The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Role of nuclear factor‐κB in the immune system and bone
Abstract
Summary: Bone metabolism is regulated by hormonal or local factors in the bone microenvironment, and recent studies have revealed that bone homeostasis is also influenced by immune system. The term ‘osteoimmunology’ has been proposed to explain the cross‐talk between bone and the immune system. A critical element in this cross‐talk is the inducible transcription factor nuclear factor‐κB (NF‐κB), which regulates gene expression during inflammatory and immune responses. However, NF‐κB‐signaling pathways are also important for bone homeostasis, in particular for osteoclast differentiation. By bridging inflammation and bone homeostasis, NF‐κB also contributes to the onset and progression of arthritis. Several natural compounds, synthetic drugs, and gene‐transfer technologies that lead to inhibition of the inhibitor of NF‐κB kinase (IKK)/NF‐κB activation pathway can prevent arthritis in animal models. In this review, we discuss the signaling pathway that leads to NF‐κB activation and the role of NF‐κB on osteoclast differentiation. Furthermore, we discuss the possibility that inhibition of NF‐κB might provide novel therapeutic approach for inhibiting bone destruction in rheumatoid arthritis.
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Cites
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · cited 2×
“Bone, despite its hard structure, is actually in a constant state of dynamic turnover known as bone remodeling (4, 5).”
BackgroundNF-κB regulation in the immune system
Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007
Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842
Self-citationMissing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638
Self-citationOPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00369-6 · Cited by 2,701
The two NF-κB activation pathways and their role in innate and adaptive immunity
Bonizzi, G., & Karin, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.03.008 · Cited by 2,535
Mechanistic insight into osteoclast differentiation in osteoimmunology
Takayanagi, H. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0612-6 · Cited by 413
Cited by
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
Takayanagi, H. (2007) · Nature Reviews Immunology · doi:10.1038/nri2062 · Cited by 1,878
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Yao, Q., Wu, X., Tao, C., Gong, W., Chen, M., Qu, M., Zhong, Y., He, T., Chen, S., & Xiao, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01330-w · Cited by 1,194
Hayden, M. S., West, A. P., & Ghosh, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209943 · Cited by 1,178
Self-citationNF‐κB signaling in inflammation and cancer
Zhang, T., Ma, C., Zhang, Z., Zhang, H., & Hu, H. (2021) · MedComm · doi:10.1002/mco2.104 · Cited by 574
Nakamura, N., Shimaoka, Y., Tougan, T., Onda, H., Okuzaki, D., Zhao, H., Fujimori, A., Yabuta, N., Nagamori, I., Tanigawa, A., et al. (2006) · DNA Research · doi:10.1093/dnares/dsl006 · Cited by 94
Metadata
- Authors
- Jimi, E., & Ghosh, S.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2005-11-22
- Volume
- 208
- Issue
- 1
- Pages
- 80-87
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2151843799
- Cited by
- 163
- References
- 8
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
