontaneous Bacterial Peritonitis
Zhang, C., Zhao, L., Ma, L., Lv, C., Ding, Y., Xia, T., Wang, J., & Dou, X. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1824-6 · Cited by 22
IL-10 suppresses IL-17-mediated dermal inflammation and reduces the systemic burden of Vaccinia virus in a mouse model of eczema vaccinatum
Darling, A., Freyschmidt, E., Burton, O. T., Koleoglou, K. J., Oyoshi, M. K., & Oettgen, H. C. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.11.010 · Cited by 22
Integrated proteomics and genomics analysis of paradoxical eczema in psoriasis patients treated with biologics
Al‐Janabi, A., Martin, P., Khan, A. R., Foulkes, A., Smith, C. H., Griffiths, C. E. M., Morris, A. P., Eyre, S., Warren, R. B., Ahmed, S., et al. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.07.011 · Cited by 21
Allergen specific immunotherapy enhanced defense against bacteria via TGF-β1-induced CYP27B1 in asthma
Wang, J., Liu, X., Wang, H., Li, Y., Lan, N., Yuan, X., Wu, M., Liu, Z., & Li, G. (2017) · Oncotarget · doi:10.18632/oncotarget.19826 · Cited by 20
Gamma‐delta ( γδ ) T cell‐derived cytokines ( IL ‐4, IL ‐17, IFN ‐γ and IL ‐10) and their possible implications for atopic dermatitis development
Fagundes, B. O., de Sousa, T. R., & Victor, J. R. (2022) · International Journal of Dermatology · doi:10.1111/ijd.16364 · Cited by 21
Probing the binding selected metal ions and biologically active substances to the antimicrobial peptide LL-37 using DSC, ITC measurements and calculations
Makowska, J., Wyrzykowski, D., Kamysz, E., Tesmar, A., Kamysz, W., & Chmurzyński, L. (2019) · Journal of Thermal Analysis and Calorimetry · doi:10.1007/s10973-019-08310-9 · Cited by 19
Clinical correlations of recent developments in the pathogenesis of atopic dermatitis
Sehra, S., Barbé‐Tuana, F. M., Holbreich, M., Mousdicas, N., Kaplan, M. H., & Travers, J. B. (2008) · Anais Brasileiros de Dermatologia · doi:10.1590/s0365-05962008000100009 · Cited by 19
Antimicrobial Peptide Loss, Except for LL-37, is not Characteristic of Atopic Dermatitis
Szabó, L., Kapitány, A., Somogyi, O., Alhafez, I., Gáspár, K., Palatka, R., Soltész, L., Törőcsik, D., Hendrik, Z., Dajnoki, Z., et al. (2023) · Acta Dermato Venereologica · doi:10.2340/actadv.v103.9413 · Cited by 17
Atopic dermatitis: molecular, cellular, and clinical aspects
Salimian, J., Salehi, Z., Ahmadi, A., Emamvirdizadeh, A., Davoudi, S. M., Karimi, M., Korani, M., & Jamalkandi, S. A. (2022) · Molecular Biology Reports · doi:10.1007/s11033-021-07081-7 · Cited by 16
Association between a common IL10 distal promoter haplotype and IgE production in individuals with atopic dermatitis
Lacy, K. E., Archer, C., Wood, N., & Bidwell, J. L. (2009) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.2009.00857.x · Cited by 16
From the bench to the clinic
Sigmundsdóttir, H. (2011) · Dermato-Endocrinology · doi:10.4161/derm.15115 · Cited by 18
Human β‐defensin‐2, an antimicrobial peptide, is elevated in scales collected from tinea pedis patients
Kawai, M., Yamazaki, M., Tsuboi, R., Miyajima, H., Ogawa, H., & Tsuboi, R. (2006) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2006.03111.x · Cited by 17
Red face revisited: Endogenous dermatitis in the form of atopic dermatitis and seborrheic dermatitis
Ramos-e-Silva, M., Sampaio, A. L., & Carneiro, S. (2014) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2013.05.032 · Cited by 16
Therapeutic strategies in extrinsic atopic dermatitis: focus on inhibition of IL-4 as a new pharmacological approach
Lernia, V. G. D. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.965682 · Cited by 15
Potential therapeutic efficacy of a bactericidal–immunomodulatory fusion peptide against methicillin-resistant Staphylococcus aureus skin infection
Li, Q., Zhou, Y., Dong, K., & Guo, X. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2313-0 · Cited by 14
Break on Through: The Role of Innate Immunity and Barrier Defence in Atopic Dermatitis and Psoriasis
Hawerkamp, H. C., Fahy, C. M. R., Fallon, P. G., & Schwartz, C. (2022) · Skin Health and Disease · doi:10.1002/ski2.99 · Cited by 15
Altered expression of antimicrobial peptide genes in the skin of dogs with atopic dermatitis and other inflammatory skin conditions
Lancto, C. A., Torres, S. M. F., Hendrickson, J. A., Martins, K. V., & Rutherford, M. S. (2013) · Veterinary Dermatology · doi:10.1111/vde.12034 · Cited by 14
Microbiosis in pathogenesis and intervention of atopic dermatitis
Dou, J., Zeng, J., Wu, K., Tan, W., Gao, L., & Lu, J. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.01.030 · Cited by 17
Human Polymorphisms as Clinical Predictors in Leprosy
de, E. P. M. (2011) · Journal of Tropical Medicine · doi:10.1155/2011/923943 · Cited by 13
Evaluation of the levels of interleukins IL-4, IL-13, IL-5, IL-10 and IL-33 in atopic dermatitis patients with and without dupilumab therapy
Čelakovská, J., Čermáková, E., Boudková, P., & Krejsek, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1604883 · Cited by 16
A nonsteroidal alternative to impetiginized eczema in the emergency room
Stoff, B. K., MacKelfresh, J. B., Fried, L. E., Cohen, C., & Arbiser, J. L. (2010) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.05.027 · Cited by 12
Role of Staphylococcus aureus in Atopic Dermatitis
Ong, P. Y. (2009) · CRC Press eBooks · doi:10.3109/9781420077995-16 · Cited by 11
From the bench to the clinic: New aspects on immunoregulation by vitamin D analogs.
Sigmundsdóttir, H. (2011) · Europe PMC (PubMed Central) · doi:10.4161/derm.3.3.15115 · Cited by 10
Antimicrobial Peptides in Cutaneous Wound Healing
Sørensen, O. E. (2015) · Springer eBooks · doi:10.1007/978-3-319-24199-9_1 · Cited by 11
Etanercept decreases the innate immune wounding response in psoriasis
Hata, T. R., Afshar, M., Miller, J., Two, A. M., Kotol, P. F., Jackson, M., Alexandrescu, D. T., Kabigting, F. D., Gerber, M., Lai, Y., et al. (2013) · Experimental Dermatology · doi:10.1111/exd.12167 · Cited by 9
Self-citation
The role of cytokines in atopic dermatitis: a breakthrough in immunopathogenesis and treatment
Alsabbagh, M. M., & Ismaeel, A. (2022) · Acta Dermatovenerologica Alpina Pannonica et Adriatica · doi:10.15570/actaapa.2022.3 · Cited by 10
Lineage−CD34+CD31+ Cells That Appear in Association with Severe Burn Injury Are Inhibitory on the Production of Antimicrobial Peptides by Epidermal Keratinocytes
Yoshida, S., Lee, J. O., Nakamura, K., Suzuki, S., Hendon, D. N., Kobayashi, M., & Suzuki, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0082926 · Cited by 9
Topical calcineurin inhibitors
Luger, T. A., Steinhoff, M. S., Remitz, A., & Reitamo, S. (2008) · Series in dermatological treatment · doi:10.3109/9780203091449.019 · Cited by 9
Atopic Dermatitis Biomarkers and the Movement Toward Personalized Treatment
Hassan, S., Hamideh, N., Poulos, C., Cheema, S., Rangwani, S. M., & Lio, P. (2021) · Dermatitis · doi:10.1097/der.0000000000000711 · Cited by 8
Dupilumab‐induced psoriatic erythroderma with characteristic cytokine and antimicrobial peptide expression pattern in a patient with long standing atopic dermatitis
Gambichler, T., Reuther, J., Richards, C., & Doerler, M. (2020) · International Journal of Dermatology · doi:10.1111/ijd.15003 · Cited by 8
Skin Microecology
WEBSTER, G. F. (2007) · Archives of Dermatology · doi:10.1001/archderm.143.1.105 · Cited by 8
Single nucleotide polymorphisms of the genes encoding IL-10 and TGF-β1 in Iranian children with atopic dermatitis
Behniafard, N., Amirzargar, A., Gharagozlou, M., Delavari, F., Hosseinverdi, S., Sotoudeh, S., Farhadi, E., Mahmoudi, M., Khaledi, M., Moghaddam, Z. G., et al. (2018) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2017.05.007 · Cited by 7
Possible Impact of Human β-defensin 1 on sperm motility in infertile men with abnormal sperm parameters
Firouzabadi, A. M., Rezvani, M. E., Zare, F., Azizian, H., & Fesahat, F. (2024) · Reproductive Biology · doi:10.1016/j.repbio.2024.100887 · Cited by 7
Antimicrobial polypeptides and lipids as a part of innate defense mechanism of fish and human fetus
Bergsson, G. (2005) · Figshare · Cited by 7
Inflammation in Wound Repair: Role and Function of Inflammation in Wound Repair
MacLeod, A. S., & Kwock, J. T. (2017) · Wiley eBooks · doi:10.1002/9781119282518.ch14 · Cited by 7
Cytokines Levels in Children Affected by Atopic and Nonatopic Eczema
Ricci, G., Patrizi, A., Bellini, F., Calamelli, E., Dell'Omo, V., Bendandi, B., & Masi, M. (2008) · The Open Dermatology Journal · doi:10.2174/1874372200802010018 · Cited by 6
Role of Barrier Dysfunction and Immune Response in Atopic Dermatitis
Novak, N., & Leung, D. Y. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-29875-9.00050-1 · Cited by 5
Self-citation
Host Defense Peptides: Immune Modulation and Antimicrobial Activity In Vivo
Afacan, N. J., Janot, L., & Hancock, R. E. W. (2012) · Springer eBooks · doi:10.1007/978-3-0348-0541-4_13 · Cited by 4
Insights into Intrinsic Atopic Dermatitis: immunogenicity, Dysbiosis, and Imaging (Reflectance Confocal Microscopy, Optical Coherence Tomography)
Gavrilita, E., Silion, S., Bîtcă, M., & Tatu, A. L. (2024) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s459096 · Cited by 4
A Review of Atopic Dermatitis
Wise, R. D. (2006) · Comprehensive Therapy · doi:10.1385/comp:32:2:111 · Cited by 4
Atopic patients with genital warts have a more protracted clinical course and a greater probability of recurrences
Stefanaki, C., Stefanaki, I., Verra, P., Hadjivassiliou, M., Caroni, C., Bethimoutis, G., Papadogeorgaki, H., Stavropoulos, P., Kostaki, M., Antoniou, C., et al. (2010) · International Journal of STD & AIDS · doi:10.1258/ijsa.2010.010225 · Cited by 4
Antimicrobial Peptides
Jalian, H. R., & Kim, J. J. (2008) · Springer eBooks · doi:10.1007/978-1-84800-165-7_9 · Cited by 4
Evaluation of Canine Antimicrobial Peptides in Infected and Noninfected Chronic Atopic Skin
Santoro, D., Bunick, D., Graves, T. K., & Segre, M. (2013) · doi:10.1002/9781118644317.ch6 · Cited by 4
The influence of skin microbial ecology on γδ T-cell immune pathways in allergic dermatitis models in mice
You, Z., Zhang, X., Huang, S., Chen, D., Zhu, Y., Li, G. L., & Chen, X. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae244 · Cited by 3
Role of Barrier Dysfunction and Immune Response in Atopic Dermatitis
Novak, N., & Leung, D. Y. M. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4377-0271-2.00053-5 · Cited by 3
Self-citation
Occupational MRSA Infection: Risk Factor, Disposition, Prevention, and Therapy
Brans, R., Kaup, O., & Schürer, N. (2018) · Springer eBooks · doi:10.1007/978-3-319-40221-5_98-2 · Cited by 3
Role of Stratum Corneum in Permeability Barrier Function and Antimicrobial Defense
Elias, P. M. (2011) · Wiley eBooks · doi:10.1002/9781118025338.ch3 · Cited by 4
Atopic Dermatitis
Boguniewicz, M., & Leung, D. Y. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-323-08593-9.00035-8 · Cited by 2
Self-citation
IMMUNOLOGICAL FEATURES OF ALLERGIC AND NON-ALLERGIC FORMS OF ATOPIC DERMATITIS
Shestakova, N. A., Borisov, V. I., Pronkina, N. V., Trufakina, E. V., Shishkova, I. V., Демина, Д. В., Leonova, M. I., Nepomnyashikh, V. M., & Kozhevnikov, V. S. (2014) · Medical Immunology (Russia) · doi:10.15789/1563-0625-2009-6-531-540 · Cited by 2
Update on Atopic Eczema with Special Focus on Dryness and the Impact of Moisturizers
Simpson, E. L. (2012) · Springer eBooks · doi:10.1007/978-3-642-27606-4_16 · Cited by 2
Novel Endogenous Antimicrobial Peptides
Nordahl, E. A. (2009) · Cited by 2
Keratinocytes
Chan, L. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-84744-5.00011-5 · Cited by 1
Regulación de la homeostasis de la barrera cutánea: implicaciones fisiopatológicas
Truchuelo, M. T., Reyes, E., Jaén, P., Delgado, A., & Vitale, M. (2015) · Piel · doi:10.1016/j.piel.2015.04.011 · Cited by 1
Evaluation of bacterial colonization in patients with the diagnosis of mycosis fungoides
Akay, B. N., Parlak, N., Sanlı, H. E., & Azap, A. (2014) · TURKDERM · doi:10.4274/turkderm.26928 · Cited by 1
Bacterial Derivatives of Lactococcus lactis and Ectoin for Atopic Dermatitis: Dermal Compatibility and Cosmetic Acceptability
Crespo, C. (2017) · Pharmacy & Pharmacology International Journal · doi:10.15406/ppij.2017.05.00143 · Cited by 1
Atopy of the Skin
Chan, L. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-84744-5.00003-6 · Cited by 1
Occupational MRSA Infection: Risk Factor, Disposition, Prevention, and Therapy
Brans, R., Kaup, O., & Schürer, N. (2019) · Springer eBooks · doi:10.1007/978-3-319-68617-2_98 · Cited by 1
Antimikrobielle Peptide bei atopischer Dermatitis
Gläser, R., Meyer‐Hoffert, U., & Harder, J. (2009) · Der Hautarzt · doi:10.1007/s00105-009-1836-8 · Cited by 1
Atopic Dermatitis
Boguniewicz, M., & Leung, D. Y. M. (2009) · Elsevier eBooks · doi:10.1016/b978-0-323-05659-5.00062-0 · Cited by 1
Self-citation
The Immune-pathogenesis of Canine Atopic Dermatitis: Skin barrier, Microbiome and Inflammation
Chermprapai, S. (2019) · Utrecht University Repository (Utrecht University) · Cited by 1
Eziopatogenesi della dermatite atopica
Girolomoni, G., Gisondi, P., & Boner, A. L. (2008) · Springer eBooks · doi:10.1007/978-88-470-0775-8_13
Self-citation
Effect of Defensins on Susceptibility to Infection at the Mucosal Surface
Guthmiller, J. M., & Joly, S. (2007) · Wiley eBooks · doi:10.1128/9781555815851.ch18
Does dysregulation of immune responses in the tonsils play an important role in the pathology of psoriasis
Sigurdardottir, S. L. (2014) · Skemman
Neonatal innate immunity - A translational perspective
Belderbos, M. E. (2012) · Utrecht University Repository (Utrecht University)
In vivo evaluation of therapeutic options in atopic dermatitis
Oldhoff, J. M. (2006) · Utrecht University Repository (Utrecht University)
ANTIMICROBIAL ACTIVITIES OF HISTIDINE-RICH GLYCOPROTEIN AND CATIONIC PEPTIDES
Rydengård, V. (2007) · Lund University Publications (Lund University)
Original articles The relevance of microbial allergens to the IgE antibody repertoire in atopic and nonatopic eczema
Reefer, A. J., Satinover, S. M., Wilson, B. B., & Woodfolk, J. A. (2007)
ИММУНОЛОГИЧЕСКИЕАЛЛЕРГИЧЕСКОЙ И НЕАЛЛЕРГИЧЕСКОЙ ФОРМЫ АТОПИЧЕСКОГО ДЕРМАТИТА Шестакова Н.А., Борисов В.И., Пронкина Н.В., Труфакина Е.В., Шишкова И.В., Демина Д.В., Леонова М.И., Непомнящих В.М., Кожевников В.С.
Nepomnyashikh, V. M., & Kozhevnikov, V. S. (2009) · CyberLeninK (CyberLeninka)
Virus Infections in Atopic Dermatitis
Novak, N. (2009) · CRC Press eBooks · doi:10.3109/9781420077995-17
Self-citation
Neue Erkenntnisse zur Hautbarrierefunktion
Bußmann, C., & Novak, N. (2009) · Fortschritte der praktischen Dermatologie und Venerologie · doi:10.1007/978-3-540-77148-7_3
Self-citation
Innate Immunity in Atopic Dermatitis
Hata, T. R., & Gallo, R. L. (2009) · CRC Press eBooks · doi:10.3109/9781420077995-7
Self-citation
Intrinsic alterations of the skin barrier function promote the pathogenesis of atopic dermatitis in dogs
Santoro, D. (2013) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
SEVERE ATOPIC DERMATITIS AND T-CELL LYMPHOMA: SIMILARITIES AND DIFFERENCES
Niyasov, D. D., Fedenko, E. S., & Boldireva, M. N. (2012) · Russian Journal of Allergy · doi:10.36691/rja675
Experience of using peroral cosmetic products from the Emolium series in the complex therapy of children suffering from atopic dermatitis
Tekucheva, L. V., & Znamenskaya, L. F. (2011) · Vestnik dermatologii i venerologii · doi:10.25208/vdv1003
Fungi in Atopic Dermatitis
Schmid‐Grendelmeier, P., Zeller, S., & Crameri, R. (2009) · CRC Press eBooks · doi:10.3109/9781420077995-15
Topical Immune Response Modifiers: Antiinflammatories
Luger, T. A., McDonald, I., & Steinhoff, M. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-29785-9_46
Faculty Opinions recommendation of Cytokine modulation of atopic dermatitis filaggrin skin expression.
Spergel, J. M. (2007) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1087210.540206
Advances in Current Drugs and Formulations for the Management of Atopic Dermatitis
Atluri, K., Manne, S., Nalamothu, V., Mantel, A., Sharma, P. K., & Babu, R. J. (2023) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.2023042979
The incidence of antibiotic-resistant staphylococcus spp. Colonization and infection in children and adults with atopic dermatitis
Laowansiri, M. (2019) · doi:10.58837/chula.the.2019.353
Investigação de novos ligantes do peptídeo antimicrobiano LL-37 por técnica de Phage Display
Corrêa, A. B. (2023) · doi:10.11606/d.5.2023.tde-09112023-180752
Occupational MRSA Colonization and Infection: Risk Factors, Prevention, and Therapy
Brans, R., & Kaup, O. (2025) · Springer eBooks · doi:10.1007/978-3-319-40221-5_98-3
Dermatite atopica: eziopatogenesi
Girolomoni, G., Gisondi, P., & Pastore, S. (2007) · Springer eBooks · doi:10.1007/978-88-470-0593-8_5
Self-citation
Topical Immune Response Modifiers: Antiinflammatories
Luger, T. A., & Steinhoff, M. S. (2008) · Springer eBooks · doi:10.1007/978-1-84800-165-7_30
Cutaneous expression of β-defensins in atopic dogs
van Damme, C. M. M. (2008) · Utrecht University Repository (Utrecht University)
Dual role of three natural molecules in regulating the expression of β-defensin-3 and pro-inflammatory mediators
Telford, E. (2018) · theses.fr (ABES) · doi:10.70675/c566eb37zc156z4bcez9c4bz5e555b48fc14
Forensic application of CAMP expression for the determination of wound vitality in human compressed neck skin
Zhang, W., Ishida, Y., Kuninaka, Y., Ishigami, A., Nosaka, M., Kimura, A., Yamamoto, H., Osako, M., Matsuki, R., & Kondo, T. (2026) · International Journal of Legal Medicine · doi:10.1007/s00414-026-03841-x

Authors: Howell, M. D., Novak, N., Bieber, T., Pastore, S., Girolomoni, G., Boguniewicz, M., Streib, J., Wong, C., Gallo, R. L., & Leung, D. Y. M.
Affiliations: National Jewish Health (US)
University of Bonn (DE)
Istituto Dermopatico dell'Immacolata (IT)
University of California San Diego (US)
Corresponding author: Leung, Donald Y.M.
ORCID: Howell, Michael D.
Novak, Natalija
Bieber, Thomas
Girolomoni, Giampiero
Boguniewicz, Mark
Streib, Joanne
Gallo, Richard L.
Leung, Donald Y.M.
Venue: Journal of Investigative Dermatology
Publisher: Elsevier BV
Published: 2005-10
Volume: 125
Issue: 4
Pages: 738-745
ISSN: 0022-202X (ISSN-L)
DOI: 10.1111/j.0022-202x.2005.23776.x
OpenAlex: W2092527023
Cited by: 193
References: 34
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 8 · 2017: 10 · 2016: 3 · 2015: 9 · 2014: 10 · 2013: 13 · 2012: 9
FWCI: 22.98
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3714 d)
Locations: Journal of Investigative Dermatology (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (454/1-1, 454/2-1)
National Institutes of Health (T32 AI 07365)
Ministero della Salute (AI052453, HL37260, HL36577, R21 AR051634-01, AR45676, AR41256)
Cancer Center, University of Colorado
Topics: Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Keywords: IL-10, atopic dermatitis, antimicrobial peptides, human beta-defensin 2, LL-37, skin infections, intrinsic atopic dermatitis, extrinsic atopic dermatitis, keratinocytes, IL-4, IL-13, TNF-α, interferon-gamma, psoriasis
MeSH terms: Adult, Cells, Cultured, Dermatitis, Atopic, Gene Expression Regulation, Humans, Immunohistochemistry, Middle Aged, Psoriasis, Down-Regulation, Interleukin-10, Interleukin-13, beta-Defensins, Antimicrobial Cationic Peptides, Cathelicidins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interleukin-10 Downregulates Anti-Microbial Peptide Expression in Atopic Dermatitis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks