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Review article: the role of butyrate on colonic function
Open accessAbstract
Summary: Background Butyrate, a short‐chain fatty acid, is a main end‐product of intestinal microbial fermentation of mainly dietary fibre. Butyrate is an important energy source for intestinal epithelial cells and plays a role in the maintenance of colonic homeostasis. Aim To provide an overview on the present knowledge of the bioactivity of butyrate, emphasizing effects and possible mechanisms of action in relation to human colonic function. Methods A PubMed search was performed to select relevant publications using the search terms: ‘butyrate, short‐chain fatty acid, fibre, colon, inflammation, carcinogenesis, barrier, oxidative stress, permeability and satiety’. Results Butyrate exerts potent effects on a variety of colonic mucosal functions such as inhibition of inflammation and carcinogenesis, reinforcing various components of the colonic defence barrier and decreasing oxidative stress. In addition, butyrate may promote satiety. Two important mechanisms include the inhibition of nuclear factor kappa B activation and histone deacetylation. However, the observed effects of butyrate largely depend on concentrations and models used and human data are still limited. Conclusion Although most studies point towards beneficial effects of butyrate, more human in vivo studies are needed to contribute to our current understanding of butyrate‐mediated effects on colonic function in health and disease.
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Cites
Short chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119
Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091
Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
Bergman, E. N. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.567 · Cited by 2,750
Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409
Inhibition of Histone Deacetylase Activity by Butyrate
Davie, J. R. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.7.2485s · Cited by 1,515
Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease
Segain, J.-P., de la Blétière, D. R., Bourreille, A., Leray, V., Gervois, N., Rosales, C., Ferrier, L., Bonnet, C., Blottière, H. M., & Galmiche, J.-P. (2000) · Gut · doi:10.1136/gut.47.3.397 · Cited by 1,357
Bingham, S. A., Day, N., Luben, R., Ferrari, P., Slimani, N., Norat, T., Clavel‐Chapelon, F., Kesse‐Guyot, E., Nieters, A., Boeing, H., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13174-1 · Cited by 1,123
Microbial modulation of innate defense: goblet cells and the intestinal mucus layer
Deplancke, B., & Gaskins, H. R. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.6.1131s · Cited by 1,012
Gendler, S. J., & Spicer, A. P. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003135 · Cited by 1,001
Treatment of Diversion Colitis with Short-Chain-Fatty Acid Irrigation
Harig, J. M., Soergel, K. H., KOMOROWSKI, R. A., & Wood, C. M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200105 · Cited by 751
Cited by
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Items 201–300 of 1,007
Duan, H., Wang, L., Huangfu, M., & Li, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115276 · Cited by 252
Jonkers, D., Penders, J., Masclee, A., & Pierik, M. (2012) · Drugs · doi:10.2165/11632710-000000000-00000 · Cited by 240
Self-citationEmerging roles of the microbiome in cancer
Bultman, S. J. (2014) · Carcinogenesis · doi:10.1093/carcin/bgt392 · Cited by 239
Dietary fibre and the gut microbiota
Scott, K. P., Duncan, S. H., & Flint, H. J. (2008) · Nutrition Bulletin · doi:10.1111/j.1467-3010.2008.00706.x · Cited by 237
Milk, Dairy Products, and Their Functional Effects in Humans: A Narrative Review of Recent Evidence
Visioli, F., & Strata, A. (2014) · Advances in Nutrition · doi:10.3945/an.113.005025 · Cited by 237
Elamin, E. E., Masclee, A., Jan, D., Pieters, H., & Jonkers, D. M. A. E. (2013) · Journal of Nutrition · doi:10.3945/jn.113.179549 · Cited by 237
Self-citationGut Microbiota Metabolism and Interaction with Food Components
Vernocchi, P., CHIERICO, F. D., & Putignani, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103688 · Cited by 242
Butyrate utilization by the colonic mucosa in inflammatory bowel diseases
Thibault, R., Blachier, F., Darcy‐Vrillon, B., de Coppet, P., Bourreille, A., & Segain, J. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21108 · Cited by 235
Clostridium butyricum : from beneficial to a new emerging pathogen
Cassir, N., Benamar, S., & Scola, B. L. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.10.014 · Cited by 242
Birkeland, E., Gharagozlian, S., Birkeland, K. I., Valeur, J., Måge, I., Rud, I., & Aas, A. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02282-5 · Cited by 241
Intestinal Microbiota-Derived Short Chain Fatty Acids in Host Health and Disease
Cong, J., Zhou, P., & Zhang, R. (2022) · Nutrients · doi:10.3390/nu14091977 · Cited by 242
Wang, M., Li, M., Wu, S., Lebrilla, C. B., Chapkin, R. S., Ivanov, I. V., & Donovan, S. M. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000752 · Cited by 245
Mofidi, F., Poustchi, H., Yari, Z., Nourinayyer, B., Merat, S., Sharafkhah, M., Malekzadeh, R., & Hekmatdoost, A. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517000204 · Cited by 232
Davila, A.-M., Blachier, F., Gotteland, M., Andriamihaja, M., Benetti, P.-H., Sanz, Y., & Tomé, D. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.01.003 · Cited by 231
McOrist, A. L., Miller, R. B., Bird, A. R., Keogh, J. B., Noakes, M., Topping, D. L., & Conlon, M. A. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.128504 · Cited by 231
Hu, S., Dong, T. S., Dalal, S. R., Wu, F., Bissonnette, M., Kwon, J. H., & Chang, E. B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016221 · Cited by 233
van der Beek, C. M., Canfora, E. E., Lenaerts, K., Troost, F. J., Olde Damink, S. W. M., Holst, J. J., Masclee, A. A. M., Dejong, C. H. C., & Blaak, E. E. (2016) · Clinical Science · doi:10.1042/cs20160263 · Cited by 230
Self-citationReview: Roles of Prebiotics in Intestinal Ecosystem of Broilers
Teng, P.-Y., & Kim, W. K. (2018) · Frontiers in Veterinary Science · doi:10.3389/fvets.2018.00245 · Cited by 230
Microbial production of volatile fatty acids: current status and future perspectives
Bhatia, S. K., & Yang, Y. (2017) · Reviews in Environmental Science and Bio/Technology · doi:10.1007/s11157-017-9431-4 · Cited by 229
The Role of Gut Microbiome in the Pathogenesis of Prostate Cancer: A Prospective, Pilot Study
Golombos, D. M., Ayangbesan, A., O’Malley, P., Lewicki, P., Barlow, L. J., Barbieri, C. E., Chan, C., DuLong, C. R., Abu-Ali, G., Huttenhower, C., et al. (2017) · Urology · doi:10.1016/j.urology.2017.08.039 · Cited by 236
Bhat, M. I., & Kapila, R. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux001 · Cited by 233
Terova, G., Rimoldi, S., Ascione, C., Gini, E., Ceccotti, C., & Gasco, L. (2019) · Reviews in Fish Biology and Fisheries · doi:10.1007/s11160-019-09558-y · Cited by 244
Current Progress on Butyric Acid Production by Fermentation
Zhang, C., Yang, H. M., Yang, F., & Ma, Y.-J. (2009) · Current Microbiology · doi:10.1007/s00284-009-9491-y · Cited by 224
Dostal, A., Chassard, C., Hilty, F. M., Zimmermann, M. B., Jaeggi, T., Rossi, S., & Lacroix, C. (2011) · Journal of Nutrition · doi:10.3945/jn.111.148643 · Cited by 229
The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases
Ferreira, C. M., Vieira, A. T., Vinolo, M. A. R., Oliveira, F. A., Curi, R., & Martins, F. S. (2014) · Journal of Immunology Research · doi:10.1155/2014/689492 · Cited by 230
Impact of polyphenols from black tea and red wine/grape juice on a gut model microbiome
Kemperman, R. A., Gross, G., Mondot, S., Possemiers, S., Marzorati, M., Van de Wiele, T., Doré, J., & Vaughan, E. E. (2013) · Food Research International · doi:10.1016/j.foodres.2013.01.034 · Cited by 223
Bui, T. P. N., Mannerås-Holm, L., Puschmann, R., Wu, H., Troise, A. D., Nijsse, B., Boeren, S. A., Bäckhed, F., Fiedler, D., & de Vos, W. M. (2021) · Nature Communications · doi:10.1038/s41467-021-25081-w · Cited by 228
Korcz, E., Kerényi, Z., & Varga, L. (2018) · Food & Function · doi:10.1039/c8fo00118a · Cited by 222
Faecalibacterium prausnitzii supernatant improves intestinal barrier function in mice DSS colitis
Carlsson, A. H., Yakymenko, O., Olivier, I., Håkansson, F., Postma, E., Keita, Å. V., & Söderholm, J. D. (2013) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2013.828773 · Cited by 219
Rivière, A., Gagnon, M., Weckx, S., Roy, D., & Vuyst, L. D. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.02089-15 · Cited by 226
Gut microbiome production of short-chain fatty acids and obesity in children
Murugesan, S., Nirmalkar, K., Hoyo‐Vadillo, C., Garcı́a-Espitia, M., Ramírez-Sánchez, D., & Garcı́a-Mena, J. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-017-3143-0 · Cited by 227
Circadian Disruption Changes Gut Microbiome Taxa and Functional Gene Composition
Deaver, J. A., Eum, S. Y., & Toborek, M. J. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00737 · Cited by 218
Masui, R., Sasaki, M., Funaki, Y., Ogasawara, N., Mizuno, M., Iida, A., Izawa, S., Kondo, Y., Ito, Y., Tamura, Y., et al. (2013) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000435444.14860.ea · Cited by 217
Functional analysis of colonic bacterial metabolism: relevant to health?
Hamer, H. M., Preter, V. D., Windey, K., & Verbeke, K. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00048.2011 · Cited by 221
Self-citationFacchin, S., Vitulo, N., Calgaro, M., Buda, A., Romualdi, C., Pohl, D., Perini, B., Lorenzon, G., Marinelli, C., Renata D'Incà, et al. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13914 · Cited by 222
Halmos, E. P., Christophersen, C. T., Bird, A. R., Shepherd, S., Muir, J. G., & Gibson, P. R. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.22 · Cited by 212
Waddell, I. S., & Orfila, C. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2061909 · Cited by 211
Li, C., Yang, Z., Cheng, J., Guo, J., Zhang, Q., Zhang, X., Ren, J., Wang, F., Huang, J., Hu, H., et al. (2019) · Advanced Science · doi:10.1002/advs.201900610 · Cited by 209
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208
Liu, Y., Chen, Z., Dai, J., Yang, P., Xu, W., Ai, Q., Zhang, W., Zhang, Y., Zhang, Y., & Mai, K. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.02.064 · Cited by 206
Nutritional Intervention for the Intestinal Development and Health of Weaned Pigs
Xiong, X., Tan, B., Song, M., Ji, P., Kim, K., Yin, Y., & Liu, Y. (2019) · Frontiers in Veterinary Science · doi:10.3389/fvets.2019.00046 · Cited by 217
Aguirre, M., Eck, A., Koenen, M. E., Savelkoul, P. H. M., Budding, A. E., & Venema, K. (2016) · Research in Microbiology · doi:10.1016/j.resmic.2015.09.006 · Cited by 204
Self-citationThe Future of Butyric Acid in Industry
Dwidar, M., Park, J. Y., Mitchell, R. J., & Sang, B. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/471417 · Cited by 202
Kundu, P., Lee, H. U., Garcia-Perez, I., Tay, E. X. Y., Kim, H., Faylon, L. E., Martin, K. A., Purbojati, R., Drautz-Moses, D. I., Ghosh, S., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau4760 · Cited by 201
Gut microbiota, diet, and obesity-related disorders: the good, the bad, and the future challenges
Portune, K. J., Benítez‐Páez, A., Del Pulgar, E. M. G., Cerrudo, V., & Sanz, Y. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600252 · Cited by 201
Immerseel, F. V., Ducatelle, R., Vos, M. D., Boon, N., de Wiele, T. V., Verbeke, K., Rutgeerts, P. J., Sas, B., Louis, P., & Flint, H. J. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.017541-0 · Cited by 201
Longitudinal study of the early-life fecal and nasal microbiotas of the domestic pig
Slifierz, M. J., Friendship, R. M., & Weese, J. S. (2015) · BMC Microbiology · doi:10.1186/s12866-015-0512-7 · Cited by 200
Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapy
Wang, G., Yu, Y., Wang, Y., Wang, J., Guan, R., Sun, Y., Shi, F., Gao, J., & Fu, X. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28436 · Cited by 200
In vitro fermentation of 12 dietary fibres by faecal inoculum from pigs and humans
Jonathan, M. C., van den Borne, J. J. G. C., van Wiechen, P., da Silva, C. S., Schols, H. A., & Gruppen, H. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.01.110 · Cited by 197
The impact of dietary macronutrient intake on cognitive function and the brain
Muth, A.-K., & Park, S. Q. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.04.043 · Cited by 213
Hamer, H. M., Jonkers, D. M. A. E., Vanhoutvin, S. A. L. W., Troost, F. J., Rijkers, G. T., de Bruı̈ne, A. P., Bast, A., Venema, K., & Brummer, R. J. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2010.04.002 · Cited by 195
Self-citationCancer Chemoprevention and Nutri-Epigenetics: State of the Art and Future Challenges
Gerhauser, C. (2012) · Topics in Current Chemistry · doi:10.1007/128_2012_360 · Cited by 194
Beresford-Jones, B. S., Forster, S. C., Stares, M. D., Notley, G., Viciani, E., Browne, H. P., Boehmler, D. J., Soderholm, A. T., Kumar, N., Vervier, K., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2021.12.003 · Cited by 194
Food Components and Irritable Bowel Syndrome
Gibson, P. R., Varney, J. E., Malakar, S., & Muir, J. G. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.02.005 · Cited by 194
Gut microbiome and metabolic syndrome
Mazidi, M., Rezaie, P., Kengne, A. P., Ghayour‐Mobarhan, M., & Ferns, G. A. (2016) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2016.01.024 · Cited by 199
Fehlbaum, S., Prudence, K., Kieboom, J., Heerikhuisen, M., van den Broek, T., Schuren, F. H. J., Steinert, R. E., & Raederstorff, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103097 · Cited by 206
Short Chain Fatty Acid Metabolism in Relation to Gut Microbiota and Genetic Variability
Meyers, G. R., Samouda, H., & Bohn, T. (2022) · Nutrients · doi:10.3390/nu14245361 · Cited by 208
Moens, F., Verce, M., & Vuyst, L. D. (2016) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2016.10.019 · Cited by 204
Seal, C. J., Courtin, C. M., Venema, K., & de Vries, J. (2021) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12728 · Cited by 212
Self-citationButyrate Shapes Immune Cell Fate and Function in Allergic Asthma
Yip, W., Hughes, M. R., Li, Y., Cait, A., Hirst, M., Mohn, W. W., & McNagny, K. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.628453 · Cited by 197
Gilbert, M. S., Ijssennagger, N., Kies, A. K., & van Mil, S. W. C. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00319.2017 · Cited by 203
Zhang, M., Ma, W., Zhang, J., He, Y., & Wang, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-32219-2 · Cited by 188
Pieper, R., Kröger, S., Richter, J. F., Wang, J., Martin, L., Bindelle, J., Htoo, J. K. K., von Smolinski, D., Vahjen, W., Zentek, J., et al. (2012) · Journal of Nutrition · doi:10.3945/jn.111.156190 · Cited by 199
Probiotics and prebiotics and health in ageing populations
Duncan, S. H., & Flint, H. J. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.02.004 · Cited by 189
Wang, Z., Zhang, X., Zhu, L., Yang, X., He, F., Wang, T., Bao, T., Lü, H., Wang, H., & Yang, S. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.106062 · Cited by 191
The effect of feeding essential oils on broiler performance and gut microbiota
Tiihonen, K., Kettunen, H., Bento, M. H. L., Saarinen, M., Lahtinen, S., Ouwehand, A. C., Schulze, H., & Rautonen, N. (2010) · British Poultry Science · doi:10.1080/00071668.2010.496446 · Cited by 186
A Critical Look at Prebiotics Within the Dietary Fiber Concept
Verspreet, J., Damen, B., Broekaert, W. F., Verbeke, K., Delcour, J. A., & Courtin, C. M. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-081315-032749 · Cited by 194
Luu, T. H., Michel, C., Bard, J., Dravet, F., Nazih, H., & Bobin‐Dubigeon, C. (2017) · Nutrition and Cancer · doi:10.1080/01635581.2017.1263750 · Cited by 191
Starch Digestion by Gut Bacteria: Crowdsourcing for Carbs
Cerqueira, F. M., Photenhauer, A. L., Pollet, R. M., Brown, H. A., & Koropatkin, N. M. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2019.09.004 · Cited by 189
Knudsen, K. E. B. (2015) · Advances in Nutrition · doi:10.3945/an.114.007450 · Cited by 192
Impact of mycotoxins on the intestine: are mucus and microbiota new targets?
Robert, H., Payros, D., Pinton, P., Théodorou, V., Mercier‐Bonin, M., & Oswald, I. P. (2017) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2017.1326071 · Cited by 193
Beneficial Effect of Intestinal Fermentation of Natural Polysaccharides
Zhang, T., Yang, Y., Liang, Y., Jiao, X., & Zhao, C. (2018) · Nutrients · doi:10.3390/nu10081055 · Cited by 190
Gómez, B., Gullón, B., Remoroza, C., Schols, H. A., Parajó, J. C., & Alonsó, J. L. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf503475b · Cited by 183
Zhou, W., Yan, Y., Mi, J., Zhang, H., Lu, L., Luo, Q., Li, X., Zeng, X., & Cao, Y. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b05546 · Cited by 184
Beneficial roles of probiotics on the modulation of gut microbiota and immune response in pigs
Shin, D., Chang, S. Y., Bogere, P., Won, K.-H., Choi, J., Choi, Y., Lee, H., Hur, J., Park, B., Kim, Y., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220843 · Cited by 190
Rimoldi, S., Terova, G., Ascione, C., Giannico, R., & Brambilla, F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193652 · Cited by 193
Di, T., Chen, G., Sun, Y., Ou, S., Zeng, X., & Ye, H. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2017.10.040 · Cited by 181
Anti-inflammatory effects of the hydroxycarboxylic acid receptor 2
Graff, E. C., Fang, H., Wanders, D., & Judd, R. L. (2015) · Metabolism · doi:10.1016/j.metabol.2015.10.001 · Cited by 187
Hald, S., Schioldan, A. G., Moore, M. E., Dige, A., Lærke, H. N., Agnholt, J., Bach Knudsen, K. E., Hermansen, K., Marco, M. L., Gregersen, S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159223 · Cited by 180
“This finding indicates reduced protein fermentation, which counteracts the accumulation of potentially harmful metabolites.[68] Bacteroides, an abundant human gut resident[69] Arabinoxylan, Resistant Starch and SCFA”
BackgroundButyrate and Colorectal Cancer: The Role of Butyrate Transport
Gonçalves, P., & Martel, F. (2013) · Current Drug Metabolism · doi:10.2174/1389200211314090006 · Cited by 185
Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome – An Update
Takakura, W., & Pimentel, M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00664 · Cited by 184
Oozeer, R., van Limpt, K., Ludwig, T., Amor, K. B., Martín, R., Wind, R. D., Boehm, G., & Knol, J. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.038893 · Cited by 183
Holmes, Z. C., Villa, M. M., Durand, H. K., Jiang, S., Dallow, E. P., Petrone, B. L., Silverman, J. D., Lin, P., & David, L. A. (2022) · Microbiome · doi:10.1186/s40168-022-01307-x · Cited by 189
The link between inflammation, bugs, the intestine and the brain in alcohol dependence
Leclercq, S., de Timary, P., Delzenne, N. M., & Stärkel, P. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.15 · Cited by 174
Fuentes, S., van Nood, E., Tims, S., Jong, I. H., ter Braak, C. J. F., Keller, J. J., Zoetendal, E. G., & de Vos, W. M. (2014) · The ISME Journal · doi:10.1038/ismej.2014.13 · Cited by 177
Tavakoli, P., Vollmer-Conna, U. S., Hadzi-Pavlovic, D., & Grimm, M. (2021) · Public health reviews · doi:10.3389/phrs.2021.1603990 · Cited by 173
Microarray Analysis of Butyrate Regulated Genes in Colonic Epithelial Cells
Daly, K., & Shirazi‐Beechey, S. P. (2006) · DNA and Cell Biology · doi:10.1089/dna.2006.25.49 · Cited by 178
The Circadian Clock Mutation Promotes Intestinal Dysbiosis
Voigt, R. M., Summa, K. C., Forsyth, C. B., Green, S. J., Engen, P. A., Naqib, A. D., Vitaterna, M. H., Turek, F. W., & Keshavarzian, A. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12943 · Cited by 172
Oxygen metabolism and barrier regulation in the intestinal mucosa
Glover, L. E., Lee, J. S., & Colgan, S. P. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84429 · Cited by 173
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Metadata
- Authors
- HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐.
- Affiliations
- Maastricht University (NL)
- TiFN (NL)
- Corresponding author
- HAMER, H. M.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2007-10-26
- Volume
- 27
- Issue
- 2
- Pages
- 104-119
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W1934624334
- Cited by
- 2,721
- References
- 213
- Citations by year
- 2026: 116 · 2025: 195 · 2024: 203 · 2023: 203 · 2022: 207 · 2021: 238 · 2020: 201 · 2019: 196 · 2018: 176 · 2017: 147 · 2016: 159 · 2015: 134 · 2014: 124 · 2013: 113 · 2012: 78
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- TNO Repository (submittedVersion)
- Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- butyrate, short-chain fatty acids, colonic function, colonic mucosa, intestinal epithelial cells, dietary fiber fermentation, colonic inflammation, colorectal carcinogenesis, intestinal barrier, oxidative stress, satiety, NF-κB inhibition, histone deacetylation
- MeSH terms
- Animals, Butyrates, Child, Preschool, Colon, Colonic Neoplasms, Dietary Fiber, Enema, Fatty Acids, Volatile, Humans, Infant, Newborn, Inflammation, Intestinal Mucosa, Rabbits, Satiation, Oxidative Stress, Carbohydrate Metabolism, Rats
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