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Cited by 113Gastrointestinal motility and disordersFood Allergy and Anaphylaxis ResearchCeliac Disease Research and Management

Alterations of food antigen‐specific serum immunoglobulins G and E antibodies in patients with irritable bowel syndrome and functional dyspepsia

Zuo, X. L., Li, Y. Q., Li, W. J., Guo, Y. T., Lu, X. F., Li, J. M., Desmond, P. V.·2007·Clinical & Experimental Allergy
DOI 10.1111/j.1365-2222.2007.02727.x
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Abstract

Summary: Background Post‐prandial worsening of symptoms as well as adverse reactions to one or more foods are common in the patients with functional gastrointestinal diseases, such as irritable bowel syndrome (IBS) and functional dyspepsia (FD). However, the role played by true food allergy in the pathogenesis of these diseases is still controversial and there are no well‐established tests to identify food allergy in this condition. Objective To investigate serum food antigen‐specific IgG, IgE antibody and total IgE antibody titres in controls and patients with IBS and FD, and to correlate symptoms with the food antigen‐specific IgG titres in IBS and FD patients. Methods Thirty‐seven IBS patients, 28 FD patients and 20 healthy controls participated in this study. Serum IgG and IgE antibody titres to 14 common foods including beef, chicken, codfish, corn, crab, eggs, mushroom, milk, pork, rice, shrimp, soybean, tomatoes and wheat were analysed by ELISA. Serum total IgE titres were also measured. Last, symptomatology was assessed in the study. Results IBS patients had significantly higher titres of IgG antibody to crab (P=0.000), egg (P=0.000), shrimp (P=0.000), soybean (P=0.017) and wheat (P=0.004) than controls. FD patients had significantly higher titres of IgG antibody to egg (P=0.000) and soybean (P=0.017) than controls. The percentage of individuals with detectable positive food antigen‐specific IgE antibodies of the three groups did not show any significant differences (P=0.971). There were no significant differences between IBS patients, FD patients and controls in the serum total IgE antibody titres (P=0.978). Lastly, no significant correlation was seen between symptom severity and serum food antigen‐specific IgG antibody titres both in IBS and FD patients. Conclusion Serum IgG antibody titres to some common foods increased in IBS and FD patients compared to controls. But there is no significant correlation between symptom severity and elevated serum food antigen‐specific IgG antibodies in these patients.

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Crossref · 10.1111/j.1365-2222.2007.02727.x

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  • Several studies have documented IgG-mediated food hypersensitivity and demonstrated that food-elimination diets based on IgG antibodies to specific food items improved IBS symptoms.

    “However, several studies have documented IgG-mediated food hypersensitivity and demonstrated that food-elimination diets based on IgG antibodies to specific food items improved IBS symptoms (4, 195, 196), perhaps through amelioration of the immune response.”

    From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [196]

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Authors
Zuo, X. L., Li, Y. Q., Li, W. J., Guo, Y. T., Lu, X. F., Li, J. M., & Desmond, P. V.
Affiliations
  • Shandong University (CN)
  • St Vincent's Hospital Melbourne (AU)
Corresponding author
  • Li, Y. Q.
  • Li, J. M.
ORCID
Venue
Clinical & Experimental Allergy
Publisher
Wiley
Published
2007-05-17
Volume
37
Issue
6
Pages
823-830
ISSN
  • 0954-7894 (ISSN-L)
  • 1365-2222
DOI
10.1111/j.1365-2222.2007.02727.x
OpenAlex
W1986358628
Cited by
113
References
44
Citations by year
2026: 2 · 2025: 7 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 7 · 2020: 4 · 2019: 5 · 2018: 10 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 12 · 2013: 11 · 2012: 6
FWCI
8.70
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical & Experimental Allergy (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China
  • Natural Science Foundation of Shandong Province
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
Keywords
irritable bowel syndrome, functional dyspepsia, food allergy, total IgE, serum antibody titres, symptom severity, crabs, eggs, soybean, wheat
MeSH terms
Adult, Antibody Specificity, Antigens, Dyspepsia, Female, Food Hypersensitivity, Humans, Immunoglobulin E, Immunoglobulin G, Male, Severity of Illness Index, Irritable Bowel Syndrome

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