The DOI matches its Crossref record; 213 of the 213 references it cites were found in a registry or an index.
Review article: the role of butyrate on colonic function
Open accessAbstract
Summary: Background Butyrate, a short‐chain fatty acid, is a main end‐product of intestinal microbial fermentation of mainly dietary fibre. Butyrate is an important energy source for intestinal epithelial cells and plays a role in the maintenance of colonic homeostasis. Aim To provide an overview on the present knowledge of the bioactivity of butyrate, emphasizing effects and possible mechanisms of action in relation to human colonic function. Methods A PubMed search was performed to select relevant publications using the search terms: ‘butyrate, short‐chain fatty acid, fibre, colon, inflammation, carcinogenesis, barrier, oxidative stress, permeability and satiety’. Results Butyrate exerts potent effects on a variety of colonic mucosal functions such as inhibition of inflammation and carcinogenesis, reinforcing various components of the colonic defence barrier and decreasing oxidative stress. In addition, butyrate may promote satiety. Two important mechanisms include the inhibition of nuclear factor kappa B activation and histone deacetylation. However, the observed effects of butyrate largely depend on concentrations and models used and human data are still limited. Conclusion Although most studies point towards beneficial effects of butyrate, more human in vivo studies are needed to contribute to our current understanding of butyrate‐mediated effects on colonic function in health and disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Citations
Cites
Short chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119
Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091
Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
Bergman, E. N. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.567 · Cited by 2,750
Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409
Inhibition of Histone Deacetylase Activity by Butyrate
Davie, J. R. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.7.2485s · Cited by 1,515
Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease
Segain, J.-P., de la Blétière, D. R., Bourreille, A., Leray, V., Gervois, N., Rosales, C., Ferrier, L., Bonnet, C., Blottière, H. M., & Galmiche, J.-P. (2000) · Gut · doi:10.1136/gut.47.3.397 · Cited by 1,357
Bingham, S. A., Day, N., Luben, R., Ferrari, P., Slimani, N., Norat, T., Clavel‐Chapelon, F., Kesse‐Guyot, E., Nieters, A., Boeing, H., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13174-1 · Cited by 1,123
Microbial modulation of innate defense: goblet cells and the intestinal mucus layer
Deplancke, B., & Gaskins, H. R. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.6.1131s · Cited by 1,012
Gendler, S. J., & Spicer, A. P. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003135 · Cited by 1,001
Treatment of Diversion Colitis with Short-Chain-Fatty Acid Irrigation
Harig, J. M., Soergel, K. H., KOMOROWSKI, R. A., & Wood, C. M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200105 · Cited by 751
Cited by
Sorted by citations
Items 1,001–1,007 of 1,007
The Interplay between the Microbiota and Enterohemorrhagic Escherichia coli
Pifer, R., & Sperandio, V. (2014) · Microbiology Spectrum · doi:10.1128/microbiolspec.ehec-0015-2013 · Cited by 32
Narrative review on potential role of gut microbiota in certain substance addiction
Qin, C., Hu, J., Wan, Y., Cai, M., Wang, Z., Peng, Z., Liao, Y., Li, D., Yao, P., Liu, L., et al. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110093 · Cited by 32
Ni, Y., Wong, V. H. Y., Tai, W. C. S., Li, J., Wong, W. Y., Lee, M. M. L., Fong, F. L. Y., El-Nezami, H., & Panagiotou, G. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13386 · Cited by 29
Nicotinamide Riboside-Conditioned Microbiota Deflects High-Fat Diet-Induced Weight Gain in Mice
Lozada-Fernández, V. V., deLeon, O., Kellogg, S. L., Saravia, F. L., Hadiono, M. A., Atkinson, S. N., Grobe, J. L., & Kirby, J. R. (2022) · mSystems · doi:10.1128/msystems.00230-21 · Cited by 23
Socioeconomic position links circulatory microbiota differences with biological age
Craven, H., McGuinness, D., Buchanan, S., Galbraith, N., McGuinness, D. H., Jones, B., Combet, E., Mafra, D., Bergman, P., Ellaway, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-92042-0 · Cited by 21
Xu, Q., Wen, L., Wei, G., Zhao, X., Liu, Y., Xiong, W., Zhang, T., Fan, Y., Chen, C., Xiang, C., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.819523 · Cited by 11
Flegiel, E., Piotrowska, M., Ptasznik, M., Baran, A., Lenart, J., Podrażka, M., Mazurek, J., Stachowicz, H., Bartos, W., & Adamczyk, M. (2024) · Prospects in Pharmaceutical Sciences · doi:10.56782/pps.229 · Cited by 8
Metadata
- Authors
- HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐.
- Affiliations
- Maastricht University (NL)
- TiFN (NL)
- Corresponding author
- HAMER, H. M.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2007-10-26
- Volume
- 27
- Issue
- 2
- Pages
- 104-119
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W1934624334
- Cited by
- 2,721
- References
- 213
- Citations by year
- 2026: 116 · 2025: 195 · 2024: 203 · 2023: 203 · 2022: 207 · 2021: 238 · 2020: 201 · 2019: 196 · 2018: 176 · 2017: 147 · 2016: 159 · 2015: 134 · 2014: 124 · 2013: 113 · 2012: 78
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- TNO Repository (submittedVersion)
- Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- butyrate, short-chain fatty acids, colonic function, colonic mucosa, intestinal epithelial cells, dietary fiber fermentation, colonic inflammation, colorectal carcinogenesis, intestinal barrier, oxidative stress, satiety, NF-κB inhibition, histone deacetylation
- MeSH terms
- Animals, Butyrates, Child, Preschool, Colon, Colonic Neoplasms, Dietary Fiber, Enema, Fatty Acids, Volatile, Humans, Infant, Newborn, Inflammation, Intestinal Mucosa, Rabbits, Satiation, Oxidative Stress, Carbohydrate Metabolism, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
